Abstract:
BACKGROUND:The development of childhood anxiety disorders (CADs) is likely to depend on pathways that can be programmed by early-life risk factors. We test the hypothesis that early-life maternal factors can predict this programming effect on CAD. METHODS:Data were obtained from 198 women and children from the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS), a cohort study with data collected across pregnancy, postpartum and until 4 years of age. Maternal antenatal depression was measured using the Structured Clinical Interview for DSM-IV (SCID-IV), together with antenatal hair cortisol concentrations, maternal childhood trauma and parenting stress at 6 months postpartum. CAD was assessed with the Preschool Age Psychiatric Assessment and the Child Behaviour Checklist. RESULTS:Antenatal depression, a history of maternal childhood trauma and lower gestational age at birth were each associated with anxiety disorders at 4 years of age in their children. A multivariate binary logistic model with these early predictors explained approximately 9% of variance in CAD outcome at 4 years of age; however, only maternal trauma and gestational age were significant predictors in the model. The effect of early parenting stress on CAD was found to vary by the concentration of maternal antenatal hair cortisol, whereby postpartum parenting stress was associated with CAD only when there were higher maternal antenatal cortisol levels. CONCLUSIONS:This study suggests the importance of maternal factors pre-conception, pregnancy and in the postnatal period, which predict CADs and this is consistent with a developmental programming hypothesis for CAD.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Galbally M,Watson SJ,van Rossum EFC,Chen W,de Kloet ER,Lewis AJdoi
10.1017/S0033291720002147subject
Has Abstractpub_date
2020-06-29 00:00:00pages
1-9eissn
0033-2917issn
1469-8978pii
S0033291720002147pub_type
杂志文章abstract:BACKGROUND:Cognitive behavioral therapy (CBT) can be delivered efficaciously through various modalities, including telephone (T-CBT) and face-to-face (FtF-CBT). The purpose of this study was to explore predictors of outcome in T-CBT and FtF-CBT for depression. METHOD:A total of 325 depressed participants were randomiz...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291715001208
更新日期:2015-11-01 00:00:00
abstract::Suicides and suicide attempts in cancer patients were analysed by following all patients treated for cancer in Stockholm County from 1975 to 1985. Among 59,845 patients we identified 144 suicides and 196 suicide attempts during the follow-up, which represents a more than two-fold excess mortality from suicide and a mo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029962
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Delusion is the most characteristic symptom of psychosis. While researchers suggested an association between changes of the cortical salience network (CSN) and delusion, whether these CSN findings are a cause or a consequence of delusion remains unknown. METHOD:To assess the effect of CSN functioning to for...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001057
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Non-suicidal self-injury (NSSI) prospectively predicts suicidal thoughts and behaviors in civilian populations. Despite high rates of suicide among US military members, little is known about the prevalence and course of NSSI, or how NSSI relates to suicidal thoughts and behaviors, in military personnel. MET...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002015
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Men sexually interested in children of a specific combination of maturity and sex tend to show some lesser interest in other categories of persons. Patterns of men's sexual interest across erotic targets' categories of maturity and sex have both clinical and basic scientific implications. METHOD:We examined...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001476
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Studies have suggested that patients with schizophrenia are impaired at recognizing emotions. Recently, it has been shown that the neuropeptide oxytocin can have beneficial effects on social behaviors. METHOD:To examine emotion recognition deficits in patients and see whether oxytocin could improve these de...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001413
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000215
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Cannabis use is associated with an earlier age at onset of psychotic illness. The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder. METHOD:In 785 patients with a non-affective...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000062
更新日期:2012-09-01 00:00:00
abstract::Serum creatine phosphokinase (CPK) levels were compared with assaultive behaviour by 46 psychiatric patients. Significant relationships were found between CPK level and violent behaviour prior to admission and CPK level and seclusion as a danger to others while in hospital. No relationship was found between CPK level ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700003275
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds. METHODS:We examined whether polygenic risk scores (PRS) for consumption and problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in the UK Biobank (UKB; N = 121 630) correla...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719004045
更新日期:2020-01-20 00:00:00
abstract::The question addressed to in this paper is whether severely mentally ill patients are treated differently in a community mental health service without the back-up of a mental hospital (south-Verona, Italy) compared with an institution-based system in which mental hospitals, although highly modernized, are still predom...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700033754
更新日期:1996-01-01 00:00:00
abstract::Data from a general population survey of psychiatric disorder in Camberwell were used to calculate the risk of a CATEGO-defined depressive episode before the age of 65, using a modification of Strömgren's method. Current depression was defined as cases within the relevant categories of the CATEGO program and at thresh...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700012435
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Sleep disruption is a common precursor to deterioration and relapse in people living with psychotic disorders. Understanding the temporal relationship between sleep and psychopathology is important for identifying and developing interventions which target key variables that contribute to relapse. METHODS:We...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004857
更新日期:2021-01-12 00:00:00
abstract::The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034838
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002315
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:There is an emerging consensus in developmental psychopathology that irritable youth are at risk for developing internalizing problems later in life. The current study explored if irritability in youth is multifactorial and the impact of irritability dimensions on psychopathology outcomes in adulthood. METH...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002903
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Previous studies have highlighted the role of the brain reward and cognitive control systems in the etiology of anorexia nervosa (AN). In an attempt to disentangle the relative contribution of these systems to the disorder, we used functional magnetic resonance imaging (fMRI) to investigate hemodynamic respo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002161
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Evidence suggests some overlap between the pathological use of food and drugs, yet how impulsivity compares across these different clinical disorders remains unclear. Substance use disorders are commonly characterized by elevated impulsivity, and impulsivity subtypes may show commonalities and differences in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001834
更新日期:2015-03-01 00:00:00
abstract::Long-stay patients who were discharged from Friern and Claybury hospitals during the 6-year period between September 1985 and August 1991 were followed up for at least 1 year and the details of all readmissions were recorded. Of the 615 hospital leavers, some 178 (29%) were readmitted at some time during the follow-up...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035595
更新日期:1996-05-01 00:00:00
abstract:INTRODUCTION:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible alternative to electroconvulsive therapy for the treatment of selected patients with depression, bipolar affective disorder and schizophrenia. The aim of this study was to evaluate the evidence for the effectiveness of rTMS...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291701004378
更新日期:2001-10-01 00:00:00
abstract::Inhibition of central dopamine functions appears to be a common basic property of antipsychotic drugs. The mesolimbic and nigrostriatal portions of the dopaminergic system are probably the main targets of these drugs for the mental and the extrapyramidal actions respectively. Dopaminergic hyperfunction, induced by amp...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170000622x
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Despite the demonstrable influence of both genes and the family environment on children's behavioural and emotional development, the mechanisms by which these factors are transmitted from parents to their children are not known. Numerous aspects of the family have long been associated with behavioural and em...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008948
更新日期:2004-02-01 00:00:00
abstract::The prevalence of psychiatric disorder, as assessed by both the GHQ-28 and the short PSE, is described for a random community sample of New Zealand women. In contrast to previous studies, married and widowed women and mothers showed lower rates than the never married and childless women. A plausible explanation is pro...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700009909
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Although the traditional view of bipolar affective disorder is that the majority of patients have full remission between episodes, recent evidence suggests that residual cognitive deficits are present. The aim of this study was to determine whether memory and executive deficits were present in a well-defined...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002664
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Research suggests that the personality factor of self-critical or maladaptive perfectionism may be implicated in chronic fatigue syndrome (CFS). However, it is not clear whether self-critical perfectionism (SCP) also predicts daily symptoms in CFS. Method In the present study we investigated whether SCP pred...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001936
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Counselling is frequently used in the management of common mental disorders (such as anxiety and depression) in primary care. However, there are concerns over the clinical effectiveness of counselling, both in comparison with usual general practitioner care, and with other treatments such as alternative psyc...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/s0033291702006979
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Negative associations between religion and suicide, in individuals and countries, may be mediated by the degree to which suicide is tolerated. METHODS:Linear regression was used to examine ecological associations between suicide tolerance, religion and suicide rates in 19 Western countries in 1989/90. Logis...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005357
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:This study seeks to clarify the contribution of temporally stable and occasion-specific genetic and environmental influences on risk for major depression (MD). METHOD:Our sample was 2153 members of female-female twin pairs from the Virginia Twin Registry. We examined four personal interview waves conducted ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000277
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The categorical classification system for personality disorder (PD) has been frequently criticized and several alternative dimensional models have been proposed. METHOD:Antecedent, concurrent and predictive markers of construct validity were examined for three models of PDs: the Five-Factor Model (FFM), the...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706009482
更新日期:2007-07-01 00:00:00
abstract::Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029305
更新日期:1977-05-01 00:00:00