Abstract:
BACKGROUND:Excessive worry is a defining feature of generalized anxiety disorder and is present in a wide range of other psychiatric conditions. Therefore, individualized predictions of worry propensity could be highly relevant in clinical practice, with respect to the assessment of worry symptom severity at the individual level. METHODS:We applied a multivariate machine learning approach to predict dispositional worry based on microstructural integrity of white matter (WM) tracts. RESULTS:We demonstrated that the machine learning model was able to decode individual dispositional worry scores from microstructural properties in widely distributed WM tracts (mean absolute error = 10.46, p < 0.001; root mean squared error = 12.82, p < 0.001; prediction R2 = 0.17, p < 0.001). WM tracts that contributed to worry prediction included the posterior limb of internal capsule, anterior corona radiate, and cerebral peduncle, as well as the corticolimbic pathways (e.g. uncinate fasciculus, cingulum, and fornix) already known to be critical for emotion processing and regulation. CONCLUSIONS:The current work thus elucidates potential neuromarkers for clinical assessment of worry symptoms across a wide range of psychiatric disorders. In addition, the identification of widely distributed pathways underlying worry propensity serves to better improve the understanding of the neurobiological mechanisms associated with worry.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Feng C,Cui Z,Cheng D,Xu R,Gu Rdoi
10.1017/S0033291718002763subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1999-2008issue
12eissn
0033-2917issn
1469-8978pii
S0033291718002763journal_volume
49pub_type
杂志文章abstract:BACKGROUND:Although many case-control studies have replicated an association between dysfunctional parenting and a lifetime diagnosis of depression, few epidemiological studies have explored the association. In addition, little is known about the association in non-western countries. METHODS:Using logistic regression ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797006430
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Temperament and personality traits, including negative emotionality/neuroticism, may represent risk factors for eating disorders. Further, risk factors may differ by sex. We examined longitudinal temperament/personality pathways of risk for purging and binge eating in youth stratified by sex using data from ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001818
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Cannabis use is associated with altered neurocognitive functioning in severe mental disorders, but data are still inconclusive and there are no studies of bipolar disorder. The aim of this study was to investigate the association between cannabis use and neurocognition in bipolar disorder compared with schiz...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991620
更新日期:2010-08-01 00:00:00
abstract::Fifty patients attending a neurological outpatient clinic for Parkinson's disease were assessed by standardized methods for both physical and psychiatric symptoms. The patients then received treatment with L-dopa with carbidopa or anticholinergic drugs and/or amantadine. During the following six-month period the subje...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291700007467
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Pharmacological treatments targeting the neuroendocrine stress response may hold special promise in secondary prevention of posttraumatic stress disorder (PTSD). However, findings from clinical trials have been inconsistent and the efficacy of specific drugs, their temporal window of efficacy, effective dose...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001028
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:High rates of depression associated with childbirth have been reported in many parts of the developing world. However, the prevalence and associations of antenatal and post-natal depression in the rural population remain unknown. Disability associated with depression and its impact on infant health and devel...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008286
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:As children with attention-deficit/hyperactivity disorder (ADHD) usually show psychopathological signs beyond their core symptoms (e.g. elevated scores of the dysregulation profile (DP) in 30-40%), treatments with a broader approach to self-regulation skills may be supportive. Neurofeedback (NF) may reflect ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291718004130
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Non-suicidal self-injury (NSSI) prospectively predicts suicidal thoughts and behaviors in civilian populations. Despite high rates of suicide among US military members, little is known about the prevalence and course of NSSI, or how NSSI relates to suicidal thoughts and behaviors, in military personnel. MET...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002015
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Cognitive models postulate that negative-self-schemas (NSS) cause and maintain positive symptoms and that negative affect mediates this link. However, only few studies have tested the temporal mediation claim systematically using an appropriate design. METHODS:A longitudinal cohort design in an online commu...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S003329171700277X
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Despite the demonstrable influence of both genes and the family environment on children's behavioural and emotional development, the mechanisms by which these factors are transmitted from parents to their children are not known. Numerous aspects of the family have long been associated with behavioural and em...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008948
更新日期:2004-02-01 00:00:00
abstract::Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving c...
journal_title:Psychological medicine
pub_type: 社论
doi:10.1017/S0033291716003123
更新日期:2017-04-01 00:00:00
abstract::The notion that psychotic symptoms lie on a continuum with normality has become an accepted dogma. It is supported by several lines of empirical evidence, fits in with the orientation of modern services and has a 'moral' appeal. However, there is confusion as to the nature of the continuum or continua under discussion...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000188
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that postpartum psychiatric episodes may share similar etiological mechanisms with immune-related disorders. Pre-eclampsia is one of the most prevalent immune-related disorders of pregnancy. Multiple clinical features are shared between pre-eclampsia and postpartum psychiatric disord...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001385
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Although many studies have addressed the topic of stability versus change in depressive symptoms, few have further decomposed the change to continuous accumulation versus non-systematic state fluctuations or measurement errors. This further step requires a longitudinal follow-up and an appropriate stochastic...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002000
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Differences between verbal and non-verbal cognitive development from childhood to adulthood may differentiate between those with and without psychotic symptoms and affective symptoms in later life. However, there has been no study exploring this in a population-based cohort. METHOD:The sample was drawn from...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000393
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Major depressive disorder during pregnancy associates with potentially detrimental consequences for mother and child. The current study examined peripheral blood gene expression as a potential biomarker for prenatal depressive symptoms. METHOD:Maternal RNA from whole blood, plasma and the Beck Depression In...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002121
更新日期:2012-05-01 00:00:00
abstract::Results are reported from a large population study (of working people) comparing Holocaust survivors and a control group in regard to emotional distress, satisfaction in life and psychosomatic symptoms. It was found that, even 40 years after the traumatic experience, this group of survivors exhibited a slightly higher...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700002580
更新日期:1986-02-01 00:00:00
abstract::Psychiatric epidemiology has advanced considerably since early studies of hospital populations. The direction of this advance has been away from the study of populations of hospital psychiatric patients towards the study of psychiatric disorder in general practice and the community as a whole. Just as the populations ...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700039635
更新日期:1980-02-01 00:00:00
abstract::One hundred and eighteen subjects with an admission diagnosis of schizophrenia were reassessed after 12 months to establish whether hospital readmission had occurred. All subjects were rated at baseline and after 12 months on the Life Skills Profile (LSP), a 39-item measure of disability, with scores demonstrating mod...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700028178
更新日期:1995-01-01 00:00:00
abstract::The persistence of psychosis at a high and relatively constant prevalence in the various populations of the world is rendered difficult to explain by the absence of identified environmental precipitants and by reduced fertility of affected individuals. The problem is not confined to schizophrenia but applies also to a...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700000611
更新日期:1987-11-01 00:00:00
abstract::Cholecystokinin (CCK) is a peptide originally isolated from the gut. It has been investigated as a candidate treatment for schizophrenia on the assumption that the illness is associated with an imbalance between CCK and dopamine in the mesolimbic dopamine system. Many of the studies to assess the efficacy of CCK used ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,评审
doi:10.1017/s0033291700008278
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Childhood trauma is a risk factor for psychosis. Deficits in response inhibition are common to psychosis and trauma-exposed populations, and associated brain functions may be affected by trauma exposure in psychotic disorders. We aimed to identify the influence of trauma-exposure on brain activation and func...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002884
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Delusional disorder (DD) and obsessive-compulsive disorder (OCD) have been investigated in previous studies using probabilistic reasoning paradigms and abnormalities in each group have been reported. No study to date has compared results between these groups. This study compares patients with these disorders...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004175
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Social disadvantage consistently predicts both self-reported distress and clinically diagnosed disorders such as depression. Yet, many individuals who are exposed to disadvantage do not report high levels of distress. This study extends our recent work showing that high cognitive ability may protect against ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002118
更新日期:2019-07-01 00:00:00
abstract:BACKGROUNDS:Cigarette smoking is strongly associated with major depressive disorder (MDD). However, any genetic etiology of such comorbidity and causal relations is poorly understood, especially at the genome-wide level. METHODS:In the present in silico research, we analyzed summary data from the genome-wide associati...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000063X
更新日期:2020-04-06 00:00:00
abstract:BACKGROUND:Mental health morbidity in post-conflict settings is high. Nevertheless, randomized controlled trials of psychotherapy on site are rare. Our aim was to integrate rigorous research procedures into a humanitarian programme and test the efficacy of resource activation (ROTATE) in treating post-traumatic stress ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716002592
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The phenotypic stability of avoidant personality disorder (AVPD) and obsessive-compulsive personality disorder (OCPD) has previously been found to be moderate. However, little is known about the longitudinal structure of genetic and environmental factors for these disorders separately and jointly, and to wha...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001440
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In resource-poor countries, there remains an alarming treatment gap for people with schizophrenia, particularly those living in rural areas. Decentralization of mental health services, including community-based outreach programmes, represents one obvious strategy for bringing appropriate care to these commun...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291704003551
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Aggressive behaviour is increased among those with schizophrenia but less is known about those with affective psychoses. Similarly, little is known about aggressive behaviour occurring at the onset of illness. METHOD:The main reasons for presentation to services were examined among those recruited to a UK-b...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706008920
更新日期:2007-04-01 00:00:00
abstract::A survey over 2 years of all Police Referrals (Section 136 of the Mental Health Act 1983) in an inner-city health district identified 163 cases, with a core group of repeat referrals. Previous psychiatric admissions, a diagnosis of schizophrenia, social deprivation, and a bias towards young men of Afro-Caribbean ethni...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700038204
更新日期:1992-08-01 00:00:00