Abstract:
:Biochemical studies of manic-depressive psychosis usually correlates biochemical findings with current affective state and hence any significant findings could be secondary to mood change. The present study attempts to correlate measures of the erythrocyte membrane cation carrier with clinical events, remote in time from the biochemical assay. Eprythrocyte sodium concentration, ouabain-sensitive potassium influx and Na-K ATPase were estimated in 11 patients before and after the cross-over point in a 2-year double blind clinical trial ratio tended to suffer most episodes of affective illness in the 2 years. Patients who had a low initial Na-K ATPase or a high initial flux sodium ATPase ratio, or in whom this ratio fell most with lithium or whose Na-K ATPase rose most with lithium, clinically responded best to lithium.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Naylor GJ,Dick DA,Dick EGdoi
10.1017/s0033291700013805subject
Has Abstractpub_date
1976-05-01 00:00:00pages
257-63issue
2eissn
0033-2917issn
1469-8978journal_volume
6pub_type
临床试验,杂志文章abstract::It is well established that a diagnosis of cancer and the subsequent treatment can cause a great deal of stress, and the need for psychosocial support is increasingly being advocated. The data for the efficacy of intervention programmes are reviewed. The evidence relating to the benefits gained by patients is equivoca...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700051552
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The differential strength of correlation between symptoms, cognition and other patient characteristics with community functioning in first-episode psychosis has not been fully investigated. METHOD:In a sample of 66 first-episode psychosis patients demographic variables, ratings of pre-morbid adjustment, pos...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291702006050
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:While there is a growing body of research on borderline personality disorder (BPD) in children and adolescents, controversy remains regarding the validity and diagnosis of the disorder prior to adulthood. METHOD:MEDLINE, EMBASE, Psych INFO and PubMed databases were systematically searched for articles perta...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291715000318
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Research suggests that the personality factor of self-critical or maladaptive perfectionism may be implicated in chronic fatigue syndrome (CFS). However, it is not clear whether self-critical perfectionism (SCP) also predicts daily symptoms in CFS. Method In the present study we investigated whether SCP pred...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001936
更新日期:2013-05-01 00:00:00
abstract::The validity of the twin method depends on the equal environment assumption (EEA)--that monozygotic (MZ) and dizygotic (DZ) twins are equally correlated in their exposure to environmental factors of aetiological importance for the trait under study. Parents may treat MZ twins more similarly than DZ twins thereby poten...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700027732
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The importance of genetic factors in the aetiology of manic-depressive illness (MDI) has been repeatedly confirmed and indicators of vulnerability to the illness in families with affective disorders are needed. Abnormal event-related potentials (ERP) may be markers of genetic vulnerability to mental illness....
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001944
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Outcome studies of chronic fatigue, neurasthenia and other unexplained fatigue syndromes are few and have been carried out in developed Western countries. This paper aimed to study the outcome of unexplained fatigue syndromes in an international primary care sample and to identify risk factors for persistenc...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291703007566
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:A long-standing issue in the health anxiety literature is the extent to which health anxiety is a dimensional or a categorical construct. This study explores this question directly using taxometric procedures. METHOD:Seven hundred and eleven working adults completed an index of health anxiety [the Whiteley ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708003322
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Cognitive models of obsessive-compulsive disorder (OCD) posit dysfunctional appraisal of disorder-relevant stimuli in patients, suggesting disturbances in the processes relying on amygdala-prefrontal connectivity. Recent neuroanatomical models add to the traditional view of dysfunction in corticostriatal cir...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171800079X
更新日期:2019-01-01 00:00:00
abstract::Potential cases of presenile dementia of the Alzheimer type (PDAT) in the Northern Health Region (estimated population aged 45-64, 655,800) were ascertained for the years 1979-86 from in-patient ICD-9 codes and other sources. An algorithm was applied to the casenote information to distinguish between Alzheimer-type an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700025411
更新日期:1993-08-01 00:00:00
abstract::Psychiatric disorders are studied at multiple levels, but there is no agreement on how these levels are related to each other, or how they should be understood in the first place. In this paper, I provide an account of levels and their relationships that is suited for psychopathology, drawing from recent debates in ph...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002514
更新日期:2019-09-24 00:00:00
abstract:BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, wheth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000530
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Although specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000174
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Previous studies of the dimensional structure of panic attack symptoms have mostly identified a respiratory and a vestibular/mixed somatic dimension. Evidence for additional dimensions such as a cardiac dimension and the allocation of several of the panic attack symptom criteria is less consistent. Clarifyin...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291714002803
更新日期:2015-06-01 00:00:00
abstract::Over 90% of the 1202 patients investigated in the 9 centres collaborating in the International Pilot Study of Schizophrenia were traced 2 years after the initial examination and on the average over 75% of them were re-examined, using standardized instruments and methods. Results indicate that patients diagnosed as sch...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700004517
更新日期:1977-08-01 00:00:00
abstract::There have been numerous exhortations for more 'translational research'. A selective review of historical examples of research leading to health benefits is used to consider the various forms of successful interplay between basic science and clinical applications. This is followed by a consideration of key neuroscienc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170800398X
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Schizophrenia patients have a higher prevalence of type 2 diabetes mellitus with impaired glucose tolerance (IGT) than normals. We examined the relationship between IGT and clinical phenotypes or cognitive deficits in first-episode, drug-naïve (FEDN) Han Chinese patients with schizophrenia. METHOD:A total o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001902
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Counselling is frequently used in the management of common mental disorders (such as anxiety and depression) in primary care. However, there are concerns over the clinical effectiveness of counselling, both in comparison with usual general practitioner care, and with other treatments such as alternative psyc...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/s0033291702006979
更新日期:2003-02-01 00:00:00
abstract::General practitioners using DSM-III criteria have studied the incidence and prevalence of anorexia nervosa and bulimia nervosa in a large (N = 151,781) representative sample of the Dutch population. The incidence rate for anorexia nervosa is 6.3 and for bulimia nervosa 9.9 per year per 100,000 population. The prevalen...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700020560
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Geographic variations in the incidence of deliberate self-harm (DSH) and suicide have been shown to be associated with area-based measures of socio-economic deprivation and social fragmentation. Previous studies have been subject to methodological limitations. None has investigated whether ecological associa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003993
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:The present study tested the hypothesis of a differential pattern of reward and punishment responsiveness in depression measuring effort mobilization during anticipation and facial expressions during consumption. METHODS:Twenty patients with major depressive disorder (MDD) and 20 control participants worked...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001526
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Expressed emotion (EE) measured from relatives and informal carers has been consistently demonstrated to be associated with clinical outcome in schizophrenic patients. There have also been published studies that have investigated EE in professional carers that have suggested that the quality of the relations...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001579
更新日期:2000-01-01 00:00:00
abstract::In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700023163
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:Delusional disorder (DD) and obsessive-compulsive disorder (OCD) have been investigated in previous studies using probabilistic reasoning paradigms and abnormalities in each group have been reported. No study to date has compared results between these groups. This study compares patients with these disorders...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004175
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Several studies have reported smaller hippocampal volume (HcV) in depression patients; however, the temporality of the association remains unknown. One proposed hypothesis is that depression may cause HcV loss. This study evaluates whether previous depression and recent depressive symptoms are associated wit...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714003055
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Existing evidence on profiles of psychological distress across adulthood uses cross-sectional or longitudinal studies with short observation periods. The objective of this research was to study the profile of psychological distress within the same individuals from early adulthood to early old age across thre...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000327X
更新日期:2021-01-21 00:00:00
abstract:BACKGROUND:In the United States, cannabis accessibility has continued to rise as the perception of its harmfulness has decreased. Only about 30% of regular cannabis users develop cannabis use disorder (CUD), but it is unclear if individuals who use cannabis regularly without ever developing CUD experience notable psych...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003361
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:This study examined healthcare services used by adults diagnosed with an eating disorder (ED) in a large health maintenance organization in the Pacific Northwest. METHOD:Electronic medical records were used to collect information on all out-patient and in-patient visits and medication dispenses, from 2002 t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001833
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Executive impairments have been reported in affective illness, but the influence of attention on executive performance has not been fully considered. The purpose of this study was to investigate whether executive impairments in affective illness were independent of attention impairments, and whether independ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000712
更新日期:2007-11-01 00:00:00
abstract::Post-traumatic stress disorder was first recognized as a diagnostic category embracing reactions in response to overwhelming environmental stress 'outside the range of usual human experience' in DSM-III (APA, 1980). Such abnormal stressors are by no means a product of the twentieth century but have featured, sporadica...
journal_title:Psychological medicine
pub_type: 历史文章,杂志文章
doi:10.1017/s0033291700026799
更新日期:1994-02-01 00:00:00