Abstract:
BACKGROUND:Minor stresses measured in daily life have repeatedly been associated with increased momentary psychotic experiences, both in individuals with psychotic disorders and in persons who are genetically at an increased risk for these disorders. Severe hearing impairment (SHI) is an environmental risk factor for psychotic disorder, possibly due to the experience of social exclusion. The aim of the current study is to investigate whether people with SHI exhibit higher levels of psychotic reactivity to social stressors in daily life than normal-hearing controls and whether this reactivity is associated with decreased baseline dopamine (DA) D2/3 receptor availability and/or elevated DA release following a dexamphetamine challenge. METHOD:We conducted an experience sampling study in 15 young adults with SHI and 19 matched normal-hearing controls who had previously participated in a single photon emission computed tomography study measuring DA D2/3 receptor availability and DA release in response to dexamphetamine. RESULTS:The association between social stress and momentary psychotic experiences in daily life was stronger among SHI participants than among normal-hearing controls. Interactions between social stress and baseline striatal DA D2/3 receptor availability or DA release were not significant in multilevel models of momentary psychotic experiences including age, sex and tobacco use. CONCLUSIONS:While both elevated striatal DA release and elevated psychotic stress reactivity have been found in the same population defined by an environmental risk factor, SHI, their inter-relationship cannot be established. Further research is warranted to clarify the association between biological and psychological endophenotypes and psychosis risk.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Gevonden MJ,Myin-Germeys I,van den Brink W,van Os J,Selten JP,Booij Jdoi
10.1017/S0033291714002797subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1665-74issue
8eissn
0033-2917issn
1469-8978pii
S0033291714002797journal_volume
45pub_type
杂志文章abstract:BACKGROUND:Approximately 25% of people with bulimia nervosa (BN) who undertake therapy are treated in groups. National guidelines do not discriminate between group and individual therapy, yet each has potential advantages and disadvantages and it is unclear how their effects compare. We therefore evaluated how group th...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0033291713002791
更新日期:2014-08-01 00:00:00
abstract::A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant differ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291700003068
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:Psychological models of conversion disorder (CD) traditionally assume that psychosocial stressors are identifiable around symptom onset. In the face of limited supportive evidence such models are being challenged. METHOD:Forty-three motor CD patients, 28 depression patients and 28 healthy controls were asse...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716000714
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Depression can impair the immunogenicity of vaccine administration in adults. Whereas many vaccinations are administered in childhood, it is not known whether adolescent or adult onset depression is associated with impairments in the maintenance of protection of childhood vaccines. This study tested the hypo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718000661
更新日期:2019-01-01 00:00:00
abstract::Fifty-six bulimia nervosa patients were treated by means of a behavioural approach and followed for at least one year after completion or dropping out of treatment. Outcome was encouraging in about half of the patients and several psychiatric indicators, such as duration of illness and response to treatment, were iden...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700002543
更新日期:1986-02-01 00:00:00
abstract::Despite the robust body of work on cognitive aspects of bipolar disorder (BD), a clear profile of associated impairments in impulsivity, decision-making and risk-taking from studies that use behavioural measures has yet to be established. A systematic review, across four electronic databases (PsycINFO, MEDLINE/PubMed,...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003086
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Results of adulthood mental health of those born late-preterm (34 + 0-36 + 6 weeks + days of gestation) are mixed and based on national registers. We examined if late-preterm birth was associated with a higher risk for common mental disorders in young adulthood when using a diagnostic interview, and if this ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716000830
更新日期:2016-07-01 00:00:00
abstract::Couples in whom the main complaint was of a lack of female sexual response were treated using a practical counselling approach. A number of pre-treatment measures were studied to determine which factors were predictive of treatment outcome. While age and chronicity were not predictive, the quality of the general relat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170000920x
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Stress and vulnerability likely interact to play a major role in psychosis. While much has been written about the neural diathesis-stress model in psychosis and its clinical risk states, little is known about HPA axis biomarkers in non-help-seeking individuals at familial high risk (FHR). We sought to prospe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171500077X
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Psychiatric history, familial history of suicide attempts, and certain traumatic life events are important predictors of suicidal thoughts and behaviour. We examined the epidemiology and genetics of suicidality (i.e. reporting persistent suicidal thoughts or a plan or suicide attempt) in a large community-ba...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798006916
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:We developed a comprehensive, 20-hour training programme for primary-care physicians, that sought to improve their ability to detect, diagnose and manage depression. We evaluated the effects of physician training on patient outcomes, using a pre-post design. METHODS:In the pre-training phase of the study, w...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799008545
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Previous research in resting-state functional magnetic resonance imaging (rs-fMRI) has shown a mixed pattern of disrupted thalamocortical connectivity in psychosis. The clinical meaning of these findings and their stability over time remains unclear. We aimed to study thalamocortical connectivity longitudina...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004808
更新日期:2020-12-16 00:00:00
abstract:BACKGROUND:Patient satisfaction is a key indicator of inpatient care quality and is associated with clinical outcomes following admission. Different patient characteristics have been inconsistently linked with satisfaction. This study aims to overcome previous limitations by assessing which patient characteristics are ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291719000011
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Previous research has yielded conflicting evidence regarding the long-term cognitive outcome of depression. Some studies have found evidence for a higher incidence of subsequent cognitive impairment or dementia, while others have refuted this. METHOD:Depression, neuropsychological performance, functional ab...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008195
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The effects of cognitive behavioural therapy of anxiety disorders on depression has been examined in previous meta-analyses, suggesting that these treatments have considerable effects on depression. In the current meta-analysis we examined whether the effects of treatments of anxiety disorders on depression ...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291716002348
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Attention deficit hyperactivity disorder (ADHD) often, but not always, persists into adulthood. Investigations of the associations between clinical and biological markers of persistence can shed light on causal pathways. It has been proposed that compensatory improvements in executive neuropsychological func...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001761
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Cognitive behaviour therapy (CBT) for chronic fatigue syndrome (CFS) leads to a significant decrease in CFS-related symptoms and disability. The primary objective of this study was to explore whether partners' solicitous responses and patients' and partners' perceived relationship satisfaction had an effect ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000288
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:This study aimed to develop and test the feasibility of a primary care worker-led psychological intervention as the main feature of a collaborative stepped care for depression that is effective, affordable, culturally acceptable, tailored to patients' clinical condition and easily integrate-able into the pri...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002970
更新日期:2019-10-01 00:00:00
abstract::Five hundred and eighty schoolgirls living in a small North Indian industrial town were screened using the EAT-26. Although twenty-nine per cent scored above the threshold for the questionnaire (greater than or equal to 20), closer scrutiny of the pattern of responses revealed misinterpretations of a large number of q...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700005675
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Few epidemiological studies have examined the temporal relationship between chronic pain and depression using longitudinal data. In the present study, we examined major depression as both an antecedent risk factor and consequence of chronic back pain (CBP) in the general population. METHOD:Data on 9909 pain...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705004952
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703007475
更新日期:2003-05-01 00:00:00
abstract::In the literature on dementia the presence or absence of language deficits has come to occupy a pivotal position with respect to certain nosological and nosographical issues. These are reviewed critically, together with the results of experimental investigations which have sought to elucidate the nature of the languag...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700001938
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Despite methodological differences between studies, it has been suggested that psychopathy may be associated with a ventromedial prefrontal cortex (VMPFC) deficit and antisocial personality disorder (ASPD), as classified in the DSM-IV, with a broader range of deficits in dorsolateral prefrontal cortex (DLPFC...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002686
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Previous research has found that depression is a major cause of memory complaints. However, there is evidence that memory complaints also weakly predict cognitive decline and dementia. The present study examined a range of possible determinants of memory complaints, covering psychiatric and personality facto...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003162
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:The potential effects of antipsychotic drugs on brain structure represent a key factor in understanding neuroanatomical changes in psychosis. This review addresses two issues: (1) do antipsychotic medications induce changes in total or regional human brain volumes and (2) do such effects depend on antipsycho...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709005315
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:There are no risk models for the prediction of anxiety that may help in prevention. We aimed to develop a risk algorithm for the onset of generalized anxiety and panic syndromes. METHOD:Family practice attendees were recruited between April 2003 and February 2005 and followed over 24 months in the UK, Spain...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002400
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Recent cross-sectional studies have shown psychotic experiences (PEs) are associated with suicidal ideation and behaviours. We aimed to examine associations between psychotic experiences (including persistent PE), and contemporaneous and incident non-suicidal self-injury (NSSI) and suicide attempts. METHOD:...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001615
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Relapse is distressingly common after the first episode of psychosis, yet it is poorly understood and difficult to predict. Investigating changes in cognitive function preceding relapse may provide new insights into the underlying mechanism of relapse in psychosis. We hypothesized that relapse in fully remit...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716000751
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Agitated patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians differ in opinion and practice. In Lebanon, the use of the triple therapy haloperidol plus promethazine plus chlorpromazine (HPC) is frequently used but no studies involving t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004869
更新日期:2021-01-06 00:00:00
abstract::The persistence of psychosis at a high and relatively constant prevalence in the various populations of the world is rendered difficult to explain by the absence of identified environmental precipitants and by reduced fertility of affected individuals. The problem is not confined to schizophrenia but applies also to a...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700000611
更新日期:1987-11-01 00:00:00