Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania.

Abstract:

BACKGROUND:The processing of facial emotion involves a distributed network of limbic and paralimbic brain structures. Many of these regions are also implicated in the pathophysiology of mood disorders. Behavioural data indicate that depressed subjects show a state-related positive recognition bias for faces displaying negative emotions. There are sparse data to suggest there may be an analogous, state-related negative recognition bias for negative emotions in mania. We used functional magnetic resonance imaging (fMRI) to investigate the behavioural and neurocognitive correlates of happy and sad facial affect recognition in patients with mania. METHOD:Functional MRI and an explicit facial affect recognition task were used in a case-control design to measure brain activation and associated behavioural response to variable intensity of sad and happy facial expressions in 10 patients with bipolar I mania and 12 healthy comparison subjects. RESULTS:The patients with mania had attenuated subjective rating of the intensity of sad facial expressions, and associated attenuation of activation in the subgenual anterior cingulate and bilateral amygdala, with increased activation in the posterior cingulate and posterior insula. No behavioural or neurocognitive abnormalities were found in response to presentation of happy facial expressions. CONCLUSIONS:Patients with mania showed a specific, mood-congruent, negative bias in sad facial affect recognition, which was associated with an abnormal profile of brain activation in paralimbic regions implicated in affect recognition and mood disorders. Functional imaging of facial emotion recognition may be a useful probe of cortical and subcortical abnormalities in mood disorders.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Lennox BR,Jacob R,Calder AJ,Lupson V,Bullmore ET

doi

10.1017/s0033291704002557

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

795-802

issue

5

eissn

0033-2917

issn

1469-8978

journal_volume

34

pub_type

杂志文章
  • Domiciliary and out-patient treatment of self-poisoning patients by medical and non-medical staff.

    abstract::In a study of domiciliary and out-patient treatment of self-poisoning patients, using a brief problem-orientated approach, it was found that domiciliary treatment resulted in much higher attendance rates but no difference in outcome. Patients who completed out-patient treatment had a better outcome than those who fail...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700053381

    authors: Hawton K,Bancroft J,Catalan J,Kingston B,Stedeford A,Welch N

    更新日期:1981-02-01 00:00:00

  • The DSM-5 Clinical and Public Health Committee (CPHC): operations, mechanics, controversies and recommendations.

    abstract:BACKGROUND:For DSM - 5, the American Psychiatric Association Board of Trustees established a robust vetting and review process that included two review committees that did not exist in the development of prior DSMs, the Scientific Review Committee (SRC) and the Clinical and Public Health Committee (CPHC). The CPHC was ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720001415

    authors: McIntyre JS,Yager J,Everett A,Galanter CA,Lyness JM,Nininger J,Reus VI,Vergare M

    更新日期:2020-08-25 00:00:00

  • Distribution of health anxiety in a general adult population and associations with demographic and social network characteristics.

    abstract:BACKGROUND:Health anxiety (HA) is associated with increased risk of disability, increased health care utilization and reduced quality of life. However, there is no consensus on which factors are important for the level of HA. The aim of this study was to explore the distribution of HA in a general adult population and ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004122

    authors: Norbye AD,Abelsen B,Førde OH,Ringberg U

    更新日期:2020-11-13 00:00:00

  • Early motor developmental milestones and level of neuroticism in young adulthood: a 23-year follow-up study of the Copenhagen Perinatal Cohort.

    abstract:BACKGROUND:Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors and personality traits is ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291712001997

    authors: Flensborg-Madsen T,Sørensen HJ,Revsbech R,Mortensen EL

    更新日期:2013-06-01 00:00:00

  • More data on major depression as an antecedent risk factor for first onset of chronic back pain.

    abstract:BACKGROUND:Few epidemiological studies have examined the temporal relationship between chronic pain and depression using longitudinal data. In the present study, we examined major depression as both an antecedent risk factor and consequence of chronic back pain (CBP) in the general population. METHOD:Data on 9909 pain...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291705004952

    authors: Currie SR,Wang J

    更新日期:2005-09-01 00:00:00

  • Cognitive deficits in unipolar old-age depression: a population-based study.

    abstract:BACKGROUND:There is substantial variability in the degree of cognitive impairment among older depressed persons. Inconsistencies in previous findings may be due to differences in clinical and demographic characteristics across study samples. We assessed the influence of unipolar depression and severity of depression on...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713001736

    authors: Pantzar A,Laukka EJ,Atti AR,Fastbom J,Fratiglioni L,Bäckman L

    更新日期:2014-04-01 00:00:00

  • Negative self-evaluation and the genesis of internal threat: beyond a continuum of suicidal thought and behaviour.

    abstract:BACKGROUND:Death by suicide is often preceded by attempted suicide, suicidal ideation and non-suicidal self-injury. These extreme thoughts and behaviours have been considered in terms of a continuum of suicidality. Little known research, however, has considered a suicide continuum that extends beyond these extreme thou...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718003562

    authors: Butter S,Shevlin M,Murphy J

    更新日期:2019-11-01 00:00:00

  • Complex trauma of war captivity: a prospective study of attachment and post-traumatic stress disorder.

    abstract:BACKGROUND:Victims of war captivity sometimes suffer from complex post-traumatic stress disorder (PTSD), a unique form of PTSD that entails various alterations in personality. These alterations may involve changes in attachment orientation. METHOD:The sample comprised two groups of veterans from the 1973 Yom Kippur Wa...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708002808

    authors: Solomon Z,Dekel R,Mikulincer M

    更新日期:2008-10-01 00:00:00

  • Testing the association between the incidence of schizophrenia and social capital in an urban area.

    abstract:BACKGROUND:Social capital has been considered aetiologically important in schizophrenia but the empirical evidence to support this hypothesis is absent. We tested whether social capital, measured at the neighbourhood level, was associated with the incidence of schizophrenia (ICD-10 F20). MethodWe administered a cross-s...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707002085

    authors: Kirkbride JB,Boydell J,Ploubidis GB,Morgan C,Dazzan P,McKenzie K,Murray RM,Jones PB

    更新日期:2008-08-01 00:00:00

  • Sub-typing depression, II. Clinical distinction of psychotic depression and non-psychotic melancholia.

    abstract::We have attempted to clarify clinical differentiating features of psychotic depression. Forty-six depressed subjects meeting DSM-III-R criteria for major depression with psychotic features were compared with (i) DSM-defined melancholic, (ii) Newcastle-defined endogenous, and (iii) a residual DSM-defined major depressi...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700035078

    authors: Parker G,Hadzi-Pavlovic D,Brodaty H,Austin MP,Mitchell P,Wilhelm K,Hickie I

    更新日期:1995-07-01 00:00:00

  • Costing mental health services.

    abstract::In this paper four principal topics are addressed: (a) the policy and political contexts in which demands arise for cost information; (b) the nature and phasing of those demands; (c) the basic rules of empirical costs research for meeting those demands; and (d) concomitant implications for the design, execution and in...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s003329170003659x

    authors: Knapp M,Beecham J

    更新日期:1990-11-01 00:00:00

  • Fractal biomarker of activity in patients with bipolar disorder.

    abstract:BACKGROUND:The output of many healthy physiological systems displays fractal fluctuations with self-similar temporal structures. Altered fractal patterns are associated with pathological conditions. There is evidence that patients with bipolar disorder have altered daily behaviors. METHODS:To test whether fractal patt...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000331

    authors: Knapen SE,Li P,Riemersma-van der Lek RF,Verkooijen S,Boks MPM,Schoevers RA,Scheer FAJL,Hu K

    更新日期:2020-04-01 00:00:00

  • Childhood trauma- and cannabis-associated microstructural white matter changes in patients with psychotic disorder: a longitudinal family-based diffusion imaging study.

    abstract:BACKGROUND:Decreased white matter (WM) integrity in patients with psychotic disorder has been a consistent finding in diffusion tensor imaging (DTI) studies. However, the contribution of environmental risk factors to these WM alterations is rarely investigated. The current study examines whether individuals with (incre...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S0033291718001320

    authors: Domen P,Michielse S,Peeters S,Viechtbauer W,van Os J,Marcelis M,for Genetic Risk and Outcome of Psychosis (G.R.O.U.P.).

    更新日期:2019-03-01 00:00:00

  • Psychosocial intervention with cancer patients: a review.

    abstract::It is well established that a diagnosis of cancer and the subsequent treatment can cause a great deal of stress, and the need for psychosocial support is increasingly being advocated. The data for the efficacy of intervention programmes are reviewed. The evidence relating to the benefits gained by patients is equivoca...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700051552

    authors: Watson M

    更新日期:1983-11-01 00:00:00

  • Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health.

    abstract:BACKGROUND:Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to eluc...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719000357

    authors: Marees AT,Smit DJA,Ong JS,MacGregor S,An J,Denys D,Vorspan F,van den Brink W,Derks EM

    更新日期:2020-02-01 00:00:00

  • Risk of schizophrenia in second-generation immigrants: a Danish population-based cohort study.

    abstract:BACKGROUND:Urban birth, a risk factor for schizophrenia, is more frequent among second-generation immigrants. The aim of the current study was to determine whether the increased risk for schizophrenia found in second-generation immigrants is explained by the degree of urbanization of birthplace and/or factors related t...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706009652

    authors: Cantor-Graae E,Pedersen CB

    更新日期:2007-04-01 00:00:00

  • The levels problem in psychopathology.

    abstract::Psychiatric disorders are studied at multiple levels, but there is no agreement on how these levels are related to each other, or how they should be understood in the first place. In this paper, I provide an account of levels and their relationships that is suited for psychopathology, drawing from recent debates in ph...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719002514

    authors: Eronen MI

    更新日期:2019-09-24 00:00:00

  • Antidepressant-resistant depression is characterized by reduced short- and long-interval cortical inhibition.

    abstract:BACKGROUND:Major depressive disorder (MDD) is highly heterogeneous and can be classified as treatment-resistant depression (TRD) or antidepressant-responsive depression (non-TRD) based on patients' responses to antidepressant treatment. Methods for distinguishing between TRD and non-TRD are critical clinical concerns. ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719001223

    authors: Jeng JS,Li CT,Lin HC,Tsai SJ,Bai YM,Su TP,Chang YW,Cheng CM

    更新日期:2020-06-01 00:00:00

  • Associations between mood instability and emotional processing in a large cohort of bipolar patients.

    abstract:BACKGROUND:Aberrant emotional biases have been reported in bipolar disorder (BD), but results are inconsistent. Despite the clinical relevance of chronic mood variability in BD, there is no previous research investigating how the extent of symptom fluctuations in bipolar disorder might relate to emotional biases. This ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171600180X

    authors: Bilderbeck AC,Reed ZE,McMahon HC,Atkinson LZ,Price J,Geddes JR,Goodwin GM,Harmer CJ

    更新日期:2016-11-01 00:00:00

  • Lymphocyte numbers in endogenous depression.

    abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700024934

    authors: Murphy D,Gardner R,Greden JF,Carroll BJ

    更新日期:1987-05-01 00:00:00

  • Common mental disorders in young adults born late-preterm.

    abstract:BACKGROUND:Results of adulthood mental health of those born late-preterm (34 + 0-36 + 6 weeks + days of gestation) are mixed and based on national registers. We examined if late-preterm birth was associated with a higher risk for common mental disorders in young adulthood when using a diagnostic interview, and if this ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716000830

    authors: Heinonen K,Kajantie E,Pesonen AK,Lahti M,Pirkola S,Wolke D,Lano A,Sammallahti S,Lahti J,Andersson S,Eriksson JG,Raikkonen K

    更新日期:2016-07-01 00:00:00

  • Adjunctive memantine in clozapine-treated refractory schizophrenia: an open-label 1-year extension study.

    abstract:BACKGROUND:In a recent placebo-controlled, double-blind crossover trial (n = 52), significant beneficial effects on memory (d = 0.30) and negative symptoms (d = 0.29) were found after 12 weeks of memantine augmentation in patients with clozapine-refractory schizophrenia. In this open-label 1-year extension study we rep...

    journal_title:Psychological medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0033291716002476

    authors: Veerman SR,Schulte PF,Deijen JB,de Haan L

    更新日期:2017-01-01 00:00:00

  • The clinical effectiveness of counselling in primary care: a systematic review and meta-analysis.

    abstract:BACKGROUND:Counselling is frequently used in the management of common mental disorders (such as anxiety and depression) in primary care. However, there are concerns over the clinical effectiveness of counselling, both in comparison with usual general practitioner care, and with other treatments such as alternative psyc...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/s0033291702006979

    authors: Bower P,Rowland N,Hardy R

    更新日期:2003-02-01 00:00:00

  • The effect of digoxin on the response to lithium therapy in mania.

    abstract::Patients suffering from manic-depressive psychosis, manic type (ICD 296.0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 ...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291700043282

    authors: Chambers CA,Smith AH,Naylor GJ

    更新日期:1982-02-01 00:00:00

  • Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.

    abstract::The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720002172

    authors: Sideli L,Murray RM,Schimmenti A,Corso M,La Barbera D,Trotta A,Fisher HL

    更新日期:2020-08-01 00:00:00

  • Spontaneous movement disorders in antipsychotic-naive patients with first-episode psychoses: a systematic review.

    abstract:BACKGROUND:Spontaneous movement disorders (SMDs), such as spontaneous dyskinesia and parkinsonism, have been described in patients with schizophrenia who have never been treated with antipsychotic medication. Their presence has been documented extensively in chronic schizophrenia but not at the time of illness onset. ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291708004716

    authors: Pappa S,Dazzan P

    更新日期:2009-07-01 00:00:00

  • The capacity of people with a 'mental disability' to make a health care decision.

    abstract:BACKGROUND:Based on the developing clinical and legal literature, and using the framework adopted in draft legislation, capacity to make a valid decision about a clinically required blood test was investigated in three groups of people with a 'mental disability' (i.e. mental illness (chronic schizophrenia), 'learning d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700001768

    authors: Wong JG,Clare CH,Holland AJ,Watson PC,Gunn M

    更新日期:2000-03-01 00:00:00

  • Symptoms, cognition, treatment adherence and functional outcome in first-episode psychosis.

    abstract:BACKGROUND:The differential strength of correlation between symptoms, cognition and other patient characteristics with community functioning in first-episode psychosis has not been fully investigated. METHOD:In a sample of 66 first-episode psychosis patients demographic variables, ratings of pre-morbid adjustment, pos...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0033291702006050

    authors: Malla AK,Norman RM,Manchanda R,Townsend L

    更新日期:2002-08-01 00:00:00

  • Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results.

    abstract:BACKGROUND:The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. METHOD:A systematic review and meta-analysis was conducted of representative, longitudinal p...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0033291711002911

    authors: Kaymaz N,Drukker M,Lieb R,Wittchen HU,Werbeloff N,Weiser M,Lataster T,van Os J

    更新日期:2012-11-01 00:00:00

  • Language and dementia: a review.

    abstract::In the literature on dementia the presence or absence of language deficits has come to occupy a pivotal position with respect to certain nosological and nosographical issues. These are reviewed critically, together with the results of experimental investigations which have sought to elucidate the nature of the languag...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700001938

    authors: Hart S

    更新日期:1988-02-01 00:00:00