Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.

abstract：BACKGROUND:The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. It is also thought to increase the risk of a number of disorders characterized by affective mo...

journal_title：Psychological medicine

authors： Lelli-Chiesa G,Kempton MJ,Jogia J,Tatarelli R,Girardi P,Powell J,Collier DA,Frangou S

更新日期：2011-04-01 00:00:00

abstract：:Psychiatric epidemiology has advanced considerably since early studies of hospital populations. The direction of this advance has been away from the study of populations of hospital psychiatric patients towards the study of psychiatric disorder in general practice and the community as a whole. Just as the populations ...

journal_title：Psychological medicine

authors： Williams P,Tarnopolsky A,Hand D

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Recent neurobiological models provide a possible mechanism of daily life stress directly affecting the intensity of psychotic experiences in vulnerable individuals. In order to validate such a mechanism, the impact of daily life stress on psychosis intensity was investigated in two groups at increased risk o...

journal_title：Psychological medicine

authors： Myin-Germeys I,Delespaul P,van Os J

更新日期：2005-05-01 00:00:00

abstract：:We have attempted to clarify clinical differentiating features of psychotic depression. Forty-six depressed subjects meeting DSM-III-R criteria for major depression with psychotic features were compared with (i) DSM-defined melancholic, (ii) Newcastle-defined endogenous, and (iii) a residual DSM-defined major depressi...

journal_title：Psychological medicine

authors： Parker G,Hadzi-Pavlovic D,Brodaty H,Austin MP,Mitchell P,Wilhelm K,Hickie I

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Overall findings of our first direct interview family study of obsessive-compulsive disorder (OCD) indicated that OCD is familial. In this replication study, we carefully examined the role of informant data in ascertaining OCD in relatives. METHOD:We interviewed 112 relatives of 57 OCD patients and 115 rela...

journal_title：Psychological medicine

authors： Lipsitz JD,Mannuzza S,Chapman TF,Foa EB,Franklin ME,Goodwin RD,Fyer AJ

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Identifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. This review addresses two key questions: Is there a bipolar prodrome? And, if there is, what are its characteristic features? METHOD:A comprehensive search of databases ...

journal_title：Psychological medicine

authors： Howes OD,Lim S,Theologos G,Yung AR,Goodwin GM,McGuire P

更新日期：2011-08-01 00:00:00

abstract：:Individuals with high and low susceptibility to hypnosis were compared in a baseline condition and after instructions of hypnosis on tests of anterior left and right hemispheric functions--word fluency to letter categories, word fluency to semantic categories, design fluency and bilateral finger tapping dexterity. Wit...

journal_title：Psychological medicine

authors： Gruzelier J,Warren K

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:This experiment examines two aspects of delusional cognition that have been reported clinically but not investigated empirically. These are the incorporation of potentially conflicting information into the recall of delusion-related scripts and the type and amount of material produced additional to that pres...

journal_title：Psychological medicine

authors： Simpson J,Done DJ

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Psychotic symptoms occur more frequently in the general population than psychotic disorder and index risk for psychopathology. Multiple studies have reported on the prevalence of these symptoms using self-report questionnaires or clinical interviews but there is a lack of consensus about the prevalence of ps...

journal_title：Psychological medicine

authors： Kelleher I,Connor D,Clarke MC,Devlin N,Harley M,Cannon M

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:A number of scales are used to estimate the severity of depression. However, differences between self-report and clinician rating, multi-dimensionality and different weighting of individual symptoms in summed scores may affect the validity of measurement. In this study we examined and integrated the psychome...

journal_title：Psychological medicine

authors： Uher R,Farmer A,Maier W,Rietschel M,Hauser J,Marusic A,Mors O,Elkin A,Williamson RJ,Schmael C,Henigsberg N,Perez J,Mendlewicz J,Janzing JG,Zobel A,Skibinska M,Kozel D,Stamp AS,Bajs M,Placentino A,Barreto M,McGuf

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Previous work suggests that individuals with schizophrenia display an altered homovanillic acid (HVA) response to metabolic stress. The present study replicated and extended this paradigm, including individuals with elevated genetic risk for schizophrenia. METHOD:Patients with psychosis (n = 50), non-psycho...

journal_title：Psychological medicine

authors： Marcelis M,Cavalier E,Gielen J,Delespaul P,Van Os J

更新日期：2004-08-01 00:00:00

abstract：:Recent literature on insight has paid little attention to patients' social backgrounds and cultures. Discharge summaries from 357 patients with a psychotic illness were examined to investigate factors associated with insight. A highly significant association was found between British white ethnic origin and being thou...

journal_title：Psychological medicine

authors： Johnson S,Orrell M

更新日期：1996-09-01 00:00:00

abstract：:Recent studies have suggested that expanded CAG/CTG repeats contribute to the genetic aetiology of schizophrenia and bipolar disorder. However, the nature of this contribution is uncertain and difficult to predict from other known trinucleotide repeat diseases that display much simpler patterns of inheritance. We have...

journal_title：Psychological medicine

authors： O'Donovan MC,Guy C,Craddock N,Bowen T,McKeon P,Macedo A,Maier W,Wildenauer D,Aschauer HN,Sorbi S,Feldman E,Mynett-Johnson L,Claffey E,Nacmias B,Valente J,Dourado A,Grassi E,Lenzinger E,Heiden AM,Moorhead S,Harriso

更新日期：1996-11-01 00:00:00

abstract：:The relationships among symptoms, cognitive functioning and social functioning were investigated in 60 patients with recent-onset schizophrenia. Positive symptoms were unrelated to cognitive measures. Disorganization and depressive symptoms were correlated significantly with Card Sorting performance. Furthermore, only...

journal_title：Psychological medicine

authors： Van der Does AJ,Dingemans PM,Linszen DH,Nugter MA,Scholte WF

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Abnormalities in the anterior inter-hemispheric connectivity have previously been implicated in major depressive disorder. Disruptions in fractional anisotropy in the callosum and fornix have been reported in schizophrenia and major depressive disorder. Oligodendrocyte density and overall size of the callosu...

journal_title：Psychological medicine

authors： Williams MR,Sharma P,Fung KL,Pearce RK,Hirsch SR,Maier M

更新日期：2015-07-01 00:00:00

abstract：:Forty patients with Parkinson's disease underwent a detailed assessment of their psychiatric state using a standardized, semi-structured interview, the Present State Examination. Analysis of the interviews yielded a profile of depressive and neurotic syndromes. Comparing the results with population norms, however, rev...

journal_title：Psychological medicine

authors： Brown RG,MacCarthy B

更新日期：1990-02-01 00:00:00

abstract：:Previous studies have reported an increase in depression among recent birth cohorts. Concurrent with the increase in rates of depression, there have been increases in rates of drug and alcohol abuse and dependence. This study sought to determine if the recent increase in rates of depression could be attributed to co-m...

journal_title：Psychological medicine

authors： Klerman GL,Leon AC,Wickramaratne P,Warshaw MG,Mueller TI,Weissman MM,Akiskal H

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:The development of childhood anxiety disorders (CADs) is likely to depend on pathways that can be programmed by early-life risk factors. We test the hypothesis that early-life maternal factors can predict this programming effect on CAD. METHODS:Data were obtained from 198 women and children from the Mercy P...

journal_title：Psychological medicine

authors： Galbally M,Watson SJ,van Rossum EFC,Chen W,de Kloet ER,Lewis AJ

更新日期：2020-06-29 00:00:00

abstract：:This study investigates the basis of individual variation in exposure to stressful life events (SLEs). A population based sample of 547 MZ and 390 DZ female-female twin pairs, aged between 17 and 55 years, were surveyed by two structured interviews, separated by at least 1 year, that enquired about SLEs experienced du...

journal_title：Psychological medicine

authors： Foley DL,Neale MC,Kendler KS

更新日期：1996-11-01 00:00:00

abstract：:The CANTAB battery of neuropsychological tests was used to compare the performance of 28 patients with unipolar depression with that of 22 age and IQ matched controls. The patients were impaired on almost all tests studied with deficits in pattern and spatial recognition memory, matching to sample, spatial span, spati...

journal_title：Psychological medicine

authors： Elliott R,Sahakian BJ,McKay AP,Herrod JJ,Robbins TW,Paykel ES

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:This study aimed to explore the impacts of COVID-19 outbreak on mental health status in general population in different affected areas in China. METHODS:This was a comparative study including two groups of participants: (1) general population in an online survey in Ya'an and Jingzhou cities during the COVID...

journal_title：Psychological medicine

authors： Ran MS,Gao R,Lin JX,Zhang TM,Chan SKW,Deng XP,Zhang BZ,Zhang XF,Huang GP,Pu DS,Bai JZ,Xu LX,Liu B

更新日期：2020-12-10 00:00:00

abstract：BACKGROUND:Slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the frontal cortex has been suggested as a safer and better tolerable alternative to fast-frequency rTMS in the treatment of major depressive disorder (MDD). The aim of the present study was to examine the efficacy of slow-frequency rTMS t...

journal_title：Psychological medicine

authors： Schutter DJ

更新日期：2010-11-01 00:00:00

abstract：:An entire population of 32 patients on regular dialysis treatment (RDT) in their own homes were ranked according to their present mental state as assessed by a standardized semi-structured interview. The point-prevalence of psychiatric morbidity was 31% which compares closely with that of patients attending a general ...

journal_title：Psychological medicine

authors： Farmer CJ,Snowden SA,Parsons V

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Aggression has been suggested to be related to abnormal brain 5-HT activity. This amine is synthesized in brain from tryptophan, which is transported through the blood-brain barrier in competition with other amino acids. The relationship between tryptophan and its endogenous amino acid competitors in plasma ...

journal_title：Psychological medicine

authors： Eriksson T,Lidberg L

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Although family, twin and adoption studies have suggested that lifetime major depression (MD) is a heritable condition, nearly all these studies have relied for the diagnosis on long-term human memory, which is fallible and potentially biased. Could the estimates of heritability of MD be biased by the well-de...

journal_title：Psychological medicine

authors： Kendler KS,Aggen SH

更新日期：2001-07-01 00:00:00

abstract：:Belief in free will has been a mainstay in philosophy throughout history, grounded in large part in our intuitive sense that we consciously control our actions and could have done otherwise. However, psychology and psychiatry have long sought to uncover mechanistic explanations for human behavior that challenge the no...

journal_title：Psychological medicine

authors： Pierre JM

更新日期：2014-09-01 00:00:00

abstract：:Patients diagnosed on the basis of structured interviews as having affective psychoses were less sensitive in detecting the presence of a transient auditory signal than were schizophrenic patients or non-patients. Patients with affective psychoses also benefited more (their reaction time was more reduced) than the oth...

journal_title：Psychological medicine

authors： Bruder GE,Sutton S,Babkoff H,Gurland BJ,Yozawitz A,Fleiss JL

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Working memory (WM) deficits in schizophrenia (SCZ) have been linked to impairments in the encoding phase that are associated with aberrant neuronal functioning. Similar abnormalities have been observed in unaffected first-degree relatives (REL) and are thus discussed as candidate endophenotypes. The process...

journal_title：Psychological medicine

authors： Stäblein M,Storchak H,Ghinea D,Kraft D,Knöchel C,Prvulovic D,Bittner RA,Reif A,Oertel-Knöchel V

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:There are no risk models for the prediction of anxiety that may help in prevention. We aimed to develop a risk algorithm for the onset of generalized anxiety and panic syndromes. METHOD:Family practice attendees were recruited between April 2003 and February 2005 and followed over 24 months in the UK, Spain...

journal_title：Psychological medicine

authors： King M,Bottomley C,Bellón-Saameño JA,Torres-Gonzalez F,Švab I,Rifel J,Maaroos HI,Aluoja A,Geerlings MI,Xavier M,Carraça I,Vicente B,Saldivia S,Nazareth I

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:To date, there has been no large-scale survey of geriatric depression (GD) involving both rural and urban areas in China using standardized assessment tools and diagnostic criteria. This study aimed to determine the 12-month and lifetime prevalence rates of GD and sociodemographic correlates in urban and rur...

journal_title：Psychological medicine

authors： Ma X,Xiang YT,Li SR,Xiang YQ,Guo HL,Hou YZ,Cai ZJ,Li ZB,Li ZJ,Tao YF,Dang WM,Wu XM,Deng J,Ungvari GS,Chiu HF

更新日期：2008-12-01 00:00:00