Abstract:
BACKGROUND:This two-stage prevalence survey involved geographically delimited areas, four urban (Liverpool, Newcastle, Nottingham and Oxford) and two rural (Cambridgeshire and Gwynedd), including institutions. METHODS:Stratified random population samples of people in their 65th year and above, from Family Health Service Authorities were studied. The sample was stratified (65-74 years and > or = 75) to provide equal numbers. In Liverpool equal numbers in 5 year age groups were taken. After an initial screening interview, approximately 20% were selected on the basis of age, AGECAT organicity confidence level and MMSE score to proceed to a detailed assessment interview from which the full AGECAT organicity confidence level could be derived. RESULTS:Major influences on MMSE were confirmed as age, sex, social class and educational level. Estimates of prevalence of AGECAT O3 and above for each centre and the entire sample according to age are given, based on 1991 Census population structure, and suggest that around half a million (543,400) people in England and Wales would be defined as case level by this method. The five centres employing the same methodology showed no heterogeneity in prevalence. CONCLUSIONS:Prevalence of cognitive impairment and dementia appear not to vary widely across the centres examined in this study, which provides stable estimates by age and sex for AGECAT O3 and above, and norms for MMSE. Using these estimates as an indication of the size of the population affected, around 550,000 individuals in England and Wales would be expected to be suffering from dementia of mild or greater severity.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
doi
10.1017/s0033291797006272subject
Has Abstractpub_date
1998-03-01 00:00:00pages
319-35issue
2eissn
0033-2917issn
1469-8978journal_volume
28pub_type
杂志文章abstract::Cholecystokinin (CCK) is a peptide originally isolated from the gut. It has been investigated as a candidate treatment for schizophrenia on the assumption that the illness is associated with an imbalance between CCK and dopamine in the mesolimbic dopamine system. Many of the studies to assess the efficacy of CCK used ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,评审
doi:10.1017/s0033291700008278
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Both low intelligence and low emotional control have previously been linked to a higher risk of suicide, but it is unknown whether the associations apply consistently over the life course. METHODS:The study was based on data on intelligence and emotional control, collected from 48 738 Swedish men conscripte...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002423
更新日期:2020-10-01 00:00:00
abstract::Awareness of pulse rate was tested in 60 psychiatric out-patients with anxiety, phobic or hypochondriacal neuroses by asking them to record how fast their hearts were beating during exposure to short film sequences. Correlations between subjective and objective heart rate (ECG) were significantly higher in anxious and...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700039726
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:A number of scales are used to estimate the severity of depression. However, differences between self-report and clinician rating, multi-dimensionality and different weighting of individual symptoms in summed scores may affect the validity of measurement. In this study we examined and integrated the psychome...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001730
更新日期:2008-02-01 00:00:00
abstract::Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinic...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291715001609
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The USA is currently enduring an opioid crisis. Identifying cost-effective, easy-to-implement behavioral measures that predict treatment outcomes in opioid misusers is a crucial scientific, therapeutic, and epidemiological goal. METHODS:The current study used a mixed cross-sectional and longitudinal design ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000461
更新日期:2020-03-01 00:00:00
abstract::A non-recursive structural equation model designed to examine the reciprocal relationship between life event reports and depressive symptoms in women is presented. The model was fitted to data from a 2-year longitudinal study of life events and depression in a sample of women with 5-year-old children. The findings sug...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001984x
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:The effects of antidepressants for treating depressive disorders have been overestimated because of selective publication of positive trials. Reanalyses that include unpublished trials have yielded reduced effect sizes. This in turn has led to claims that antidepressants have clinically insignificant advanta...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291713000457
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:This study examined two competing hypotheses concerning the association between diabetes and treatment for depression: (1) the detection/ascertainment bias hypothesis suggesting that those with diabetes are more likely to be diagnosed with and treated for depression because of increased medical attention and...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001566
更新日期:2014-04-01 00:00:00
abstract::Sixty-four children taken to court for failure to attend school were reliably classified into 4 groups, according to whether they exhibited the features of 'school refusal' and/or 'truancy'. About a fifth of them were found to exhibit 'school refusal'; a third showed 'truancy'; less than a sixth exhibited both 'school...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700021024
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Bright light and high-density negative air ion exposure are efficacious for winter and non-seasonal depression compared with a low-density negative ion placebo. Similarly, auditory stimuli improve mood in clinical populations. This study compared the short-term effects of bright light, an auditory stimulus, ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291706008002
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Results of adulthood mental health of those born late-preterm (34 + 0-36 + 6 weeks + days of gestation) are mixed and based on national registers. We examined if late-preterm birth was associated with a higher risk for common mental disorders in young adulthood when using a diagnostic interview, and if this ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716000830
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Studies exploring gene-environment interplay in affective disorders now include very large numbers of participants. Methods for evaluating the role of adversity in such studies need to be developed that do not rely on lengthy and labour-intensive interviews. In the present study, a brief questionnaire method...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170999225X
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The ability to decode emotional information from facial expressions is crucial for successful social interaction. Borderline personality disorder (BPD) is characterized by serious problems in interpersonal relationships and emotional functioning. Empirical research on facial emotion recognition in BPD has be...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708004273
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetS) is associated with reduced life expectancy in patients with affective disorders, however, whether MetS also plays a role before the onset of affective disorder is unknown. We aimed to investigate whether MetS, inflammatory markers or oxidative stress act as risk factors for affectiv...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171900182X
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Elevated levels of circulating C-reactive protein (CRP) have been associated with coronary heart disease and, in some studies, depression. Most studies have been of populations selected by age and/or gender. We investigate these associations with depression, myocardial infarction (MI), or both, in a large ge...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000887
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:The neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression - how age affects clinical presentation in first-episode psychosis - has not been thoroughly investigated. METHODS:Using generalized additive modeling, which allo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003463
更新日期:2020-10-06 00:00:00
abstract:BACKGROUND:Different versions of the General Health Questionnaire (GHQ), including the GHQ-12 and GHQ-28 have been subjected to factor analysis in a variety of countries. The World Health Organization study of psychological disorders in general health care offered the opportunity to investigate the factor structure of ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291799002287
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000166X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Identifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. This review addresses two key questions: Is there a bipolar prodrome? And, if there is, what are its characteristic features? METHOD:A comprehensive search of databases ...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291710001790
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Generalized anxiety disorder is a common condition of excessive worry and tension which tends to run a chronic course associated with significant psychiatric and medical problems. Cognitive behaviour therapy (CBT) has been shown to be of clinical value in about 50% of cases with treatment gains maintained ov...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702007079
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Moodscope is an entirely service-user-developed online mood-tracking and feedback tool with built-in social support, designed to stabilize and improve mood. Many free internet tools are available with no assessment of acceptability, validity or usefulness. This study provides an exemplar for future assessmen...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002280
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:High expressed emotion (EE) in families reliably predicts relapse in schizophrenia leading to the assumption that high EE stresses patients and is the cause of relapse. Attempts at validating the stressful properties of high EE using autonomic skin conductance measures have been inconclusive. Since memory lo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002718
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Although attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BPD) co-occur frequently and represent a particularly morbid clinical form of both disorders, neuroimaging research addressing this co-morbidity is scarce. Our aim was to evaluate the morphometric magnetic resonance imaging (MRI) ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001791
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Certain personality traits predispose to criminal behavior (CB). We further clarify this relationship in a Swedish national sample. METHOD:Psychological strength (PS) was assessed on a nine-point scale at personal interview in 1 653 721 Swedish men aged 18-20 years. We examined the association between PS an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001403
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The past two decades have seen a great improvement in the care of people with Prader-Willi syndrome (PWS), particularly with regard to control of diet and behaviour management. Has this affected mortality rates or thrown up new issues regarding premature ageing or dementia? We investigated two aspects of age...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001755
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The reasons for high use of primary care, and in particular the role of psychosocial factors, remain unclear. METHODS:We identified and interviewed 236 frequent attenders and 420 normal users, matched by age and sex, of a public Health Centre in Granada, Spain. Users were questioned about mental health (GHQ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799008995
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Working memory (WM) deficits in schizophrenia (SCZ) have been linked to impairments in the encoding phase that are associated with aberrant neuronal functioning. Similar abnormalities have been observed in unaffected first-degree relatives (REL) and are thus discussed as candidate endophenotypes. The process...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171800051X
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Psychosocial and inflammatory factors have been associated with fatigue in breast cancer survivors. Nevertheless, the relative contribution and/or interaction of these factors with cancer-related fatigue have not been well documented. METHOD:This cross-sectional study enrolled 111 stage 0-III breast cancer ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000150
更新日期:2017-07-01 00:00:00
abstract::The persistence of psychosis at a high and relatively constant prevalence in the various populations of the world is rendered difficult to explain by the absence of identified environmental precipitants and by reduced fertility of affected individuals. The problem is not confined to schizophrenia but applies also to a...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700000611
更新日期:1987-11-01 00:00:00