Abstract:
:The examination of moment-to-moment, 'micro-level' patterns of experience and behaviour using experience sampling methodology has contributed to our understanding of the 'macro-level' development of full-blown symptoms and disorders. This paper argues that the micro-level perspective can be used to identify the smallest building blocks underlying the onset and course of mental ill-health. Psychopathology may be the result of the continuous dynamic interplay between micro-level moment-to-moment experiences and behavioural patterns over time. Reinforcing loops between momentary states may alter the course of mental health towards either a more or less healthy state. An example with observed data, from a population of individuals with depressive symptoms, supports the validity of a dynamic network model of psychopathology and shows that together and over time, this continuous interplay between momentary states may result in the cluster of symptoms we call major depressive disorder. This approach may help conceptualize the nature of mental disorders, and generate individualized insights useful for diagnosis and treatment in psychiatry.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Wichers Mdoi
10.1017/S0033291713001979subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1349-60issue
7eissn
0033-2917issn
1469-8978pii
S0033291713001979journal_volume
44pub_type
杂志文章,评审abstract:BACKGROUND:Individual variation in the clinical course of bipolar disorder may have prognostic and therapeutic implications but is poorly reflected in current classifications. We aimed to establish a typology of the individual clinical trajectories based on detailed prospective medium-term follow-up. Method Latent clas...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001523
更新日期:2013-04-01 00:00:00
abstract::The notion that psychotic symptoms lie on a continuum with normality has become an accepted dogma. It is supported by several lines of empirical evidence, fits in with the orientation of modern services and has a 'moral' appeal. However, there is confusion as to the nature of the continuum or continua under discussion...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000188
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Research exploring the longitudinal course of posttraumatic stress disorder (PTSD) symptoms has documented four modal trajectories (low, remitting, high, and delayed), with proportions varying across studies. Heterogeneity could be due to differences in trauma types and patient demographic characteristics. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719004008
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Different versions of the General Health Questionnaire (GHQ), including the GHQ-12 and GHQ-28 have been subjected to factor analysis in a variety of countries. The World Health Organization study of psychological disorders in general health care offered the opportunity to investigate the factor structure of ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291799002287
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:The diagnosis of bipolar disorder in pre-pubertal populations remains difficult and often controversial. Consequently, the clinical and neuropsychological characteristics of mania in the child and adolescent years remain poorly defined. This review provides a clinical account of childhood and adolescent bipo...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291706007446
更新日期:2006-09-01 00:00:00
abstract::To isolate determinants of any female preponderance in depressive disorder, we earlier selected a sample of young adults, then similar in terms of several potential social determinants of depression and with equivalent rates of lifetime depression. We now report a 10-year review, which initially suggested a female pre...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700026878
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Subjects at 'ultra high risk' (UHR) for developing psychosis have differences in white matter (WM) compared with healthy controls. WM integrity has not yet been investigated in UHR subjects in relation to the development of subsequent psychosis. Hence, we investigated a prospective cohort of UHR subjects com...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991711
更新日期:2010-08-01 00:00:00
abstract::In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700023163
更新日期:1977-02-01 00:00:00
abstract::The Geriatric Mental State and a new computerized diagnostic system, AGECAT, are briefly described. A nomenclature for designating cases for epidemiological work is introduced. Concordance between AGECAT and psychiatrists' diagnoses for these studies, hospital and community based (total of 541 subjects), achieved over...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700057779
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:In other branches of epidemiology, stratum specific likelihood ratios (SSLRs) have been found to be preferable to fixed best threshold approaches to screening instruments. This paper presents SSLRs of GHQ-12 and GHQ-28 and compares the SSLR method with the traditional optimal threshold approach. METHODS:Ran...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1017/s0033291701003713
更新日期:2001-04-01 00:00:00
abstract::The tests that have been used to assess glomerular and tubular function in patients receiving treatment with lithium have been reviewed. The advantages and disadvantages of these are discussed. The most useful tests are the creatinine clearance, which may be predicted from the serum creatinine using a formula or nomog...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Bipolar disorder I (BD-I) is defined by episodes of mania, depression and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood. METHODS:We...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000801
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Although cannabis is the most widely used illicit drug in the United States, few recent American studies have examined the attributes of long-term heavy cannabis users. METHOD:Using a case-control design, we obtained psychological and demographic measures on 108 individuals, age 30-55, who had smoked cannab...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008560
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:An uneven neurocognitive profile is a hallmark of autism spectrum disorder (ASD). Studies focusing on the visual memory performance in ASD have shown controversial results. We investigated visual memory and sustained attention in youths with ASD and typically developing (TD) youths. METHOD:We recruited 143 ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714003201
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Although the traditional view of bipolar affective disorder is that the majority of patients have full remission between episodes, recent evidence suggests that residual cognitive deficits are present. The aim of this study was to determine whether memory and executive deficits were present in a well-defined...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002664
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002039
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Almost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-ana...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291716001562
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003555
更新日期:2018-09-01 00:00:00
abstract::The age of onset in bipolar affective disorder was determined in 200 hospitalized patients. The mean age of their first affective syndrome was 28.3 years, and the mean age of first hospitalization was 30.8 years. However, the median age for first affective syndrome was 23 years (26 years for first hospitalization), an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700003147
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:Non-clinical psychosis-like symptoms (PLIKS) occur in about 15% of the population. It is not clear whether adverse events during early development alter the risk of developing PLIKS. We aimed to examine whether maternal infection, diabetes or pre-eclampsia during pregnancy, gestational age, perinatal cardiop...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708005126
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Decreased white matter (WM) integrity in patients with psychotic disorder has been a consistent finding in diffusion tensor imaging (DTI) studies. However, the contribution of environmental risk factors to these WM alterations is rarely investigated. The current study examines whether individuals with (incre...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291718001320
更新日期:2019-03-01 00:00:00
abstract::The present study examined sensitivity to noise in subjects with Type A and Type B behaviour patterns as a function of the type of task being performed. Twenty Type A and 20 Type B subjects, selected by means of Bortner's scale (French version), were exposed to steadily increasing noise levels (68-110 dBA) while perfo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700015245
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Working memory (WM) deficits in schizophrenia (SCZ) have been linked to impairments in the encoding phase that are associated with aberrant neuronal functioning. Similar abnormalities have been observed in unaffected first-degree relatives (REL) and are thus discussed as candidate endophenotypes. The process...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171800051X
更新日期:2019-01-01 00:00:00
abstract::In the face of shifting demographics and an increase in human longevity, it is important to examine carefully what is known about cognitive ageing, and to identify and promote possibly malleable lifestyle and health-related factors that might mitigate age-associated cognitive decline. The Lothian Birth Cohorts of 1921...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717001489
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Although numerous studies have examined the latent structure of major depression, less attention has focused on mania. This paper presents the first investigation outside the USA to evaluate the psychometric properties of the DSM-IV criterion B mania symptoms using item response theory (IRT). METHOD:Data we...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000980
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Accumulating evidence links blood pressure variability (BPV) with white matter hyperintensities (WMH) and stroke. The longitudinal association between BPV with late onset depression (LOD) and cognitive decline remains unexplored. METHODS:Prospective cohort study of 2812 participant's age ⩾65 years (median a...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002756
更新日期:2018-07-01 00:00:00
abstract::Serum total androgens were estimated by radioimmunoassay on blood samples of treatment-seeking homosexuals and heterosexual controls. There was no significant difference in androgen levels between the homosexual and control group, nor was there any relationship between androgen levels and response to treatment. These ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700004396
更新日期:1977-08-01 00:00:00
abstract::This paper describes a modified version of the MRC Needs for Care Schedule (the Cardinal Needs Schedule), for measuring needs for psychiatric and social care amongst patients with severe psychiatric disorders. The modified schedule has three new features: (i) it is quick and easy to use; (ii) it takes systematic accou...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700033511
更新日期:1995-05-01 00:00:00
abstract::The CANTAB battery of neuropsychological tests was used to compare the performance of 28 patients with unipolar depression with that of 22 age and IQ matched controls. The patients were impaired on almost all tests studied with deficits in pattern and spatial recognition memory, matching to sample, spatial span, spati...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035303
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Oral contraceptive use has been previously associated with an increased risk of suicidal behavior in some, but not all, samples. The use of large, representative, longitudinally-assessed samples may clarify the nature of this potential association. METHODS:We used Swedish national registries to identify wom...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003475
更新日期:2020-10-21 00:00:00