Lithium and erythrocyte membrane cation carrier studies in normal and manic depressive subjects.

Abstract:

:Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies of lithium in manic depressive psychosis. The fluctuations in the erythrocyte membrane cation carrier were studied in 5 normal subjects over 12 weeks and the correlations between the parameters calculated. The erythrocyte sodium concentration correlated positively with the ouabain sensitive potassium influx. This too contrasts with findings in manic depressive psychosis.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Naylor GJ,Smith A,Boardman LJ,Dick DA,Dick EG,Dick P

doi

10.1017/s0033291700029305

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

229-33

issue

2

eissn

0033-2917

issn

1469-8978

journal_volume

7

pub_type

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