Abstract:
BACKGROUND:Cannabis use is associated with an earlier age at onset of psychotic illness. The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder. METHOD:In 785 patients with a non-affective psychotic disorder, regression analysis was used to investigate the independent effects of gender, cannabis use and other drug use on age at onset of first psychosis. RESULTS:Age at onset was 1.8 years earlier in cannabis users compared to non-users, controlling for gender and other possible confounders. Use of other drugs did not have an additional effect on age at onset when cannabis use was taken into account. In 63.5% of cannabis-using patients, age at most intense cannabis use preceded the age at onset of first psychosis. In males, the mean age at onset was 1.3 years lower than in females, controlling for cannabis use and other confounders. CONCLUSIONS:Cannabis use and gender are independently associated with an earlier onset of psychotic illness. Our findings also suggest that cannabis use may precipitate psychosis. More research is needed to clarify the neurobiological factors that make people vulnerable to this precipitating effect of cannabis.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Dekker N,Meijer J,Koeter M,van den Brink W,van Beveren N,Kahn RS,Linszen DH,van Os J,Wiersma D,Bruggeman R,Cahn W,de Haan L,Krabbendam L,Myin-Germeys I,GROUP Investigators.doi
10.1017/S0033291712000062subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1903-11issue
9eissn
0033-2917issn
1469-8978pii
S0033291712000062journal_volume
42pub_type
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