Abstract:
:This study investigates the basis of individual variation in exposure to stressful life events (SLEs). A population based sample of 547 MZ and 390 DZ female-female twin pairs, aged between 17 and 55 years, were surveyed by two structured interviews, separated by at least 1 year, that enquired about SLEs experienced during the preceding 12 months. Data were analysed with a model that resolves occasion specific ("random') versus enduring ("stable') influences on SLEs. The latter is partitioned into that due to genetic, familial environmental and unique environmental factors. We demonstrate that both random factors and stable individual differences underlie variation in self-reported exposure to SLEs. For most network events this stable variance makes a relatively small contribution to the total variance in SLEs exposure and is almost entirely due to genetic or familial environmental effects. Stable individual differences are more important determinants of personal SLEs, and these reflect both familial factors as well as previous experiences unshared by relatives.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Foley DL,Neale MC,Kendler KSdoi
10.1017/s0033291700035960subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1239-52issue
6eissn
0033-2917issn
1469-8978journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Somatoform disorders are costly for society in terms of increased healthcare expenditure. Patients' illness perceptions have been found to play a role in somatoform disorders. However, it is unclear whether illness perceptions predict higher health costs in these patients. METHOD:A total of 1785 primary car...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171400035X
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Genetic influences contribute significantly to co-morbidity between conduct disorder and substance use disorders. Estimating the extent of overlap can assist in the development of phenotypes for genomic analyses. METHOD:Multivariate quantitative genetic analyses were conducted using data from 9577 individua...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001518
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003555
更新日期:2018-09-01 00:00:00
abstract::Schizophrenia and affective disorders selected according to the Feighner criteria can be differentiated on the basis of 40-year outcome. Within schizophrenia the presence of disorganized thoughts at the index admission was associated with poor outcome, whereas better outcome was associated with the presence of delusio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700052107
更新日期:1981-05-01 00:00:00
abstract:BACKGROUND:The output of many healthy physiological systems displays fractal fluctuations with self-similar temporal structures. Altered fractal patterns are associated with pathological conditions. There is evidence that patients with bipolar disorder have altered daily behaviors. METHODS:To test whether fractal patt...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000331
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that profoundly affects quality of life. Although mounting evidence now suggests uncontrolled mind-wandering as a core aspect of the attentional problems associated with ADHD, the neural mechanisms underpinning this deficit remains ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003598
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. It is also thought to increase the risk of a number of disorders characterized by affective mo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001431
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:In previous studies an association between deployment to Iraq or Afghanistan and an overall increased risk for post-traumatic stress disorder (PTSD) in UK armed forces has not been found. The lack of a deployment effect might be explained by including, in the comparison group, personnel deployed on other ope...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291712002619
更新日期:2013-08-01 00:00:00
abstract::Parental representation was assessed with the Parental Bonding Instrument (PBI) in 12 monozygotic (MZ) and 19 dizygotic (DZ) same-sexed twin pairs discordant for DSM-III-R schizophrenia. The schizophrenic twins reported less care and more overprotection from both parents than the non-schizophrenic co-twins. Multiple r...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700028439
更新日期:1993-05-01 00:00:00
abstract::Ten depressed patients were assessed on an auditory signal detection task; testing was repeated on remission. The patients' clinical state was monitored by means of the Hamilton rating scale and the Beck Depression Inventory. The task was performed under three conditions: 2 button (Yes/No); 1 button (Yes); 1 button (N...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700006383
更新日期:1977-11-01 00:00:00
abstract::Some experiments, reported in detail elsewhere, on the effects of mother-infant separation in rhesus monkeys are here reviewed and compared. They involved 4 groups--one in which mothers were removed for 13 days leaving the infant in the social group; one in which infants were removed; one in which mothers and infants ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029275
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. METHOD:A systematic review and meta-analysis was conducted of representative, longitudinal p...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0033291711002911
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Twenty states currently require that women seeking abortion be counseled on possible psychological responses, with six states stressing negative responses. The majority of research finds that women whose unwanted pregnancies end in abortion do not subsequently have adverse mental health outcomes; scant resea...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717001684
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Maternal depression during pregnancy increases the risk for adverse developmental outcomes in children. However, the underpinning biological mechanisms remain unknown. We tested whether depression was associated with levels of and change in the inflammatory state during pregnancy, if early pregnancy overweig...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001909
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:There are no tested methods for conducting epidemiological studies of autism spectrum disorders (ASDs) in adult general population samples. We tested the validity of the Autism Diagnostic Observation Schedule module-4 (ADOS-4) and the 20-item Autism-Spectrum Quotient (AQ-20). METHOD:Randomly sampled adults ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001292
更新日期:2012-03-01 00:00:00
abstract::Hypothalamic-pituitary-adrenal axis function was investigated in 72 patients with primary depression. Forty-four per cent of the patients demonstrated abnormal suppression of their cortisol levels after a 1 mg overnight dexamethasone suppression test. Patients with abnormal suppression ('non-suppressors') were not cle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700019711
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Depressed individuals demonstrate a poorer ability to recognize the emotions of others, which could contribute to difficulties in interpersonal behaviour. This emotion recognition deficit appears related to the depressive state and is particularly pronounced when emotions are labelled semantically. Here, we ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002084
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Capturing service users' perspectives can highlight additional and different concerns to those of clinicians, but there are no up to date, self-report psychometrically sound measures of side effects of antipsychotic medications. Aim To develop a psychometrically sound measure to identify antipsychotic side e...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000903
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Prevalence of childhood anxiety disorders at specific ages and genetic etiological influences on anxiety disorders in young children have been little studied. The present study reports prevalence estimates in a community sample of 6-year-old twins, and patterns of genetic and environmental influences on thes...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705006537
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Clinical intuition suggests that personality disorders hinder the treatment of depression, but research findings are mixed. One reason for this might be the way in which current assessment measures conflate general aspects of personality disorders, such as overall severity, with specific aspects, such as sty...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000361X
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is highly heterogeneous and can be classified as treatment-resistant depression (TRD) or antidepressant-responsive depression (non-TRD) based on patients' responses to antidepressant treatment. Methods for distinguishing between TRD and non-TRD are critical clinical concerns. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001223
更新日期:2020-06-01 00:00:00
abstract::Post-traumatic stress disorder was first recognized as a diagnostic category embracing reactions in response to overwhelming environmental stress 'outside the range of usual human experience' in DSM-III (APA, 1980). Such abnormal stressors are by no means a product of the twentieth century but have featured, sporadica...
journal_title:Psychological medicine
pub_type: 历史文章,杂志文章
doi:10.1017/s0033291700026799
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder which frequently persists into adulthood. The primary goal of the current study was to (a) investigate attentional functions of stimulant medication-naïve adults with ADHD, and (b) investigate the effects of 6 weeks of methylphe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003628
更新日期:2019-11-01 00:00:00
abstract::Despite the robust body of work on cognitive aspects of bipolar disorder (BD), a clear profile of associated impairments in impulsivity, decision-making and risk-taking from studies that use behavioural measures has yet to be established. A systematic review, across four electronic databases (PsycINFO, MEDLINE/PubMed,...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003086
更新日期:2020-10-01 00:00:00
abstract::Suicides and suicide attempts in cancer patients were analysed by following all patients treated for cancer in Stockholm County from 1975 to 1985. Among 59,845 patients we identified 144 suicides and 196 suicide attempts during the follow-up, which represents a more than two-fold excess mortality from suicide and a mo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029962
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:The association between cigarette smoking and psychosis remains unexplained, but could relate to causal effects in both directions, confounding by socioeconomic factors, such as ethnicity, or use of other substances, including cannabis. Few studies have evaluated the association between cigarettes and psycho...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717001556
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:In a recent placebo-controlled, double-blind crossover trial (n = 52), significant beneficial effects on memory (d = 0.30) and negative symptoms (d = 0.29) were found after 12 weeks of memantine augmentation in patients with clozapine-refractory schizophrenia. In this open-label 1-year extension study we rep...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716002476
更新日期:2017-01-01 00:00:00
abstract::The numbers of long-stay patients in Danish psychiatric hospitals were studied, based on information from the Danish cumulative psychiatric register and from the census studies of patients in Danish psychiatric hospitals, performed at 5-year intervals since 1957. In 1977, 2079 (20%) of the in-patient population which ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700032116
更新日期:1979-08-01 00:00:00
abstract::The cognitive theories of depression put forward by Beck and his colleagues (1980), Brown & Harris (1978) and Abramson and her colleagues (1978) are described and compared. Although each theory has its strengths, it is argued that an adequate cognitive account of depression is awaited. Such a theory must link specific...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700004992
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Compassion-focused therapy (CFT) is a relatively novel form of psychotherapy that was developed for people who have mental health problems primarily linked to high shame and self-criticism. The aim of this early systematic review was to draw together the current research evidence of the effectiveness of CFT ...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291714002141
更新日期:2015-04-01 00:00:00