Abstract：
BACKGROUND:Aberrant emotional biases have been reported in bipolar disorder (BD), but results are inconsistent. Despite the clinical relevance of chronic mood variability in BD, there is no previous research investigating how the extent of symptom fluctuations in bipolar disorder might relate to emotional biases. This exploratory study investigated, in a large cohort of bipolar patients, whether instability in weekly mood episode symptoms and other clinical and demographic factors were related to emotional bias as measured in a simple laboratory task. METHOD:Participants (N = 271, BDI = 206, BDII = 121) completed an 'emotional categorization and memory' task. Weekly self-reported symptoms of depression and mania were collected prospectively. In linear regression analyses, associations between cognitive bias and mood variability were explored together with the influence of demographic and clinical factors, including current medication. RESULTS:Greater accuracy in the classification of negative words relative to positive words was associated with greater instability in depressive symptoms. Furthermore, greater negative bias in free recall was associated with higher instability in manic symptoms. Participants diagnosed with BDII, compared with BDI, showed overall better word recognition and recall. Current antipsychotic use was associated with reduced instability in manic symptoms but this did not impact on emotional processing performance. CONCLUSIONS:Emotional processing biases in bipolar disorder are related to instability in mood. These findings prompt further investigation into the underpinnings as well as clinical significance of mood instability.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Bilderbeck AC,Reed ZE,McMahon HC,Atkinson LZ,Price J,Geddes JR,Goodwin GM,Harmer CJdoi
10.1017/S003329171600180Xsubject
Has Abstractpub_date
2016-11-01 00:00:00pages
3151-3160issue
15eissn
0033-2917issn
1469-8978pii
S003329171600180Xjournal_volume
46pub_type
杂志文章abstract：BACKGROUND:There are no risk models for the prediction of anxiety that may help in prevention. We aimed to develop a risk algorithm for the onset of generalized anxiety and panic syndromes. METHOD:Family practice attendees were recruited between April 2003 and February 2005 and followed over 24 months in the UK, Spain...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291710002400
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Post-traumatic symptomatology is one of the signature effects of the pernicious exposures endured by responders to the World Trade Center (WTC) disaster of 11 September 2001 (9/11), but the long-term extent of diagnosed Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) post-traumati...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291715002184
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The ability to appreciate humour is essential to successful human interactions. In this study, we hypothesized that individuals with schizophrenia would have diminished ability to recognize and appreciate humour. The relationship between humour experience and clinical symptoms, cognitive and social functioni...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291707002528
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Minor stresses measured in daily life have repeatedly been associated with increased momentary psychotic experiences, both in individuals with psychotic disorders and in persons who are genetically at an increased risk for these disorders. Severe hearing impairment (SHI) is an environmental risk factor for p...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291714002797
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Stress questionnaires are included in many epidemiological cohort studies but the psychometric characteristics of these questionnaires are largely unknown. The aim of this study was to describe these characteristics for two short questionnaires measuring the lifetime and past year occurrence of stress: the L...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291712000608
更新日期：2012-12-01 00:00:00
abstract：:National statistics for railway fatalities in England and Wales show a reduction of train crashes and a fluctuating level of deaths, of which an increasing proportion is from suicide. A closer examination of a two-year sample from the South of England revealed a large proportion of probable suicides and a small propor...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700031469
更新日期：1985-08-01 00:00:00
abstract：BACKGROUND:It is unknown whether patient disengagement from early intervention services for psychosis is as prevalent in low- and middle-income countries (LMICs) like India, as it is in high-income countries (HICs). Addressing this gap, we studied two first-episode psychosis programs in Montreal, Canada and Chennai, In...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291720003359
更新日期：2020-09-28 00:00:00
abstract：BACKGROUND:The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. It is also thought to increase the risk of a number of disorders characterized by affective mo...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291710001431
更新日期：2011-04-01 00:00:00
abstract：:Biochemical studies of manic-depressive psychosis usually correlates biochemical findings with current affective state and hence any significant findings could be secondary to mood change. The present study attempts to correlate measures of the erythrocyte membrane cation carrier with clinical events, remote in time f...
journal_title：Psychological medicine
pub_type： 临床试验,杂志文章
doi：10.1017/s0033291700013805
更新日期：1976-05-01 00:00:00
abstract：:Levinger & Clarke (1961) found that subjects tended to forget more word associations to emotional rather than neutral words. Kline (1981) regarded this study as providing 'irrefutable evidence for the Freudian concept of repression'. On the other hand, results from Kleinsmith & Kaplan (1964) suggested that this effect...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700017669
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Epidemiological evidence suggests a link between cannabis use and psychosis. A variety of factors have been proposed to mediate an individual's vulnerability to the harmful effects of the drug, one of which is their psychosis proneness. We hypothesized that highly psychosis-prone individuals would report mor...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291708004741
更新日期：2009-06-01 00:00:00
abstract：:Because of the potential importance of prolonged action neuroleptics for the delivery of care to schizophrenic patients, and because of the availability of new, extensive data from clinical trials on the utility of these drugs, a workshop conference was convened by the United States National Institute of Mental Health...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700030907
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:Genetic studies of single gene variants have been criticized as providing a simplistic characterization of the genetic basis of illness risk that ignores the effects of other variants within the same biological pathways. Of candidate biological pathways for schizophrenia (SZ), the cell adhesion molecule (CAM...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291713002663
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Previous studies suggest that offspring of mothers with psychotic disorders have an almost two-fold higher mortality risk from birth until early adulthood. We investigated predictors of mortality from late adolescence until middle age in offspring of mothers with psychotic disorders. METHOD:The Helsinki Hig...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291707002383
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:This study aimed to develop and test the feasibility of a primary care worker-led psychological intervention as the main feature of a collaborative stepped care for depression that is effective, affordable, culturally acceptable, tailored to patients' clinical condition and easily integrate-able into the pri...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291718002970
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Recent cross-sectional studies have shown psychotic experiences (PEs) are associated with suicidal ideation and behaviours. We aimed to examine associations between psychotic experiences (including persistent PE), and contemporaneous and incident non-suicidal self-injury (NSSI) and suicide attempts. METHOD:...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291714001615
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Recent neurobiological models provide a possible mechanism of daily life stress directly affecting the intensity of psychotic experiences in vulnerable individuals. In order to validate such a mechanism, the impact of daily life stress on psychosis intensity was investigated in two groups at increased risk o...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291704004179
更新日期：2005-05-01 00:00:00
abstract：:Serum creatine phosphokinase (CPK) levels were compared with assaultive behaviour by 46 psychiatric patients. Significant relationships were found between CPK level and violent behaviour prior to admission and CPK level and seclusion as a danger to others while in hospital. No relationship was found between CPK level ...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700003275
更新日期：1984-02-01 00:00:00
abstract：BACKGROUND:Trans and gender diverse (TGD) young people worldwide experience high rates of poor mental health; however, these rates were unknown in Australia. In addition, how negative life events affect the mental health of TGD young people has been largely unexplored. METHODS:This paper reports on novel mental health...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291719000643
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Controlled prospective studies of the simultaneous long-term outcome of several mental disorders are rare. This study sought to determine if there were important differences between the outcome of anxiety and depressive disorders after 12 years and to examine their main predictors. METHOD:A cohort of 210 pe...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291704002569
更新日期：2004-11-01 00:00:00
abstract：:In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700023163
更新日期：1977-02-01 00:00:00
abstract：:There is little evidence of a curvilinear relationship between pre-operative emotionality and post-operative adjustment, as predicted by a model which supposes that moderate preoperative anxiety assists adjustment. This paper suggests that the negative affect, or stress, associated with the work of worry should be dis...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700041246
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:Previous studies have provided initial evidence that people at risk for psychosis (PR) suffer from stigma and discrimination related to their condition. However, no study has systematically reviewed stigma and discrimination associated with being at PR and the potential underlying mechanisms. METHODS:This w...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291720000148
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Sibling resemblance in crime may be due to genetic relatedness, shared environment, and/or the interpersonal influence of siblings on each other. This latter process can be understood as a type of 'peer effect' in that it is based on social learning between individuals occupying the same status in the social...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291720003724
更新日期：2020-10-21 00:00:00
abstract：:Messenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly l...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700029858
更新日期：1991-11-01 00:00:00
abstract：:In a prospective cohort study of consecutive primary care attenders in south London, the estimated prevalence of non-psychotic psychiatric disorder was 45.6%, using the Revised Clinical Interview Schedule (CIS-R). The estimated 12-month incidence rate was 15.7%. Extremely high stability was found in CIS-R scores over ...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291796004023
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Excessive worry is required by DSM-IV, but not ICD-10, for a diagnosis of generalized anxiety disorder (GAD). No large-scale epidemiological study has ever examined the implications of this requirement for estimates of prevalence, severity, or correlates of GAD. METHOD:Data were analyzed from the US Nationa...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291705005908
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Risk factors that are associated with depression in the mother also negatively affect the child. This research sought to extend current knowledge by examining the duration and timing of maternal depression as a moderator of: (1) the impact of dependent interpersonal stress (DIS), such as partner conflict or ...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/S0033291712002450
更新日期：2013-08-01 00:00:00
abstract：:In a retrospective case note study, 73 young females with anorexia nervosa were compared with 88 young females with affective psychosis. These groups of patients did not differ in terms of place of residence, birth order or social class. They differed very significantly, however, in terms of age at onset of symptoms, ...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700013295
更新日期：1990-02-01 00:00:00
abstract：:The CAMCOG, the cognitive section of the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX), was administered twice to 53 patients with a clinical diagnosis ranging from no dementia to severe dementia. The stability of the total CAMCOG score was high (0.97). Patients with less than moderate dementia we...
journal_title：Psychological medicine
pub_type： 杂志文章
doi：10.1017/s0033291700039003
更新日期：1993-02-01 00:00:00
