Abstract:
:There have been numerous exhortations for more 'translational research'. A selective review of historical examples of research leading to health benefits is used to consider the various forms of successful interplay between basic science and clinical applications. This is followed by a consideration of key neuroscience findings that might be relevant for translation, and then by a discussion of the challenges and opportunities in relation to mental disorders. The time-frame for the pathway from science findings to health benefits is usually long, and generally requires an interactive interplay among different scientific strategies. There is a false dichotomy between so-called basic and applied research and translation needs to proceed from the bedside to the laboratory as well as in the opposite direction. There is a key need for bridging research of the hypothesis-testing experimental medicine variety. Health benefits may involve either public health considerations or the treatment of individual patients, or both. There are now some opportunities for direct translational research but there is a much greater need for hypothesis-based bridging studies that occupy a crucial mid-phase in the pathway from science findings to health benefits.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Rutter M,Plomin Rdoi
10.1017/S003329170800398Xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
529-42issue
4eissn
0033-2917issn
1469-8978pii
S003329170800398Xjournal_volume
39pub_type
杂志文章abstract:BACKGROUND:Meta-analyses link childhood trauma to depression, mania, anxiety disorders, and psychosis. It is unclear, however, whether these outcomes truly represent distinct disorders following childhood trauma, or that childhood trauma is associated with admixtures of affective, psychotic, anxiety and manic psychopat...
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doi:10.1017/S0033291714002372
更新日期:2015-04-01 00:00:00
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doi:10.1017/s0033291700008345
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更新日期:1994-08-01 00:00:00
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更新日期:2014-05-01 00:00:00
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更新日期:1993-05-01 00:00:00
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更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-08-01 00:00:00
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doi:10.1017/S0033291720000914
更新日期:2020-04-23 00:00:00
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doi:10.1017/s0033291700029858
更新日期:1991-11-01 00:00:00
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doi:10.1017/S0033291709005601
更新日期:2009-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291704001928
更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/S0033291719002204
更新日期:2019-09-04 00:00:00
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pub_type: 杂志文章
doi:10.1017/S0033291711000043
更新日期:2011-09-01 00:00:00
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doi:10.1017/S003329171600180X
更新日期:2016-11-01 00:00:00
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更新日期:1984-02-01 00:00:00
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更新日期:2010-08-01 00:00:00
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更新日期:2006-10-01 00:00:00
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更新日期:2001-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1017/s0033291799001841
更新日期:2000-05-01 00:00:00
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