Abstract:
:Cholecystokinin (CCK) is a peptide originally isolated from the gut. It has been investigated as a candidate treatment for schizophrenia on the assumption that the illness is associated with an imbalance between CCK and dopamine in the mesolimbic dopamine system. Many of the studies to assess the efficacy of CCK used open designs and are prone to observer bias and over-optimistic reporting. Most of the studies used CCK as an adjunct to standard neuroleptic treatment and are too small to be able to demonstrate extra efficacy above that of the active compound. Only three out of ten studies using CCK or placebo as an adjunct to neuroleptics reported limited efficacy. Of the 14 placebo-controlled reports only three were in drug-free patients. These were unfortunately too small, or too brief, to draw valid conclusions of efficacy. A summary of these data suggests that although 500 patients have received CCK, its efficacy in the treatment of schizophrenia has not been properly tested.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Montgomery SA,Green MCdoi
10.1017/s0033291700008278subject
Has Abstractpub_date
1988-08-01 00:00:00pages
593-603issue
3eissn
0033-2917issn
1469-8978journal_volume
18pub_type
临床试验,杂志文章,评审abstract::This paper analyses patterns of episodes of anxiety and depression as recorded by 22 general practices which took part in the Second National Morbidity Survey (RCGP, 1980). The data comprise 6 years' records. Simple Markov chains are fitted to each age-group of men and women, and the inter-practice variation in the re...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700051643
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Geographic variations in the incidence of deliberate self-harm (DSH) and suicide have been shown to be associated with area-based measures of socio-economic deprivation and social fragmentation. Previous studies have been subject to methodological limitations. None has investigated whether ecological associa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003993
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Exclusion criteria are present in almost all diagnostic categories in both DSM-IV and ICD-10. These exclusion criteria state that one diagnosis is not made if it is 'due to' another disorder. However, there is little empirical evidence demonstrating that the hierarchy imposed by the exclusion criteria is mea...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291702006189
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Discontinuation of antipsychotics predisposes patients with remitted/stable first-episode psychosis (FEP) to a higher risk of relapse, but it remains unclear how long discontinuation increases the relapse rate in these patients compared with maintenance. METHODS:This meta-analysis of randomized controlled t...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291718001393
更新日期:2019-04-01 00:00:00
abstract::This is a study of the criterion validity of a newly developed computerized assessment (PROQSY) of minor psychological morbidity based on the Clinical Interview Schedule, employing a single GP's assessments as criterion measures of such morbidity and Relative Operating Characteristic (ROC) analysis. Two-stage screenin...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700011193
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Recent neurodevelopmental models of schizophrenia, together with substantial evidence of neurocognitive dysfunction among people with schizophrenia, have led to a widespread view that general cognitive deficits are a central aspect of schizophrenic pathology. However, the temporal relationships between intel...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001820
更新日期:2011-06-01 00:00:00
abstract::Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptamine) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Res...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001583x
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:Euthanasia and assisted suicide (EAS) based on a psychiatric disorder (psychiatric EAS) continue to pose ethical and policy challenges, even in countries where the practice has been allowed for years. We conducted a systematic review of reasons, a specific type of review for bioethical questions designed to ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001543
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Although positive effects of physical activity on mental health indicators have been reported, the relationship between physical activity and the development of specific mental disorders is unclear. METHOD:A cross-sectional (12-month) and prospective-longitudinal epidemiological study over 4 years in a comm...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170700089X
更新日期:2007-11-01 00:00:00
abstract::A non-recursive structural equation model designed to examine the reciprocal relationship between life event reports and depressive symptoms in women is presented. The model was fitted to data from a 2-year longitudinal study of life events and depression in a sample of women with 5-year-old children. The findings sug...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001984x
更新日期:1984-11-01 00:00:00
abstract::A case is reported in which platelet monoamine oxidase (MAO) activity fluctuated in the course of a schizophreniform psychosis in a way which suggests a direct relationship between low levels of MAO activity and the psychosis. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700056701
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Anxiety disorders are very common and increase risk for suicide attempts. Little is known about predictors of increased risk specifically among individuals with anxiety disorders. The purpose of this study was to investigate whether specific anxiety disorders and other co-morbid psychiatric disorders, physic...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002504
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The methodology for measuring the needs of patients with severe mental illness is now well established through the MRC Needs for Care Assessment Schedule and its modification in the form of the Cardinal Needs Assessment. This paper reports the rationale and construction of a relatives' version of the Cardina...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329179800662x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Aberrant emotional biases have been reported in bipolar disorder (BD), but results are inconsistent. Despite the clinical relevance of chronic mood variability in BD, there is no previous research investigating how the extent of symptom fluctuations in bipolar disorder might relate to emotional biases. This ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171600180X
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001314
更新日期:2020-06-01 00:00:00
abstract::Twenty schizophrenic patients with tardive dyskinesia and an equal number of matched controls were tested on a novel cognitive task. The task had two components: cued response and spatial memory. Relative to controls, the dyskinetic subjects showed a superior cued response performance but an equal spatial memory abili...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700023588
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Retrospective studies have consistently indicated an association between maladaptive parenting and borderline personality disorder (BPD). This requires corroboration with prospective, longitudinal designs. We investigated the association between suboptimal parenting and parent conflict in childhood and BPD s...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000542
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:We sought to clarify the etiological contribution of genetic and environmental factors to total criminal behavior (CB) measured as criminal convictions in men and women, and to violent (VCB), white-collar (WCCB) and property criminal behavior (PCB) in men only. METHOD:In 21 603 twin pairs from the Swedish T...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714002098
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Impaired emotion regulation may underlie exaggerated emotional reactivity in patients with obsessive compulsive disorder (OCD), yet instructed emotion regulation has never been studied in the disorder. METHOD:This study aimed to assess the neural correlates of emotion processing and regulation in 43 medicat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001026
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Generalized anxiety disorder is a common condition of excessive worry and tension which tends to run a chronic course associated with significant psychiatric and medical problems. Cognitive behaviour therapy (CBT) has been shown to be of clinical value in about 50% of cases with treatment gains maintained ov...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702007079
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg). The aim of this study was: (1) to compare the NOS activity of patients with a MDE to that of healthy controls (HC); (2)...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001749
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, wheth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000530
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Childhood trauma is a non specific risk factor for adult eating disorders (ED), and the hypothalamic-pituitary-adrenal (HPA) axis seems to mediate such a risk. Here we explored the impact of different types of childhood trauma and of traumatic load on the cortisol awakening response (CAR) of women with anore...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002409
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:There are no evidence-based treatments for severe and enduring anorexia nervosa (SE-AN). This study evaluated the relative efficacy of cognitive behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM) for adults with SE-AN. METHOD:Sixty-three participants with a diagnosis of AN, who...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1017/S0033291713000949
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. METHOD:A systematic review and meta-analysis was conducted of representative, longitudinal p...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0033291711002911
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Physical symptoms are commonly presented for treatment in the absence of physical pathology. This study tests predictions arising from the theory that childhood sexual abuse leads to emotional distress, illness orientation and social dysfunction as adults and that one or more of these effects, in turn, leads...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007892
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:The categorical classification system for personality disorder (PD) has been frequently criticized and several alternative dimensional models have been proposed. METHOD:Antecedent, concurrent and predictive markers of construct validity were examined for three models of PDs: the Five-Factor Model (FFM), the...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706009482
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:There are no risk models for the prediction of anxiety that may help in prevention. We aimed to develop a risk algorithm for the onset of generalized anxiety and panic syndromes. METHOD:Family practice attendees were recruited between April 2003 and February 2005 and followed over 24 months in the UK, Spain...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002400
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Despite the demonstrable influence of both genes and the family environment on children's behavioural and emotional development, the mechanisms by which these factors are transmitted from parents to their children are not known. Numerous aspects of the family have long been associated with behavioural and em...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008948
更新日期:2004-02-01 00:00:00
abstract::Fifty patients attending a neurological outpatient clinic for Parkinson's disease were assessed by standardized methods for both physical and psychiatric symptoms. The patients then received treatment with L-dopa with carbidopa or anticholinergic drugs and/or amantadine. During the following six-month period the subje...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291700007467
更新日期:1976-02-01 00:00:00