Abstract:
:The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by magnetic resonance imaging (MRI). Significantly higher incidence of Grade 3-4 CSP (moderate to large) compared with the controls was found only in the schizophrenics. When a broader interpretation of CSP, including indeterminant (Grade 1) and small (Grade 2) CSP was used, three additional patients with bipolar disorder were found to have Grade 1-2 CSP, and the total prevalence of Grade 1-4 CSP in the patients with bipolar disorder was significantly higher than that in the control subjects but slightly lower than that in the schizophrenic patients. CSP was not observed in any patient with major depression. There were no differences between the patients with and without CSP in age, sex, education, or the duration of illness. These findings are consistent with the hypothesis that neurodevelopmental abnormality may be present in schizophrenia, and such an abnormality may also be present in some patients with bipolar disorder.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Shioiri T,Oshitani Y,Kato T,Murashita J,Hamakawa H,Inubushi T,Nagata T,Takahashi Sdoi
10.1017/s0033291700034838subject
Has Abstractpub_date
1996-03-01 00:00:00pages
431-4issue
2eissn
0033-2917issn
1469-8978journal_volume
26pub_type
杂志文章abstract::There have been numerous exhortations for more 'translational research'. A selective review of historical examples of research leading to health benefits is used to consider the various forms of successful interplay between basic science and clinical applications. This is followed by a consideration of key neuroscienc...
journal_title:Psychological medicine
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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更新日期:1997-07-01 00:00:00
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pub_type: 传,历史文章,杂志文章,meta分析
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更新日期:1993-11-01 00:00:00
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doi:10.1017/s0033291700014811
更新日期:1991-02-01 00:00:00
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更新日期:1977-05-01 00:00:00
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更新日期:2005-10-01 00:00:00
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更新日期:2006-05-01 00:00:00
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更新日期:2004-05-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2009-10-01 00:00:00
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更新日期:2015-10-01 00:00:00