Explaining why childhood abuse is a risk factor for poorer clinical course in bipolar disorder: a path analysis of 923 people with bipolar I disorder.

abstract：BACKGROUND:Prevalence of childhood anxiety disorders at specific ages and genetic etiological influences on anxiety disorders in young children have been little studied. The present study reports prevalence estimates in a community sample of 6-year-old twins, and patterns of genetic and environmental influences on thes...

journal_title：Psychological medicine

authors： Bolton D,Eley TC,O'Connor TG,Perrin S,Rabe-Hesketh S,Rijsdijk F,Smith P

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Assaultive violence events are associated with increased risk for adverse psychiatric outcomes, including post-traumatic stress (PTS), depression, and generalized anxiety. Prior research has indicated that economic, legal, and social stressors that could follow assaultive events may explain the increased ris...

journal_title：Psychological medicine

authors： Lowe SR,Joshi S,Galea S,Aiello AE,Uddin M,Koenen KC,Cerdá M

更新日期：2017-10-01 00:00:00

abstract：:We recently completed a case-control study of 100 literally homeless and 100 never homeless indigent schizophrenic men in New York City, in which concurrent substance abuse and antisocial personality disorder were widespread. In this paper we probe the correlates of 'pure' schizophrenia (single disorder, N = 60), schi...

journal_title：Psychological medicine

authors： Caton CL,Shrout PE,Eagle PF,Opler LA,Felix A

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Depressed individuals demonstrate a poorer ability to recognize the emotions of others, which could contribute to difficulties in interpersonal behaviour. This emotion recognition deficit appears related to the depressive state and is particularly pronounced when emotions are labelled semantically. Here, we ...

journal_title：Psychological medicine

authors： van Wingen GA,van Eijndhoven P,Tendolkar I,Buitelaar J,Verkes RJ,Fernández G

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:High rates of depression associated with childbirth have been reported in many parts of the developing world. However, the prevalence and associations of antenatal and post-natal depression in the rural population remain unknown. Disability associated with depression and its impact on infant health and devel...

journal_title：Psychological medicine

authors： Rahman A,Iqbal Z,Harrington R

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Classification of psychosis lacks a biological basis and current diagnostic categories may obscure underlying continuities. Data reduction methods of symptom profiles within a population-based cohort of people with a wide range of affective and non-affective psychoses may permit an empirical classification o...

journal_title：Psychological medicine

authors： Murray V,McKee I,Miller PM,Young D,Muir WJ,Pelosi AJ,Blackwood DH

更新日期：2005-04-01 00:00:00

abstract：:A case is reported in which platelet monoamine oxidase (MAO) activity fluctuated in the course of a schizophreniform psychosis in a way which suggests a direct relationship between low levels of MAO activity and the psychosis. ...

journal_title：Psychological medicine

authors： Cookson IB,Owen F,Ridges AP

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) is a chronic, relapsing mental illness. Selective serotonin reuptake inhibitors block serotonin transporters (SERTs) and are the mainstay of treatment for OCD. SERT abnormalities are reported in drug-free patients with OCD, but it is not known what happens to SERT levels d...

journal_title：Psychological medicine

authors： Kim E,Howes OD,Park JW,Kim SN,Shin SA,Kim BH,Turkheimer FE,Lee YS,Kwon JS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Older adults have the lowest prevalence and incidence of major depressive disorder, although it has been hypothesized that this finding is due in part to differences in expression of psychopathology in later life. The aim of this study was to examine variation in depressive symptomatology in the general popu...

journal_title：Psychological medicine

authors： Mezuk B,Kendler KS

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The mechanisms that contribute to emotion dysregulation in anxiety disorders are not well understood. Two common disorders, generalized anxiety disorder (GAD) and panic disorder (PD), were examined to test the hypothesis that both disorders are characterized by hypo-activation in prefrontal cortex (PFC) duri...

journal_title：Psychological medicine

authors： Ball TM,Ramsawh HJ,Campbell-Sills L,Paulus MP,Stein MB

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors and personality traits is ...

journal_title：Psychological medicine

authors： Flensborg-Madsen T,Sørensen HJ,Revsbech R,Mortensen EL

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:In people with bulimic eating disorders, exposure to high-calorie foods can result in increases in food craving, raised subjective stress and salivary cortisol concentrations. This cue-induced food craving can be reduced by repetitive transcranial magnetic stimulation (rTMS). We investigated whether rTMS has...

journal_title：Psychological medicine

authors： Claudino AM,Van den Eynde F,Stahl D,Dew T,Andiappan M,Kalthoff J,Schmidt U,Campbell IC

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Individual-level measures of acculturation (e.g. age of immigration) have a complex relationship with psychiatric disorders. Fine-grained analyses that tap various acculturation dimensions and population subgroups are needed to generate hypotheses regarding the mechanisms of action for the association betwee...

journal_title：Psychological medicine

authors： Fernández RL,Morcillo C,Wang S,Duarte CS,Aggarwal NK,Sánchez-Lacay JA,Blanco C

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Dysregulation of the striatum and altered corticostriatal connectivity have been associated with psychotic disorders. Social anhedonia has been identified as a predictor for the development of schizophrenia spectrum disorders. The aim of the present study was to examine corticostriatal functional connectivit...

journal_title：Psychological medicine

authors： Wang Y,Liu WH,Li Z,Wei XH,Jiang XQ,Geng FL,Zou LQ,Lui SS,Cheung EF,Pantelis C,Chan RC

更新日期：2016-01-01 00:00:00

abstract：:Brown and his colleagues have presented evidence for the social origins of depression from results of 2 community surveys in Camberwell. This paper examines critically their methodology, conceptualization of variables, mode of argument and statistical techniques. Log-linear analysis of their published data fails to su...

journal_title：Psychological medicine

authors： Tennant C,Bebbington P

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND:Cannabis use is associated with an earlier age at onset of psychotic illness. The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder. METHOD:In 785 patients with a non-affective...

journal_title：Psychological medicine

authors： Dekker N,Meijer J,Koeter M,van den Brink W,van Beveren N,Kahn RS,Linszen DH,van Os J,Wiersma D,Bruggeman R,Cahn W,de Haan L,Krabbendam L,Myin-Germeys I,GROUP Investigators.

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The processing of facial emotion involves a distributed network of limbic and paralimbic brain structures. Many of these regions are also implicated in the pathophysiology of mood disorders. Behavioural data indicate that depressed subjects show a state-related positive recognition bias for faces displaying ...

journal_title：Psychological medicine

authors： Lennox BR,Jacob R,Calder AJ,Lupson V,Bullmore ET

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Stress and vulnerability likely interact to play a major role in psychosis. While much has been written about the neural diathesis-stress model in psychosis and its clinical risk states, little is known about HPA axis biomarkers in non-help-seeking individuals at familial high risk (FHR). We sought to prospe...

journal_title：Psychological medicine

authors： Shah JL,Tandon N,Howard ER,Mermon D,Miewald JM,Montrose DM,Keshavan MS

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Preclinical and human studies suggest an association between chronic inflammation and the development of depressive behaviors. This is proposed to occur through downstream effects of inflammatory cytokines on neuroplasticity, neurogenesis and neurotransmitter function, although the neural correlates remain p...

journal_title：Psychological medicine

authors： Ironside M,Admon R,Maddox SA,Mehta M,Douglas S,Olson DP,Pizzagalli DA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between su...

journal_title：Psychological medicine

authors： Buchy L,Cadenhead KS,Cannon TD,Cornblatt BA,McGlashan TH,Perkins DO,Seidman LJ,Tsuang MT,Walker EF,Woods SW,Heinssen R,Bearden CE,Mathalon D,Addington J

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Structural models of emotional disorders propose that anxiety disorders can be classified into fear and distress disorders. Sources of evidence for this distinction come from genetic, self-report and neurophysiological data from adults. The present study examined whether this distinction relates to cognitive...

journal_title：Psychological medicine

authors： Waters AM,Bradley BP,Mogg K

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia ...

journal_title：Psychological medicine

authors： Silverstein SM,Paterno D,Cherneski L,Green S

更新日期：2018-09-01 00:00:00

abstract：:A community survey of psychiatric disorder carried out in South London enabled the authors to investigate the 'vulnerability model' proposed by Brown & Harris (1978). In the current study none of the 'vulnerability factors' proposed by Brown & Harris fulfilled the requirements of the model. It was, however, found that...

journal_title：Psychological medicine

authors： Bebbington PE,Sturt E,Tennant C,Hurry J

更新日期：1984-05-01 00:00:00

abstract：:Biochemical studies of manic-depressive psychosis usually correlates biochemical findings with current affective state and hence any significant findings could be secondary to mood change. The present study attempts to correlate measures of the erythrocyte membrane cation carrier with clinical events, remote in time f...

journal_title：Psychological medicine

authors： Naylor GJ,Dick DA,Dick EG

更新日期：1976-05-01 00:00:00

abstract：:Diffuse loss of cortical volume and ventricular enlargement have been demonstrated in schizophrenia using imaging. In addition, histological studies have provided evidence that the number of neurons in the medial temporal lobe structures is reduced and that the cytoarchitecture is abnormal. In an attempt to correlate ...

journal_title：Psychological medicine

authors： Maier M,Ron MA,Barker GJ,Tofts PS

更新日期：1995-11-01 00:00:00

abstract：:A review of research on kleptomania--the syndrome of compulsive stealing--suggests that kleptomania may be a common disorder, especially among women, and that it may frequently be associated with other forms of psychopathology, such as mood, anxiety, and eating disorders. There appears to be a range of abnormal or non...

journal_title：Psychological medicine

authors： McElroy SL,Hudson JI,Pope HG,Keck PE

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg). The aim of this study was: (1) to compare the NOS activity of patients with a MDE to that of healthy controls (HC); (2)...

journal_title：Psychological medicine

authors： Loeb E,El Asmar K,Trabado S,Gressier F,Colle R,Rigal A,Martin S,Verstuyft C,Fève B,Chanson P,Becquemont L,Corruble E

更新日期：2020-06-11 00:00:00

abstract：BACKGROUND:Research on the structure of co-morbidity among common mental disorders has largely focused on current prevalence rather than on the development of co-morbidity. This report presents preliminary results of the latter type of analysis based on the US National Comorbidity Survey Replication Adolescent Suppleme...

journal_title：Psychological medicine

authors： Kessler RC,Avenevoli S,McLaughlin KA,Green JG,Lakoma MD,Petukhova M,Pine DS,Sampson NA,Zaslavsky AM,Merikangas KR

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Quetiapine (ICI 204,636, 'Seroquel') is a new atypical antipsychotic agent with a similar binding profile to the original atypical antipsychotic, clozapine. Its clinical efficacy has already been demonstrated at multiple fixed doses (150-750 mg/day) and has been suggested to be comparable with haloperidol (1...

journal_title：Psychological medicine

authors： Copolov DL,Link CG,Kowalcyk B

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Mild traumatic brain injury (mTBI) is being claimed as the 'signature' injury of the Iraq war, and is believed to be the cause of long-term symptomatic ill health (post-concussional syndrome; PCS) in an unknown proportion of military personnel. METHOD:We analysed cross-sectional data from a large, randomly ...

journal_title：Psychological medicine

authors： Fear NT,Jones E,Groom M,Greenberg N,Hull L,Hodgetts TJ,Wessely S

更新日期：2009-08-01 00:00:00