Abstract:
:Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptamine) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Results suggest an association between affective state and the above precursor amino acids with lower concentrations in primary depression and higher ones when anxiety or agitation predominate. This leads to lower 5-hydroxyindoleacetic acid concentrations in depression and higher concentrations in anxiety and agitation.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Bridges PK,Bartlett JR,Sepping P,Kantamaneni BD,Curzon Gdoi
10.1017/s003329170001583xsubject
Has Abstractpub_date
1976-08-01 00:00:00pages
399-405issue
3eissn
0033-2917issn
1469-8978journal_volume
6pub_type
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