The use of cholecystokinin in schizophrenia: a review.

Abstract:

:Cholecystokinin (CCK) is a peptide originally isolated from the gut. It has been investigated as a candidate treatment for schizophrenia on the assumption that the illness is associated with an imbalance between CCK and dopamine in the mesolimbic dopamine system. Many of the studies to assess the efficacy of CCK used open designs and are prone to observer bias and over-optimistic reporting. Most of the studies used CCK as an adjunct to standard neuroleptic treatment and are too small to be able to demonstrate extra efficacy above that of the active compound. Only three out of ten studies using CCK or placebo as an adjunct to neuroleptics reported limited efficacy. Of the 14 placebo-controlled reports only three were in drug-free patients. These were unfortunately too small, or too brief, to draw valid conclusions of efficacy. A summary of these data suggests that although 500 patients have received CCK, its efficacy in the treatment of schizophrenia has not been properly tested.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Montgomery SA,Green MC

doi

10.1017/s0033291700008278

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

593-603

issue

3

eissn

0033-2917

issn

1469-8978

journal_volume

18

pub_type

临床试验,杂志文章,评审
  • Associations between negative life experiences and the mental health of trans and gender diverse young people in Australia: findings from Trans Pathways.

    abstract:BACKGROUND:Trans and gender diverse (TGD) young people worldwide experience high rates of poor mental health; however, these rates were unknown in Australia. In addition, how negative life events affect the mental health of TGD young people has been largely unexplored. METHODS:This paper reports on novel mental health...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719000643

    authors: Strauss P,Cook A,Winter S,Watson V,Wright Toussaint D,Lin A

    更新日期:2020-04-01 00:00:00

  • The neuroscience of free will: implications for psychiatry.

    abstract::Belief in free will has been a mainstay in philosophy throughout history, grounded in large part in our intuitive sense that we consciously control our actions and could have done otherwise. However, psychology and psychiatry have long sought to uncover mechanistic explanations for human behavior that challenge the no...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291713002985

    authors: Pierre JM

    更新日期:2014-09-01 00:00:00

  • Childhood adversities and risk for suicidal ideation and attempts: a longitudinal population-based study.

    abstract:BACKGROUND:Developmental adversities may be risk factors for adult suicidal behavior, but this relationship has rarely been studied prospectively. The present study examined the association between childhood adversities and new onset suicidal ideation and attempts in an adult population-based sample. METHOD:The study ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706008646

    authors: Enns MW,Cox BJ,Afifi TO,De Graaf R,Ten Have M,Sareen J

    更新日期:2006-12-01 00:00:00

  • Associations between mood instability and emotional processing in a large cohort of bipolar patients.

    abstract:BACKGROUND:Aberrant emotional biases have been reported in bipolar disorder (BD), but results are inconsistent. Despite the clinical relevance of chronic mood variability in BD, there is no previous research investigating how the extent of symptom fluctuations in bipolar disorder might relate to emotional biases. This ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171600180X

    authors: Bilderbeck AC,Reed ZE,McMahon HC,Atkinson LZ,Price J,Geddes JR,Goodwin GM,Harmer CJ

    更新日期:2016-11-01 00:00:00

  • An attention and interpretation bias for illness-specific information in chronic fatigue syndrome.

    abstract:BACKGROUND:Studies have shown that specific cognitions and behaviours play a role in maintaining chronic fatigue syndrome (CFS). However, little research has investigated illness-specific cognitive processing in CFS. This study investigated whether CFS participants had an attentional bias for CFS-related stimuli and a ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716002890

    authors: Hughes AM,Chalder T,Hirsch CR,Moss-Morris R

    更新日期:2017-04-01 00:00:00

  • Dimensional structure of bodily panic attack symptoms and their specific connections to panic cognitions, anxiety sensitivity and claustrophobic fears.

    abstract:BACKGROUND:Previous studies of the dimensional structure of panic attack symptoms have mostly identified a respiratory and a vestibular/mixed somatic dimension. Evidence for additional dimensions such as a cardiac dimension and the allocation of several of the panic attack symptom criteria is less consistent. Clarifyin...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S0033291714002803

    authors: Drenckhan I,Glöckner-Rist A,Rist F,Richter J,Gloster AT,Fehm L,Lang T,Alpers GW,Hamm AO,Fydrich T,Kircher T,Arolt V,Deckert J,Ströhle A,Wittchen HU,Gerlach AL

    更新日期:2015-06-01 00:00:00

  • The Cardinal Needs Schedule--a modified version of the MRC Needs for Care Assessment Schedule.

    abstract::This paper describes a modified version of the MRC Needs for Care Schedule (the Cardinal Needs Schedule), for measuring needs for psychiatric and social care amongst patients with severe psychiatric disorders. The modified schedule has three new features: (i) it is quick and easy to use; (ii) it takes systematic accou...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700033511

    authors: Marshall M,Hogg LI,Gath DH,Lockwood A

    更新日期:1995-05-01 00:00:00

  • Do risk factors for suicidal behavior differ by affective disorder polarity?

    abstract:BACKGROUND:Suicide is a leading cause of death and has been strongly associated with affective disorders. The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort. METHOD:Participants...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S0033291708004078

    authors: Fiedorowicz JG,Leon AC,Keller MB,Solomon DA,Rice JP,Coryell WH

    更新日期:2009-05-01 00:00:00

  • The long-term outcome of subthreshold depression in later life.

    abstract:BACKGROUND:Subthreshold depression (SUBD) in later life is common and important as prodromal state and prominent risk factor in the development of major depressive disorder (MDD). Indicated prevention can reduce the incidence of MDD among people with SUBD substantially, but needs to be targeted to those that are truly ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716001549

    authors: Jeuring HW,Huisman M,Comijs HC,Stek ML,Beekman AT

    更新日期:2016-10-01 00:00:00

  • Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: a systematic review.

    abstract::Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinic...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291715001609

    authors: Noda Y,Silverstein WK,Barr MS,Vila-Rodriguez F,Downar J,Rajji TK,Fitzgerald PB,Mulsant BH,Vigod SN,Daskalakis ZJ,Blumberger DM

    更新日期:2015-12-01 00:00:00

  • Reduction in the occurrence of distressing involuntary memories following propranolol or hydrocortisone in healthy women.

    abstract:BACKGROUND:Pharmacological treatments targeting the neuroendocrine stress response may hold special promise in secondary prevention of posttraumatic stress disorder (PTSD). However, findings from clinical trials have been inconsistent and the efficacy of specific drugs, their temporal window of efficacy, effective dose...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719001028

    authors: Kamboj SK,Gong AT,Sim Z,Rashid AA,Baba A,Iskandar G,Das RK,Curran HV

    更新日期:2020-05-01 00:00:00

  • The effect of rehabilitation combined with cognitive remediation on functioning in persons with severe mental illness: systematic review and meta-analysis.

    abstract:BACKGROUND:Psychiatric rehabilitation (PR) can improve functioning in people with severe mental illness (SMI), but outcomes are still suboptimal. Cognitive impairments have severe implications for functioning and might reduce the effects of PR. It has been demonstrated that performance in cognitive tests can be improve...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析

    doi:10.1017/S003329171800418X

    authors: van Duin D,de Winter L,Oud M,Kroon H,Veling W,van Weeghel J

    更新日期:2019-07-01 00:00:00

  • Parental mental illness and fatal birth defects in a national birth cohort.

    abstract:BACKGROUND:Few large studies describe links between maternal mental illness and risk of major birth defect in offspring. Evidence is sparser still for how effects vary between maternal diagnoses and no previous study has assessed risk with paternal illnesses. METHOD:A population-based birth cohort was created by linki...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707002280

    authors: Webb RT,Pickles AR,King-Hele SA,Appleby L,Mortensen PB,Abel KM

    更新日期:2008-10-01 00:00:00

  • Mood and anxiety disorders across the adult lifespan: a European perspective.

    abstract:BACKGROUND:The World Mental Health Survey Initiative (WMHSI) has advanced our understanding of mental disorders by providing data suitable for analysis across many countries. However, these data have not yet been fully explored from a cross-national lifespan perspective. In particular, there is a shortage of research o...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713001116

    authors: McDowell RD,Ryan A,Bunting BP,O'Neill SM,Alonso J,Bruffaerts R,de Graaf R,Florescu S,Vilagut G,de Almeida JM,de Girolamo G,Haro JM,Hinkov H,Kovess-Masfety V,Matschinger H,Tomov T

    更新日期:2014-03-01 00:00:00

  • Sense of hyper-positive self and response to cognitive therapy in bipolar disorder.

    abstract:INTRODUCTION:Cognitive therapy (CT) for bipolar disorder emphasizes the monitoring and regulation of mood, thoughts and behaviour. The Sense of Hyper-Positive Self Scale (SHPSS) measures the extent to which bipolar patients value themselves and perceive themselves to possess personal attributes (e.g. dynamism, persuasi...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291704002910

    authors: Lam D,Wright K,Sham P

    更新日期:2005-01-01 00:00:00

  • The acute and medium-term effects of treatment with electroconvulsive therapy on memory in patients with major depressive disorder.

    abstract:BACKGROUND:Current literature provides insufficient information on the degree of cognitive impairment during and after electroconvulsive therapy (ECT), mostly due to the fact that applied tests lacked sensitivity and flexibility. Our goal was to evaluate cognitive functioning in adult depressed patients treated with bi...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715002287

    authors: Maric NP,Stojanovic Z,Andric S,Soldatovic I,Dolic M,Spiric Z

    更新日期:2016-03-01 00:00:00

  • Life events and depression in women: a structural equation model.

    abstract::A non-recursive structural equation model designed to examine the reciprocal relationship between life event reports and depressive symptoms in women is presented. The model was fitted to data from a 2-year longitudinal study of life events and depression in a sample of women with 5-year-old children. The findings sug...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170001984x

    authors: Fergusson DM,Horwood LJ

    更新日期:1984-11-01 00:00:00

  • Variations in referral pattern to the psychiatric services by general practitioners.

    abstract::Referral rates to psychiatric services in North-East Scotland by 147 individual urban and rural general practitioners were calculated. Among city doctors, the greater the number of years since qualification the more patients were referred. Single-handed city doctors also had very high referral rates. Subsequent interv...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700030865

    authors: Robertson NC

    更新日期:1979-05-01 00:00:00

  • The neuropsychology of prefrontal function in antisocial personality disordered offenders with varying degrees of psychopathy.

    abstract:BACKGROUND:Despite methodological differences between studies, it has been suggested that psychopathy may be associated with a ventromedial prefrontal cortex (VMPFC) deficit and antisocial personality disorder (ASPD), as classified in the DSM-IV, with a broader range of deficits in dorsolateral prefrontal cortex (DLPFC...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002686

    authors: Dolan M

    更新日期:2012-08-01 00:00:00

  • An analysis of suicide and undetermined deaths in 17 predominantly Islamic countries contrasted with the UK.

    abstract:BACKGROUND:Suicide is expressly condemned in the Qu'ran, and traditionally few Islamic countries have reported suicide. Undetermined deaths are classified by the World Health Organization (WHO) as Other Violent Deaths (OVD) in ICD-9, or Other External Causes (OEC) in ICD-10. It has been suggested that to avoid under-re...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706009159

    authors: Pritchard C,Amanullah S

    更新日期:2007-03-01 00:00:00

  • Undue influence of weight and shape: is it distinct from body dissatisfaction and concern about weight and shape?

    abstract:BACKGROUND:Three cognitive constructs are risk factors for eating disorders: undue influence of weight and shape, concern about weight and shape, and body dissatisfaction (BD). Undue influence, a diagnostic criterion for eating disorders, is postulated to be closely associated with self-esteem whereas BD is postulated ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291710001066

    authors: Wade TD,Zhu G,Martin NG

    更新日期:2011-04-01 00:00:00

  • A direct interview family study of obsessive-compulsive disorder. II. Contribution of proband informant information.

    abstract:BACKGROUND:Overall findings of our first direct interview family study of obsessive-compulsive disorder (OCD) indicated that OCD is familial. In this replication study, we carefully examined the role of informant data in ascertaining OCD in relatives. METHOD:We interviewed 112 relatives of 57 OCD patients and 115 rela...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170500543X

    authors: Lipsitz JD,Mannuzza S,Chapman TF,Foa EB,Franklin ME,Goodwin RD,Fyer AJ

    更新日期:2005-11-01 00:00:00

  • Generalized anxiety and C-reactive protein levels: a prospective, longitudinal analysis.

    abstract:BACKGROUND:Generalized anxiety disorder (GAD) is highly co-morbid with depression. Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP), cross-sectionally and over time. To date, no studies have looked at the association between CRP and GAD. METHOD:A total of nine waves of ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291712000554

    authors: Copeland WE,Shanahan L,Worthman C,Angold A,Costello EJ

    更新日期:2012-12-01 00:00:00

  • Smooth pursuit deficits in schizophrenia, affective disorder and obsessive-compulsive disorder.

    abstract:BACKGROUND:In schizophrenia, affective disorders, and obsessive-compulsive disorder (OCD) dysfunction of frontal neuronal circuits has been suggested. Such impairments imply corresponding oculomotor deficits. METHOD:Eye movement response to foveofugal and foveopetal step-ramp stimuli was recorded within the same study...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291703001314

    authors: Lencer R,Trillenberg P,Trillenberg-Krecker K,Junghanns K,Kordon A,Broocks A,Hohagen F,Heide W,Arolt V

    更新日期:2004-04-01 00:00:00

  • On establishing the validity of 'objective' data: can we rely on cross-interview agreement?

    abstract::It has been proposed that a high level of agreement between informants' reports about events and happenings ('objective' data) is a sound basis for establishing (a) the validity of the measure which is based on the reports, and (b) the nature of objective reality. In this paper it is argued that such agreement may not...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700047486

    authors: Platt S

    更新日期:1980-08-01 00:00:00

  • No evidence of increased risk for schizophrenia or bipolar affective disorder in persons with aneuploidies of the sex chromosomes.

    abstract:BACKGROUND:Several case reports and reviews have suggested an increased incidence of schizophrenia or bipolar disorder among persons with sex chromosome aneuploidies, but this observation may have been caused by biased sampling. METHODS:The 1122 individuals with sex chromosome aneuploidies registered in the Danish Cyt...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291701003476

    authors: Mors O,Mortensen PB,Ewald H

    更新日期:2001-04-01 00:00:00

  • Brain response to emotional faces in anxiety and depression: neural predictors of cognitive behavioral therapy outcome and predictor-based subgroups following therapy.

    abstract:BACKGROUND:Neuroimaging studies have shown variance in brain response to emotional faces predicts cognitive behavioral therapy (CBT) outcome. An important next step is to determine if individual differences in neural predictors of CBT response represent distinct patient groups. METHODS:In total, 90 patients with inter...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720003979

    authors: Klumpp H,Jimmy J,Burkhouse KL,Bhaumik R,Francis J,Craske MG,Phan KL,Ajilore O

    更新日期:2020-11-10 00:00:00

  • Cortical salience network activation precedes the development of delusion severity.

    abstract:BACKGROUND:Delusion is the most characteristic symptom of psychosis. While researchers suggested an association between changes of the cortical salience network (CSN) and delusion, whether these CSN findings are a cause or a consequence of delusion remains unknown. METHOD:To assess the effect of CSN functioning to for...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716001057

    authors: Raij TT,Mäntylä T,Mantere O,Kieseppä T,Suvisaari J

    更新日期:2016-10-01 00:00:00

  • Translating the promise of 5HT4 receptor agonists for the treatment of depression.

    abstract::Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are post-synaptic receptors that are located in striatal and limbic areas known to be involved in cognition and mood. Consistent with this, 5-HT4 ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000604

    authors: Murphy SE,de Cates AN,Gillespie AL,Godlewska BR,Scaife JC,Wright LC,Cowen PJ,Harmer CJ

    更新日期:2020-04-03 00:00:00

  • Aggressive behaviour at first contact with services: findings from the AESOP First Episode Psychosis Study.

    abstract:BACKGROUND:Aggressive behaviour is increased among those with schizophrenia but less is known about those with affective psychoses. Similarly, little is known about aggressive behaviour occurring at the onset of illness. METHOD:The main reasons for presentation to services were examined among those recruited to a UK-b...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706008920

    authors: Dean K,Walsh E,Morgan C,Demjaha A,Dazzan P,Morgan K,Lloyd T,Fearon P,Jones PB,Murray RM

    更新日期:2007-04-01 00:00:00