Abstract:
:Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445 CNVs. The SNPs, INDELs, and CNVs were similarly distributed throughout the genome, and highly variable regions were shown to contain the BoLA family and GPR180, which are related to adaptive immunity. We also identified the domestication footprints of the Hanwoo population by searching for selective sweep signatures, which revealed the RCN2 gene related to BPV resistance. The results of this study may contribute to genetic improvement of the Hanwoo population in Korea.
journal_name
BMB Repjournal_title
BMB reportsauthors
Lee T,Cho S,Seo KS,Chang J,Kim H,Yoon Ddoi
10.5483/bmbrep.2013.46.7.211subject
Has Abstractpub_date
2013-07-01 00:00:00pages
346-51issue
7eissn
1976-6696issn
1976-670Xjournal_volume
46pub_type
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