The effect of digoxin on the response to lithium therapy in mania.

Abstract:

:Patients suffering from manic-depressive psychosis, manic type (ICD 296.0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 and by nurses daily on the Hargreaves Rating Scale, Psychotic Rating. Fourteen patients received digoxin and lithium carbonate and 14 patients received placebo and lithium carbonate. Improvement in the placebo lithium group was significantly greater than that in the digoxin lithium group. This trial suggests, therefore, that the effect of inhibition of membrane cation carrier is to reduce the response to lithium. This result is in keeping with our hypothesis that an increase in Na-K ATPase is essential to the therapeutic effect of lithium carbonate. It does not, however, exclude the possibility that the observations resulted from the inhibition by digoxin of lithium entry into the brain.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Chambers CA,Smith AH,Naylor GJ

doi

10.1017/s0033291700043282

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

57-60

issue

1

eissn

0033-2917

issn

1469-8978

journal_volume

12

pub_type

临床试验,杂志文章,随机对照试验
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