Abstract:
:The persistence of psychosis at a high and relatively constant prevalence in the various populations of the world is rendered difficult to explain by the absence of identified environmental precipitants and by reduced fertility of affected individuals. The problem is not confined to schizophrenia but applies also to affective disorder. The 'virogene' concept attempts to explain this paradox as follows. (1) Psychosis in general is, as suggested by Böök (1953) and Lewis (1958) for schizophrenia, associated with a high rate of mutation. (2) The new mutations occur at a specific site (a 'hot-spot') in the genome and consist of rearrangements (e.g. transpositions or new insertions occurring as a result of unequal recombination) in a sequence which has a degree of potential autonomy, i.e. an integrated pathogen or 'virogene'. (3) The mutations occur specifically in the courses of gametogenesis in the male. By its location in the scrotal sac and its extended time course, gametogenesis in the male is susceptible to insertional mutagenesis as a function of variations in environmental temperature. Such temperature-dependent mutations are reflected in the seasonality of birth seen in both schizophrenic and affective illnesses. The increased likelihood of such mutations occurring with time is held to account for the association of psychosis with increased paternal age. (4) Such new events are held responsible not only for 'sporadic' cases in individuals without a family history of psychosis, but also for increases in severity of illness between generations. Psychosis is viewed as a continuum extending from unipolar through bipolar affective disorder and schizoaffective illness to schizophrenia with increasing degrees of defect.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Crow TJdoi
10.1017/s0033291700000611subject
Has Abstractpub_date
1987-11-01 00:00:00pages
821-8issue
4eissn
0033-2917issn
1469-8978journal_volume
17pub_type
杂志文章,评审abstract:BACKGROUND:This study aimed to determine whether depression in patients with long-term conditions is associated with the number of morbidities or the type of co-morbidity. Method A cohort study of 299 912 participants aged 30-100 years. The prevalence of depression, rates of health-care utilization and costs were evalu...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002498
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Suicide is expressly condemned in the Qu'ran, and traditionally few Islamic countries have reported suicide. Undetermined deaths are classified by the World Health Organization (WHO) as Other Violent Deaths (OVD) in ICD-9, or Other External Causes (OEC) in ICD-10. It has been suggested that to avoid under-re...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706009159
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Transdiagnostic group cognitive-behavioral therapy (tCBT) is a delivery model that could help overcome barriers to large-scale implementation of evidence-based psychotherapy for anxiety disorders. The aim of this study was to assess the effectiveness of combining group tCBT with treatment-as-usual (TAU), com...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004316
更新日期:2020-12-02 00:00:00
abstract:INTRODUCTION:Patients with unipolar depression show impaired performance on the Tower of London planning task. Positron emission tomography, which has previously identified resting state blood flow abnormalities in depression, was used to investigate neural activity associated with performance of this task in depressed...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005187
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Feedback learning is essential for behavioral development. We investigated feedback learning in relation to behavior problems after pediatric traumatic brain injury (TBI). METHOD:Children aged 6-13 years diagnosed with TBI (n = 112; 1.7 years post-injury) were compared with children with traumatic control (...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716000106
更新日期:2016-05-01 00:00:00
abstract::On the basis of information abstracted from case histories, 41 patients who had experienced epileptic seizures thought to be due either to treatment with psychiatric drugs or to withdrawal from sedative drugs were compared with a control group of patients. Those who had experienced seizures were more commonly first bo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029354
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Psychological traumatic events, such as war or road traffic accidents, are widespread. A small but significant proportion of survivors develop post-traumatic stress disorder (PTSD). Distressing, sensory-based involuntary memories of trauma (henceforth 'flashbacks') are the hallmark symptom of PTSD. Understan...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002358
更新日期:2013-07-01 00:00:00
abstract::In an earlier paper we found that a model of depression developed on a sample of women in a London population was confirmed in a female population in the Outer Hebrides. Differences in the rates of onset and chronic cases between the two populations, however, suggested that the Scottish women might be more likely to b...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700052892
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:Cognitive-behavioral therapy (CBT) is thought to be useful for chronic pain, with the pathology of the latter being closely associated with cognitive-emotional components. However, there are few resting-state functional magnetic resonance imaging (R-fMRI) studies. We used the independent component analysis m...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002598
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001161
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Cognitive models propose that auditory verbal hallucinations arise through defective self-monitoring and external attribution of inner speech. We used a paradigm that engages verbal self-monitoring to examine how deficits in this process are related to symptoms and diagnosis in patients with psychosis. METH...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705006628
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:The correlates of insight in early-onset psychosis have received little previous attention. METHOD:We studied clinical correlates of insight in a sample of 110 adolescent recent-onset psychosis patients (mean age 15.53 years; psychotic symptoms present for <6 months). Insight was measured with the Scale to ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708004868
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:A combined family study and recovered study design was utilized to examine several hypothesized relationships between personality and bulimia nervosa (BN). METHODS:We studied 47 women with a lifetime history of DSM-III-R BN (31 currently ill and 16 recovered), 44 matched control women (CW) with no history o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002792
更新日期:2000-11-01 00:00:00
abstract::A sample of over 6000 women was recruited in the last trimester of pregnancy and administered a 40-item self-report questionnaire designed to detect the presence of factors that were likely to increase the risk of postpartum depression. The mental state of almost 5000 of these women was determined at around 6 to 8 wee...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035698
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:The methodology for measuring the needs of patients with severe mental illness is now well established through the MRC Needs for Care Assessment Schedule and its modification in the form of the Cardinal Needs Assessment. This paper reports the rationale and construction of a relatives' version of the Cardina...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329179800662x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:We studied to what extent internet-based cognitive behaviour therapy (CBT) programs for symptoms of depression and anxiety are effective. METHOD:A meta-analysis of 12 randomized controlled trials. RESULTS:The effects of internet-based CBT were compared to control conditions in 13 contrast groups with a tot...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291706008944
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:There are no risk models for the prediction of anxiety that may help in prevention. We aimed to develop a risk algorithm for the onset of generalized anxiety and panic syndromes. METHOD:Family practice attendees were recruited between April 2003 and February 2005 and followed over 24 months in the UK, Spain...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002400
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Pharmacological treatments targeting the neuroendocrine stress response may hold special promise in secondary prevention of posttraumatic stress disorder (PTSD). However, findings from clinical trials have been inconsistent and the efficacy of specific drugs, their temporal window of efficacy, effective dose...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001028
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:We investigated whether schizophrenic subjects are impaired in non-routine behaviour because of the dysfunction of a general executive component labelled, in neuropsychological terms, the supervisory system. METHODS:A specific verbal sequencing test was designed for this purpose. Subjects had to perform seq...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005515
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:There have been conflicting reports on time trends in urban-rural differences in the incidence of schizophrenia. This study explored the potential time trends in these differences with regard to birth cohort and age at onset. METHOD:Linking data from the Danish Civil Registration system with data from the D...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170500663X
更新日期:2006-02-01 00:00:00
abstract::Cognitive-behavioural therapy (CBT) is an effective treatment for depressed adults. CBT interventions are complex, as they include multiple content components and can be delivered in different ways. We compared the effectiveness of different types of therapy, different components and combinations of components and asp...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S003329171900120X
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:As children with attention-deficit/hyperactivity disorder (ADHD) usually show psychopathological signs beyond their core symptoms (e.g. elevated scores of the dysregulation profile (DP) in 30-40%), treatments with a broader approach to self-regulation skills may be supportive. Neurofeedback (NF) may reflect ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291718004130
更新日期:2020-01-01 00:00:00
abstract::Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinic...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291715001609
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:We aimed to evaluate the diagnostic accuracy of a highly structured diagnostic interview in relation to a semi-structured diagnostic procedure. We compared the World Health Organization Composite International Diagnostic Interview Short Form (CIDI-SF) in diagnosing major depressive episode (MDE) to consensus...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291702005810
更新日期:2002-10-01 00:00:00
abstract::Difficulties in set-shifting are commonly reported in both autism spectrum disorder (ASD) and anorexia nervosa (AN) populations. Despite this, it is not known whether this cognitive profile persists across different ages, or whether the profiles seen in ASD and AN are comparable. This systematic review and meta-analys...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0033291716000581
更新日期:2016-07-01 00:00:00
abstract::Levinger & Clarke (1961) found that subjects tended to forget more word associations to emotional rather than neutral words. Kline (1981) regarded this study as providing 'irrefutable evidence for the Freudian concept of repression'. On the other hand, results from Kleinsmith & Kaplan (1964) suggested that this effect...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700017669
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:The development of childhood anxiety disorders (CADs) is likely to depend on pathways that can be programmed by early-life risk factors. We test the hypothesis that early-life maternal factors can predict this programming effect on CAD. METHODS:Data were obtained from 198 women and children from the Mercy P...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002147
更新日期:2020-06-29 00:00:00
abstract::Anthropometric and biochemical indices of nutritional status and weighed dietary intake have been studied in hospitalized patients with senile dementia, demented patients living in the community and age-matched control subjects who were not cognitively impaired. Demented patients were lighter than control subjects, an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700012423
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000166X
更新日期:2020-06-09 00:00:00
abstract::Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029305
更新日期:1977-05-01 00:00:00