What have the genomics ever done for the psychoses?

abstract：BACKGROUND:Generalized anxiety disorder is a common condition of excessive worry and tension which tends to run a chronic course associated with significant psychiatric and medical problems. Cognitive behaviour therapy (CBT) has been shown to be of clinical value in about 50% of cases with treatment gains maintained ov...

journal_title：Psychological medicine

authors： Durham RC,Chambers JA,MacDonald RR,Power KG,Major K

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:This study integrated an experimental medicine approach and a randomized cross-over clinical trial design following CONSORT recommendations to evaluate a cognitive training (CT) intervention for attention deficit hyperactivity disorder (ADHD). The experimental medicine approach was adopted because of documen...

journal_title：Psychological medicine

authors： Wexler BE,Vitulano LA,Moore C,Katsovich L,Smith SD,Rush C,Grantz H,Dong J,Leckman JF

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Although many studies have addressed the topic of stability versus change in depressive symptoms, few have further decomposed the change to continuous accumulation versus non-systematic state fluctuations or measurement errors. This further step requires a longitudinal follow-up and an appropriate stochastic...

journal_title：Psychological medicine

authors： Rosenström T,Jokela M,Hintsanen M,Pulkki-Råback L,Hutri-Kähönen N,Keltikangas-Järvinen L

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Most evidence in the UK on the effectiveness of brief therapy for depression concerns cognitive behaviour therapy (CBT). In a trial published in 2000, we showed that non-directive counselling and CBT were equally effective in general practice for patients with depression and mixed anxiety and depression. Our...

journal_title：Psychological medicine

authors： King M,Marston L,Bower P

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The mental and physical health of individuals with a psychotic illness are typically poor. Access to psychosocial interventions is important but currently limited. Telephone-delivered interventions may assist. In the current systematic review, we aim to summarise and critically analyse evidence for telephone...

journal_title：Psychological medicine

authors： Baker AL,Turner A,Beck A,Berry K,Haddock G,Kelly PJ,Bucci S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Patients treated in primary care settings report better mental outcomes when they agree with practitioners about the nature of their core presenting problems. However, no study has examined the impact of staff-patient agreement on treatment outcomes in specialist mental health services. We investigated wheth...

journal_title：Psychological medicine

authors： Lasalvia A,Bonetto C,Tansella M,Stefani B,Ruggeri M

更新日期：2008-01-01 00:00:00

abstract：:A retrospective study of alcoholic psychoses is reported. The phenomena of the illnesses corresponded poorly with classical descriptions of alcoholic hallucinosis, delirium tremens and alcoholic paranoia. Alternative diagnostic approaches were tried (Catego, restrictive definition of alcoholic hallucinosis). The probl...

journal_title：Psychological medicine

authors： Cutting J

更新日期：1978-05-01 00:00:00

abstract：:Inhibition of central dopamine functions appears to be a common basic property of antipsychotic drugs. The mesolimbic and nigrostriatal portions of the dopaminergic system are probably the main targets of these drugs for the mental and the extrapyramidal actions respectively. Dopaminergic hyperfunction, induced by amp...

journal_title：Psychological medicine

authors： Carlsson A

更新日期：1977-11-01 00:00:00

abstract：:Data from a case-control study of Alzheimer's disease (AD) were analysed in relation to age of onset and familial/sporadic status. The analyses were restricted to environmental exposures which might injure the brain. Later-onset AD was found to be positively associated with starvation/malnutrition and with nose-pickin...

journal_title：Psychological medicine

authors： Henderson AS,Jorm AF,Korten AE,Creasey H,McCusker E,Broe GA,Longley W,Anthony JC

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Several studies have reported smaller hippocampal volume (HcV) in depression patients; however, the temporality of the association remains unknown. One proposed hypothesis is that depression may cause HcV loss. This study evaluates whether previous depression and recent depressive symptoms are associated wit...

journal_title：Psychological medicine

authors： Elbejjani M,Fuhrer R,Abrahamowicz M,Mazoyer B,Crivello F,Tzourio C,Dufouil C

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Understanding the pathways to psychiatric care and recognition of delay points are crucial for the development of interventions that aim to improve access to mental health-care services. METHOD:Over a 2-month period in 2003, a total of 1044 patients at the commencement of new episodes of care at Amanuel Spe...

journal_title：Psychological medicine

authors： Bekele YY,Flisher AJ,Alem A,Baheretebeb Y

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...

journal_title：Psychological medicine

authors： Pozzato I,Kifley A,Craig A,Gopinath B,Tran Y,Jagnoor J,Cameron ID

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia ...

journal_title：Psychological medicine

authors： Silverstein SM,Paterno D,Cherneski L,Green S

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Cognitive behaviour therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) but access to CBT is limited. Internet-based CBT (ICBT) with therapist support is potentially a more accessible treatment. There are no randomized controlled trials testing ICBT for OCD. The aim of this study ...

journal_title：Psychological medicine

authors： Andersson E,Enander J,Andrén P,Hedman E,Ljótsson B,Hursti T,Bergström J,Kaldo V,Lindefors N,Andersson G,Rück C

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Interest in the mental health of women deployed to modern military campaigns is increasing, although research examining gender differences is limited. Little is known about experiences women have had on these deployments, or whether men and women respond differently to combat exposure. METHOD:The current st...

journal_title：Psychological medicine

authors： Woodhead C,Wessely S,Jones N,Fear NT,Hatch SL

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Childhood trauma is a risk factor for psychosis. Deficits in response inhibition are common to psychosis and trauma-exposed populations, and associated brain functions may be affected by trauma exposure in psychotic disorders. We aimed to identify the influence of trauma-exposure on brain activation and func...

journal_title：Psychological medicine

authors： Quidé Y,O'Reilly N,Watkeys OJ,Carr VJ,Green MJ

更新日期：2018-07-01 00:00:00

abstract：:Some experiments, reported in detail elsewhere, on the effects of mother-infant separation in rhesus monkeys are here reviewed and compared. They involved 4 groups--one in which mothers were removed for 13 days leaving the infant in the social group; one in which infants were removed; one in which mothers and infants ...

journal_title：Psychological medicine

authors： Hinde RA,Mcginnis L

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Current mental health legislation in the UK makes provision for the use of certain treatments in severely ill patients who are unable, or unwilling, to give informed consent. Under the terms of this legislation, electroconvulsive therapy (ECT) may be used, usually to treat severely depressed patients. A numb...

journal_title：Psychological medicine

authors： Wheeldon TJ,Robertson C,Eagles JM,Reid IC

更新日期：1999-01-01 00:00:00

abstract：:Twenty schizophrenic patients with tardive dyskinesia and an equal number of matched controls were tested on a novel cognitive task. The task had two components: cued response and spatial memory. Relative to controls, the dyskinetic subjects showed a superior cued response performance but an equal spatial memory abili...

journal_title：Psychological medicine

authors： Collerton D,Fairbairn A,Britton P

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:The experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the relationship between childhood trauma and sleep disturbances in severe mental disorders including the role of s...

journal_title：Psychological medicine

authors： Laskemoen JF,Aas M,Vaskinn A,Berg AO,Lunding SH,Barrett EA,Melle I,Simonsen C

更新日期：2020-04-23 00:00:00

abstract：:A monotonous voice is produced by schizophrenic patients whose expression of emotion is damped down and by patients with a severe degree of depression. Clinically, the distinction between these two diagnostic entities is virtually impossible to establish auditorily on the basis of voice quality alone. The laryngograph...

journal_title：Psychological medicine

authors： Leff J,Abberton E

更新日期：1981-11-01 00:00:00

abstract：:This is a study of the criterion validity of a newly developed computerized assessment (PROQSY) of minor psychological morbidity based on the Clinical Interview Schedule, employing a single GP's assessments as criterion measures of such morbidity and Relative Operating Characteristic (ROC) analysis. Two-stage screenin...

journal_title：Psychological medicine

authors： Wilkinson G,Markus AC

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Based on the developing clinical and legal literature, and using the framework adopted in draft legislation, capacity to make a valid decision about a clinically required blood test was investigated in three groups of people with a 'mental disability' (i.e. mental illness (chronic schizophrenia), 'learning d...

journal_title：Psychological medicine

authors： Wong JG,Clare CH,Holland AJ,Watson PC,Gunn M

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Early life maltreatment (ELM), borderline personality disorder (BPD), and major depressive disorder (MDD) have been associated with empathy deficits in different domains. Lack of maternal empathy has also been related to child behavioral problems. As ELM, BPD, and MDD often co-occur, we aimed to identify dis...

journal_title：Psychological medicine

authors： Dittrich K,Bermpohl F,Kluczniok D,Hindi Attar C,Jaite C,Fuchs A,Neukel C,Herpertz SC,Brunner R,Winter SM,Lehmkuhl U,Roepke S,Kaess M,Heim C,Boedeker K

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:In resource-poor countries, there remains an alarming treatment gap for people with schizophrenia, particularly those living in rural areas. Decentralization of mental health services, including community-based outreach programmes, represents one obvious strategy for bringing appropriate care to these commun...

journal_title：Psychological medicine

authors： Srinivasa Murthy R,Kishore Kumar KV,Chisholm D,Thomas T,Sekar K,Chandrashekari CR

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:While there is a growing body of research on borderline personality disorder (BPD) in children and adolescents, controversy remains regarding the validity and diagnosis of the disorder prior to adulthood. METHOD:MEDLINE, EMBASE, Psych INFO and PubMed databases were systematically searched for articles perta...

journal_title：Psychological medicine

authors： Winsper C,Marwaha S,Lereya ST,Thompson A,Eyden J,Singh SP

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS...

journal_title：Psychological medicine

authors： Engelbrecht A,Burdett H,Silva MJ,Bhui K,Jones E

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, wheth...

journal_title：Psychological medicine

authors： Lau MA,Christensen BK,Hawley LL,Gemar MS,Segal ZV

更新日期：2007-09-01 00:00:00

abstract：:Eighty-three chronic obstructive bronchitic patients were psychologically assessed before being randomly allocated to 1 of 3 management regimes. The following measures were taken: psychiatric disturbance, personality, social-desirability response set, vocabulary, expectations about treatment, attitudes and beliefs abo...

journal_title：Psychological medicine

authors： Rutter BM

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate...

journal_title：Psychological medicine

authors： Ferentinos P,Koukounari A,Power R,Rivera M,Uher R,Craddock N,Owen MJ,Korszun A,Jones L,Jones I,Gill M,Rice JP,Ising M,Maier W,Mors O,Rietschel M,Preisig M,Binder EB,Aitchison KJ,Mendlewicz J,Souery D,Hauser J,

更新日期：2015-07-01 00:00:00