The dynamic nature of depression: a new micro-level perspective of mental disorder that meets current challenges.


:The examination of moment-to-moment, 'micro-level' patterns of experience and behaviour using experience sampling methodology has contributed to our understanding of the 'macro-level' development of full-blown symptoms and disorders. This paper argues that the micro-level perspective can be used to identify the smallest building blocks underlying the onset and course of mental ill-health. Psychopathology may be the result of the continuous dynamic interplay between micro-level moment-to-moment experiences and behavioural patterns over time. Reinforcing loops between momentary states may alter the course of mental health towards either a more or less healthy state. An example with observed data, from a population of individuals with depressive symptoms, supports the validity of a dynamic network model of psychopathology and shows that together and over time, this continuous interplay between momentary states may result in the cluster of symptoms we call major depressive disorder. This approach may help conceptualize the nature of mental disorders, and generate individualized insights useful for diagnosis and treatment in psychiatry.


Psychol Med


Psychological medicine


Wichers M




Has Abstract


2014-05-01 00:00:00














  • Tolerance of suicide, religion and suicide rates: an ecological and individual study in 19 Western countries.

    abstract:BACKGROUND:Negative associations between religion and suicide, in individuals and countries, may be mediated by the degree to which suicide is tolerated. METHODS:Linear regression was used to examine ecological associations between suicide tolerance, religion and suicide rates in 19 Western countries in 1989/90. Logis...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Neeleman J,Halpern D,Leon D,Lewis G

    更新日期:1997-09-01 00:00:00

  • Cost-effectiveness of electroconvulsive therapy compared to repetitive transcranial magnetic stimulation for treatment-resistant severe depression: a decision model.

    abstract:BACKGROUND:Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standard treatment. Results from previous studies comparing the cost-effectiveness of this technique with treatment alternatives such as repetitive transcranial magnetic stimulation (rTMS) are conflicting. METHOD:We co...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析


    authors: Vallejo-Torres L,Castilla I,González N,Hunter R,Serrano-Pérez P,Perestelo-Pérez L

    更新日期:2015-05-01 00:00:00

  • Suicides and suicide attempts in cancer patients.

    abstract::Suicides and suicide attempts in cancer patients were analysed by following all patients treated for cancer in Stockholm County from 1975 to 1985. Among 59,845 patients we identified 144 suicides and 196 suicide attempts during the follow-up, which represents a more than two-fold excess mortality from suicide and a mo...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Allebeck P,Bolund C

    更新日期:1991-11-01 00:00:00

  • Sensitivity to noise in a community sample: II. Measurement of psychophysiological indices.

    abstract::A sample of 77 women of high and low noise sensitivity in 1977, living in areas of high and low exposure to aircraft noise, were interviewed in the community in 1980. High, intermediate and low noise sensitive women were compared, using measures of blood pressure, heart rate, skin conductance, hearing threshold, uncom...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Stansfeld SA,Clark CR,Turpin G,Jenkins LM,Tarnopolsky A

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  • Factors predisposing to suspected offending by adults with self-reported learning disabilities.

    abstract:BACKGROUND:This study investigated factors contributing to suspected offending behaviour by adults with a history of learning disabilities taken into custody at a city police station. METHODS:Adults charged with offences, and/or leaving custody, during a defined period, were identified as having a possible learning di...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Winter N,Holland AJ,Collins S

    更新日期:1997-05-01 00:00:00

  • Trauma, time and mental health: a study of temporal reintegration and Depressive Disorder among Southeast Asian refugees.

    abstract:BACKGROUND:Prior research suggested that time splitting--suppressing the past and dissociating it from present and future--protected refugee mental health in the aftermath of catastrophe. The current study investigates temporal reintegration, defined as cognitive recapture of the past and reconnecting it with present a...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Beiser M,Wickrama KA

    更新日期:2004-07-01 00:00:00

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    journal_title:Psychological medicine

    pub_type: 杂志文章


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    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Keilp JG,Gorlyn M,Russell M,Oquendo MA,Burke AK,Harkavy-Friedman J,Mann JJ

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    abstract:BACKGROUND:Recent studies have suggested that major depressive disorders are associated with a breakdown in the organization of ultradian rhythm in sleep EEG. The present study used cross-spectral analysis of sleep EEG to confirm this finding, in a larger-scale study, evaluating the influence of gender and age on ultra...

    journal_title:Psychological medicine

    pub_type: 杂志文章


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    更新日期:1999-11-01 00:00:00

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    journal_title:Psychological medicine

    pub_type: 杂志文章,评审


    authors: Berrios GE,Dening TR

    更新日期:1996-07-01 00:00:00

  • Social anxiety disorder and alcohol use disorder co-morbidity in the National Epidemiologic Survey on Alcohol and Related Conditions.

    abstract:BACKGROUND:To assess the prevalence and clinical impact of co-morbid social anxiety disorder (SAD) and alcohol use disorders (AUD, i.e. alcohol abuse and alcohol dependence) in a nationally representative sample of adults in the United States. METHOD:Data came from a large representative sample of the US population. F...

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    pub_type: 杂志文章


    authors: Schneier FR,Foose TE,Hasin DS,Heimberg RG,Liu SM,Grant BF,Blanco C

    更新日期:2010-06-01 00:00:00

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    abstract:BACKGROUND:Depressive syndromes not fulfilling the criteria for specified disorders (subthreshold depression, SD) may be clinically important. We aimed to study SD in old and very old age, in comparison with subjects with no depressive symptoms (NDS) and subjects with major depression (MD). METHODS:A community-based r...

    journal_title:Psychological medicine

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:1998-05-01 00:00:00

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    abstract:BACKGROUND:Bright light and high-density negative air ion exposure are efficacious for winter and non-seasonal depression compared with a low-density negative ion placebo. Similarly, auditory stimuli improve mood in clinical populations. This study compared the short-term effects of bright light, an auditory stimulus, ...

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    pub_type: 杂志文章,随机对照试验


    authors: Goel N,Etwaroo GR

    更新日期:2006-09-01 00:00:00

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    abstract:BACKGROUND:Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate...

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    pub_type: 杂志文章


    authors: Ferentinos P,Koukounari A,Power R,Rivera M,Uher R,Craddock N,Owen MJ,Korszun A,Jones L,Jones I,Gill M,Rice JP,Ising M,Maier W,Mors O,Rietschel M,Preisig M,Binder EB,Aitchison KJ,Mendlewicz J,Souery D,Hauser J,

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    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Cookson IB,Owen F,Ridges AP

    更新日期:1975-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Eronen MI

    更新日期:2019-09-24 00:00:00

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    pub_type: 杂志文章


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    更新日期:2018-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Fresco DM,Coles ME,Heimberg RG,Liebowitz MR,Hami S,Stein MB,Goetz D

    更新日期:2001-08-01 00:00:00

  • Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder.

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    pub_type: 杂志文章


    authors: Bremner JD,Vermetten E,Schmahl C,Vaccarino V,Vythilingam M,Afzal N,Grillon C,Charney DS

    更新日期:2005-06-01 00:00:00

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    abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) develops in a minority of traumatized individuals. Attention biases to threat and abnormalities in fear learning and extinction are processes likely to play a critical role in the creation and/or maintenance of PTSD symptomatology. However, the relationship between these...

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    pub_type: 杂志文章


    authors: Fani N,Tone EB,Phifer J,Norrholm SD,Bradley B,Ressler KJ,Kamkwalala A,Jovanovic T

    更新日期:2012-03-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1994-08-01 00:00:00

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    abstract:BACKGROUND:This experiment examines two aspects of delusional cognition that have been reported clinically but not investigated empirically. These are the incorporation of potentially conflicting information into the recall of delusion-related scripts and the type and amount of material produced additional to that pres...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Simpson J,Done DJ

    更新日期:2002-04-01 00:00:00

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    abstract:BACKGROUND:Clinical intuition suggests that personality disorders hinder the treatment of depression, but research findings are mixed. One reason for this might be the way in which current assessment measures conflate general aspects of personality disorders, such as overall severity, with specific aspects, such as sty...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Constantinou MP,Frueh BC,Fowler JC,Allen JG,Madan A,Oldham JM,Fonagy P

    更新日期:2020-10-08 00:00:00

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    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析


    authors: van Duin D,de Winter L,Oud M,Kroon H,Veling W,van Weeghel J

    更新日期:2019-07-01 00:00:00

  • Assortative mating for major psychiatric diagnoses in two population-based samples.

    abstract:BACKGROUND:Previous studies on assortment for psychiatric disorders have reported discrepant findings. We aimed to test whether there is a significant association for psychiatric diagnoses, including alcoholism, generalized anxiety disorder, major depressive disorder, panic disorder and phobias between husbands and wiv...

    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Maes HH,Neale MC,Kendler KS,Hewitt JK,Silberg JL,Foley DL,Meyer JM,Rutter M,Simonoff E,Pickles A,Eaves LJ

    更新日期:1998-11-01 00:00:00

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    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Blakely AA,Howard RC,Sosich RM,Murdoch JC,Menkes DB,Spears GF

    更新日期:1991-05-01 00:00:00

  • A comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group.

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    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Van Os J,Gilvarry C,Bale R,Van Horn E,Tattan T,White I,Murray R

    更新日期:1999-05-01 00:00:00

  • Migration and dementia: a meta-analysis of epidemiological studies in Europe.

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    pub_type: 杂志文章


    authors: Selten JP,Termorshuizen F,van Sonsbeek M,Bogers J,Schmand B

    更新日期:2020-04-08 00:00:00

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    journal_title:Psychological medicine

    pub_type: 杂志文章


    authors: Rosmalen JG,Bos EH,de Jonge P

    更新日期:2012-12-01 00:00:00