Abstract：
BACKGROUND:Learning and memory impairments in older adults with depression are linked to hippocampal atrophy. However, other subcortical regions may also be contributing to these deficits. We aimed to examine whether anterior caudate nucleus volume is significantly reduced in older adults with depression compared to controls; whether anterior caudate volume is associated with performance on tasks of episodic learning and memory, and if so, whether this association is independent of the effects of the hippocampus. METHOD:Eighty-four health-seeking participants meeting criteria for lifetime major depressive disorder (mean age = 64.2, s.d. = 9.1 years) and 27 never-depressed control participants (mean age = 63.9, s.d. = 8.0 years) underwent neuropsychological assessment including verbal episodic memory tests [Rey Auditory Verbal Learning Test and Logical Memory (WMS-III)]. Magnetic resonance imaging was conducted, from which subregions of the caudate nucleus were manually demarcated bilaterally and hippocampal volume was calculated using semi-automated methods. RESULTS:Depressed subjects had smaller right anterior caudate (RAC) (t = 2.3, p = 0.026) and poorer memory compared to controls (t = 2.5, p < 0.001). For depressed subjects only, smaller RAC was associated with poorer verbal memory (r = 0.3, p = 0.003) and older age (r = -0.46, p < 0.001). Multivariable regression showed that the RAC and hippocampus volume uniquely accounted for 5% and 3% of the variance in memory, respectively (β = 0.25, t = 2.16, p = 0.033; β = 0.19, t = 1.71, p = 0.091). CONCLUSIONS:In older people with depression, the anterior caudate nucleus and the hippocampus play independent roles in mediating memory. While future studies examining this structure should include larger sample sizes and adjust for multiple comparisons, these findings support the critical role of the striatum in depression.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Jayaweera HK,Hickie IB,Duffy SL,Mowszowski L,Norrie L,Lagopoulos J,Naismith SLdoi
10.1017/S0033291716000787subject
Has Abstractpub_date
2016-07-01 00:00:00pages
2189-99issue
10eissn
0033-2917issn
1469-8978pii
S0033291716000787journal_volume
46pub_type
杂志文章abstract：:Monthly hospital admission rates (HA) for mania were classified by sex, type of admission (first, or re-admission) and by country (England and Wales or Scotland). Of the 8 classes thus created, all but one showed a statistically significant annual cycle with a peak in Summer and trough in Winter. There was no signific...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s003329170001610x
更新日期：1978-08-01 00:00:00
abstract：:In the face of shifting demographics and an increase in human longevity, it is important to examine carefully what is known about cognitive ageing, and to identify and promote possibly malleable lifestyle and health-related factors that might mitigate age-associated cognitive decline. The Lothian Birth Cohorts of 1921...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291717001489
更新日期：2018-01-01 00:00:00
abstract：:A non-recursive structural equation model designed to examine the reciprocal relationship between life event reports and depressive symptoms in women is presented. The model was fitted to data from a 2-year longitudinal study of life events and depression in a sample of women with 5-year-old children. The findings sug...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s003329170001984x
更新日期：1984-11-01 00:00:00
abstract：BACKGROUND:Sternberg's Memory Scanning Test (MST) is a useful paradigm for evaluating the speed and efficiency of information processing in working memory. Unfortunately, the classical MST has major drawbacks for use in applied settings such as the clinic. For example, its administration time is long and the test is to...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291707000360
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standard treatment. Results from previous studies comparing the cost-effectiveness of this technique with treatment alternatives such as repetitive transcranial magnetic stimulation (rTMS) are conflicting. METHOD:We co...
journal_title：Psychological medicine
pub_type： 杂志文章,meta分析
doi：10.1017/S0033291714002554
更新日期：2015-05-01 00:00:00
abstract：:The authors review the evidence that parental death in childhood predisposes to depressive disorders in later life. The findings in general are quite inconsistent; this is due in part to the methodological limitations of most studies, principally that of inadequate control of potentially confounding variables. Where e...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700044044
更新日期：1980-05-01 00:00:00
abstract：:This study investigates the basis of individual variation in exposure to stressful life events (SLEs). A population based sample of 547 MZ and 390 DZ female-female twin pairs, aged between 17 and 55 years, were surveyed by two structured interviews, separated by at least 1 year, that enquired about SLEs experienced du...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700035960
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:Research on the structure of co-morbidity among common mental disorders has largely focused on current prevalence rather than on the development of co-morbidity. This report presents preliminary results of the latter type of analysis based on the US National Comorbidity Survey Replication Adolescent Suppleme...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291712000025
更新日期：2012-09-01 00:00:00
abstract：:Data from a case-control study of Alzheimer's disease (AD) were analysed in relation to age of onset and familial/sporadic status. The analyses were restricted to environmental exposures which might injure the brain. Later-onset AD was found to be positively associated with starvation/malnutrition and with nose-pickin...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700030373
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Geographic variations in the incidence of deliberate self-harm (DSH) and suicide have been shown to be associated with area-based measures of socio-economic deprivation and social fragmentation. Previous studies have been subject to methodological limitations. None has investigated whether ecological associa...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291701003993
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Virtual reality (VR) may enhance the effectiveness of psychological interventions for acute pain. We conducted a meta-analysis to assess the efficacy and safety of VR-based interventions for pain associated with medical procedures. METHODS:We searched PubMed, EMBASE, the Cochrane Library, and PsycINFO until...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291719001855
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Transdiagnostic group cognitive-behavioral therapy (tCBT) is a delivery model that could help overcome barriers to large-scale implementation of evidence-based psychotherapy for anxiety disorders. The aim of this study was to assess the effectiveness of combining group tCBT with treatment-as-usual (TAU), com...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291720004316
更新日期：2020-12-02 00:00:00
abstract：:The validity and reliability of an empirically defined fatigue syndrome were tested in a prospective cohort study of 245 primary care patients, with glandular fever or an upper respiratory tract infection. Subjects were interviewed three times in the 6 months after onset. Subjects with the empirically defined fatigue ...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700037405
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:The coronavirus [coronavirus disease 2019 (COVID-19)] pandemic has introduced extraordinary life changes and stress, particularly in adolescents and young adults. Initial reports suggest that depression and anxiety are elevated during COVID-19, but no prior study has explored changes at the within-person lev...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291720005358
更新日期：2021-01-13 00:00:00
abstract：BACKGROUND:This study examined healthcare services used by adults diagnosed with an eating disorder (ED) in a large health maintenance organization in the Pacific Northwest. METHOD:Electronic medical records were used to collect information on all out-patient and in-patient visits and medication dispenses, from 2002 t...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291707001833
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:This study aimed to determine whether depression in patients with long-term conditions is associated with the number of morbidities or the type of co-morbidity. Method A cohort study of 299 912 participants aged 30-100 years. The prevalence of depression, rates of health-care utilization and costs were evalu...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291712002498
更新日期：2013-07-01 00:00:00
abstract：:The expressed emotion (EE) measure is a robust predictor of relapse in schizophrenia. At least twelve studies from a range of cultures have now shown this, although the authors of one maintain their findings are the result of confounding factors. A thirteenth study which failed to demonstrate a predictive effect was s...
journal_title：Psychological medicine
pub_type： 杂志文章,评审
doi：10.1017/s0033291700009831
更新日期：1988-11-01 00:00:00
abstract：:The examination of moment-to-moment, 'micro-level' patterns of experience and behaviour using experience sampling methodology has contributed to our understanding of the 'macro-level' development of full-blown symptoms and disorders. This paper argues that the micro-level perspective can be used to identify the smalle...
journal_title：Psychological medicine
pub_type： 杂志文章,评审
doi：10.1017/S0033291713001979
更新日期：2014-05-01 00:00:00
abstract：:Recent research on unemployment and health has depended heavily on macro-social and ecological data analyses. In order to redress this imbalance, the report summarizes the methods and results of a prospective study of a permanent factory shutdown, thereby illustrating and dissecting some of the strengths and weaknesse...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700055744
更新日期：1982-08-01 00:00:00
abstract：BACKGROUND:Death by suicide is often preceded by attempted suicide, suicidal ideation and non-suicidal self-injury. These extreme thoughts and behaviours have been considered in terms of a continuum of suicidality. Little known research, however, has considered a suicide continuum that extends beyond these extreme thou...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291718003562
更新日期：2019-11-01 00:00:00
abstract：:In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700023163
更新日期：1977-02-01 00:00:00
abstract：BACKGROUND:Public figures are at increased risk of attracting unwanted attention in the form of intrusions, stalking and, occasionally, attack. Whereas the potential threat to the British Royal Family from terrorists and organized groups is clearly defined, there is a dearth of knowledge about that from individual hara...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291709005443
更新日期：2009-09-01 00:00:00
abstract：:A number of computerized tests were used to study visual attention, memory and learning in elderly depressed patients. Impairment was found in approximately 70% of depressed patients and was seen particularly in memory and in measures of latency. Depressed patients showed equivalent impairment in short-term memory but...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700017025
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:A dysfunctional network of prefrontal and (para-)limbic brain region has been suggested to underlie emotional dysregulation in borderline personality disorder (BPD). Abnormal activity in this network may be due to structural alterations in white-matter tracts connecting prefrontal and (para-)limbic brain reg...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291715001142
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Parental characteristics and practices predict borderline personality disorder (BPD) symptoms in children. However, it is difficult to disentangle whether these effects are genetically or environmentally mediated. The present study examines the contributions of genetic and environmental influences by compari...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291719001260
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Stress and vulnerability likely interact to play a major role in psychosis. While much has been written about the neural diathesis-stress model in psychosis and its clinical risk states, little is known about HPA axis biomarkers in non-help-seeking individuals at familial high risk (FHR). We sought to prospe...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S003329171500077X
更新日期：2015-10-01 00:00:00
abstract：:Long-stay patients who were discharged from Friern and Claybury hospitals during the 6-year period between September 1985 and August 1991 were followed up for at least 1 year and the details of all readmissions were recorded. Of the 615 hospital leavers, some 178 (29%) were readmitted at some time during the follow-up...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700035595
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:The methodology for measuring the needs of patients with severe mental illness is now well established through the MRC Needs for Care Assessment Schedule and its modification in the form of the Cardinal Needs Assessment. This paper reports the rationale and construction of a relatives' version of the Cardina...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s003329179800662x
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:Psychiatric disorders are common following traumatic brain injury (TBI). However, few studies have examined the course of disorder development and the influence of pre-injury psychiatric history. The present study aimed to examine the frequency of, and association between, psychiatric disorders occurring pre...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S003329171100033X
更新日期：2011-10-01 00:00:00
abstract：:The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700034838
更新日期：1996-03-01 00:00:00
