Abstract:
:A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant difference between the prophylactic efficacy of the 2 antidepressants. An account is given of the relative adverse effects of the treatments, and the implications of the findings are discussed.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Glen AI,Johnson AL,Shepherd Mdoi
10.1017/s0033291700003068subject
Has Abstractpub_date
1984-02-01 00:00:00pages
37-50issue
1eissn
0033-2917issn
1469-8978journal_volume
14pub_type
临床试验,杂志文章,随机对照试验abstract::National statistics for railway fatalities in England and Wales show a reduction of train crashes and a fluctuating level of deaths, of which an increasing proportion is from suicide. A closer examination of a two-year sample from the South of England revealed a large proportion of probable suicides and a small propor...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700031469
更新日期:1985-08-01 00:00:00
abstract:BACKGROUNDS:Cigarette smoking is strongly associated with major depressive disorder (MDD). However, any genetic etiology of such comorbidity and causal relations is poorly understood, especially at the genome-wide level. METHODS:In the present in silico research, we analyzed summary data from the genome-wide associati...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000063X
更新日期:2020-04-06 00:00:00
abstract:BACKGROUND:The mechanisms that contribute to emotion dysregulation in anxiety disorders are not well understood. Two common disorders, generalized anxiety disorder (GAD) and panic disorder (PD), were examined to test the hypothesis that both disorders are characterized by hypo-activation in prefrontal cortex (PFC) duri...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002383
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Substantial variability in age at onset of illness and course of illness exists between patients with schizophrenia. Recent studies suggest that age at illness onset may be useful in defining biologically and clinically distinct subgroups of patients. METHODS:Two hundred and ten males with schizophrenia wer...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797006405
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Empirical data regarding prevalence of sexual and physical abuse histories in Japanese patients with eating disorders is lacking, in contrast to Western countries. This study investigated the prevalence of traumatic events in Japanese patients with eating disorders, and examined the relationship between such...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799008557
更新日期:1999-07-01 00:00:00
abstract::A sample of over 6000 women was recruited in the last trimester of pregnancy and administered a 40-item self-report questionnaire designed to detect the presence of factors that were likely to increase the risk of postpartum depression. The mental state of almost 5000 of these women was determined at around 6 to 8 wee...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035698
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:As part of a collaborative linkage study, the authors obtained clinical and demographic data on 160 families in which more than one sibling was affected with a bipolar illness. The aim of the study was to identify clinical characteristics that had a high degree of familiality. METHOD:Data on age at onset, g...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004986
更新日期:2002-01-01 00:00:00
abstract::Instruments designed to assess psychiatric disorders in people with learning difficulties (mental handicap) were critically reviewed from a psychometric perspective. Major trends were found in the assessment of psychopathology related to DSM-III and depressive disorders although research in other areas was patchy. Alt...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700014732
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Many studies have reported an increased incidence of psychiatric disorder (particularly psychotic disorders) among first generation adult immigrants, along with an increasing risk for ethnic minorities living in low-minority concentration neighborhoods. These studies have depended mostly on European case-bas...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711000213
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Twenty states currently require that women seeking abortion be counseled on possible psychological responses, with six states stressing negative responses. The majority of research finds that women whose unwanted pregnancies end in abortion do not subsequently have adverse mental health outcomes; scant resea...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717001684
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cognitive models postulate that negative-self-schemas (NSS) cause and maintain positive symptoms and that negative affect mediates this link. However, only few studies have tested the temporal mediation claim systematically using an appropriate design. METHODS:A longitudinal cohort design in an online commu...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S003329171700277X
更新日期:2018-06-01 00:00:00
abstract::Potential cases of presenile dementia of the Alzheimer type (PDAT) in the Northern Health Region (estimated population aged 45-64, 655,800) were ascertained for the years 1979-86 from in-patient ICD-9 codes and other sources. An algorithm was applied to the casenote information to distinguish between Alzheimer-type an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700025411
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000215
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Many preschool-age children meet criteria for psychiatric disorders, and rates approach those observed in later childhood and adolescence. However, there is a paucity of longitudinal research examining the outcomes of preschool diagnoses. METHODS:Families with a 3-year-old child (N = 559) were recruited fro...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003646
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Most evidence in the UK on the effectiveness of brief therapy for depression concerns cognitive behaviour therapy (CBT). In a trial published in 2000, we showed that non-directive counselling and CBT were equally effective in general practice for patients with depression and mixed anxiety and depression. Our...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291713002377
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Mental health morbidity in post-conflict settings is high. Nevertheless, randomized controlled trials of psychotherapy on site are rare. Our aim was to integrate rigorous research procedures into a humanitarian programme and test the efficacy of resource activation (ROTATE) in treating post-traumatic stress ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716002592
更新日期:2017-02-01 00:00:00
abstract::Anthropometric and biochemical indices of nutritional status and weighed dietary intake have been studied in hospitalized patients with senile dementia, demented patients living in the community and age-matched control subjects who were not cognitively impaired. Demented patients were lighter than control subjects, an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700012423
更新日期:1989-05-01 00:00:00
abstract::The examination of moment-to-moment, 'micro-level' patterns of experience and behaviour using experience sampling methodology has contributed to our understanding of the 'macro-level' development of full-blown symptoms and disorders. This paper argues that the micro-level perspective can be used to identify the smalle...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291713001979
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Childhood abuse is a risk factor for poorer illness course in bipolar disorder, but the reasons why are unclear. Trait-like features such as affective instability and impulsivity could be part of the explanation. We aimed to examine whether childhood abuse was associated with clinical features of bipolar dis...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002411
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:There is not yet consensus on the best diagnostic definition of mixed bipolar episodes. Many have suggested the DSM-III-R/-IV definition is too rigid. We propose alternative criteria using data from a large patient cohort. METHODS:We evaluated 237 manic in-patients using DSM-III-R criteria and the Scale for...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001312
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Mental disorders often begin during the formative years of education. They may disrupt education and lead to social underachievement. METHODS:We examined the impact of mental disorders treated in hospital (ages 16-29) on educational attainment up to 31 years in the Northern Finland 1966 Birth Cohort (N = 10...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170100304x
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Current mental health legislation in the UK makes provision for the use of certain treatments in severely ill patients who are unable, or unwilling, to give informed consent. Under the terms of this legislation, electroconvulsive therapy (ECT) may be used, usually to treat severely depressed patients. A numb...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007193
更新日期:1999-01-01 00:00:00
abstract::Personality characteristics of 87 parents of autistic probands and 38 parents of Down's syndrome probands were examined using a standardized personality interview. Using best-estimate ratings derived from subject and informant interviews, parents of autistic individuals were rated significantly higher than controls on...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700027938
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Outcome studies of chronic fatigue, neurasthenia and other unexplained fatigue syndromes are few and have been carried out in developed Western countries. This paper aimed to study the outcome of unexplained fatigue syndromes in an international primary care sample and to identify risk factors for persistenc...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291703007566
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Adverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use. METHOD:Antidepressant use and work-related injuries between ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002925
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Several psychological and neurobiological models imply that patients with schizophrenia (SCZ) are more inclined to utilize emotional cues as response determinants to the detriment of more task-appropriate cognitive or contextual cues. However, there is a lack of behavioural data from human clinical studies t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713000445
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Psychological traumatic events, such as war or road traffic accidents, are widespread. A small but significant proportion of survivors develop post-traumatic stress disorder (PTSD). Distressing, sensory-based involuntary memories of trauma (henceforth 'flashbacks') are the hallmark symptom of PTSD. Understan...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002358
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Psychological literature and clinical lore suggest that there may be systematic differences in how various demographic groups experience depressive symptoms, particularly somatic symptoms. The aim of the current study was to use methods based on item response theory (IRT) to examine whether, when equating fo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708003875
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The ability to appreciate humour is essential to successful human interactions. In this study, we hypothesized that individuals with schizophrenia would have diminished ability to recognize and appreciate humour. The relationship between humour experience and clinical symptoms, cognitive and social functioni...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707002528
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:There is increasing recognition that, in addition to negative psychological consequences of trauma such as post-traumatic stress disorder (PTSD), some individuals may develop post-traumatic growth (PTG) following such experiences. To date, however, data regarding the prevalence, correlates and functional sig...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001202
更新日期:2015-01-01 00:00:00