Cognitive deficits in unipolar old-age depression: a population-based study.

Abstract:

BACKGROUND:There is substantial variability in the degree of cognitive impairment among older depressed persons. Inconsistencies in previous findings may be due to differences in clinical and demographic characteristics across study samples. We assessed the influence of unipolar depression and severity of depression on cognitive performance in a population-based sample of elderly persons aged ⩾60 years. METHOD:Eighty-nine persons fulfilled ICD-10 criteria for unipolar depression (mild, n = 48; moderate, n = 38; severe, n = 3) after thorough screening for dementia (DSM-IV criteria), psychiatric co-morbidities and antidepressant pharmacotherapy. Participants (n = 2486) were administered an extensive cognitive test battery. RESULTS:Moderate/severe unipolar depression was associated with poorer performance on tasks assessing processing speed, attention, executive function, verbal fluency, episodic memory and vocabulary. Mild depression was associated with poorer performance in processing speed, and few differences between mild and moderate/severe depression were observed. No association between depression and short-term memory, general knowledge or spatial ability was observed. Increasing age did not exacerbate the depression-related cognitive deficits, and the deficits remained largely unchanged after excluding persons in a preclinical phase of dementia. Furthermore, depression-related cognitive deficits were not associated with other pharmacological treatments that may affect cognitive performance. CONCLUSIONS:Cognitive deficits in unipolar old-age depression involve a range of domains and the cognitive deficits seem to follow the spectrum of depression severity. The finding that mild depression was also associated with poorer cognitive functioning underscores the importance of detecting mild depression in elderly persons.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Pantzar A,Laukka EJ,Atti AR,Fastbom J,Fratiglioni L,Bäckman L

doi

10.1017/S0033291713001736

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

937-47

issue

5

eissn

0033-2917

issn

1469-8978

pii

S0033291713001736

journal_volume

44

pub_type

杂志文章
  • Bipolar depression: relationship between episode length and antidepressant treatment.

    abstract:BACKGROUND:The role of antidepressant medications in bipolar depression remains controversial, mainly due to a lack of research in this area. In this study the authors examined the episode length in bipolar depression and the relationship between antidepressant therapy and episode length. METHOD:A retrospective chart ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291702006165

    authors: Frankle WG,Perlis RH,Deckersbach T,Grandin LD,Gray SM,Sachs GS,Nierenberg AA

    更新日期:2002-11-01 00:00:00

  • Comparison of alternative models for personality disorders, II: 6-, 8- and 10-year follow-up.

    abstract:BACKGROUND:Several conceptual models have been considered for the assessment of personality pathology in DSM-5. This study sought to extend our previous findings to compare the long-term predictive validity of three such models: the five-factor model (FFM), the schedule for nonadaptive and adaptive personality (SNAP), ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002601

    authors: Morey LC,Hopwood CJ,Markowitz JC,Gunderson JG,Grilo CM,McGlashan TH,Shea MT,Yen S,Sanislow CA,Ansell EB,Skodol AE

    更新日期:2012-08-01 00:00:00

  • A longitudinal examination of neuropsychological and clinical functioning in boys with attention deficit hyperactivity disorder (ADHD): improvements in executive functioning do not explain clinical improvement.

    abstract:BACKGROUND:Attention deficit hyperactivity disorder (ADHD) often, but not always, persists into adulthood. Investigations of the associations between clinical and biological markers of persistence can shed light on causal pathways. It has been proposed that compensatory improvements in executive neuropsychological func...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713001761

    authors: Coghill DR,Hayward D,Rhodes SM,Grimmer C,Matthews K

    更新日期:2014-04-01 00:00:00

  • Hedonic tone is associated with left supero-lateral medial forebrain bundle microstructure.

    abstract:BACKGROUND:The medial forebrain bundle (MFB) is an important pathway of the reward system. Two branches have been described using diffusion magnetic resonance imaging (MRI)-based tractography: the infero-medial MFB (imMFB) and the supero-lateral MFB (slMFB). Previous studies point to white-matter microstructural altera...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291714001949

    authors: Bracht T,Doidge AN,Keedwell PA,Jones DK

    更新日期:2015-03-01 00:00:00

  • Posttraumatic stress disorder symptom trajectories within the first year following emergency department admissions: pooled results from the International Consortium to predict PTSD.

    abstract:BACKGROUND:Research exploring the longitudinal course of posttraumatic stress disorder (PTSD) symptoms has documented four modal trajectories (low, remitting, high, and delayed), with proportions varying across studies. Heterogeneity could be due to differences in trauma types and patient demographic characteristics. ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719004008

    authors: Lowe SR,Ratanatharathorn A,Lai BS,van der Mei W,Barbano AC,Bryant RA,Delahanty DL,Matsuoka YJ,Olff M,Schnyder U,Laska E,Koenen KC,Shalev AY,Kessler RC

    更新日期:2020-02-03 00:00:00

  • Pathways to psychiatric care in Ethiopia.

    abstract:BACKGROUND:Understanding the pathways to psychiatric care and recognition of delay points are crucial for the development of interventions that aim to improve access to mental health-care services. METHOD:Over a 2-month period in 2003, a total of 1044 patients at the commencement of new episodes of care at Amanuel Spe...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708003929

    authors: Bekele YY,Flisher AJ,Alem A,Baheretebeb Y

    更新日期:2009-03-01 00:00:00

  • Beyond not bad or just okay: social predictors of young adults' wellbeing and functioning (a TRAILS study).

    abstract:BACKGROUND:Various childhood social experiences have been reported to predict adult outcomes. However, it is unclear how different social contexts may influence each other's effects in the long run. This study examined the joint contribution of adolescent family and peer experiences to young adult wellbeing and functio...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001976

    authors: Richards JS,Hartman CA,Jeronimus BF,Ormel J,Reijneveld SA,Veenstra R,Verhulst FC,Vollebergh WAM,Oldehinkel AJ

    更新日期:2019-07-01 00:00:00

  • Measuring social relationships. The Interview Schedule for Social Interaction.

    abstract::It is generally recognized that social relationships occupy a central position in psychiatry. To examine the role of social relationships in the onset of minor psychiatric morbidity it is necessary to construct an instrument which will meet the need for a valid, reliable and comprehensive index of social relationships...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170005501x

    authors: Henderson S,Duncan-Jones P,Byrne DG,Scott R

    更新日期:1980-11-01 00:00:00

  • The capacity of people with a 'mental disability' to make a health care decision.

    abstract:BACKGROUND:Based on the developing clinical and legal literature, and using the framework adopted in draft legislation, capacity to make a valid decision about a clinically required blood test was investigated in three groups of people with a 'mental disability' (i.e. mental illness (chronic schizophrenia), 'learning d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700001768

    authors: Wong JG,Clare CH,Holland AJ,Watson PC,Gunn M

    更新日期:2000-03-01 00:00:00

  • Dieting changes serotonergic function in women, not men: implications for the aetiology of anorexia nervosa?

    abstract::The increase in plasma prolactin which follows intravenous administration of L-tryptophan (LTP) was used to assess changes in brain 5-hydroxytryptamine (5-HT) function in normal male and female subjects, following a three week period of dieting. In women, but not men, there was a marked increase in the prolactin respo...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700000635

    authors: Goodwin GM,Fairburn CG,Cowen PJ

    更新日期:1987-11-01 00:00:00

  • One-year outcome of unexplained fatigue syndromes in primary care: results from an international study.

    abstract:BACKGROUND:Outcome studies of chronic fatigue, neurasthenia and other unexplained fatigue syndromes are few and have been carried out in developed Western countries. This paper aimed to study the outcome of unexplained fatigue syndromes in an international primary care sample and to identify risk factors for persistenc...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/s0033291703007566

    authors: Skapinakis P,Lewis G,Mavreas V

    更新日期:2003-07-01 00:00:00

  • Health problems, impairment and illnesses associated with bulimia nervosa and binge eating disorder among primary care and obstetric gynaecology patients.

    abstract:BACKGROUND:Although psychiatric patients with eating disorders are known to be at risk for a variety of health problems, relatively little is known about eating disorders and associated health problems in other populations. An epidemiological study was conducted to investigate health problems and impairment associated ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/s0033291701004640

    authors: Johnson JG,Spitzer RL,Williams JB

    更新日期:2001-11-01 00:00:00

  • Sleep disturbance mediates the link between childhood trauma and clinical outcome in severe mental disorders.

    abstract:BACKGROUND:The experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the relationship between childhood trauma and sleep disturbances in severe mental disorders including the role of s...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000914

    authors: Laskemoen JF,Aas M,Vaskinn A,Berg AO,Lunding SH,Barrett EA,Melle I,Simonsen C

    更新日期:2020-04-23 00:00:00

  • Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk.

    abstract:BACKGROUND:White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and i...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716001161

    authors: Roberts G,Wen W,Frankland A,Perich T,Holmes-Preston E,Levy F,Lenroot RK,Hadzi-Pavlovic D,Nurnberger JI,Breakspear M,Mitchell PB

    更新日期:2016-08-01 00:00:00

  • Impaired verbal self-monitoring in psychosis: effects of state, trait and diagnosis.

    abstract:BACKGROUND:Cognitive models propose that auditory verbal hallucinations arise through defective self-monitoring and external attribution of inner speech. We used a paradigm that engages verbal self-monitoring to examine how deficits in this process are related to symptoms and diagnosis in patients with psychosis. METH...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291705006628

    authors: Johns LC,Gregg L,Allen P,McGuire PK

    更新日期:2006-04-01 00:00:00

  • What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review.

    abstract::The powerful genome-wide association studies (GWAS) revealed common mutations that increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority were not known to be functional or associated with these illnesses. To help fill this gap, their impact on human brain structure and functio...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291715000537

    authors: Gurung R,Prata DP

    更新日期:2015-01-01 00:00:00

  • Should the diagnosis of major depression be made independent of or dependent upon the psychosocial context?

    abstract:BACKGROUND:The diagnosis of certain psychiatric syndromes (e.g. panic attacks, post-traumatic stress disorder) is crucially dependent on the psychosocial context in which they arise. For other syndromes (e.g. schizophrenia), the context is generally irrelevant. Should the diagnosis of major depression (MD) be made depe...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709990845

    authors: Kendler KS,Myers J,Halberstadt LJ

    更新日期:2010-05-01 00:00:00

  • The effect of rehabilitation combined with cognitive remediation on functioning in persons with severe mental illness: systematic review and meta-analysis.

    abstract:BACKGROUND:Psychiatric rehabilitation (PR) can improve functioning in people with severe mental illness (SMI), but outcomes are still suboptimal. Cognitive impairments have severe implications for functioning and might reduce the effects of PR. It has been demonstrated that performance in cognitive tests can be improve...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析

    doi:10.1017/S003329171800418X

    authors: van Duin D,de Winter L,Oud M,Kroon H,Veling W,van Weeghel J

    更新日期:2019-07-01 00:00:00

  • Visual memory and sustained attention impairment in youths with autism spectrum disorders.

    abstract:BACKGROUND:An uneven neurocognitive profile is a hallmark of autism spectrum disorder (ASD). Studies focusing on the visual memory performance in ASD have shown controversial results. We investigated visual memory and sustained attention in youths with ASD and typically developing (TD) youths. METHOD:We recruited 143 ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291714003201

    authors: Chien YL,Gau SS,Shang CY,Chiu YN,Tsai WC,Wu YY

    更新日期:2015-08-01 00:00:00

  • Cognitive function in unaffected twins discordant for affective disorder.

    abstract:BACKGROUND:Patients may present with cognitive impairment in the euthymic phase of affective disorder, but it is unclear whether the impairment is prevalent before onset of the illness. The aim of the present study was to examine the hypothesis that genetic liability to affective disorder is associated with cognitive i...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706007896

    authors: Christensen MV,Kyvik KO,Kessing LV

    更新日期:2006-08-01 00:00:00

  • Sibling pairs with affective disorders: resemblance of demographic and clinical features.

    abstract:BACKGROUND:As part of a collaborative linkage study, the authors obtained clinical and demographic data on 160 families in which more than one sibling was affected with a bipolar illness. The aim of the study was to identify clinical characteristics that had a high degree of familiality. METHOD:Data on age at onset, g...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291701004986

    authors: O'Mahony E,Corvin A,O'Connell R,Comerford C,Larsen B,Jones R,McCandless F,Kirov G,Cardno AG,Craddock N,Gill M

    更新日期:2002-01-01 00:00:00

  • Information processing deficits in relatives of manic depressive patients.

    abstract:BACKGROUND:The importance of genetic factors in the aetiology of manic-depressive illness (MDI) has been repeatedly confirmed and indicators of vulnerability to the illness in families with affective disorders are needed. Abnormal event-related potentials (ERP) may be markers of genetic vulnerability to mental illness....

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799001944

    authors: Pierson A,Jouvent R,Quintin P,Perez-Diaz F,Leboyer M

    更新日期:2000-05-01 00:00:00

  • Age of major depression onset, depressive symptoms, and risk for subsequent dementia: results of the German study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).

    abstract:BACKGROUND:Whether late-onset depression is a risk factor for or a prodrome of dementia remains unclear. We investigated the impact of depressive symptoms and early- v. late-onset depression on subsequent dementia in a cohort of elderly general-practitioner patients (n = 2663, mean age = 81.2 years). METHOD:Risk for s...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S0033291712002449

    authors: Heser K,Tebarth F,Wiese B,Eisele M,Bickel H,Köhler M,Mösch E,Weyerer S,Werle J,König HH,Leicht H,Pentzek M,Fuchs A,Riedel-Heller SG,Luppa M,Prokein J,Scherer M,Maier W,Wagner M,Age CoDe Study Group.

    更新日期:2013-08-01 00:00:00

  • Alcohol consumption as a risk factor for non-recovery from common mental disorder: results from the longitudinal follow-up of the National Psychiatric Morbidity Survey.

    abstract:BACKGROUND:Alcohol is commonly considered to be associated with persistence of common mental disorder (CMD; anxiety/depression). However no community-based longitudinal studies have investigated the direction of causality. METHOD:We examined the association between alcohol consumption and recovery from CMD using data ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707002000

    authors: Haynes JC,Farrell M,Singleton N,Meltzer H,Araya R,Lewis G,Wiles NJ

    更新日期:2008-03-01 00:00:00

  • Axonal myelin increase in the callosal genu in depression but not schizophrenia.

    abstract:BACKGROUND:Abnormalities in the anterior inter-hemispheric connectivity have previously been implicated in major depressive disorder. Disruptions in fractional anisotropy in the callosum and fornix have been reported in schizophrenia and major depressive disorder. Oligodendrocyte density and overall size of the callosu...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715000136

    authors: Williams MR,Sharma P,Fung KL,Pearce RK,Hirsch SR,Maier M

    更新日期:2015-07-01 00:00:00

  • Lymphocyte numbers in endogenous depression.

    abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700024934

    authors: Murphy D,Gardner R,Greden JF,Carroll BJ

    更新日期:1987-05-01 00:00:00

  • Evidence for an interrelated cluster of Hallucinatory experiences in the general population: an incidence study.

    abstract:BACKGROUND:Although hallucinations have been studied in terms of prevalence and its associations with psychopathology and functional impairment, very little is known about sensory modalities other than auditory (i.e. haptic, visual and olfactory), as well the incidence of hallucinations, factors predicting incidence an...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000793

    authors: Moriyama TS,Drukker M,Guloksuz S,Ten Have M,de Graaf R,van Dorsselaer S,Gunther N,Bak M,van Os J

    更新日期:2020-04-22 00:00:00

  • Predicting depression outcomes throughout inpatient treatment using the general and specific personality disorder factors.

    abstract:BACKGROUND:Clinical intuition suggests that personality disorders hinder the treatment of depression, but research findings are mixed. One reason for this might be the way in which current assessment measures conflate general aspects of personality disorders, such as overall severity, with specific aspects, such as sty...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329172000361X

    authors: Constantinou MP,Frueh BC,Fowler JC,Allen JG,Madan A,Oldham JM,Fonagy P

    更新日期:2020-10-08 00:00:00

  • From laboratory to life: associating brain reward processing with real-life motivated behaviour and symptoms of depression in non-help-seeking young adults.

    abstract:BACKGROUND:Depression has been associated with abnormalities in neural underpinnings of Reward Learning (RL). However, inconsistencies have emerged, possibly owing to medication effects. Additionally, it remains unclear how neural RL signals relate to real-life behaviour. The current study, therefore, examined neural R...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718003446

    authors: Bakker JM,Goossens L,Kumar P,Lange IMJ,Michielse S,Schruers K,Bastiaansen JA,Lieverse R,Marcelis M,van Amelsvoort T,van Os J,Myin-Germeys I,Pizzagalli DA,Wichers M

    更新日期:2019-10-01 00:00:00

  • Characterizing the effects of sertraline in post-traumatic stress disorder.

    abstract:BACKGROUND:Sertraline has a proved efficacy in post-traumatic stress disorder (PTSD), but it is unknown which symptoms respond or in what sequence this occurs. Such information might be useful clinically and heuristically. METHOD:The study examined the effects of sertraline on the individual symptoms of PTSD. It also ...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291702005469

    authors: Davidson JR,Landerman LR,Farfel GM,Clary CM

    更新日期:2002-05-01 00:00:00