Abstract:
BACKGROUND:Although many studies have addressed the topic of stability versus change in depressive symptoms, few have further decomposed the change to continuous accumulation versus non-systematic state fluctuations or measurement errors. This further step requires a longitudinal follow-up and an appropriate stochastic model; it would, for example, evaluate the hypothesis that women accumulate more susceptibility events than men. Method A linear stochastic differential equation model was estimated for a 16-year longitudinal course of depressive symptoms in the Young Finns community sample of 3596 participants (1832 women, 1764 men). This model enabled us to decompose the variance in depression symptoms into a stable trait, cumulative effects and state/error fluctuations. RESULTS:Women showed higher mean levels and higher variance of depressive symptoms than men. In men, the stable trait accounted for the majority [61%, 90% confidence interval (CI) 48.9-69.2] of the total variance, followed by cumulative effects (23%, 90% CI 9.9-41.7) and state/error fluctuations (16%, 90% CI 5.6-23.2). In women, the cumulative sources were more important than among men and accounted for 44% (90% CI 23.6-58.9) of the variance, followed by stable individual differences (32%, 90% CI 18.5-54.2) and state fluctuations (24%, 90% CI 19.1-27.3). CONCLUSIONS:The results are consistent with previous observations that women suffer more depression than men, and have more variance in depressive symptoms. We also found that continuously accumulating effects are a significant contributor to between-individual differences in depression, especially for women. Although the accumulating effects are often confounded with non-systematic state fluctuations, the latter are unlikely to exceed 27% of the total variance of depressive symptoms.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Rosenström T,Jokela M,Hintsanen M,Pulkki-Råback L,Hutri-Kähönen N,Keltikangas-Järvinen Ldoi
10.1017/S0033291712002000subject
Has Abstractpub_date
2013-05-01 00:00:00pages
933-44issue
5eissn
0033-2917issn
1469-8978pii
S0033291712002000journal_volume
43pub_type
杂志文章abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703007475
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:We studied whether heterogeneous profiles of cognitive function are relevant to survival in patients with early Alzheimer's disease. METHODS:CAMCOG subscales of cognitive function were used as predictors of survival, together with gender in 157 consecutively referred patients with early Alzheimer's disease....
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007375
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:This study aimed to explore the impacts of COVID-19 outbreak on mental health status in general population in different affected areas in China. METHODS:This was a comparative study including two groups of participants: (1) general population in an online survey in Ya'an and Jingzhou cities during the COVID...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004717
更新日期:2020-12-10 00:00:00
abstract:BACKGROUND:Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his cognitive triad and other clinical features and risk factors among those with major depression (MD) has rarely been systematically studied. METHOD:The three key cognitive symptoms of worthle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713000160
更新日期:2013-11-01 00:00:00
abstract::91 women were assessed early in pregnancy and again 3 and 6 months postpartum. Women who persisted in breastfeeding were less neurotic on the EPI but did not differ from artificial feeders in psychiatric history or sexuality before pregnancy. Breast feeders showed greater impairment of sexuality and slightly more depr...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700007935
更新日期:1988-05-01 00:00:00
abstract::Long-stay patients who were discharged from Friern and Claybury hospitals during the 6-year period between September 1985 and August 1991 were followed up for at least 1 year and the details of all readmissions were recorded. Of the 615 hospital leavers, some 178 (29%) were readmitted at some time during the follow-up...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035595
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between su...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291715000227
更新日期:2015-08-01 00:00:00
abstract::Sixty surviving patients from a community-based stroke register who had CT scan evidence of a single brain lesion and neurological signs appropriate to it were interviewed three to five years following their first-ever stroke. Mood disorder (anxiety and depression), physical disability, and intellectual impairment wer...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700036503
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Post-traumatic symptomatology is one of the signature effects of the pernicious exposures endured by responders to the World Trade Center (WTC) disaster of 11 September 2001 (9/11), but the long-term extent of diagnosed Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) post-traumati...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002184
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The effects of cognitive behavioural therapy of anxiety disorders on depression has been examined in previous meta-analyses, suggesting that these treatments have considerable effects on depression. In the current meta-analysis we examined whether the effects of treatments of anxiety disorders on depression ...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291716002348
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Neurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related disorders represents a core feature of these illnesses, possibly a marker of underlying pathophysiology. Substantial overlap in domains of neuropsychological deficits has been reported among these disorders after illness onset. Howeve...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291710001042
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:There is evidence of executive function impairment in obsessive compulsive disorder (OCD) that potentially contributes to symptom development and maintenance. Nevertheless, the precise nature of these executive impairments and their neural basis remains to be defined. METHOD:We compared stopping and shiftin...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002330
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:This two-stage prevalence survey involved geographically delimited areas, four urban (Liverpool, Newcastle, Nottingham and Oxford) and two rural (Cambridgeshire and Gwynedd), including institutions. METHODS:Stratified random population samples of people in their 65th year and above, from Family Health Servi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797006272
更新日期:1998-03-01 00:00:00
abstract::We found diurnal weight gain to be abnormal among 28 institutionalized chronically psychotic patients. They were weighed daily for 15 days at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and th...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700011065
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVE:Although family, twin and adoption studies have suggested that lifetime major depression (MD) is a heritable condition, nearly all these studies have relied for the diagnosis on long-term human memory, which is fallible and potentially biased. Could the estimates of heritability of MD be biased by the well-de...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003695
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Causal attributions about bodily sensations may determine help-seeking and influence patients' demands for medical treatment. The present study aimed to differentiate the causal attributions associated with health-related and non-health-related anxiety. METHODS:Anxious hypochondriacal, generally anxious, an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005849
更新日期:1998-01-01 00:00:00
abstract::We recently completed a case-control study of 100 literally homeless and 100 never homeless indigent schizophrenic men in New York City, in which concurrent substance abuse and antisocial personality disorder were widespread. In this paper we probe the correlates of 'pure' schizophrenia (single disorder, N = 60), schi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700027835
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Research on the subject of insight has been hampered by difficulties in definition and reliable measurement. METHODS:We compared several rating scales to measure insight on a group of 33 psychotic patients as well as assessing patients' psychopathology, clinical characteristics and cognitive functioning. R...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797006296
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:This study examined two competing hypotheses concerning the association between diabetes and treatment for depression: (1) the detection/ascertainment bias hypothesis suggesting that those with diabetes are more likely to be diagnosed with and treated for depression because of increased medical attention and...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001566
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Genetic influences on alcoholism risk are well-documented in men, but uncertain in women. We tested for gender differences in genetic influences on, and risk-factors for, DSM-III-R alcohol dependence (AD). METHOD:Diagnostic follow-up interviews were conducted in 1992-3 by telephone with twins from an Austra...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005643
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Although accurate differentiation between bipolar disorder (BD) and unipolar major depressive disorder (MDD) has important prognostic and therapeutic implications, the distinction is often challenging based on clinical grounds alone. In this study, we tested whether psychiatric polygenic risk scores (PRSs) i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000015X
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:Classification of psychosis lacks a biological basis and current diagnostic categories may obscure underlying continuities. Data reduction methods of symptom profiles within a population-based cohort of people with a wide range of affective and non-affective psychoses may permit an empirical classification o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003745
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Civilian suicide rates vary by occupation in ways related to occupational stress exposure. Comparable military research finds suicide rates elevated in combat arms occupations. However, no research has evaluated variation in this pattern by deployment history, the indicator of occupation stress widely consid...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001294
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the frontal cortex has been suggested as a safer and better tolerable alternative to fast-frequency rTMS in the treatment of major depressive disorder (MDD). The aim of the present study was to examine the efficacy of slow-frequency rTMS t...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S003329171000005X
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Controlled prospective studies of the simultaneous long-term outcome of several mental disorders are rare. This study sought to determine if there were important differences between the outcome of anxiety and depressive disorders after 12 years and to examine their main predictors. METHOD:A cohort of 210 pe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704002569
更新日期:2004-11-01 00:00:00
abstract::In a study of domiciliary and out-patient treatment of self-poisoning patients, using a brief problem-orientated approach, it was found that domiciliary treatment resulted in much higher attendance rates but no difference in outcome. Patients who completed out-patient treatment had a better outcome than those who fail...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700053381
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Mild traumatic brain injury (mTBI) is being claimed as the 'signature' injury of the Iraq war, and is believed to be the cause of long-term symptomatic ill health (post-concussional syndrome; PCS) in an unknown proportion of military personnel. METHOD:We analysed cross-sectional data from a large, randomly ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708004595
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000166X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Moodscope is an entirely service-user-developed online mood-tracking and feedback tool with built-in social support, designed to stabilize and improve mood. Many free internet tools are available with no assessment of acceptability, validity or usefulness. This study provides an exemplar for future assessmen...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002280
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Delusion is the most characteristic symptom of psychosis. While researchers suggested an association between changes of the cortical salience network (CSN) and delusion, whether these CSN findings are a cause or a consequence of delusion remains unknown. METHOD:To assess the effect of CSN functioning to for...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001057
更新日期:2016-10-01 00:00:00