Abstract:
BACKGROUND:Whether late-onset depression is a risk factor for or a prodrome of dementia remains unclear. We investigated the impact of depressive symptoms and early- v. late-onset depression on subsequent dementia in a cohort of elderly general-practitioner patients (n = 2663, mean age = 81.2 years). METHOD:Risk for subsequent dementia was estimated over three follow-ups (each 18 months apart) depending on history of depression, particularly age of depression onset, and current depressive symptoms using proportional hazard models. We also examined the additive prediction of incident dementia by depression beyond cognitive impairment. RESULTS:An increase of dementia risk for higher age cut-offs of late-onset depression was found. In analyses controlling for age, sex, education, and apolipoprotein E4 genotype, we found that very late-onset depression (aged ≥ 70 years) and current depressive symptoms separately predicted all-cause dementia. Combined very late-onset depression with current depressive symptoms was specifically predictive for later Alzheimer's disease (AD; adjusted hazard ratio 5.48, 95% confidence interval 2.41-12.46, p < 0.001). This association was still significant after controlling for cognitive measures, but further analyses suggested that it was mediated by subjective memory impairment with worries. CONCLUSIONS:Depression might be a prodrome of AD but not of dementia of other aetiology as very late-onset depression in combination with current depressive symptoms, possibly emerging as a consequence of subjectively perceived worrisome cognitive deterioration, was most predictive. As depression parameters and subjective memory impairment predicted AD independently of objective cognition, clinicians should take this into account.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Heser K,Tebarth F,Wiese B,Eisele M,Bickel H,Köhler M,Mösch E,Weyerer S,Werle J,König HH,Leicht H,Pentzek M,Fuchs A,Riedel-Heller SG,Luppa M,Prokein J,Scherer M,Maier W,Wagner M,Age CoDe Study Group.doi
10.1017/S0033291712002449subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1597-610issue
8eissn
0033-2917issn
1469-8978pii
S0033291712002449journal_volume
43pub_type
杂志文章,多中心研究abstract::The Eating Attitudes Test (EAT) and General Health Questionnaire (GHQ) have been validated in an unselected population of 15-year-old South London schoolgirls. Scores on the questionnaires were compared with the results of standard interview. The EAT was found to be an efficient screening instrument for abnormal eatin...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700047991
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:Several studies during recent years have reported an increased occurrence of schizophrenia in selected immigrant groups. However, difficulties in establishing the population denominator for immigrant rates of mental disorder, selective referral for treatment, and other problems may have influenced such resul...
journal_title:Psychological medicine
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doi:10.1017/s0033291797004741
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abstract:BACKGROUND:Although depression and mania are often assumed to be polar opposites, studies have shown that, in patients with bipolar disorder, they are weakly positively correlated and vary somewhat independently over time. Thus, when investigating relationships between specific psychological processes and specific symp...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002711
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Recent studies have suggested that major depressive disorders are associated with a breakdown in the organization of ultradian rhythm in sleep EEG. The present study used cross-spectral analysis of sleep EEG to confirm this finding, in a larger-scale study, evaluating the influence of gender and age on ultra...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001300
更新日期:1999-11-01 00:00:00
abstract::Between 1968 and 1975 there was a marked, non-artefactual rise in the numbers of young female parasuicides admitted to the Regional Poisoning Treatment Centre in Edinburgh. The greatest increase in rates occurred among girls aged 15--19 (for events, persons and 'first-ever' episodes). Among teenagers the most marked i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700032013
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Research into violence among military personnel has not differentiated between stranger- and family-directed violence. While military factors (combat exposure and post-deployment mental health problems) are risk factors for general violence, there has been limited research on their impact on violence within ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003695
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:In a recent placebo-controlled, double-blind crossover trial (n = 52), significant beneficial effects on memory (d = 0.30) and negative symptoms (d = 0.29) were found after 12 weeks of memantine augmentation in patients with clozapine-refractory schizophrenia. In this open-label 1-year extension study we rep...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The prevalence of anxiety and mood disorders in adolescents is a growing public health concern worldwide. Given the high rates of drop-out and limited resources available in psychiatric settings, the importance of engaging adolescents in evidence-based treatments cannot be understated. The aim of the study w...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716000568
更新日期:2016-07-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002756
更新日期:2018-07-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171100290X
更新日期:2012-09-01 00:00:00
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journal_title:Psychological medicine
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doi:10.1017/s0033291700006383
更新日期:1977-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707002280
更新日期:2008-10-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171200181X
更新日期:2013-05-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291707000542
更新日期:2007-12-01 00:00:00
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doi:10.1017/s0033291704004180
更新日期:2005-05-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001314
更新日期:2020-06-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291714002773
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Prosocial emotions related to self-blame are important in guiding human altruistic decisions. These emotions are elevated in major depressive disorder (MDD), such that MDD has been associated with guilt-driven pathological hyper-altruism. However, the impact of such emotional impairments in MDD on different ...
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doi:10.1017/S0033291714002414
更新日期:2015-04-01 00:00:00
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doi:10.1017/S0033291715000136
更新日期:2015-07-01 00:00:00
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journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-09-01 00:00:00
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doi:10.1017/s0033291798007892
更新日期:1999-03-01 00:00:00
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doi:10.1017/S0033291709005443
更新日期:2009-09-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005643
更新日期:1997-11-01 00:00:00
abstract::We found diurnal weight gain to be abnormal among 28 institutionalized chronically psychotic patients. They were weighed daily for 15 days at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and th...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700011065
更新日期:1989-02-01 00:00:00
abstract::Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptamine) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Res...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001583x
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:. A variety of factors are related to compliance with medication in schizophrenia, but little attention has been paid to the role of families. Carers' knowledge or expressed emotion (EE) may be related to compliance. The aim of the present study was to evaluate the relevance of these two factors, as well as ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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更新日期:2020-12-03 00:00:00
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journal_title:Psychological medicine
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doi:10.1017/S003329171600180X
更新日期:2016-11-01 00:00:00