Abstract:
:Schizophrenia and affective disorders selected according to the Feighner criteria can be differentiated on the basis of 40-year outcome. Within schizophrenia the presence of disorganized thoughts at the index admission was associated with poor outcome, whereas better outcome was associated with the presence of delusions or hallucinations. Within the affective disorders, bipolar patients with grandiose delusions or ideas showed a poor outcome; a better outcome was found in unipolar patients with complaints of fatiguability or tiredness at the time of the index admission.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Tsuang MT,Woolson RF,Simpson JCdoi
10.1017/s0033291700052107subject
Has Abstractpub_date
1981-05-01 00:00:00pages
281-7issue
2eissn
0033-2917issn
1469-8978journal_volume
11pub_type
杂志文章abstract:BACKGROUND:The usefulness of any diagnostic scheme is directly related to its ability to provide clinically useful information on need for care. In this study, the clinical usefulness of dimensional and categorical representations of psychotic psychopathology were compared. METHOD:A total of 706 patients aged 16-65 ye...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291798008162
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Recently released prisoners are at markedly higher risk of suicide than the general population. The aim of this study was to identify key risk factors for suicide by offenders released from prisons in England and Wales. METHOD:All suicides committed by offenders within 12 months of their release from prison...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991048
更新日期:2010-05-01 00:00:00
abstract::The expressed emotion (EE) measure is a robust predictor of relapse in schizophrenia. At least twelve studies from a range of cultures have now shown this, although the authors of one maintain their findings are the result of confounding factors. A thirteenth study which failed to demonstrate a predictive effect was s...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700009831
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:There is substantial variability in the degree of cognitive impairment among older depressed persons. Inconsistencies in previous findings may be due to differences in clinical and demographic characteristics across study samples. We assessed the influence of unipolar depression and severity of depression on...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001736
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior ci...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000859
更新日期:2020-04-24 00:00:00
abstract:BACKGROUND:Life events and social problems are common in primary-care attenders and contribute to the high rate of emotional distress observed in this setting but are often not disclosed during the consultation. Physicians' characteristics associated with patients' disclosure of psychosocial problems are well documente...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007478
更新日期:1998-11-01 00:00:00
abstract::We have attempted to clarify clinical differentiating features of psychotic depression. Forty-six depressed subjects meeting DSM-III-R criteria for major depression with psychotic features were compared with (i) DSM-defined melancholic, (ii) Newcastle-defined endogenous, and (iii) a residual DSM-defined major depressi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035078
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:The aims of this study were to examine the associations between exposure to unemployment following school leaving and rates of psychiatric disorder using data gathered on a birth cohort of New Zealand young people studied up to the age of 18. METHODS:At age 18 cohort members were assessed on: (a) duration o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004412
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The extant major psychiatric classifications, DSM-IV and ICD-10, are purportedly atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis is greatly enhanced by an understanding of both risk factors and clinical history. In an effort to group mental d...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709990304
更新日期:2009-12-01 00:00:00
abstract::The present study examined sensitivity to noise in subjects with Type A and Type B behaviour patterns as a function of the type of task being performed. Twenty Type A and 20 Type B subjects, selected by means of Bortner's scale (French version), were exposed to steadily increasing noise levels (68-110 dBA) while perfo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700015245
更新日期:1984-08-01 00:00:00
abstract::Social anxiety disorder is one of the most common comorbid conditions in eating disorders (EDs). The aim of the current review and meta-analysis is to provide a qualitative summary of what is known about social anxiety (SA) in EDs, as well as to compare levels of SA in those with EDs and healthy controls. Electronic d...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291718000752
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001314
更新日期:2020-06-01 00:00:00
abstract::Serum total androgens were estimated by radioimmunoassay on blood samples of treatment-seeking homosexuals and heterosexual controls. There was no significant difference in androgen levels between the homosexual and control group, nor was there any relationship between androgen levels and response to treatment. These ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700004396
更新日期:1977-08-01 00:00:00
abstract:BACKGROUND:Cognitive models postulate that negative-self-schemas (NSS) cause and maintain positive symptoms and that negative affect mediates this link. However, only few studies have tested the temporal mediation claim systematically using an appropriate design. METHODS:A longitudinal cohort design in an online commu...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S003329171700277X
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Patients may present with cognitive impairment in the euthymic phase of affective disorder, but it is unclear whether the impairment is prevalent before onset of the illness. The aim of the present study was to examine the hypothesis that genetic liability to affective disorder is associated with cognitive i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706007896
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Discontinuation of antipsychotics predisposes patients with remitted/stable first-episode psychosis (FEP) to a higher risk of relapse, but it remains unclear how long discontinuation increases the relapse rate in these patients compared with maintenance. METHODS:This meta-analysis of randomized controlled t...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291718001393
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The processing of facial emotion involves a distributed network of limbic and paralimbic brain structures. Many of these regions are also implicated in the pathophysiology of mood disorders. Behavioural data indicate that depressed subjects show a state-related positive recognition bias for faces displaying ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704002557
更新日期:2004-07-01 00:00:00
abstract::Functional and phenotypic immunological parameters were examined immediately before, after, and 30 minutes after experimentally-induced short-term positive (happiness) and negative (anxiety, depression) affective states and a neutral state, in five healthy subjects. Results indicated that all affective states induced ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170003289x
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Results of previous research examining long-term residual effects of marijuana use on cognition are conflicting. A major methodological limitation of prior studies is the inability to determine whether differences between users and non-users are due to differences in genetic vulnerability preceding drug use ...
journal_title:Psychological medicine
pub_type:
doi:10.1017/s0033291704002260
更新日期:2004-10-01 00:00:00
abstract::The powerful genome-wide association studies (GWAS) revealed common mutations that increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority were not known to be functional or associated with these illnesses. To help fill this gap, their impact on human brain structure and functio...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291715000537
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between su...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291715000227
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Studies have suggested that patients with schizophrenia are impaired at recognizing emotions. Recently, it has been shown that the neuropeptide oxytocin can have beneficial effects on social behaviors. METHOD:To examine emotion recognition deficits in patients and see whether oxytocin could improve these de...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001413
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The reasons for high use of primary care, and in particular the role of psychosocial factors, remain unclear. METHODS:We identified and interviewed 236 frequent attenders and 420 normal users, matched by age and sex, of a public Health Centre in Granada, Spain. Users were questioned about mental health (GHQ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799008995
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:A dysfunctional network of prefrontal and (para-)limbic brain region has been suggested to underlie emotional dysregulation in borderline personality disorder (BPD). Abnormal activity in this network may be due to structural alterations in white-matter tracts connecting prefrontal and (para-)limbic brain reg...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001142
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Developmental adversities may be risk factors for adult suicidal behavior, but this relationship has rarely been studied prospectively. The present study examined the association between childhood adversities and new onset suicidal ideation and attempts in an adult population-based sample. METHOD:The study ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706008646
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Previous imaging studies have revealed that acute major depression is characterized by altered neural responses to negative emotional stimuli. Typically, responses in limbic regions such as the amygdala are increased while activity in cortical regulatory regions such as the dorsolateral prefrontal cortex (DL...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709990596
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Anorexia nervosa and bulimia nervosa are two severe eating disorders associated with high premature mortality, suicidal risk and serious medical complications. Transition between anorexia nervosa and bulimia nervosa over the illness course and familial co-aggregation of the two eating disorders imply aetiolo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002976
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Dysregulation of the striatum and altered corticostriatal connectivity have been associated with psychotic disorders. Social anhedonia has been identified as a predictor for the development of schizophrenia spectrum disorders. The aim of the present study was to examine corticostriatal functional connectivit...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001592
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Many preschool-age children meet criteria for psychiatric disorders, and rates approach those observed in later childhood and adolescence. However, there is a paucity of longitudinal research examining the outcomes of preschool diagnoses. METHODS:Families with a 3-year-old child (N = 559) were recruited fro...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003646
更新日期:2018-10-01 00:00:00
abstract::Preliminary data from the National Institute of Mental Health-Clinical Research Branch Collaborative Program on the Psychobiology of Depression dealing with the human growth hormone (hGH) response to the Insulin Tolerance Test (ITT) during the pre-treatment (drug-free) period of the study are presented in this paper. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700043270
更新日期:1982-02-01 00:00:00