Inhibitory deficits for negative information in persons with major depressive disorder.

Abstract:

BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, whether valence-specific inhibitory deficits are associated with increased negative cognition and whether such deficits are specific to depression per se remains unexamined. The authors posit the theory that inhibitory dysfunction may influence the degree to which activated self-schemas result in the production of depressive cognition. METHOD:Individuals with major depressive disorder (MDD, n=43) versus healthy (n=36) and non-depressed anxious (n=32) controls were assessed on the Prose Distraction Task (PDT), a measure of cognitive inhibition, and the Stop-Signal Task (SST), a measure of motor response inhibition. These two tasks were modified in order to present emotionally valenced semantic stimuli (i.e. negative, neutral, positive). RESULTS:Participants with MDD demonstrated performance impairments on the PDT, which were most pronounced for negatively valenced adjectives, relative to both control groups. Moreover, these impairments correlated with self-report measures of negative thinking and rumination. Conversely, the performance of the MDD participants did not differ from either control group on the SST. CONCLUSIONS:Implications of these findings for understanding the mechanisms underlying the development and maintenance of depressive cognition are discussed.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Lau MA,Christensen BK,Hawley LL,Gemar MS,Segal ZV

doi

10.1017/S0033291707000530

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

1249-59

issue

9

eissn

0033-2917

issn

1469-8978

pii

S0033291707000530

journal_volume

37

pub_type

杂志文章
  • The family and compliance in schizophrenia: the influence of clinical variables, relatives' knowledge and expressed emotion.

    abstract:BACKGROUND:. A variety of factors are related to compliance with medication in schizophrenia, but little attention has been paid to the role of families. Carers' knowledge or expressed emotion (EE) may be related to compliance. The aim of the present study was to evaluate the relevance of these two factors, as well as ...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291702006888

    authors: Sellwood W,Tarrier N,Quinn J,Barrowclough C

    更新日期:2003-01-01 00:00:00

  • Prognosis of schizophrenia in persons with and without a history of cannabis use.

    abstract:BACKGROUND:The aim of the study was to determinate whether schizophrenia patients with a history of cannabis use have a different prognosis, with regards to readmission and hospital duration, compared with those without a history of cannabis use. METHOD:The present investigation was a cohort study of 50,087 Swedish me...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291714000191

    authors: Manrique-Garcia E,Zammit S,Dalman C,Hemmingsson T,Andreasson S,Allebeck P

    更新日期:2014-09-01 00:00:00

  • The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders.

    abstract:BACKGROUND:Genetic influences contribute significantly to co-morbidity between conduct disorder and substance use disorders. Estimating the extent of overlap can assist in the development of phenotypes for genomic analyses. METHOD:Multivariate quantitative genetic analyses were conducted using data from 9577 individua...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715001518

    authors: Grant JD,Lynskey MT,Madden PA,Nelson EC,Few LR,Bucholz KK,Statham DJ,Martin NG,Heath AC,Agrawal A

    更新日期:2015-12-01 00:00:00

  • Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms.

    abstract:BACKGROUND:Reward dysfunction is a major dimension of depressive symptomatology, but it remains obscure if that dysfunction varies across different reward types. In this study, we focus on the abnormalities in anticipatory/consummatory processing of monetary and social reward associated with depressive symptoms. METHO...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720003967

    authors: Zhang D,Shen J,Bi R,Zhang Y,Zhou F,Feng C,Gu R

    更新日期:2020-11-04 00:00:00

  • Dimensions of irritability in adolescents: longitudinal associations with psychopathology in adulthood.

    abstract:BACKGROUND:There is an emerging consensus in developmental psychopathology that irritable youth are at risk for developing internalizing problems later in life. The current study explored if irritability in youth is multifactorial and the impact of irritability dimensions on psychopathology outcomes in adulthood. METH...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719002903

    authors: Hawes MT,Carlson GA,Finsaas MC,Olino TM,Seely JR,Klein DN

    更新日期:2020-12-01 00:00:00

  • Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis.

    abstract::Major depressive disorder (MDD) is a mental illness with high socio-economic burden, but its pathophysiology has not been fully elucidated. Recently, the cortical excitatory and inhibitory imbalance hypothesis and neuroplasticity hypothesis have been proposed for MDD. Although several studies have examined the neuroph...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004729

    authors: Kinjo M,Wada M,Nakajima S,Tsugawa S,Nakahara T,Blumberger DM,Mimura M,Noda Y

    更新日期:2021-01-01 00:00:00

  • Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls.

    abstract:BACKGROUND:The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002315

    authors: Haukvik UK,Schaer M,Nesvåg R,McNeil T,Hartberg CB,Jönsson EG,Eliez S,Agartz I

    更新日期:2012-06-01 00:00:00

  • Cognitive impairment in the euthymic phase of affective disorder.

    abstract:BACKGROUND:A review of studies of cognition in the euthymic phase of unipolar and bipolar affective disorder reveals diverging results. METHODS:The study was designed as a controlled cohort study, with the Danish psychiatric case register of admissions used to identify patients and the Danish civil register to identif...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0033291798006862

    authors: Kessing LV

    更新日期:1998-09-01 00:00:00

  • Strategies of research on economic instability and health.

    abstract::Recent research on unemployment and health has depended heavily on macro-social and ecological data analyses. In order to redress this imbalance, the report summarizes the methods and results of a prospective study of a permanent factory shutdown, thereby illustrating and dissecting some of the strengths and weaknesse...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700055744

    authors: Kasl SV

    更新日期:1982-08-01 00:00:00

  • No evidence of time trends in the urban-rural differences in schizophrenia risk among five million people born in Denmark from 1910 to 1986.

    abstract:BACKGROUND:There have been conflicting reports on time trends in urban-rural differences in the incidence of schizophrenia. This study explored the potential time trends in these differences with regard to birth cohort and age at onset. METHOD:Linking data from the Danish Civil Registration system with data from the D...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170500663X

    authors: Pedersen CB

    更新日期:2006-02-01 00:00:00

  • Does Internet-based guided-self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials.

    abstract:BACKGROUND:Almost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-ana...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析

    doi:10.1017/S0033291716001562

    authors: Ebert DD,Donkin L,Andersson G,Andrews G,Berger T,Carlbring P,Rozenthal A,Choi I,Laferton JA,Johansson R,Kleiboer A,Lange A,Lehr D,Reins JA,Funk B,Newby J,Perini S,Riper H,Ruwaard J,Sheeber L,Snoek FJ,Titov N,Ü

    更新日期:2016-10-01 00:00:00

  • Psychological and hormonal factors in the treatment of female sexual dysfunction.

    abstract::Forty-eight couples with a presenting problem of female sexual unresponsiveness were treated in a controlled study using a balanced factorial design. The factors varied in this design were medication (testosterone or placebo), treatment frequency (weekly or monthly sessions), and the number of therapists involved (one...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0033291700050091

    authors: Mathews A,Whitehead A,Kellett J

    更新日期:1983-02-01 00:00:00

  • Psychiatric disorder in a rural and an urban population: 2. Sensitivity to loss.

    abstract::In an earlier paper we found that a model of depression developed on a sample of women in a London population was confirmed in a female population in the Outer Hebrides. Differences in the rates of onset and chronic cases between the two populations, however, suggested that the Scottish women might be more likely to b...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700052892

    authors: Prudo R,Brown GW,Harris T,Dowland J

    更新日期:1981-08-01 00:00:00

  • Which boys respond to stimulant medication? A controlled trial of methylphenidate in boys with disruptive behaviour.

    abstract::Thirty-eight boys, referred for psychiatric treatment because of serious problems of behaviour, underwent a double-blind, placebo-controlled, crossover trial of methylphenidate and placebo. Methylphenidate was an effective treatment over a 3-week period. A good response to methylphenidate was predicted by higher level...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0033291700013039

    authors: Taylor E,Schachar R,Thorley G,Wieselberg HM,Everitt B,Rutter M

    更新日期:1987-02-01 00:00:00

  • Post-traumatic stress disorder: findings from the Australian National Survey of Mental Health and Well-being.

    abstract:BACKGROUND:We report on the epidemiology of post-traumatic stress disorder (PTSD) in the Australian community, including information on lifetime exposure to trauma, 12-month prevalence of PTSD, sociodemographic correlates and co-morbidity. METHODS:Data were obtained from a stratified sample of 10,641 participants as p...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291701004287

    authors: Creamer M,Burgess P,McFarlane AC

    更新日期:2001-10-01 00:00:00

  • Cognitive profiles in childhood and adolescence differ between adult psychotic and affective symptoms: a prospective birth cohort study.

    abstract:BACKGROUND:Differences between verbal and non-verbal cognitive development from childhood to adulthood may differentiate between those with and without psychotic symptoms and affective symptoms in later life. However, there has been no study exploring this in a population-based cohort. METHOD:The sample was drawn from...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717000393

    authors: Koike S,Barnett J,Jones PB,Richards M

    更新日期:2018-01-01 00:00:00

  • Movement disorders and psychological tests of frontal lobe function in schizophrenic patients.

    abstract::Neuropsychological tests of frontal lobe functions were undertaken in 46 chronic schizophrenic patients who were also rated for movement disorders. Tardive dyskinesia was found to have significant associations with most of these psychological tests. The possible mechanisms are discussed within the context of known neo...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700032748

    authors: Brown KW,White T,Palmer D

    更新日期:1992-02-01 00:00:00

  • Transdiagnostic dimensions in obsessive-compulsive and related disorders: associations with internalizing and externalizing symptoms.

    abstract:BACKGROUND:Hierarchical structural models of psychopathology rarely extend to obsessive-compulsive spectrum disorders. The current study sought to examine the higher-order structure of the obsessive-compulsive and related disorders (OCRDs) in DSM-5: obsessive-compulsive disorder (OCD), hoarding disorder (HD), body dysm...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000380

    authors: Snorrason I,Beard C,Peckham AD,Björgvinsson T

    更新日期:2020-03-06 00:00:00

  • Increased plasma concentrations of the 5-HT precursor amino acid tryptophan and other large neutral amino acids in violent criminals.

    abstract:BACKGROUND:Aggression has been suggested to be related to abnormal brain 5-HT activity. This amine is synthesized in brain from tryptophan, which is transported through the blood-brain barrier in competition with other amino acids. The relationship between tryptophan and its endogenous amino acid competitors in plasma ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291796003935

    authors: Eriksson T,Lidberg L

    更新日期:1997-03-01 00:00:00

  • Serum creatine phosphokinase levels and assaultive behaviour of psychotic patients.

    abstract::Serum creatine phosphokinase (CPK) levels were compared with assaultive behaviour by 46 psychiatric patients. Significant relationships were found between CPK level and violent behaviour prior to admission and CPK level and seclusion as a danger to others while in hospital. No relationship was found between CPK level ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700003275

    authors: Isaacs JS,Yesavage JA

    更新日期:1984-02-01 00:00:00

  • Does early-onset chronic or recurrent major depression impact outcomes with antidepressant medications? A CO-MED trial report.

    abstract:BACKGROUND:Prior studies have suggested that major depressive disorder (MDD) with pre-adult onset represents a distinct subtype with greater symptom severity and higher rates of suicidal ideation. Whether these patients have poorer response to various types of antidepressant treatment than those with adult-onset MDD is...

    journal_title:Psychological medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0033291712001742

    authors: Sung SC,Wisniewski SR,Balasubramani GK,Zisook S,Kurian B,Warden D,Trivedi MH,Rush AJ,CO-MED Study Team.

    更新日期:2013-05-01 00:00:00

  • The role of drug and alcohol abuse in recent increases in depression in the US.

    abstract::Previous studies have reported an increase in depression among recent birth cohorts. Concurrent with the increase in rates of depression, there have been increases in rates of drug and alcohol abuse and dependence. This study sought to determine if the recent increase in rates of depression could be attributed to co-m...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700034735

    authors: Klerman GL,Leon AC,Wickramaratne P,Warshaw MG,Mueller TI,Weissman MM,Akiskal H

    更新日期:1996-03-01 00:00:00

  • Diagnostic disclosure: a tale in two cultures.

    abstract::Diagnostic communication between doctors and patients is thought to differ radically between Japan and Western countries. To understand diagnostic disclosure to psychiatric patients, a questionnaire with six case vignettes was sent to practising psychiatrists in Japan (N = 166) and North America (N = 112). While over ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700032803

    authors: McDonald-Scott P,Machizawa S,Satoh H

    更新日期:1992-02-01 00:00:00

  • Reduced directed forgetting for negative words suggests schizophrenia-related disinhibition of emotional cues.

    abstract:BACKGROUND:Several psychological and neurobiological models imply that patients with schizophrenia (SCZ) are more inclined to utilize emotional cues as response determinants to the detriment of more task-appropriate cognitive or contextual cues. However, there is a lack of behavioural data from human clinical studies t...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713000445

    authors: Patrick RE,Christensen BK

    更新日期:2013-11-01 00:00:00

  • Quantitative review of the efficacy of slow-frequency magnetic brain stimulation in major depressive disorder.

    abstract:BACKGROUND:Slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the frontal cortex has been suggested as a safer and better tolerable alternative to fast-frequency rTMS in the treatment of major depressive disorder (MDD). The aim of the present study was to examine the efficacy of slow-frequency rTMS t...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S003329171000005X

    authors: Schutter DJ

    更新日期:2010-11-01 00:00:00

  • Psychiatric aspects of railway fatalities.

    abstract::National statistics for railway fatalities in England and Wales show a reduction of train crashes and a fluctuating level of deaths, of which an increasing proportion is from suicide. A closer examination of a two-year sample from the South of England revealed a large proportion of probable suicides and a small propor...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700031469

    authors: Symonds RL

    更新日期:1985-08-01 00:00:00

  • Nitric Oxide Synthase activity in major depressive episodes before and after antidepressant treatment: Results of a large case-control treatment study.

    abstract:BACKGROUND:Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg). The aim of this study was: (1) to compare the NOS activity of patients with a MDE to that of healthy controls (HC); (2)...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720001749

    authors: Loeb E,El Asmar K,Trabado S,Gressier F,Colle R,Rigal A,Martin S,Verstuyft C,Fève B,Chanson P,Becquemont L,Corruble E

    更新日期:2020-06-11 00:00:00

  • Patterns of co-morbidity of eating disorders and substance use in Swedish females.

    abstract:BACKGROUND:Little is known about the association of eating disorder subtypes across multiple categories of substance use in population-based samples. We examined the association between eating disorders and substance use in a large population-based sample. METHOD:Female participants (n=13 297) were from the Swedish Tw...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709005662

    authors: Root TL,Pisetsky EM,Thornton L,Lichtenstein P,Pedersen NL,Bulik CM

    更新日期:2010-01-01 00:00:00

  • Coordination difficulties, IQ and psychopathology in children with high-risk copy number variants.

    abstract:BACKGROUND:The prevalence and impact of motor coordination difficulties in children with copy number variants associated with neurodevelopmental disorders (ND-CNVs) remains unknown. This study aims to advance understanding of motor coordination difficulties in children with ND-CNVs and establish relationships between i...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719003210

    authors: Cunningham AC,Hall J,Owen MJ,van den Bree MBM

    更新日期:2019-11-19 00:00:00

  • The association of sexual and physical abuse with somatization: characteristics of patients presenting with irritable bowel syndrome and non-epileptic attack disorder.

    abstract:BACKGROUND:Physical symptoms are commonly presented for treatment in the absence of physical pathology. This study tests predictions arising from the theory that childhood sexual abuse leads to emotional distress, illness orientation and social dysfunction as adults and that one or more of these effects, in turn, leads...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291798007892

    authors: Reilly J,Baker GA,Rhodes J,Salmon P

    更新日期:1999-03-01 00:00:00