Abstract:
BACKGROUND:Executive functions have been proposed as endophenotypes for attention deficit hyperactivity disorder (ADHD); however, data regarding visual memory are lacking. We therefore assessed visual memory in adolescents with ADHD and their unaffected siblings compared with controls. METHOD:The participants included 279 adolescents with ADHD, 108 unaffected siblings, and 173 unaffected school controls. They were assessed by using the visual memory tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB): Delayed Matching to Sample (DMS), Spatial Recognition Memory (SRM), Paired Associates Learning (PAL), and Pattern Recognition Memory (PRM). RESULTS:Compared with the controls, probands with ADHD had a significantly lower number of correct responses, a higher probability of an error following a correct response and following an error response in the DMS, and a lower percentage of correct responses in the SRM. Their unaffected siblings occupied an intermediate position between ADHD probands and controls in the probability of an error following a correct response and following an error response in the DMS, and in the percentage of correct responses in the SRM. In general, lower IQ and current use of and duration of treatment with methylphenidate were associated with more severe visual memory deficits. CONCLUSIONS:The present results suggest that ADHD is associated with poorer visual memory function. Visual memory assessed by the DMS and SRM tasks in the CANTAB may be a useful endophenotype for ADHD.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Shang CY,Gau SSdoi
10.1017/S0033291711000857subject
Has Abstractpub_date
2011-12-01 00:00:00pages
2603-14issue
12eissn
0033-2917issn
1469-8978pii
S0033291711000857journal_volume
41pub_type
杂志文章abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that profoundly affects quality of life. Although mounting evidence now suggests uncontrolled mind-wandering as a core aspect of the attentional problems associated with ADHD, the neural mechanisms underpinning this deficit remains ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003598
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Patients with anorexia nervosa (AN) run a high risk of becoming chronically ill and of dying. In the acute phase of their illness they present with numerous physical and laboratory abnormalities. However, little is known about the long-term prognostic value of these findings or about the medical morbidity in...
journal_title:Psychological medicine
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doi:10.1017/s0033291796004394
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Depressed individuals demonstrate a poorer ability to recognize the emotions of others, which could contribute to difficulties in interpersonal behaviour. This emotion recognition deficit appears related to the depressive state and is particularly pronounced when emotions are labelled semantically. Here, we ...
journal_title:Psychological medicine
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doi:10.1017/S0033291710002084
更新日期:2011-07-01 00:00:00
abstract::The authors review the evidence that parental death in childhood predisposes to depressive disorders in later life. The findings in general are quite inconsistent; this is due in part to the methodological limitations of most studies, principally that of inadequate control of potentially confounding variables. Where e...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700044044
更新日期:1980-05-01 00:00:00
abstract::The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...
journal_title:Psychological medicine
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doi:10.1017/s0033291700034838
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:A growing body of neuropsychological and neurobiological research shows a relationship between functioning of the prefrontal cortex and criminal and violent behaviour. The prefrontal cortex is crucial for executive functions such as inhibition, attention, working memory, set-shifting and planning. A deficit ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000241
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Executive dysfunction, distinct from other cognitive deficits in depression, has been associated with suicidal behavior. However, this dysfunction is not found consistently across samples. METHOD:Medication-free subjects with DSM-IV major depressive episode (major depressive disorder and bipolar type I diso...
journal_title:Psychological medicine
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doi:10.1017/S0033291712001419
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Sleep disruption is a common precursor to deterioration and relapse in people living with psychotic disorders. Understanding the temporal relationship between sleep and psychopathology is important for identifying and developing interventions which target key variables that contribute to relapse. METHODS:We...
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doi:10.1017/S0033291720004857
更新日期:2021-01-12 00:00:00
abstract::One hundred and sixteen working-class housewives, part-time and full-time employees were compared on a range of well-being measures in three different lifestages. A group of factory employees was contrasted with a 'mixed occupation' group for a comparison of type of employment. The general contention that the associat...
journal_title:Psychological medicine
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doi:10.1017/s0033291700034978
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Patients may present with cognitive impairment in the euthymic phase of affective disorder, but it is unclear whether the impairment is prevalent before onset of the illness. The aim of the present study was to examine the hypothesis that genetic liability to affective disorder is associated with cognitive i...
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doi:10.1017/S0033291706007896
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and...
journal_title:Psychological medicine
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doi:10.1017/S003329172000389X
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) develops in a minority of traumatized individuals. Attention biases to threat and abnormalities in fear learning and extinction are processes likely to play a critical role in the creation and/or maintenance of PTSD symptomatology. However, the relationship between these...
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doi:10.1017/S0033291711001565
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Learning and memory impairments in older adults with depression are linked to hippocampal atrophy. However, other subcortical regions may also be contributing to these deficits. We aimed to examine whether anterior caudate nucleus volume is significantly reduced in older adults with depression compared to co...
journal_title:Psychological medicine
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doi:10.1017/S0033291716000787
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Little is known about the association of eating disorder subtypes across multiple categories of substance use in population-based samples. We examined the association between eating disorders and substance use in a large population-based sample. METHOD:Female participants (n=13 297) were from the Swedish Tw...
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doi:10.1017/S0033291709005662
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:We report on the epidemiology of post-traumatic stress disorder (PTSD) in the Australian community, including information on lifetime exposure to trauma, 12-month prevalence of PTSD, sociodemographic correlates and co-morbidity. METHODS:Data were obtained from a stratified sample of 10,641 participants as p...
journal_title:Psychological medicine
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doi:10.1017/s0033291701004287
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Restrictive food intake in anorexia nervosa (AN) has been related to an overactive cognitive control network inhibiting intuitive motivational responses to food stimuli. However, the influence of short-term homeostatic signaling on the neural regulation of cue-induced food craving in AN is still unclear. ME...
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doi:10.1017/S0033291719003970
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:Previous studies suggest that offspring of mothers with psychotic disorders have an almost two-fold higher mortality risk from birth until early adulthood. We investigated predictors of mortality from late adolescence until middle age in offspring of mothers with psychotic disorders. METHOD:The Helsinki Hig...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707002383
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:This study examined two competing hypotheses concerning the association between diabetes and treatment for depression: (1) the detection/ascertainment bias hypothesis suggesting that those with diabetes are more likely to be diagnosed with and treated for depression because of increased medical attention and...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001566
更新日期:2014-04-01 00:00:00
abstract::Age and sex-adjusted first admission rates for operationally-defined schizophrenia and other non-affective psychosis in different ethnic groups were calculated over the period 1988-1992 in a defined catchment area in South London. Standardized rates for schizophrenia, corrected for age- and gender-related under-report...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700033845
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...
journal_title:Psychological medicine
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doi:10.1017/s0033291703007475
更新日期:2003-05-01 00:00:00
abstract::Major depressive disorder (MDD) is a mental illness with high socio-economic burden, but its pathophysiology has not been fully elucidated. Recently, the cortical excitatory and inhibitory imbalance hypothesis and neuroplasticity hypothesis have been proposed for MDD. Although several studies have examined the neuroph...
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doi:10.1017/S0033291720004729
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:There are no evidence-based treatments for severe and enduring anorexia nervosa (SE-AN). This study evaluated the relative efficacy of cognitive behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM) for adults with SE-AN. METHOD:Sixty-three participants with a diagnosis of AN, who...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The past two decades have seen exponential clinical and research interest in help-seeking individuals presenting with potentially prodromal symptoms for psychosis. However, the epidemiological validity of this paradigm has been neglected, limiting future advancements in the field. METHOD:We undertook a crit...
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pub_type: 杂志文章,评审
doi:10.1017/S0033291713000184
更新日期:2014-01-01 00:00:00
abstract::Couples in whom the main complaint was of a lack of female sexual response were treated using a practical counselling approach. A number of pre-treatment measures were studied to determine which factors were predictive of treatment outcome. While age and chronicity were not predictive, the quality of the general relat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170000920x
更新日期:1986-05-01 00:00:00
abstract::Sixty-four children taken to court for failure to attend school were reliably classified into 4 groups, according to whether they exhibited the features of 'school refusal' and/or 'truancy'. About a fifth of them were found to exhibit 'school refusal'; a third showed 'truancy'; less than a sixth exhibited both 'school...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700021024
更新日期:1985-02-01 00:00:00
abstract::We have attempted to clarify clinical differentiating features of psychotic depression. Forty-six depressed subjects meeting DSM-III-R criteria for major depression with psychotic features were compared with (i) DSM-defined melancholic, (ii) Newcastle-defined endogenous, and (iii) a residual DSM-defined major depressi...
journal_title:Psychological medicine
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doi:10.1017/s0033291700035078
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Psychosocial and inflammatory factors have been associated with fatigue in breast cancer survivors. Nevertheless, the relative contribution and/or interaction of these factors with cancer-related fatigue have not been well documented. METHOD:This cross-sectional study enrolled 111 stage 0-III breast cancer ...
journal_title:Psychological medicine
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doi:10.1017/S0033291717000150
更新日期:2017-07-01 00:00:00
abstract::Comparison between general practice attenders and community subjects with emotional distress (as measured by GHQ-12) showed that women from a general practice sample reported more social problems than those from the community. In both men and women, problems with their spouse or partner were far more likely among gene...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700028063
更新日期:1995-01-01 00:00:00
abstract::Information regarding the physical and mental health of clients referred to social workers in a local authority intake team and to a general practice attachment scheme was collected over a 3-month period. Although returns to the Department of Health and Social Security during this period indicated that a very low prop...
journal_title:Psychological medicine
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doi:10.1017/s0033291700032153
更新日期:1979-08-01 00:00:00
abstract::This study examined the relationship between personality factors and depression in subjects who may have a familial vulnerability to depression (i.e. first-degree relatives of depressed patients). Four groups comprised our study sample: relatives who had never experienced a psychiatric episode of depression; relatives...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700013052
更新日期:1987-02-01 00:00:00