Effects of childhood trauma on left inferior frontal gyrus function during response inhibition across psychotic disorders.

Abstract:

BACKGROUND:Childhood trauma is a risk factor for psychosis. Deficits in response inhibition are common to psychosis and trauma-exposed populations, and associated brain functions may be affected by trauma exposure in psychotic disorders. We aimed to identify the influence of trauma-exposure on brain activation and functional connectivity during a response inhibition task. METHODS:We used functional magnetic resonance imaging to examine brain function within regions-of-interest [left and right inferior frontal gyrus (IFG), right dorsolateral prefrontal cortex, right supplementary motor area, right inferior parietal lobule and dorsal anterior cingulate cortex], during the performance of a Go/No-Go Flanker task, in 112 clinical cases with psychotic disorders and 53 healthy controls (HCs). Among the participants, 71 clinical cases and 21 HCs reported significant levels of childhood trauma exposure, while 41 clinical cases and 32 HCs did not. RESULTS:In the absence of effects on response inhibition performance, childhood trauma exposure was associated with increased activation in the left IFG, and increased connectivity between the left IFG seed region and the cerebellum and calcarine sulcus, in both cases and healthy individuals. There was no main effect of psychosis, and no trauma-by-psychosis interaction for any other region-of-interest. Within the clinical sample, the effects of trauma-exposure on the left IFG activation were mediated by symptom severity. CONCLUSIONS:Trauma-related increases in activation of the left IFG were not associated with performance differences, or dependent on clinical diagnostic status; increased IFG functionality may represent a compensatory (overactivation) mechanism required to exert adequate inhibitory control of the motor response.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Quidé Y,O'Reilly N,Watkeys OJ,Carr VJ,Green MJ

doi

10.1017/S0033291717002884

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

1454-1463

issue

9

eissn

0033-2917

issn

1469-8978

pii

S0033291717002884

journal_volume

48

pub_type

杂志文章
  • Day hospital versus intensive outpatient mentalization-based treatment: 3-year follow-up of patients treated for borderline personality disorder in a multicentre randomized clinical trial.

    abstract:BACKGROUND:Two types of mentalization-based treatment (MBT), day hospital MBT (MBT-DH) and intensive outpatient MBT (MBT-IOP), have been shown to be effective in treating patients with borderline personality disorder (BPD). This study evaluated trajectories of change in a multi-site trial of MBT-DH and MBT-IOP at 36 mo...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720002123

    authors: Smits ML,Feenstra DJ,Bales DL,Blankers M,Dekker JJM,Lucas Z,Kamphuis JH,Busschbach JJV,Verheul R,Luyten P

    更新日期:2020-06-30 00:00:00

  • A comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group.

    abstract:BACKGROUND:The usefulness of any diagnostic scheme is directly related to its ability to provide clinically useful information on need for care. In this study, the clinical usefulness of dimensional and categorical representations of psychotic psychopathology were compared. METHOD:A total of 706 patients aged 16-65 ye...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291798008162

    authors: Van Os J,Gilvarry C,Bale R,Van Horn E,Tattan T,White I,Murray R

    更新日期:1999-05-01 00:00:00

  • Risk markers for both chronic fatigue and irritable bowel syndromes: a prospective case-control study in primary care.

    abstract:BACKGROUND:Fatigue syndromes and irritable bowel syndrome (IBS) often occur together. Explanations include being different manifestations of the same condition and simply sharing some symptoms. METHOD:A matched case-control study in UK primary care, using data collected prospectively in the General Practice Research D...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709005601

    authors: Hamilton WT,Gallagher AM,Thomas JM,White PD

    更新日期:2009-11-01 00:00:00

  • Prevalence and determinants of cognitive impairment in the euthymic phase of bipolar disorders: results from the FACE-BD cohort.

    abstract:BACKGROUND:Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001186

    authors: Roux P,Etain B,Cannavo AS,Aubin V,Aouizerate B,Azorin JM,Bellivier F,Belzeaux R,Bougerol T,Cussac I,Courtet P,Kahn JP,Leboyer M,M'Bailara K,Payet MP,Olié E,FondaMental Advanced Centers of Expertise in Bipolar Disorders (F

    更新日期:2019-02-01 00:00:00

  • Cognitive trio: relationship with major depression and clinical predictors in Han Chinese women.

    abstract:BACKGROUND:Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his cognitive triad and other clinical features and risk factors among those with major depression (MD) has rarely been systematically studied. METHOD:The three key cognitive symptoms of worthle...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713000160

    authors: Wang L,Liu L,Shi S,Gao J,Liu Y,Li Y,Zhang Z,Wang G,Zhang K,Tao M,Gao C,Li K,Wang X,Lv L,Jiang G,Wang X,Jia H,Zhang J,Lu C,Li Y,Li K,Hu C,Ning Y,Li Y,Sun J,Liu T,Zhang Y,Ha B,Tian H,Meng H,Hu J

    更新日期:2013-11-01 00:00:00

  • Negative bias in fast emotion discrimination in borderline personality disorder.

    abstract:BACKGROUND:The ability to decode emotional information from facial expressions is crucial for successful social interaction. Borderline personality disorder (BPD) is characterized by serious problems in interpersonal relationships and emotional functioning. Empirical research on facial emotion recognition in BPD has be...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708004273

    authors: Dyck M,Habel U,Slodczyk J,Schlummer J,Backes V,Schneider F,Reske M

    更新日期:2009-05-01 00:00:00

  • The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression.

    abstract:BACKGROUND:Converging evidence implicates basal ganglia alterations in impulsivity and suicidal behavior. For example, D2/D3 agonists and subthalamic nucleus stimulation in Parkinson's disease (PD) trigger impulse control disorders and possibly suicidal behavior. Furthermore, suicidal behavior has been associated with ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002133

    authors: Dombrovski AY,Siegle GJ,Szanto K,Clark L,Reynolds CF,Aizenstein H

    更新日期:2012-06-01 00:00:00

  • Mood and anxiety disorders across the adult lifespan: a European perspective.

    abstract:BACKGROUND:The World Mental Health Survey Initiative (WMHSI) has advanced our understanding of mental disorders by providing data suitable for analysis across many countries. However, these data have not yet been fully explored from a cross-national lifespan perspective. In particular, there is a shortage of research o...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713001116

    authors: McDowell RD,Ryan A,Bunting BP,O'Neill SM,Alonso J,Bruffaerts R,de Graaf R,Florescu S,Vilagut G,de Almeida JM,de Girolamo G,Haro JM,Hinkov H,Kovess-Masfety V,Matschinger H,Tomov T

    更新日期:2014-03-01 00:00:00

  • Psychotherapeutic benefits of compassion-focused therapy: an early systematic review.

    abstract:BACKGROUND:Compassion-focused therapy (CFT) is a relatively novel form of psychotherapy that was developed for people who have mental health problems primarily linked to high shame and self-criticism. The aim of this early systematic review was to draw together the current research evidence of the effectiveness of CFT ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291714002141

    authors: Leaviss J,Uttley L

    更新日期:2015-04-01 00:00:00

  • The cross-national epidemiology of specific phobia in the World Mental Health Surveys.

    abstract:BACKGROUND:Although specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717000174

    authors: Wardenaar KJ,Lim CCW,Al-Hamzawi AO,Alonso J,Andrade LH,Benjet C,Bunting B,de Girolamo G,Demyttenaere K,Florescu SE,Gureje O,Hisateru T,Hu C,Huang Y,Karam E,Kiejna A,Lepine JP,Navarro-Mateu F,Oakley Browne M,Piazza M

    更新日期:2017-07-01 00:00:00

  • The incidence and prevalence of pervasive developmental disorders: a Danish population-based study.

    abstract:BACKGROUND:Based on prevalence studies and the few incidence studies of pervasive developmental disorders (PDDs) the prevalence and incidence of these disorders have been claimed to be increasing. METHOD:The annual and age-specific prevalence and incidence rates of childhood autism, atypical autism, Asperger's disorde...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291704002387

    authors: Lauritsen MB,Pedersen CB,Mortensen PB

    更新日期:2004-10-01 00:00:00

  • Are illness perceptions related to future healthcare expenditure in patients with somatoform disorders?

    abstract:BACKGROUND:Somatoform disorders are costly for society in terms of increased healthcare expenditure. Patients' illness perceptions have been found to play a role in somatoform disorders. However, it is unclear whether illness perceptions predict higher health costs in these patients. METHOD:A total of 1785 primary car...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171400035X

    authors: Frostholm L,Petrie KJ,Ornbøl E,Fink P

    更新日期:2014-10-01 00:00:00

  • Cognition as a treatment target in depression.

    abstract::Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving c...

    journal_title:Psychological medicine

    pub_type: 社论

    doi:10.1017/S0033291716003123

    authors: Kaser M,Zaman R,Sahakian BJ

    更新日期:2017-04-01 00:00:00

  • An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder.

    abstract:BACKGROUND:This study integrated an experimental medicine approach and a randomized cross-over clinical trial design following CONSORT recommendations to evaluate a cognitive training (CT) intervention for attention deficit hyperactivity disorder (ADHD). The experimental medicine approach was adopted because of documen...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000288

    authors: Wexler BE,Vitulano LA,Moore C,Katsovich L,Smith SD,Rush C,Grantz H,Dong J,Leckman JF

    更新日期:2020-02-24 00:00:00

  • What have the genomics ever done for the psychoses?

    abstract:BACKGROUND:Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed. METHODS:selective review of the recent literature on molecular genetic and genomic approaches to the ps...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291709991139

    authors: Gill M,Donohoe G,Corvin A

    更新日期:2010-04-01 00:00:00

  • Intellectual disability and mental disorders in a US population representative sample of adolescents.

    abstract:BACKGROUND:Most research on the prevalence, distribution, and psychiatric comorbidity of intellectual disability (ID) relies on clinical samples, limiting the generalizability and utility of ID assessment in a legal context. This study assessed ID prevalence in a population-representative sample of US adolescents and e...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001605

    authors: Platt JM,Keyes KM,McLaughlin KA,Kaufman AS

    更新日期:2019-04-01 00:00:00

  • The association between systolic blood pressure variability with depression, cognitive decline and white matter hyperintensities: the 3C Dijon MRI study.

    abstract:BACKGROUND:Accumulating evidence links blood pressure variability (BPV) with white matter hyperintensities (WMH) and stroke. The longitudinal association between BPV with late onset depression (LOD) and cognitive decline remains unexplored. METHODS:Prospective cohort study of 2812 participant's age ⩾65 years (median a...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717002756

    authors: Tully PJ,Debette S,Tzourio C

    更新日期:2018-07-01 00:00:00

  • Transcranial magnetic stimulation for depression and other psychiatric disorders.

    abstract:INTRODUCTION:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible alternative to electroconvulsive therapy for the treatment of selected patients with depression, bipolar affective disorder and schizophrenia. The aim of this study was to evaluate the evidence for the effectiveness of rTMS...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291701004378

    authors: McNamara B,Ray JL,Arthurs OJ,Boniface S

    更新日期:2001-10-01 00:00:00

  • Psychotic illness in ethnic minorities: clarification from the 1991 census.

    abstract::Age and sex-adjusted first admission rates for operationally-defined schizophrenia and other non-affective psychosis in different ethnic groups were calculated over the period 1988-1992 in a defined catchment area in South London. Standardized rates for schizophrenia, corrected for age- and gender-related under-report...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700033845

    authors: Van OS J,Castle DJ,Takei N,Der G,Murray RM

    更新日期:1996-01-01 00:00:00

  • Non-presentation at hospital following a suicide attempt: a national survey.

    abstract:BACKGROUND:A few previous studies suggest that a large number of individuals do not present at hospital following a suicide attempt, complicating recurrence prevention and prevalence estimation. METHODS:Data were extracted from a regular phone survey in representative samples of the French population aged 18-75 years ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720002305

    authors: Jollant F,Hawton K,Vaiva G,Chan-Chee C,du Roscoat E,Leon C

    更新日期:2020-07-03 00:00:00

  • Insight correlates in child- and adolescent-onset first episodes of psychosis: results from the CAFEPS study.

    abstract:BACKGROUND:The correlates of insight in early-onset psychosis have received little previous attention. METHOD:We studied clinical correlates of insight in a sample of 110 adolescent recent-onset psychosis patients (mean age 15.53 years; psychotic symptoms present for <6 months). Insight was measured with the Scale to ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708004868

    authors: Parellada M,Fraguas D,Bombín I,Otero S,Castro-Fornieles J,Baeza I,Gonzalez-Pinto A,Graell M,Soutullo C,Paya B,Arango C

    更新日期:2009-09-01 00:00:00

  • Two-year follow-up of the patients included in the WHO International Pilot Study of Schizophrenia.

    abstract::Over 90% of the 1202 patients investigated in the 9 centres collaborating in the International Pilot Study of Schizophrenia were traced 2 years after the initial examination and on the average over 75% of them were re-examined, using standardized instruments and methods. Results indicate that patients diagnosed as sch...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700004517

    authors: Sartorius N,Jablensky A,Shapiro R

    更新日期:1977-08-01 00:00:00

  • Strategies of research on economic instability and health.

    abstract::Recent research on unemployment and health has depended heavily on macro-social and ecological data analyses. In order to redress this imbalance, the report summarizes the methods and results of a prospective study of a permanent factory shutdown, thereby illustrating and dissecting some of the strengths and weaknesse...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700055744

    authors: Kasl SV

    更新日期:1982-08-01 00:00:00

  • Patterns of co-morbidity of eating disorders and substance use in Swedish females.

    abstract:BACKGROUND:Little is known about the association of eating disorder subtypes across multiple categories of substance use in population-based samples. We examined the association between eating disorders and substance use in a large population-based sample. METHOD:Female participants (n=13 297) were from the Swedish Tw...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709005662

    authors: Root TL,Pisetsky EM,Thornton L,Lichtenstein P,Pedersen NL,Bulik CM

    更新日期:2010-01-01 00:00:00

  • The capacity of a measure of disability (the LSP) to predict hospital readmission in those with schizophrenia.

    abstract::One hundred and eighteen subjects with an admission diagnosis of schizophrenia were reassessed after 12 months to establish whether hospital readmission had occurred. All subjects were rated at baseline and after 12 months on the Life Skills Profile (LSP), a 39-item measure of disability, with scores demonstrating mod...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700028178

    authors: Parker G,Hadzi-Pavlovic D

    更新日期:1995-01-01 00:00:00

  • Dimensions and classes of psychosis in a population cohort: a four-class, four-dimension model of schizophrenia and affective psychoses.

    abstract:BACKGROUND:Classification of psychosis lacks a biological basis and current diagnostic categories may obscure underlying continuities. Data reduction methods of symptom profiles within a population-based cohort of people with a wide range of affective and non-affective psychoses may permit an empirical classification o...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291704003745

    authors: Murray V,McKee I,Miller PM,Young D,Muir WJ,Pelosi AJ,Blackwood DH

    更新日期:2005-04-01 00:00:00

  • Kleptomania: clinical characteristics and associated psychopathology.

    abstract::A review of research on kleptomania--the syndrome of compulsive stealing--suggests that kleptomania may be a common disorder, especially among women, and that it may frequently be associated with other forms of psychopathology, such as mood, anxiety, and eating disorders. There appears to be a range of abnormal or non...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700014690

    authors: McElroy SL,Hudson JI,Pope HG,Keck PE

    更新日期:1991-02-01 00:00:00

  • The inability to ignore: distractibility in women with restricting anorexia nervosa.

    abstract:BACKGROUND:Attentional difficulties reported in individuals with anorexia nervosa (AN) may be due to preferential processing of disease-salient stimuli at a pre-attentive or at a conscious level or to a general problem in attention. Attentional difficulties may be associated with duration of illness. METHOD:Female par...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708002961

    authors: Dickson H,Brooks S,Uher R,Tchanturia K,Treasure J,Campbell IC

    更新日期:2008-12-01 00:00:00

  • Maternal depressive symptoms and children's academic performance: sex differences in the mediating role of school experiences.

    abstract:BACKGROUND:Maternal depressive symptoms (MDSs) are negatively associated with children's academic performance, with stronger effects sometimes reported in boys. However, few studies have tested the mechanisms of this association. We examined the mediating role of school engagement and peer victimization in this associa...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004298

    authors: Ahun MN,Psychogiou L,Guay F,Boivin M,Tremblay RE,Côté SM

    更新日期:2020-12-04 00:00:00

  • Application of network methods for understanding mental disorders: pitfalls and promise.

    abstract::Galvanized with the availability of sophisticated statistical techniques and large datasets, network medicine has emerged as an active area of investigation. Following this trend, network methods have been utilized to understand the interplay between symptoms of mental disorders. This realistic approach that may provi...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291717001350

    authors: Guloksuz S,Pries LK,van Os J

    更新日期:2017-12-01 00:00:00