Abstract:
BACKGROUND:Studies have suggested that patients with schizophrenia are impaired at recognizing emotions. Recently, it has been shown that the neuropeptide oxytocin can have beneficial effects on social behaviors. METHOD:To examine emotion recognition deficits in patients and see whether oxytocin could improve these deficits, we carried out two experiments. In the first experiment we recruited 30 patients with schizophrenia and 29 age- and IQ-matched control subjects, and gave them an emotion recognition task. Following this, we carried out a second experiment in which we recruited 21 patients with schizophrenia for a double-blind, placebo-controlled cross-over study of the effects of oxytocin on the same emotion recognition task. RESULTS:In the first experiment we found that patients with schizophrenia had a deficit relative to controls in recognizing emotions. In the second experiment we found that administration of oxytocin improved the ability of patients to recognize emotions. The improvement was consistent and occurred for most emotions, and was present whether patients were identifying morphed or non-morphed faces. CONCLUSIONS:These data add to a growing literature showing beneficial effects of oxytocin on social-behavioral tasks, as well as clinical symptoms.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Averbeck BB,Bobin T,Evans S,Shergill SSdoi
10.1017/S0033291711001413subject
Has Abstractpub_date
2012-02-01 00:00:00pages
259-66issue
2eissn
0033-2917issn
1469-8978pii
S0033291711001413journal_volume
42pub_type
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