Abstract:
:In the literature on dementia the presence or absence of language deficits has come to occupy a pivotal position with respect to certain nosological and nosographical issues. These are reviewed critically, together with the results of experimental investigations which have sought to elucidate the nature of the language deficit(s) in patients with dementia, especially that of the Alzheimer type. Attention is drawn to important gaps in current knowledge and suggestions are made regarding the direction of future research.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Hart Sdoi
10.1017/s0033291700001938subject
Has Abstractpub_date
1988-02-01 00:00:00pages
99-112issue
1eissn
0033-2917issn
1469-8978journal_volume
18pub_type
杂志文章,评审abstract:BACKGROUND:Preparing for potentially threatening events in the future is essential for survival. Anticipating the future to be unpleasant is also a cognitive key feature of depression. We hypothesized that 'pessimism'-related emotion processing would characterize brain activity in major depression.MethodDuring function...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991073
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:There is uncertainty about the incidence of breakthrough psychosis in treatment adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play in this phenomenon. METHODS:In a nationwide cohort of individuals treated for schizophrenia-spectrum disorders in Finland between 1 Ja...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001296
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Refugees commonly experience difficulties with emotional processing, such as alexithymia, due to stressful or traumatic experiences. However, the functional connectivity of the amygdala, which is central to emotional processing, has yet to be assessed in refugees. Thus, the present study investigated the res...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000175
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Cognitive theory points to the importance of negative self-schemas in the onset and maintenance of depression and anxiety disorders. Hereby, it is important to distinguish between automatic and explicit self-schemas, reflecting different cognitive-motivational systems. This study tested whether patients with...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991371
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Capturing service users' perspectives can highlight additional and different concerns to those of clinicians, but there are no up to date, self-report psychometrically sound measures of side effects of antipsychotic medications. Aim To develop a psychometrically sound measure to identify antipsychotic side e...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000903
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Most evidence in the UK on the effectiveness of brief therapy for depression concerns cognitive behaviour therapy (CBT). In a trial published in 2000, we showed that non-directive counselling and CBT were equally effective in general practice for patients with depression and mixed anxiety and depression. Our...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291713002377
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Various childhood social experiences have been reported to predict adult outcomes. However, it is unclear how different social contexts may influence each other's effects in the long run. This study examined the joint contribution of adolescent family and peer experiences to young adult wellbeing and functio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001976
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Childhood abuse is a risk factor for poorer illness course in bipolar disorder, but the reasons why are unclear. Trait-like features such as affective instability and impulsivity could be part of the explanation. We aimed to examine whether childhood abuse was associated with clinical features of bipolar dis...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002411
更新日期:2020-10-01 00:00:00
abstract::Five hundred and eighty schoolgirls living in a small North Indian industrial town were screened using the EAT-26. Although twenty-nine per cent scored above the threshold for the questionnaire (greater than or equal to 20), closer scrutiny of the pattern of responses revealed misinterpretations of a large number of q...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700005675
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Geographic variations in the incidence of deliberate self-harm (DSH) and suicide have been shown to be associated with area-based measures of socio-economic deprivation and social fragmentation. Previous studies have been subject to methodological limitations. None has investigated whether ecological associa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003993
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Psychiatric disorders and related intermediate phenotypes are highly heritable and have a complex, overlapping polygenic architecture. A large-scale genome-wide association study (GWAS) of anxiety disorders identified genetic variants that are significant on a genome-wide. The current study investigated the ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171900059X
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Whether late-onset depression is a risk factor for or a prodrome of dementia remains unclear. We investigated the impact of depressive symptoms and early- v. late-onset depression on subsequent dementia in a cohort of elderly general-practitioner patients (n = 2663, mean age = 81.2 years). METHOD:Risk for s...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291712002449
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Elevated levels of circulating C-reactive protein (CRP) have been associated with coronary heart disease and, in some studies, depression. Most studies have been of populations selected by age and/or gender. We investigate these associations with depression, myocardial infarction (MI), or both, in a large ge...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000887
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior ci...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000859
更新日期:2020-04-24 00:00:00
abstract:BACKGROUND:Anorexia nervosa and bulimia nervosa are two severe eating disorders associated with high premature mortality, suicidal risk and serious medical complications. Transition between anorexia nervosa and bulimia nervosa over the illness course and familial co-aggregation of the two eating disorders imply aetiolo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002976
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:In resource-poor countries, there remains an alarming treatment gap for people with schizophrenia, particularly those living in rural areas. Decentralization of mental health services, including community-based outreach programmes, represents one obvious strategy for bringing appropriate care to these commun...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291704003551
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of othe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002288
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Pharmacological treatments targeting the neuroendocrine stress response may hold special promise in secondary prevention of posttraumatic stress disorder (PTSD). However, findings from clinical trials have been inconsistent and the efficacy of specific drugs, their temporal window of efficacy, effective dose...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001028
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Stress questionnaires are included in many epidemiological cohort studies but the psychometric characteristics of these questionnaires are largely unknown. The aim of this study was to describe these characteristics for two short questionnaires measuring the lifetime and past year occurrence of stress: the L...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000608
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Two types of mentalization-based treatment (MBT), day hospital MBT (MBT-DH) and intensive outpatient MBT (MBT-IOP), have been shown to be effective in treating patients with borderline personality disorder (BPD). This study evaluated trajectories of change in a multi-site trial of MBT-DH and MBT-IOP at 36 mo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002123
更新日期:2020-06-30 00:00:00
abstract:BACKGROUND:UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001460
更新日期:2019-04-01 00:00:00
abstract::We recently completed a case-control study of 100 literally homeless and 100 never homeless indigent schizophrenic men in New York City, in which concurrent substance abuse and antisocial personality disorder were widespread. In this paper we probe the correlates of 'pure' schizophrenia (single disorder, N = 60), schi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700027835
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The present study tested the hypothesis of a differential pattern of reward and punishment responsiveness in depression measuring effort mobilization during anticipation and facial expressions during consumption. METHODS:Twenty patients with major depressive disorder (MDD) and 20 control participants worked...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001526
更新日期:2019-04-01 00:00:00
abstract::The concept of allusive thinking is briefly reviewed and a Pavlovian model of thinking advanced. It is hypothesized that allusive, as compared with non-allusive thinkers, have a broader but less intense attention process associated with weaker inhibition. From this model it was predicted that on word tests which requi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700004414
更新日期:1977-08-01 00:00:00
abstract::General practitioners using DSM-III criteria have studied the incidence and prevalence of anorexia nervosa and bulimia nervosa in a large (N = 151,781) representative sample of the Dutch population. The incidence rate for anorexia nervosa is 6.3 and for bulimia nervosa 9.9 per year per 100,000 population. The prevalen...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700020560
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:To assess the prevalence and clinical impact of co-morbid social anxiety disorder (SAD) and alcohol use disorders (AUD, i.e. alcohol abuse and alcohol dependence) in a nationally representative sample of adults in the United States. METHOD:Data came from a large representative sample of the US population. F...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991231
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, wheth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000530
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Reward dysfunction is a major dimension of depressive symptomatology, but it remains obscure if that dysfunction varies across different reward types. In this study, we focus on the abnormalities in anticipatory/consummatory processing of monetary and social reward associated with depressive symptoms. METHO...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003967
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is accompanied by alterations in grey matter volume. However, the biological processes associated with regional structural perturbations remain elusive. METHODS:We applied integrative omics analysis to investigate specialized transcriptome signatures and translational determi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002676
更新日期:2020-07-29 00:00:00
abstract::Potential cases of presenile dementia of the Alzheimer type (PDAT) in the Northern Health Region (estimated population aged 45-64, 655,800) were ascertained for the years 1979-86 from in-patient ICD-9 codes and other sources. An algorithm was applied to the casenote information to distinguish between Alzheimer-type an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700025411
更新日期:1993-08-01 00:00:00