Abstract:
:Cholecystokinin (CCK) is a peptide originally isolated from the gut. It has been investigated as a candidate treatment for schizophrenia on the assumption that the illness is associated with an imbalance between CCK and dopamine in the mesolimbic dopamine system. Many of the studies to assess the efficacy of CCK used open designs and are prone to observer bias and over-optimistic reporting. Most of the studies used CCK as an adjunct to standard neuroleptic treatment and are too small to be able to demonstrate extra efficacy above that of the active compound. Only three out of ten studies using CCK or placebo as an adjunct to neuroleptics reported limited efficacy. Of the 14 placebo-controlled reports only three were in drug-free patients. These were unfortunately too small, or too brief, to draw valid conclusions of efficacy. A summary of these data suggests that although 500 patients have received CCK, its efficacy in the treatment of schizophrenia has not been properly tested.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Montgomery SA,Green MCdoi
10.1017/s0033291700008278subject
Has Abstractpub_date
1988-08-01 00:00:00pages
593-603issue
3eissn
0033-2917issn
1469-8978journal_volume
18pub_type
临床试验,杂志文章,评审abstract:BACKGROUND:Trans and gender diverse (TGD) young people worldwide experience high rates of poor mental health; however, these rates were unknown in Australia. In addition, how negative life events affect the mental health of TGD young people has been largely unexplored. METHODS:This paper reports on novel mental health...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000643
更新日期:2020-04-01 00:00:00
abstract::Belief in free will has been a mainstay in philosophy throughout history, grounded in large part in our intuitive sense that we consciously control our actions and could have done otherwise. However, psychology and psychiatry have long sought to uncover mechanistic explanations for human behavior that challenge the no...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291713002985
更新日期:2014-09-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706008646
更新日期:2006-12-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171600180X
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/S0033291716002890
更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/s0033291700033511
更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291708004078
更新日期:2009-05-01 00:00:00
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journal_title:Psychological medicine
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更新日期:2015-12-01 00:00:00
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1017/S0033291707002280
更新日期:2008-10-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001116
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/s0033291704002910
更新日期:2005-01-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002287
更新日期:2016-03-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001984x
更新日期:1984-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700030865
更新日期:1979-05-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002686
更新日期:2012-08-01 00:00:00
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journal_title:Psychological medicine
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doi:10.1017/S0033291706009159
更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/S0033291710001066
更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/S003329170500543X
更新日期:2005-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000554
更新日期:2012-12-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703001314
更新日期:2004-04-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700047486
更新日期:1980-08-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003476
更新日期:2001-04-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003979
更新日期:2020-11-10 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001057
更新日期:2016-10-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000604
更新日期:2020-04-03 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706008920
更新日期:2007-04-01 00:00:00