Abstract:
:Patients suffering from manic-depressive psychosis, manic type (ICD 296.0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 and by nurses daily on the Hargreaves Rating Scale, Psychotic Rating. Fourteen patients received digoxin and lithium carbonate and 14 patients received placebo and lithium carbonate. Improvement in the placebo lithium group was significantly greater than that in the digoxin lithium group. This trial suggests, therefore, that the effect of inhibition of membrane cation carrier is to reduce the response to lithium. This result is in keeping with our hypothesis that an increase in Na-K ATPase is essential to the therapeutic effect of lithium carbonate. It does not, however, exclude the possibility that the observations resulted from the inhibition by digoxin of lithium entry into the brain.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Chambers CA,Smith AH,Naylor GJdoi
10.1017/s0033291700043282subject
Has Abstractpub_date
1982-02-01 00:00:00pages
57-60issue
1eissn
0033-2917issn
1469-8978journal_volume
12pub_type
临床试验,杂志文章,随机对照试验abstract::A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant differ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291700003068
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:We studied to what extent internet-based cognitive behaviour therapy (CBT) programs for symptoms of depression and anxiety are effective. METHOD:A meta-analysis of 12 randomized controlled trials. RESULTS:The effects of internet-based CBT were compared to control conditions in 13 contrast groups with a tot...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291706008944
更新日期:2007-03-01 00:00:00
abstract::We measured multiple dimensions of distress among spouses (N = 440) of patients hospitalized for serious illness or elective surgery and compared the course of distress over 2 years of follow-up among five groups according to whether and when spouses were bereaved. Distress was related to the severity of the patient's...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029019
更新日期:1994-11-01 00:00:00
abstract::Five hundred and eighty schoolgirls living in a small North Indian industrial town were screened using the EAT-26. Although twenty-nine per cent scored above the threshold for the questionnaire (greater than or equal to 20), closer scrutiny of the pattern of responses revealed misinterpretations of a large number of q...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700005675
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:The coronavirus [coronavirus disease 2019 (COVID-19)] pandemic has introduced extraordinary life changes and stress, particularly in adolescents and young adults. Initial reports suggest that depression and anxiety are elevated during COVID-19, but no prior study has explored changes at the within-person lev...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720005358
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:Although many studies have addressed the topic of stability versus change in depressive symptoms, few have further decomposed the change to continuous accumulation versus non-systematic state fluctuations or measurement errors. This further step requires a longitudinal follow-up and an appropriate stochastic...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002000
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The clinician-administered version of the Liebowitz Social Anxiety Scale (LSAS-CA) is a commonly used assessment device for the evaluation of social anxiety disorder and has been shown to have strong psychometric characteristics. Because of its apparently straightforward rating format and potential savings i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004056
更新日期:2001-08-01 00:00:00
abstract::This paper describes a modified version of the MRC Needs for Care Schedule (the Cardinal Needs Schedule), for measuring needs for psychiatric and social care amongst patients with severe psychiatric disorders. The modified schedule has three new features: (i) it is quick and easy to use; (ii) it takes systematic accou...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700033511
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Epidemiological evidence suggests a link between cannabis use and psychosis. A variety of factors have been proposed to mediate an individual's vulnerability to the harmful effects of the drug, one of which is their psychosis proneness. We hypothesized that highly psychosis-prone individuals would report mor...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708004741
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Rumination is an important cognitive risk factor for onset and relapse of depression. However, no studies have employed a dimensional approach in investigating the neural correlates of rumination and the relationship with depression. METHOD:Non-clinical healthy subjects (n = 306), who completed the classica...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000938
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Patients treated in primary care settings report better mental outcomes when they agree with practitioners about the nature of their core presenting problems. However, no study has examined the impact of staff-patient agreement on treatment outcomes in specialist mental health services. We investigated wheth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000785
更新日期:2008-01-01 00:00:00
abstract::Schizophrenia and affective disorders selected according to the Feighner criteria can be differentiated on the basis of 40-year outcome. Within schizophrenia the presence of disorganized thoughts at the index admission was associated with poor outcome, whereas better outcome was associated with the presence of delusio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700052107
更新日期:1981-05-01 00:00:00
abstract::Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving c...
journal_title:Psychological medicine
pub_type: 社论
doi:10.1017/S0033291716003123
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Schizophrenia is associated with perceptual organization deficits and abnormal neuronal connectivity has been described in early visual areas. The purpose of this study was to investigate the functional integrity of lateral connections in early visual areas of patients with schizophrenia and type I bipolar d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291705004381
更新日期:2005-07-01 00:00:00
abstract::Previous studies have reported an increase in depression among recent birth cohorts. Concurrent with the increase in rates of depression, there have been increases in rates of drug and alcohol abuse and dependence. This study sought to determine if the recent increase in rates of depression could be attributed to co-m...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034735
更新日期:1996-03-01 00:00:00
abstract:INTRODUCTION:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible alternative to electroconvulsive therapy for the treatment of selected patients with depression, bipolar affective disorder and schizophrenia. The aim of this study was to evaluate the evidence for the effectiveness of rTMS...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291701004378
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Geographic variations in the incidence of deliberate self-harm (DSH) and suicide have been shown to be associated with area-based measures of socio-economic deprivation and social fragmentation. Previous studies have been subject to methodological limitations. None has investigated whether ecological associa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003993
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Depression is associated with alterations of emotional and cognitive processing, and executive control in particular. Previous research has shown that depressed patients are impaired in their ability to shift attention from one emotional category to another, but whether this shifting deficit is more evident ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002418
更新日期:2012-07-01 00:00:00
abstract::The prevalence of culture-bound syndromes such as eating disorders in the countries of Central and Eastern Europe is unclear and comparative epidemiological studies are lacking. Before the political changes in 1989 we therefore investigated eating disorders, eating attitudes and psychological health in two Eastern Eur...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700037521
更新日期:1995-09-01 00:00:00
abstract::Sixty-four children taken to court for failure to attend school were reliably classified into 4 groups, according to whether they exhibited the features of 'school refusal' and/or 'truancy'. About a fifth of them were found to exhibit 'school refusal'; a third showed 'truancy'; less than a sixth exhibited both 'school...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700021024
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:The methodology for measuring the needs of patients with severe mental illness is now well established through the MRC Needs for Care Assessment Schedule and its modification in the form of the Cardinal Needs Assessment. This paper reports the rationale and construction of a relatives' version of the Cardina...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329179800662x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:The outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date. METHOD:We conducted a first-episode follow-up study of 97 patients with DSM-IV schizop...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170800336X
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Genetic influences contribute significantly to co-morbidity between conduct disorder and substance use disorders. Estimating the extent of overlap can assist in the development of phenotypes for genomic analyses. METHOD:Multivariate quantitative genetic analyses were conducted using data from 9577 individua...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001518
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In a recent placebo-controlled, double-blind crossover trial (n = 52), significant beneficial effects on memory (d = 0.30) and negative symptoms (d = 0.29) were found after 12 weeks of memantine augmentation in patients with clozapine-refractory schizophrenia. In this open-label 1-year extension study we rep...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716002476
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:High rates of depression associated with childbirth have been reported in many parts of the developing world. However, the prevalence and associations of antenatal and post-natal depression in the rural population remain unknown. Disability associated with depression and its impact on infant health and devel...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008286
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The aims of this study were to examine the associations between exposure to unemployment following school leaving and rates of psychiatric disorder using data gathered on a birth cohort of New Zealand young people studied up to the age of 18. METHODS:At age 18 cohort members were assessed on: (a) duration o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004412
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The World Mental Health Survey Initiative (WMHSI) has advanced our understanding of mental disorders by providing data suitable for analysis across many countries. However, these data have not yet been fully explored from a cross-national lifespan perspective. In particular, there is a shortage of research o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001116
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:A combined family study and recovered study design was utilized to examine several hypothesized relationships between personality and bulimia nervosa (BN). METHODS:We studied 47 women with a lifetime history of DSM-III-R BN (31 currently ill and 16 recovered), 44 matched control women (CW) with no history o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002792
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:There is not yet consensus on the best diagnostic definition of mixed bipolar episodes. Many have suggested the DSM-III-R/-IV definition is too rigid. We propose alternative criteria using data from a large patient cohort. METHODS:We evaluated 237 manic in-patients using DSM-III-R criteria and the Scale for...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001312
更新日期:2000-03-01 00:00:00
abstract::The factor structure of the 60-item version of the General Health Questionnaire was explored, using data collected in a community study in a rural area of northern Spain. Six principal components, similar to those previously reported with this instrument, were found to provide a good description of the data structure....
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700002038
更新日期:1988-02-01 00:00:00