Abstract:
BACKGROUND:Urban birth, a risk factor for schizophrenia, is more frequent among second-generation immigrants. The aim of the current study was to determine whether the increased risk for schizophrenia found in second-generation immigrants is explained by the degree of urbanization of birthplace and/or factors related to parentage, such as geographic origin or history of residence abroad during upbringing. METHOD:Using data from the Danish Civil Registration System (CRS), we established a population-based cohort of 2.0 million Danes (persons born in Denmark). Schizophrenia in cohort members was identified by cross-linkage with the Danish Psychiatric Central Register. RESULTS:The relative risk of developing schizophrenia was 1.93 [95% confidence interval (CI) 1.79-2.08] and 2.96 (95% CI 2.49-3.51) among persons with one or both parents foreign-born respectively compared to native Danes. Adjustment for urbanization of birthplace and parental characteristics reduced these risks slightly. However, urbanization had a lesser effect in second-generation immigrants than in Danes. History of residence abroad was a risk factor for schizophrenia, regardless of whether parents were foreign-born or native Danes. CONCLUSION:The increased risk found in second-generation immigrants cannot be explained by urbanization or parental characteristics pertaining to age, mental illness, geographic origin or residence abroad during a child's upbringing.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Cantor-Graae E,Pedersen CBdoi
10.1017/S0033291706009652subject
Has Abstractpub_date
2007-04-01 00:00:00pages
485-94issue
4eissn
0033-2917issn
1469-8978pii
S0033291706009652journal_volume
37pub_type
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