Abstract:
BACKGROUND:Accumulating evidence links blood pressure variability (BPV) with white matter hyperintensities (WMH) and stroke. The longitudinal association between BPV with late onset depression (LOD) and cognitive decline remains unexplored. METHODS:Prospective cohort study of 2812 participant's age ⩾65 years (median age 72 years, 63.6% female) without dementia or stroke. Serial clinic visits assessed blood pressure, cognitive function, depression disorder, and depressive symptoms. A brain magnetic resonance imaging (MRI) substudy was performed in 1275 persons to examine possible associations with WMH. RESULTS:The interaction between symptomatic LOD and systolic BPV was associated with cognitive decline on the Isaac Set Test [slope -4.45; 95% confidence interval (CI) -8.92 to -0.16, p = 0.04], Benton Visual Retention Test (slope -0.89; 95% CI -1.77 to -0.01, p = 0.049), Mini Mental State Examination (slope -1.08; 95% CI -1.86 to -0.30, p = 0.007) and Finger Tapping Test (slope -7.53; 95% CI -13.71 to -1.34, p = 0.017) but not Trail Making Test-A or -B/A. The MRI substudy demonstrated that systolic BPV was associated with cognitive decline via interactions with depression and total WMH volume, but this was not dependent on either deep or periventricular WMH volumes. CONCLUSIONS:The findings show that the interaction between systolic BPV with symptomatic depression and WMH increases cognitive decline in persons ⩾65 years of age. Future work could extend these findings by examining systolic BPV in relation to cognitive decline and WMH in older populations with depression.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Tully PJ,Debette S,Tzourio Cdoi
10.1017/S0033291717002756subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1444-1453issue
9eissn
0033-2917issn
1469-8978pii
S0033291717002756journal_volume
48pub_type
杂志文章abstract:BACKGROUND:Depression can impair the immunogenicity of vaccine administration in adults. Whereas many vaccinations are administered in childhood, it is not known whether adolescent or adult onset depression is associated with impairments in the maintenance of protection of childhood vaccines. This study tested the hypo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718000661
更新日期:2019-01-01 00:00:00
abstract::Seventy eight men were assessed one month before coronary artery bypass graft surgery using standardized measures of psychiatric morbidity and personality as well as a measure of emotional expression (the CECS). All patients had at least one coronary vessel occluded by 75% or more of its diameter, and functional capac...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700025939
更新日期:1987-08-01 00:00:00
abstract::The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002172
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Schizophrenia is associated with perceptual organization deficits and abnormal neuronal connectivity has been described in early visual areas. The purpose of this study was to investigate the functional integrity of lateral connections in early visual areas of patients with schizophrenia and type I bipolar d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291705004381
更新日期:2005-07-01 00:00:00
abstract::Awareness of pulse rate was tested in 60 psychiatric out-patients with anxiety, phobic or hypochondriacal neuroses by asking them to record how fast their hearts were beating during exposure to short film sequences. Correlations between subjective and objective heart rate (ECG) were significantly higher in anxious and...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700039726
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:In other branches of epidemiology, stratum specific likelihood ratios (SSLRs) have been found to be preferable to fixed best threshold approaches to screening instruments. This paper presents SSLRs of GHQ-12 and GHQ-28 and compares the SSLR method with the traditional optimal threshold approach. METHODS:Ran...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1017/s0033291701003713
更新日期:2001-04-01 00:00:00
abstract::Over 90% of the 1202 patients investigated in the 9 centres collaborating in the International Pilot Study of Schizophrenia were traced 2 years after the initial examination and on the average over 75% of them were re-examined, using standardized instruments and methods. Results indicate that patients diagnosed as sch...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700004517
更新日期:1977-08-01 00:00:00
abstract::Fifty-six bulimia nervosa patients were treated by means of a behavioural approach and followed for at least one year after completion or dropping out of treatment. Outcome was encouraging in about half of the patients and several psychiatric indicators, such as duration of illness and response to treatment, were iden...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700002543
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Men sexually interested in children of a specific combination of maturity and sex tend to show some lesser interest in other categories of persons. Patterns of men's sexual interest across erotic targets' categories of maturity and sex have both clinical and basic scientific implications. METHOD:We examined...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001476
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Bipolar disorder I (BD-I) is defined by episodes of mania, depression and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood. METHODS:We...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000801
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Cognitive theory points to the importance of negative self-schemas in the onset and maintenance of depression and anxiety disorders. Hereby, it is important to distinguish between automatic and explicit self-schemas, reflecting different cognitive-motivational systems. This study tested whether patients with...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991371
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Recent studies have suggested that major depressive disorders are associated with a breakdown in the organization of ultradian rhythm in sleep EEG. The present study used cross-spectral analysis of sleep EEG to confirm this finding, in a larger-scale study, evaluating the influence of gender and age on ultra...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001300
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Prior studies have suggested that major depressive disorder (MDD) with pre-adult onset represents a distinct subtype with greater symptom severity and higher rates of suicidal ideation. Whether these patients have poorer response to various types of antidepressant treatment than those with adult-onset MDD is...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291712001742
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:To our knowledge, there are no universal screening tools for substance dependence that (1) were developed using a population-based sample, (2) estimate total risk briefly and inexpensively by incorporating a relatively small number of well-established risk factors, and (3) aggregate risk factors using a simp...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002482
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:To provide an overview of epidemiological studies of dementia among migrant groups in Europe and to estimate their pooled odds ratio (OR) v. the reference population. METHODS:Search for articles reporting on incidence or prevalence of dementia among ethnic minorities and migrants in Europe, published before...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000586
更新日期:2020-04-08 00:00:00
abstract::Clinical psychiatric and medical assessments were carried out on a randomly selected sample of Australian prisoners of war captured by the Japanese in 1942 and a sample of combatants from Pacific theatres of war who were not captured. Prisoners of war had significantly more anxiety and depressive 'neuroses' and more m...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700011843
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Studies exploring gene-environment interplay in affective disorders now include very large numbers of participants. Methods for evaluating the role of adversity in such studies need to be developed that do not rely on lengthy and labour-intensive interviews. In the present study, a brief questionnaire method...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170999225X
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Depressed individuals demonstrate a poorer ability to recognize the emotions of others, which could contribute to difficulties in interpersonal behaviour. This emotion recognition deficit appears related to the depressive state and is particularly pronounced when emotions are labelled semantically. Here, we ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002084
更新日期:2011-07-01 00:00:00
abstract::Recent research on unemployment and health has depended heavily on macro-social and ecological data analyses. In order to redress this imbalance, the report summarizes the methods and results of a prospective study of a permanent factory shutdown, thereby illustrating and dissecting some of the strengths and weaknesse...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700055744
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Research exploring the longitudinal course of posttraumatic stress disorder (PTSD) symptoms has documented four modal trajectories (low, remitting, high, and delayed), with proportions varying across studies. Heterogeneity could be due to differences in trauma types and patient demographic characteristics. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719004008
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:The role of antidepressant medications in bipolar depression remains controversial, mainly due to a lack of research in this area. In this study the authors examined the episode length in bipolar depression and the relationship between antidepressant therapy and episode length. METHOD:A retrospective chart ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291702006165
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Neurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related disorders represents a core feature of these illnesses, possibly a marker of underlying pathophysiology. Substantial overlap in domains of neuropsychological deficits has been reported among these disorders after illness onset. Howeve...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291710001042
更新日期:2011-02-01 00:00:00
abstract::A survey over 2 years of all Police Referrals (Section 136 of the Mental Health Act 1983) in an inner-city health district identified 163 cases, with a core group of repeat referrals. Previous psychiatric admissions, a diagnosis of schizophrenia, social deprivation, and a bias towards young men of Afro-Caribbean ethni...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700038204
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Although symptoms such as fatigue, headache and pain in bones and muscles are common after disasters, risk factors for these symptoms among disaster survivors have rarely been studied. We examined predisposing, precipitating and perpetuating factors for these physical symptoms among survivors of a man-made d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170700133X
更新日期:2008-04-01 00:00:00
abstract::Fifty patients attending a neurological outpatient clinic for Parkinson's disease were assessed by standardized methods for both physical and psychiatric symptoms. The patients then received treatment with L-dopa with carbidopa or anticholinergic drugs and/or amantadine. During the following six-month period the subje...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291700007467
更新日期:1976-02-01 00:00:00
abstract::Platelet MAO activity was found to be elevated in primary depressive illness, and the severity to correlate positively with MAO activity. The reactive depression subgroup's mean platelet MAO activity was not significantly different from that of the controls. The endogenous group's unipolar and bipolar subgroups had si...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034048
更新日期:1979-11-01 00:00:00
abstract::Biochemical studies of manic-depressive psychosis usually correlates biochemical findings with current affective state and hence any significant findings could be secondary to mood change. The present study attempts to correlate measures of the erythrocyte membrane cation carrier with clinical events, remote in time f...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291700013805
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001314
更新日期:2020-06-01 00:00:00
abstract::A review of research on kleptomania--the syndrome of compulsive stealing--suggests that kleptomania may be a common disorder, especially among women, and that it may frequently be associated with other forms of psychopathology, such as mood, anxiety, and eating disorders. There appears to be a range of abnormal or non...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700014690
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Belief inflexibility is a thinking style observed in patients with schizophrenia, in which patients tend to refute evidence that runs counter to their prior beliefs. This bias has been related to a dominance of prior expectations (prior beliefs) over incoming sensory evidence. In this study we investigated t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000384
更新日期:2012-11-01 00:00:00