Abstract:
BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, whether valence-specific inhibitory deficits are associated with increased negative cognition and whether such deficits are specific to depression per se remains unexamined. The authors posit the theory that inhibitory dysfunction may influence the degree to which activated self-schemas result in the production of depressive cognition. METHOD:Individuals with major depressive disorder (MDD, n=43) versus healthy (n=36) and non-depressed anxious (n=32) controls were assessed on the Prose Distraction Task (PDT), a measure of cognitive inhibition, and the Stop-Signal Task (SST), a measure of motor response inhibition. These two tasks were modified in order to present emotionally valenced semantic stimuli (i.e. negative, neutral, positive). RESULTS:Participants with MDD demonstrated performance impairments on the PDT, which were most pronounced for negatively valenced adjectives, relative to both control groups. Moreover, these impairments correlated with self-report measures of negative thinking and rumination. Conversely, the performance of the MDD participants did not differ from either control group on the SST. CONCLUSIONS:Implications of these findings for understanding the mechanisms underlying the development and maintenance of depressive cognition are discussed.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Lau MA,Christensen BK,Hawley LL,Gemar MS,Segal ZVdoi
10.1017/S0033291707000530subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1249-59issue
9eissn
0033-2917issn
1469-8978pii
S0033291707000530journal_volume
37pub_type
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