Abstract:
:Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies of lithium in manic depressive psychosis. The fluctuations in the erythrocyte membrane cation carrier were studied in 5 normal subjects over 12 weeks and the correlations between the parameters calculated. The erythrocyte sodium concentration correlated positively with the ouabain sensitive potassium influx. This too contrasts with findings in manic depressive psychosis.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Naylor GJ,Smith A,Boardman LJ,Dick DA,Dick EG,Dick Pdoi
10.1017/s0033291700029305subject
Has Abstractpub_date
1977-05-01 00:00:00pages
229-33issue
2eissn
0033-2917issn
1469-8978journal_volume
7pub_type
杂志文章abstract::The SIDAM--a new instrument for the symptomatic diagnosis and measurement of dementia according to DSM-III-R and ICD-10--is described. It comprises a brief structured clinical interview, a range of cognitive tests (e.g. including the Mini-Mental State (Folstein et al. 1975)) which constitute a short neuropsychological...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700014811
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Cognitive remediation (CR) is an effective treatment for several psychiatric disorders. To date, there have been no published studies examining solely first-episode psychiatric cohorts, despite the merits demonstrated by early intervention CR studies. The current study aimed to assess the effectiveness of CR...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291712002127
更新日期:2013-06-01 00:00:00
abstract::Patients suffering from manic-depressive psychosis, manic type (ICD 296.0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291700043282
更新日期:1982-02-01 00:00:00
abstract::Messenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly l...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029858
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Impaired emotion regulation may underlie exaggerated emotional reactivity in patients with obsessive compulsive disorder (OCD), yet instructed emotion regulation has never been studied in the disorder. METHOD:This study aimed to assess the neural correlates of emotion processing and regulation in 43 medicat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001026
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Pharmaceutical industry funding of psychiatric research has increased significantly in recent decades, raising the question of a relationship between pharmaceutical company funding of clinical psychiatric studies and the outcomes of those studies. This study examines this relationship. METHOD:Abstracts of a...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706008567
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Cannabis use is associated with altered neurocognitive functioning in severe mental disorders, but data are still inconclusive and there are no studies of bipolar disorder. The aim of this study was to investigate the association between cannabis use and neurocognition in bipolar disorder compared with schiz...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991620
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The incidence of schizophrenia in the African-Caribbean population in England is reported to be raised. We sought to clarify whether (a) the rates of other psychotic disorders are increased, (b) whether psychosis is increased in other ethnic minority groups, and (c) whether particular age or gender groups ar...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291706008774
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Hip fracture is common in the elderly. Previous studies suggest that psychiatric illness is common and predicts poor outcome, but have methodological weaknesses. Further studies are required to address this important issue. METHODS:We prospectively recruited 731 elderly participants with hip fracture in two...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002548
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that postpartum psychiatric episodes may share similar etiological mechanisms with immune-related disorders. Pre-eclampsia is one of the most prevalent immune-related disorders of pregnancy. Multiple clinical features are shared between pre-eclampsia and postpartum psychiatric disord...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001385
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Working memory (WM) deficits in schizophrenia (SCZ) have been linked to impairments in the encoding phase that are associated with aberrant neuronal functioning. Similar abnormalities have been observed in unaffected first-degree relatives (REL) and are thus discussed as candidate endophenotypes. The process...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171800051X
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Although numerous studies have examined the latent structure of major depression, less attention has focused on mania. This paper presents the first investigation outside the USA to evaluate the psychometric properties of the DSM-IV criterion B mania symptoms using item response theory (IRT). METHOD:Data we...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000980
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Although depression and mania are often assumed to be polar opposites, studies have shown that, in patients with bipolar disorder, they are weakly positively correlated and vary somewhat independently over time. Thus, when investigating relationships between specific psychological processes and specific symp...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002711
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:For DSM - 5, the American Psychiatric Association Board of Trustees established a robust vetting and review process that included two review committees that did not exist in the development of prior DSMs, the Scientific Review Committee (SRC) and the Clinical and Public Health Committee (CPHC). The CPHC was ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001415
更新日期:2020-08-25 00:00:00
abstract::Age and sex-adjusted first admission rates for operationally-defined schizophrenia and other non-affective psychosis in different ethnic groups were calculated over the period 1988-1992 in a defined catchment area in South London. Standardized rates for schizophrenia, corrected for age- and gender-related under-report...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700033845
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The long-term outcomes of bipolar disorder range from lasting remission to chronic course or frequent recurrences requiring admissions. The distinction between bipolar I and II disorders has limited utility in outcome prediction. It is unclear to what extent the clinical course of bipolar disorder predicts l...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001678
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to eluc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000357
更新日期:2020-02-01 00:00:00
abstract::One hundred and sixteen working-class housewives, part-time and full-time employees were compared on a range of well-being measures in three different lifestages. A group of factory employees was contrasted with a 'mixed occupation' group for a comparison of type of employment. The general contention that the associat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034978
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:The clinical picture of schizophrenia is frequently worsened by manifestations of impulsivity. However, the neural correlates of impulsivity in this disorder are poorly known. Although impulsivity has been related to disturbances of the neural processes underlying response inhibition, no studies have yet exa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000796
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Prosocial emotions related to self-blame are important in guiding human altruistic decisions. These emotions are elevated in major depressive disorder (MDD), such that MDD has been associated with guilt-driven pathological hyper-altruism. However, the impact of such emotional impairments in MDD on different ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714002414
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Compassion-focused therapy (CFT) is a relatively novel form of psychotherapy that was developed for people who have mental health problems primarily linked to high shame and self-criticism. The aim of this early systematic review was to draw together the current research evidence of the effectiveness of CFT ...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291714002141
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Prior research suggested that time splitting--suppressing the past and dissociating it from present and future--protected refugee mental health in the aftermath of catastrophe. The current study investigates temporal reintegration, defined as cognitive recapture of the past and reconnecting it with present a...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703001703
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Maternal depression during pregnancy increases the risk for adverse developmental outcomes in children. However, the underpinning biological mechanisms remain unknown. We tested whether depression was associated with levels of and change in the inflammatory state during pregnancy, if early pregnancy overweig...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001909
更新日期:2020-08-01 00:00:00
abstract::A non-recursive structural equation model designed to examine the reciprocal relationship between life event reports and depressive symptoms in women is presented. The model was fitted to data from a 2-year longitudinal study of life events and depression in a sample of women with 5-year-old children. The findings sug...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001984x
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors and personality traits is ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001997
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003555
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Maternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation. METHOD...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716003627
更新日期:2017-01-19 00:00:00
abstract:BACKGROUND:Recent anthropological studies have documented the importance of understanding the relation of culture to the experience of mental illness. The use of interviews that elicit explanatory models has facilitated such research, but currently available interviews are lengthy and impractical for epidemiological st...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007065
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703007475
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Spontaneous movement disorders (SMDs), such as spontaneous dyskinesia and parkinsonism, have been described in patients with schizophrenia who have never been treated with antipsychotic medication. Their presence has been documented extensively in chronic schizophrenia but not at the time of illness onset. ...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291708004716
更新日期:2009-07-01 00:00:00