Abstract:
BACKGROUND:The long-term outcomes of bipolar disorder range from lasting remission to chronic course or frequent recurrences requiring admissions. The distinction between bipolar I and II disorders has limited utility in outcome prediction. It is unclear to what extent the clinical course of bipolar disorder predicts long-term outcomes. METHODS:A representative sample of 191 individuals diagnosed with bipolar I or II disorder was recruited and followed for up to 5 years using a life-chart method. We previously described the clinical course over the first 18 months with dimensional course characteristics and latent classes. Now we test if these course characteristics predict long-term outcomes, including time ill (time with any mood symptoms) and hospital admissions over a second non-overlapping follow-up period in 111 individuals with available data from both 18 months and 5 years follow-ups. RESULTS:Dimensional course characteristics from the first 18 months prospectively predicted outcomes over the following 3.5 years. The proportion of time depressed, the severity of depressive symptoms and the proportion of time manic predicted more time ill. The proportion of time manic, the severity of manic symptoms and depression-to-mania switching predicted a greater likelihood of hospital admissions. All predictions remained significant after controlling for age, sex and bipolar I v. II disorder. CONCLUSIONS:Differential associations with long-term outcomes suggest that course characteristics may facilitate care planning with greater predictive validity than established types of bipolar disorders. A clinical course dominated by depressive symptoms predicts a greater proportion of time ill. A clinical course characterized by manic episodes predicts hospital admissions.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Uher R,Pallaskorpi S,Suominen K,Mantere O,Pavlova B,Isometsä Edoi
10.1017/S0033291718001678subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1109-1117issue
7eissn
0033-2917issn
1469-8978pii
S0033291718001678journal_volume
49pub_type
杂志文章abstract:BACKGROUND:Studies evaluating depression's role in lung cancer risk revealed contradictory findings, partly because of the small number of cases, short follow-up periods, and failure to account for key covariates including smoking exposure. We investigated the association of depressive symptoms with lung cancer risk in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004390
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND:An uneven neurocognitive profile is a hallmark of autism spectrum disorder (ASD). Studies focusing on the visual memory performance in ASD have shown controversial results. We investigated visual memory and sustained attention in youths with ASD and typically developing (TD) youths. METHOD:We recruited 143 ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714003201
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:According to the stress sensitization hypothesis, prior exposure to extreme stressors may lead to increased responsiveness to subsequent stressors. It is unclear whether disaster exposure is associated with stress sensitization and, if so, whether this effect is lasting or temporary. This study aimed to inve...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002765
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002794
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Euthanasia and assisted suicide (EAS) based on a psychiatric disorder (psychiatric EAS) continue to pose ethical and policy challenges, even in countries where the practice has been allowed for years. We conducted a systematic review of reasons, a specific type of review for bioethical questions designed to ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001543
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Hypochondriasis is recognized as an important disorder in clinical populations, associated with increased health care utilization, disability and psychiatric co-morbidity. Few studies have investigated hypochondriasis in the community. We report on the broader concept of illness worry in a community populati...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003737
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Epidemiological evidence suggests a link between cannabis use and psychosis. A variety of factors have been proposed to mediate an individual's vulnerability to the harmful effects of the drug, one of which is their psychosis proneness. We hypothesized that highly psychosis-prone individuals would report mor...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708004741
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression - how age affects clinical presentation in first-episode psychosis - has not been thoroughly investigated. METHODS:Using generalized additive modeling, which allo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003463
更新日期:2020-10-06 00:00:00
abstract:BACKGROUND:Previous research in resting-state functional magnetic resonance imaging (rs-fMRI) has shown a mixed pattern of disrupted thalamocortical connectivity in psychosis. The clinical meaning of these findings and their stability over time remains unclear. We aimed to study thalamocortical connectivity longitudina...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004808
更新日期:2020-12-16 00:00:00
abstract::Diffuse loss of cortical volume and ventricular enlargement have been demonstrated in schizophrenia using imaging. In addition, histological studies have provided evidence that the number of neurons in the medial temporal lobe structures is reduced and that the cytoarchitecture is abnormal. In an attempt to correlate ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700033171
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had jus...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000280
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The differential strength of correlation between symptoms, cognition and other patient characteristics with community functioning in first-episode psychosis has not been fully investigated. METHOD:In a sample of 66 first-episode psychosis patients demographic variables, ratings of pre-morbid adjustment, pos...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291702006050
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:A long-standing issue in the health anxiety literature is the extent to which health anxiety is a dimensional or a categorical construct. This study explores this question directly using taxometric procedures. METHOD:Seven hundred and eleven working adults completed an index of health anxiety [the Whiteley ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708003322
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Capturing service users' perspectives can highlight additional and different concerns to those of clinicians, but there are no up to date, self-report psychometrically sound measures of side effects of antipsychotic medications. Aim To develop a psychometrically sound measure to identify antipsychotic side e...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000903
更新日期:2017-10-01 00:00:00
abstract::Social anxiety disorder is one of the most common comorbid conditions in eating disorders (EDs). The aim of the current review and meta-analysis is to provide a qualitative summary of what is known about social anxiety (SA) in EDs, as well as to compare levels of SA in those with EDs and healthy controls. Electronic d...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291718000752
更新日期:2018-11-01 00:00:00
abstract::Monthly hospital admission rates (HA) for mania were classified by sex, type of admission (first, or re-admission) and by country (England and Wales or Scotland). Of the 8 classes thus created, all but one showed a statistically significant annual cycle with a peak in Summer and trough in Winter. There was no signific...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001610x
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Meta-analyses support the efficacy of cognitive-behavioural therapy (CBT) for schizophrenia in western cultures. This study aimed to compare the efficacy of CBT and supportive therapy (ST) for patients with schizophrenia in China. METHOD:A multicentre randomized controlled, single-blinded, parallel-group tr...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1017/S0033291714002992
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:There is uncertainty about the incidence of breakthrough psychosis in treatment adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play in this phenomenon. METHODS:In a nationwide cohort of individuals treated for schizophrenia-spectrum disorders in Finland between 1 Ja...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001296
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001186
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Cognitive models of obsessive-compulsive disorder (OCD) posit dysfunctional appraisal of disorder-relevant stimuli in patients, suggesting disturbances in the processes relying on amygdala-prefrontal connectivity. Recent neuroanatomical models add to the traditional view of dysfunction in corticostriatal cir...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171800079X
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Although psychiatric patients with eating disorders are known to be at risk for a variety of health problems, relatively little is known about eating disorders and associated health problems in other populations. An epidemiological study was conducted to investigate health problems and impairment associated ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291701004640
更新日期:2001-11-01 00:00:00
abstract::Sixty-four children taken to court for failure to attend school were reliably classified into 4 groups, according to whether they exhibited the features of 'school refusal' and/or 'truancy'. About a fifth of them were found to exhibit 'school refusal'; a third showed 'truancy'; less than a sixth exhibited both 'school...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700021024
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:This study examined the associations between accelerometer-derived sedentary time (ST), lower intensity physical activity (LPA), higher intensity physical activity (HPA) and the incidence of depressive symptoms over 4 years of follow-up. METHODS:We included 2082 participants from The Maastricht Study (mean ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004924
更新日期:2020-12-18 00:00:00
abstract:BACKGROUND:Electronic medical records (EMR) provide a unique opportunity for efficient, large-scale clinical investigation in psychiatry. However, such studies will require development of tools to define treatment outcome. METHOD:Natural language processing (NLP) was applied to classify notes from 127 504 patients wit...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711000997
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Although symptoms such as fatigue, headache and pain in bones and muscles are common after disasters, risk factors for these symptoms among disaster survivors have rarely been studied. We examined predisposing, precipitating and perpetuating factors for these physical symptoms among survivors of a man-made d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170700133X
更新日期:2008-04-01 00:00:00
abstract::Serum total androgens were estimated by radioimmunoassay on blood samples of treatment-seeking homosexuals and heterosexual controls. There was no significant difference in androgen levels between the homosexual and control group, nor was there any relationship between androgen levels and response to treatment. These ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700004396
更新日期:1977-08-01 00:00:00
abstract:BACKGROUND:Generalized anxiety disorder is a common condition of excessive worry and tension which tends to run a chronic course associated with significant psychiatric and medical problems. Cognitive behaviour therapy (CBT) has been shown to be of clinical value in about 50% of cases with treatment gains maintained ov...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702007079
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of othe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002288
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Excessive worry is a defining feature of generalized anxiety disorder and is present in a wide range of other psychiatric conditions. Therefore, individualized predictions of worry propensity could be highly relevant in clinical practice, with respect to the assessment of worry symptom severity at the indivi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002763
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. METHOD:We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (90...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714002451
更新日期:2015-05-01 00:00:00