Translating the promise of 5HT4 receptor agonists for the treatment of depression.

abstract：BACKGROUND:Patients with anorexia nervosa (AN) run a high risk of becoming chronically ill and of dying. In the acute phase of their illness they present with numerous physical and laboratory abnormalities. However, little is known about the long-term prognostic value of these findings or about the medical morbidity in...

journal_title：Psychological medicine

authors： Herzog W,Deter HC,Fiehn W,Petzold E

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Individual-level measures of acculturation (e.g. age of immigration) have a complex relationship with psychiatric disorders. Fine-grained analyses that tap various acculturation dimensions and population subgroups are needed to generate hypotheses regarding the mechanisms of action for the association betwee...

journal_title：Psychological medicine

authors： Fernández RL,Morcillo C,Wang S,Duarte CS,Aggarwal NK,Sánchez-Lacay JA,Blanco C

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Existing evidence on profiles of psychological distress across adulthood uses cross-sectional or longitudinal studies with short observation periods. The objective of this research was to study the profile of psychological distress within the same individuals from early adulthood to early old age across thre...

journal_title：Psychological medicine

authors： Gondek D,Bann D,Patalay P,Goodman A,McElroy E,Richards M,Ploubidis GB

更新日期：2021-01-21 00:00:00

abstract：BACKGROUND:The excess mortality following first-contact psychosis is well recognized. However, the causes of death in a complete incidence cohort and mortality patterns over time compared with the general population are unknown. METHOD:All 2723 patients who presented for the first time with psychosis in three defined ...

journal_title：Psychological medicine

authors： Dutta R,Murray RM,Allardyce J,Jones PB,Boydell JE

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Previous studies have highlighted the role of the brain reward and cognitive control systems in the etiology of anorexia nervosa (AN). In an attempt to disentangle the relative contribution of these systems to the disorder, we used functional magnetic resonance imaging (fMRI) to investigate hemodynamic respo...

journal_title：Psychological medicine

authors： Boehm I,King JA,Bernardoni F,Geisler D,Seidel M,Ritschel F,Goschke T,Haynes JD,Roessner V,Ehrlich S

更新日期：2018-04-01 00:00:00

abstract：:In the literature on dementia the presence or absence of language deficits has come to occupy a pivotal position with respect to certain nosological and nosographical issues. These are reviewed critically, together with the results of experimental investigations which have sought to elucidate the nature of the languag...

journal_title：Psychological medicine

authors： Hart S

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:The significant proportion of schizophrenia patients refractory to treatment, primarily directed at the dopamine system, suggests that multiple mechanisms may underlie psychotic symptoms. Reinforcement learning tasks have been employed in schizophrenia to assess dopaminergic functioning and reward processing...

journal_title：Psychological medicine

authors： Vanes LD,Mouchlianitis E,Collier T,Averbeck BB,Shergill SS

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Clinical intuition suggests that personality disorders hinder the treatment of depression, but research findings are mixed. One reason for this might be the way in which current assessment measures conflate general aspects of personality disorders, such as overall severity, with specific aspects, such as sty...

journal_title：Psychological medicine

authors： Constantinou MP,Frueh BC,Fowler JC,Allen JG,Madan A,Oldham JM,Fonagy P

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:Temperament and personality traits, including negative emotionality/neuroticism, may represent risk factors for eating disorders. Further, risk factors may differ by sex. We examined longitudinal temperament/personality pathways of risk for purging and binge eating in youth stratified by sex using data from ...

journal_title：Psychological medicine

authors： Brown M,Hochman A,Micali N

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Although numerous studies have examined the latent structure of major depression, less attention has focused on mania. This paper presents the first investigation outside the USA to evaluate the psychometric properties of the DSM-IV criterion B mania symptoms using item response theory (IRT). METHOD:Data we...

journal_title：Psychological medicine

authors： Carragher N,Weinstock LM,Strong D

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Physical symptoms are commonly presented for treatment in the absence of physical pathology. This study tests predictions arising from the theory that childhood sexual abuse leads to emotional distress, illness orientation and social dysfunction as adults and that one or more of these effects, in turn, leads...

journal_title：Psychological medicine

authors： Reilly J,Baker GA,Rhodes J,Salmon P

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The goal of this study is to determine the association between panic attacks in adolescence and the risk of personality disorders during young adulthood. METHOD:Data were drawn from the Children in the Community Study, a longitudinal epidemiological study of psychopathology across the life-course in 717 indi...

journal_title：Psychological medicine

authors： Goodwin RD,Brook JS,Cohen P

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The incidence of schizophrenia in the African-Caribbean population in England is reported to be raised. We sought to clarify whether (a) the rates of other psychotic disorders are increased, (b) whether psychosis is increased in other ethnic minority groups, and (c) whether particular age or gender groups ar...

journal_title：Psychological medicine

authors： Fearon P,Kirkbride JB,Morgan C,Dazzan P,Morgan K,Lloyd T,Hutchinson G,Tarrant J,Fung WL,Holloway J,Mallett R,Harrison G,Leff J,Jones PB,Murray RM,AESOP Study Group.

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Aggressive behaviour is increased among those with schizophrenia but less is known about those with affective psychoses. Similarly, little is known about aggressive behaviour occurring at the onset of illness. METHOD:The main reasons for presentation to services were examined among those recruited to a UK-b...

journal_title：Psychological medicine

authors： Dean K,Walsh E,Morgan C,Demjaha A,Dazzan P,Morgan K,Lloyd T,Fearon P,Jones PB,Murray RM

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Childhood early life stress (ELS) increases risk of adulthood major depressive disorder (MDD) and is associated with altered brain structure and function. It is unclear whether specific ELSs affect depression risk, cognitive function and brain structure. METHOD:This cross-sectional study included 64 antidep...

journal_title：Psychological medicine

authors： Saleh A,Potter GG,McQuoid DR,Boyd B,Turner R,MacFall JR,Taylor WD

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Although specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-...

journal_title：Psychological medicine

authors： Wardenaar KJ,Lim CCW,Al-Hamzawi AO,Alonso J,Andrade LH,Benjet C,Bunting B,de Girolamo G,Demyttenaere K,Florescu SE,Gureje O,Hisateru T,Hu C,Huang Y,Karam E,Kiejna A,Lepine JP,Navarro-Mateu F,Oakley Browne M,Piazza M

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Causal attributions about bodily sensations may determine help-seeking and influence patients' demands for medical treatment. The present study aimed to differentiate the causal attributions associated with health-related and non-health-related anxiety. METHODS:Anxious hypochondriacal, generally anxious, an...

journal_title：Psychological medicine

authors： MacLeod AK,Haynes C,Sensky T

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:There is evidence that patients with chronic fatigue syndrome (CFS) have mild hypocortisolism. The clinical significance of this is unclear. We aimed to determine whether hypocortisolism exerted any effect on the response of CFS to cognitive behavioural therapy (CBT). METHOD:We measured 24-h urinary free co...

journal_title：Psychological medicine

authors： Roberts AD,Charler ML,Papadopoulos A,Wessely S,Chalder T,Cleare AJ

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Structural models of emotional disorders propose that anxiety disorders can be classified into fear and distress disorders. Sources of evidence for this distinction come from genetic, self-report and neurophysiological data from adults. The present study examined whether this distinction relates to cognitive...

journal_title：Psychological medicine

authors： Waters AM,Bradley BP,Mogg K

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior ci...

journal_title：Psychological medicine

authors： Csukly G,Szabó Á,Polgár P,Farkas K,Gyebnár G,Kozák LR,Stefanics G

更新日期：2020-04-24 00:00:00

abstract：BACKGROUND:We investigated whether schizophrenic subjects are impaired in non-routine behaviour because of the dysfunction of a general executive component labelled, in neuropsychological terms, the supervisory system. METHODS:A specific verbal sequencing test was designed for this purpose. Subjects had to perform seq...

journal_title：Psychological medicine

authors： Robert PH,Migneco V,Chaix I,Berthet L,Kazes M,Danion JM,Baudu C,Darcourt G

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:To provide an overview of epidemiological studies of dementia among migrant groups in Europe and to estimate their pooled odds ratio (OR) v. the reference population. METHODS:Search for articles reporting on incidence or prevalence of dementia among ethnic minorities and migrants in Europe, published before...

journal_title：Psychological medicine

authors： Selten JP,Termorshuizen F,van Sonsbeek M,Bogers J,Schmand B

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:This study investigated factors contributing to suspected offending behaviour by adults with a history of learning disabilities taken into custody at a city police station. METHODS:Adults charged with offences, and/or leaving custody, during a defined period, were identified as having a possible learning di...

journal_title：Psychological medicine

authors： Winter N,Holland AJ,Collins S

更新日期：1997-05-01 00:00:00

abstract：:Major depressive disorder (MDD) is a mental illness with high socio-economic burden, but its pathophysiology has not been fully elucidated. Recently, the cortical excitatory and inhibitory imbalance hypothesis and neuroplasticity hypothesis have been proposed for MDD. Although several studies have examined the neuroph...

journal_title：Psychological medicine

authors： Kinjo M,Wada M,Nakajima S,Tsugawa S,Nakahara T,Blumberger DM,Mimura M,Noda Y

更新日期：2021-01-01 00:00:00

abstract：:The authors review the evidence that parental death in childhood predisposes to depressive disorders in later life. The findings in general are quite inconsistent; this is due in part to the methodological limitations of most studies, principally that of inadequate control of potentially confounding variables. Where e...

journal_title：Psychological medicine

authors： Tennant C,Bebbington P,Hurry J

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:The aims of the present study were to examine serum activities of peptidases, i.e. prolyl endopeptidase (PEP) and dipeptidyl peptidase IV (DPP IV), in patients with fibromyalgia and to examine the effects of subchronic treatment with sertraline on these variables. METHOD:Serum PEP and DPP IV activity were m...

journal_title：Psychological medicine

authors： Maes M,Libbrecht I,Van Hunsel F,Lin AH,Bonaccorso S,Goossens F,De Meester I,De Clerck L,Biondi M,Scharpe S,Janca A

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:The development of childhood anxiety disorders (CADs) is likely to depend on pathways that can be programmed by early-life risk factors. We test the hypothesis that early-life maternal factors can predict this programming effect on CAD. METHODS:Data were obtained from 198 women and children from the Mercy P...

journal_title：Psychological medicine

authors： Galbally M,Watson SJ,van Rossum EFC,Chen W,de Kloet ER,Lewis AJ

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:There have been conflicting reports on time trends in urban-rural differences in the incidence of schizophrenia. This study explored the potential time trends in these differences with regard to birth cohort and age at onset. METHOD:Linking data from the Danish Civil Registration system with data from the D...

journal_title：Psychological medicine

authors： Pedersen CB

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Suicide is a leading cause of death and has been strongly associated with affective disorders. The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort. METHOD:Participants...

journal_title：Psychological medicine

authors： Fiedorowicz JG,Leon AC,Keller MB,Solomon DA,Rice JP,Coryell WH

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Previous research has yielded conflicting evidence regarding the long-term cognitive outcome of depression. Some studies have found evidence for a higher incidence of subsequent cognitive impairment or dementia, while others have refuted this. METHOD:Depression, neuropsychological performance, functional ab...

journal_title：Psychological medicine

authors： Brodaty H,Luscombe G,Anstey KJ,Cramsie J,Andrews G,Peisah C

更新日期：2003-10-01 00:00:00