Abstract:
:Diffuse loss of cortical volume and ventricular enlargement have been demonstrated in schizophrenia using imaging. In addition, histological studies have provided evidence that the number of neurons in the medial temporal lobe structures is reduced and that the cytoarchitecture is abnormal. In an attempt to correlate these histological findings with in vivo estimates of neuronal integrity we have studied the concentration of the neuronal marker N-acetyl aspartate (NAA) in the hippocampi of schizophrenics using in vivo Magnetic Resonance Spectroscopy (MRS). Compared with a group of healthy volunteers schizophrenics showed a 22% loss of NAA in the left hippocampus. Two other metabolites, choline and creatine showed bilateral reduction in schizophrenics and these achieved significance in the left hippocampus. These results indicate a significant depletion of NAA in schizophrenia and are in close agreement with the reported neuronal loss in the hippocampus detected histologically. We propose that in vivo MRS is a valid measure of integrity of neuronal populations in schizophrenia.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Maier M,Ron MA,Barker GJ,Tofts PSdoi
10.1017/s0033291700033171subject
Has Abstractpub_date
1995-11-01 00:00:00pages
1201-9issue
6eissn
0033-2917issn
1469-8978journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Neuroimaging studies have shown variance in brain response to emotional faces predicts cognitive behavioral therapy (CBT) outcome. An important next step is to determine if individual differences in neural predictors of CBT response represent distinct patient groups. METHODS:In total, 90 patients with inter...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003979
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:The differential strength of correlation between symptoms, cognition and other patient characteristics with community functioning in first-episode psychosis has not been fully investigated. METHOD:In a sample of 66 first-episode psychosis patients demographic variables, ratings of pre-morbid adjustment, pos...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291702006050
更新日期:2002-08-01 00:00:00
abstract::In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700023163
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:Various childhood social experiences have been reported to predict adult outcomes. However, it is unclear how different social contexts may influence each other's effects in the long run. This study examined the joint contribution of adolescent family and peer experiences to young adult wellbeing and functio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001976
更新日期:2019-07-01 00:00:00
abstract::Parental representation was assessed with the Parental Bonding Instrument (PBI) in 12 monozygotic (MZ) and 19 dizygotic (DZ) same-sexed twin pairs discordant for DSM-III-R schizophrenia. The schizophrenic twins reported less care and more overprotection from both parents than the non-schizophrenic co-twins. Multiple r...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700028439
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Previous research has yielded conflicting evidence regarding the long-term cognitive outcome of depression. Some studies have found evidence for a higher incidence of subsequent cognitive impairment or dementia, while others have refuted this. METHOD:Depression, neuropsychological performance, functional ab...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008195
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Although specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000174
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Little research has examined genetic and environmental contributions to psychopathic personality traits. Additionally, no studies have examined etiological connections between psychopathic traits and the broad psychopathological domains of internalizing (mood and anxiety) and externalizing (antisocial behavi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704004180
更新日期:2005-05-01 00:00:00
abstract::Seventy-six women, with a mean age of 35.7 years, who reported premenstrual craving for sweet foods in a retrospective questionnaire, were assessed prospectively with a pre- and post-menstrual eating questionnaire and daily ratings of craving, mood, irritability and breast tenderness over two menstrual cycles. In 72% ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170000979x
更新日期:1988-11-01 00:00:00
abstract::Fifty patients with bulimia nervosa were followed up for a minimum length of 5 years. Standardized interviews, observer-rated instruments and self-rated questionnaires were employed both at entry and at completion of the follow-up period. After tracing, the positive response rate was 72%; one patient had died. At the ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700038526
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003555
更新日期:2018-09-01 00:00:00
abstract::In an effort to distil major findings about the nature of human ageing, seven propositions are presented as a guiding frame of reference. This propositional framework is then used to specify some conditions for a positive culture of old age and to advance one possible model of good psychological ageing. This model foc...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700029846
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Alterations in self-monitoring have been reported in patients with psychotic disorders, but it remains unclear to what degree they represent true indicators of familial vulnerability for psychosis. METHOD:An error-correction action-monitoring task was used to examine self-monitoring in 42 patients with schi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001152
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Intrusive memories of traumatic events are a core feature of post-traumatic stress disorder but little is known about the neurobiological formation of intrusions. The aim of this study was to determine whether the activity of the noradrenergic system during an intrusion-inducing stressor would influence subs...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716001379
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date. METHOD:We conducted a first-episode follow-up study of 97 patients with DSM-IV schizop...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170800336X
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Neuropsychological impairment is a common finding in schizophrenia. However, a significant proportion of patients are not impaired in conventional neuropsychological tests. In this study, we investigated whether remitted patients with schizophreniform disorder exhibited dysfunctions in specific cognitive tas...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008754
更新日期:2004-02-01 00:00:00
abstract::The tests that have been used to assess glomerular and tubular function in patients receiving treatment with lithium have been reviewed. The advantages and disadvantages of these are discussed. The most useful tests are the creatinine clearance, which may be predicted from the serum creatinine using a formula or nomog...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Moodscope is an entirely service-user-developed online mood-tracking and feedback tool with built-in social support, designed to stabilize and improve mood. Many free internet tools are available with no assessment of acceptability, validity or usefulness. This study provides an exemplar for future assessmen...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002280
更新日期:2013-07-01 00:00:00
abstract::In the face of shifting demographics and an increase in human longevity, it is important to examine carefully what is known about cognitive ageing, and to identify and promote possibly malleable lifestyle and health-related factors that might mitigate age-associated cognitive decline. The Lothian Birth Cohorts of 1921...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717001489
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Current literature provides insufficient information on the degree of cognitive impairment during and after electroconvulsive therapy (ECT), mostly due to the fact that applied tests lacked sensitivity and flexibility. Our goal was to evaluate cognitive functioning in adult depressed patients treated with bi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002287
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Several studies during recent years have reported an increased occurrence of schizophrenia in selected immigrant groups. However, difficulties in establishing the population denominator for immigrant rates of mental disorder, selective referral for treatment, and other problems may have influenced such resul...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797004741
更新日期:1997-07-01 00:00:00
abstract::The CANTAB battery of neuropsychological tests was used to compare the performance of 28 patients with unipolar depression with that of 22 age and IQ matched controls. The patients were impaired on almost all tests studied with deficits in pattern and spatial recognition memory, matching to sample, spatial span, spati...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035303
更新日期:1996-09-01 00:00:00
abstract::Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029305
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:The effectiveness of therapeutic interventions in psychosis is increasingly reported in terms of reductions in different symptom dimensions. It remains unclear, however, to what degree such symptomatic changes are accompanied by improvement in other measures such as service use, quality of life, and needs fo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001014
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Individual-level measures of acculturation (e.g. age of immigration) have a complex relationship with psychiatric disorders. Fine-grained analyses that tap various acculturation dimensions and population subgroups are needed to generate hypotheses regarding the mechanisms of action for the association betwee...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716000763
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The potential effects of antipsychotic drugs on brain structure represent a key factor in understanding neuroanatomical changes in psychosis. This review addresses two issues: (1) do antipsychotic medications induce changes in total or regional human brain volumes and (2) do such effects depend on antipsycho...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709005315
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Attention-deficit hyperactivity disorder (ADHD) is associated with poorer cognitive functioning. We used a developmental, genetically-sensitive approach to examine intelligence quotient (IQ) from early childhood to young adulthood among those with different ADHD courses to investigate whether changes in ADHD...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719003015
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:As part of a collaborative linkage study, the authors obtained clinical and demographic data on 160 families in which more than one sibling was affected with a bipolar illness. The aim of the study was to identify clinical characteristics that had a high degree of familiality. METHOD:Data on age at onset, g...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004986
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Resting pulse is robustly and inversely associated with the risk for externalizing disorders and may be positively associated with internalizing disorders. We know little about the causal nature of these associations. METHODS:We examined resting pulse at conscription examination in 369 301 males born 1960-8...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000549
更新日期:2020-03-24 00:00:00
abstract:INTRODUCTION:Patients with unipolar depression show impaired performance on the Tower of London planning task. Positron emission tomography, which has previously identified resting state blood flow abnormalities in depression, was used to investigate neural activity associated with performance of this task in depressed...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005187
更新日期:1997-07-01 00:00:00