Abstract:
:Quantified magnetic resonance measurements were made of superior temporal gyrus, parahippocampal gyrus, hippocampal, frontal and temporal lobe volumes and of the planar area of the thalamus and basal ganglia structures in 47 late paraphrenic patients and 33 healthy elderly controls. The late paraphrenics were divided into 31 schizophrenics and 16 patients with delusional disorder according to ICD-10 guidelines. Patients with delusional disorder tended to have smaller left temporal volumes compared with control subjects and patients with schizophrenia, but this difference failed to reach accepted levels of statistical significance after correction for the effects of multiple statistical comparisons, age and total brain size. Physiological right-left asymmetry, reported for temporal and frontal lobe volumes, was present in control, schizophrenic and delusional disorder subjects but delusional disorder patients had a significantly greater degree of temporal lobe asymmetry. The results add to the evidence for heterogeneity among late-onset psychoses and emphasize the subtle nature of any structural brain abnormalities in these patients.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Howard R,Mellers J,Petty R,Bonner D,Menon R,Almeida O,Graves M,Renshaw C,Levy Rdoi
10.1017/s0033291700033419subject
Has Abstractpub_date
1995-05-01 00:00:00pages
495-503issue
3eissn
0033-2917issn
1469-8978journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Previous research suggests that genetic influences on disordered eating may be greater in pubertal than pre-pubertal girls. Although these findings are consistent with pubertal activation of genetic influences on disordered eating, earlier studies were unable to directly test this hypothesis. The purpose of ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000189
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:The histological basis of schizophrenia is unknown, but it appears to affect the hippocampal and neocortical cytoarchitecture. Some cytoarchitectural parameters normally differ between the two cerebral hemispheres. Moreover, schizophrenia is associated with altered structural cerebral asymmetry. However, few...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004618
更新日期:1997-05-01 00:00:00
abstract::The effects of physostigmine on test performance of a patient with multiple cognitive deficits were observed in a double-blind, placebo-controlled study. Scores on tests of learning and memory and tests of visuo-spatial and constructional ability were both improved by physostigmine, while lecithin improved scores only...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291700024867
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his cognitive triad and other clinical features and risk factors among those with major depression (MD) has rarely been systematically studied. METHOD:The three key cognitive symptoms of worthle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713000160
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Previous research has established the relationship between cannabis use and psychotic disorders. Whether cannabis use is related to transition to psychosis in patients at ultra-high risk (UHR) for psychosis remains unclear. The present study aimed to review the existing evidence on the association between ca...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0033291715002329
更新日期:2016-03-01 00:00:00
abstract::In this paper four principal topics are addressed: (a) the policy and political contexts in which demands arise for cost information; (b) the nature and phasing of those demands; (c) the basic rules of empirical costs research for meeting those demands; and (d) concomitant implications for the design, execution and in...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s003329170003659x
更新日期:1990-11-01 00:00:00
abstract::Patients diagnosed on the basis of structured interviews as having affective psychoses were less sensitive in detecting the presence of a transient auditory signal than were schizophrenic patients or non-patients. Patients with affective psychoses also benefited more (their reaction time was more reduced) than the oth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700056622
更新日期:1975-08-01 00:00:00
abstract::A Fijian community affected by a cyclone was compared with an unaffected but similar community. Two months after the cyclone both psychological and physical morbidity was 2-3 times greater in the affected community than in controls. By the third month morbidity had resolved to levels similar to those in the unaffected...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700010412
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Studies investigating neurocognitive impairment in subjects with eating disorders (EDs) have reported heterogeneous patterns of impairment and, in some instances, no dysfunction. The present study aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001303
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Mental stress is associated with higher mortality, but it remains controversial whether the association is causal or a consequence of a higher physical disease burden in those with a high mental stress load. Understanding causality is important when developing targeted interventions. We aimed to estimate the...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002380
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Psychosocial and inflammatory factors have been associated with fatigue in breast cancer survivors. Nevertheless, the relative contribution and/or interaction of these factors with cancer-related fatigue have not been well documented. METHOD:This cross-sectional study enrolled 111 stage 0-III breast cancer ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000150
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Subjects at 'ultra high risk' (UHR) for developing psychosis have differences in white matter (WM) compared with healthy controls. WM integrity has not yet been investigated in UHR subjects in relation to the development of subsequent psychosis. Hence, we investigated a prospective cohort of UHR subjects com...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991711
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Pharmaceutical industry funding of psychiatric research has increased significantly in recent decades, raising the question of a relationship between pharmaceutical company funding of clinical psychiatric studies and the outcomes of those studies. This study examines this relationship. METHOD:Abstracts of a...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706008567
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:This study investigated factors contributing to suspected offending behaviour by adults with a history of learning disabilities taken into custody at a city police station. METHODS:Adults charged with offences, and/or leaving custody, during a defined period, were identified as having a possible learning di...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797004777
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Maternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation. METHOD...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716003627
更新日期:2017-01-19 00:00:00
abstract:BACKGROUND:Studies have suggested that patients with schizophrenia are impaired at recognizing emotions. Recently, it has been shown that the neuropeptide oxytocin can have beneficial effects on social behaviors. METHOD:To examine emotion recognition deficits in patients and see whether oxytocin could improve these de...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001413
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Refugees commonly experience difficulties with emotional processing, such as alexithymia, due to stressful or traumatic experiences. However, the functional connectivity of the amygdala, which is central to emotional processing, has yet to be assessed in refugees. Thus, the present study investigated the res...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000175
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000166X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:The medial forebrain bundle (MFB) is an important pathway of the reward system. Two branches have been described using diffusion magnetic resonance imaging (MRI)-based tractography: the infero-medial MFB (imMFB) and the supero-lateral MFB (slMFB). Previous studies point to white-matter microstructural altera...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001949
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Early life maltreatment (ELM), borderline personality disorder (BPD), and major depressive disorder (MDD) have been associated with empathy deficits in different domains. Lack of maternal empathy has also been related to child behavioral problems. As ELM, BPD, and MDD often co-occur, we aimed to identify dis...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001107
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Neuroimaging studies have shown variance in brain response to emotional faces predicts cognitive behavioral therapy (CBT) outcome. An important next step is to determine if individual differences in neural predictors of CBT response represent distinct patient groups. METHODS:In total, 90 patients with inter...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003979
更新日期:2020-11-10 00:00:00
abstract::This paper presents the results of a study of unemployment among British Asians living in the north of England. The sample comprises 139 employed and unemployed men. Using standardized psychological questionnaires with a semi-structured interview schedule, the psychological consequences of unemployment are examined in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170002732x
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The extant major psychiatric classifications, DSM-IV and ICD-10, are purportedly atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis is greatly enhanced by an understanding of both risk factors and clinical history. In an effort to group mental d...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709990304
更新日期:2009-12-01 00:00:00
abstract::The validity and reliability of an empirically defined fatigue syndrome were tested in a prospective cohort study of 245 primary care patients, with glandular fever or an upper respiratory tract infection. Subjects were interviewed three times in the 6 months after onset. Subjects with the empirically defined fatigue ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700037405
更新日期:1995-09-01 00:00:00
abstract::Unnatural causes of death due to traffic accidents (TA) and suicide attempts (SA) constitute a major burden on global health, which remained stable in the last decade despite widespread efforts of prevention. Recently, latent infection with Toxoplasma gondii (T. gondii) has been suggested to be a biological risk facto...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291719000813
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Early Intervention in Psychosis Services (EIS) for young people in England experiencing first-episode psychosis (FEP) were commissioned in 2002, based on an expected incidence of 15 cases per 100 000 person-years, as reported by schizophrenia epidemiology in highly urban settings. Unconfirmed reports from EI...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002461
更新日期:2011-05-01 00:00:00
abstract::We have attempted to clarify clinical differentiating features of psychotic depression. Forty-six depressed subjects meeting DSM-III-R criteria for major depression with psychotic features were compared with (i) DSM-defined melancholic, (ii) Newcastle-defined endogenous, and (iii) a residual DSM-defined major depressi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035078
更新日期:1995-07-01 00:00:00
abstract::The examination of moment-to-moment, 'micro-level' patterns of experience and behaviour using experience sampling methodology has contributed to our understanding of the 'macro-level' development of full-blown symptoms and disorders. This paper argues that the micro-level perspective can be used to identify the smalle...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291713001979
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Self-harm among young adults is a common and increasing phenomenon in many parts of the world. The long-term prognosis after self-harm at young age is inadequately known. We aimed to estimate the risk of mental illness and suicide in adult life after self-harm in young adulthood and to identify prognostic fa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716002282
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Cognitive behavioral therapy (CBT) can be delivered efficaciously through various modalities, including telephone (T-CBT) and face-to-face (FtF-CBT). The purpose of this study was to explore predictors of outcome in T-CBT and FtF-CBT for depression. METHOD:A total of 325 depressed participants were randomiz...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291715001208
更新日期:2015-11-01 00:00:00