Abstract:
:The effects of physostigmine on test performance of a patient with multiple cognitive deficits were observed in a double-blind, placebo-controlled study. Scores on tests of learning and memory and tests of visuo-spatial and constructional ability were both improved by physostigmine, while lecithin improved scores only on the former tests.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Sahakian B,Joyce E,Lishman WAdoi
10.1017/s0033291700024867subject
Has Abstractpub_date
1987-05-01 00:00:00pages
329-33issue
2eissn
0033-2917issn
1469-8978journal_volume
17pub_type
临床试验,杂志文章abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700024934
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Prevalence of childhood anxiety disorders at specific ages and genetic etiological influences on anxiety disorders in young children have been little studied. The present study reports prevalence estimates in a community sample of 6-year-old twins, and patterns of genetic and environmental influences on thes...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705006537
更新日期:2006-03-01 00:00:00
abstract::Although most chronically impaired psychiatric patients now reside in community-based residential homes, a substantial number show little progress in their social rehabilitation. To establish the rehabilitative needs of this population, the current study sought to examine the social behaviour of residents of a large r...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700050960
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:There is increasing recognition that, in addition to negative psychological consequences of trauma such as post-traumatic stress disorder (PTSD), some individuals may develop post-traumatic growth (PTG) following such experiences. To date, however, data regarding the prevalence, correlates and functional sig...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001202
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000166X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Existing evidence on profiles of psychological distress across adulthood uses cross-sectional or longitudinal studies with short observation periods. The objective of this research was to study the profile of psychological distress within the same individuals from early adulthood to early old age across thre...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000327X
更新日期:2021-01-21 00:00:00
abstract::Consciousness has evolved and is a feature of all animals with sufficiently complex nervous systems. It is, therefore, primarily a problem for biology, rather than physics. In this review, I will consider three aspects of consciousness: level of consciousness, whether we are awake or in a coma; the contents of conscio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002204
更新日期:2019-09-04 00:00:00
abstract:BACKGROUND:. A variety of factors are related to compliance with medication in schizophrenia, but little attention has been paid to the role of families. Carers' knowledge or expressed emotion (EE) may be related to compliance. The aim of the present study was to evaluate the relevance of these two factors, as well as ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702006888
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Pharmaceutical industry funding of psychiatric research has increased significantly in recent decades, raising the question of a relationship between pharmaceutical company funding of clinical psychiatric studies and the outcomes of those studies. This study examines this relationship. METHOD:Abstracts of a...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706008567
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Studies investigating neurocognitive impairment in subjects with eating disorders (EDs) have reported heterogeneous patterns of impairment and, in some instances, no dysfunction. The present study aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001303
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Risk factors that are associated with depression in the mother also negatively affect the child. This research sought to extend current knowledge by examining the duration and timing of maternal depression as a moderator of: (1) the impact of dependent interpersonal stress (DIS), such as partner conflict or ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002450
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Patients treated in primary care settings report better mental outcomes when they agree with practitioners about the nature of their core presenting problems. However, no study has examined the impact of staff-patient agreement on treatment outcomes in specialist mental health services. We investigated wheth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000785
更新日期:2008-01-01 00:00:00
abstract::The Geriatric Mental State and a new computerized diagnostic system, AGECAT, are briefly described. A nomenclature for designating cases for epidemiological work is introduced. Concordance between AGECAT and psychiatrists' diagnoses for these studies, hospital and community based (total of 541 subjects), achieved over...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700057779
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Rumination is an important cognitive risk factor for onset and relapse of depression. However, no studies have employed a dimensional approach in investigating the neural correlates of rumination and the relationship with depression. METHOD:Non-clinical healthy subjects (n = 306), who completed the classica...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000938
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:With regard to current neurobiological theories, the aim of our study was to examine possible alterations of temporal and frontal lobe volume in panic disorder (PD). METHOD:Seventeen in-patients with PD and a group of healthy control subjects (HC) matched for age and gender were investigated by quantitative...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991930
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001161
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Difficulties in regulating emotions are linked to the core symptoms of premenstrual dysphoric disorder (PMDD). We therefore investigated the neural substrates of emotion-regulation problems in women with PMDD. METHODS:On the basis of self-evaluations over 2 months on the Daily Record of Severity of Problems...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003270
更新日期:2018-08-01 00:00:00
abstract::The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002172
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Although alcohol use disorder (AUD) is associated with future risk for psychosocial dysfunction, the degree to which this arises from a direct causal effect of AUD on functioning v. from correlated risk factors (also known as confounders) is less clearly established. METHOD:AUD was assessed from Swedish med...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716003032
更新日期:2017-04-01 00:00:00
abstract::The theory that many diseases were produced by focal infection or chronic sepsis enjoyed a brief vogue in general medicine in the first quarter of the twentieth century. This paper explores its practical applications in psychiatry, which extended well into the 1930s. The analysis focuses particularly closely on the ac...
journal_title:Psychological medicine
pub_type: 历史文章,杂志文章,评审
doi:10.1017/s0033291700025824
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Although psychiatric patients with eating disorders are known to be at risk for a variety of health problems, relatively little is known about eating disorders and associated health problems in other populations. An epidemiological study was conducted to investigate health problems and impairment associated ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291701004640
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Twenty states currently require that women seeking abortion be counseled on possible psychological responses, with six states stressing negative responses. The majority of research finds that women whose unwanted pregnancies end in abortion do not subsequently have adverse mental health outcomes; scant resea...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717001684
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. METHOD:We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (90...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714002451
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:An uneven neurocognitive profile is a hallmark of autism spectrum disorder (ASD). Studies focusing on the visual memory performance in ASD have shown controversial results. We investigated visual memory and sustained attention in youths with ASD and typically developing (TD) youths. METHOD:We recruited 143 ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714003201
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Results of adulthood mental health of those born late-preterm (34 + 0-36 + 6 weeks + days of gestation) are mixed and based on national registers. We examined if late-preterm birth was associated with a higher risk for common mental disorders in young adulthood when using a diagnostic interview, and if this ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716000830
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Accumulating evidence links blood pressure variability (BPV) with white matter hyperintensities (WMH) and stroke. The longitudinal association between BPV with late onset depression (LOD) and cognitive decline remains unexplored. METHODS:Prospective cohort study of 2812 participant's age ⩾65 years (median a...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002756
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Although attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BPD) co-occur frequently and represent a particularly morbid clinical form of both disorders, neuroimaging research addressing this co-morbidity is scarce. Our aim was to evaluate the morphometric magnetic resonance imaging (MRI) ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001791
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Psychological literature and clinical lore suggest that there may be systematic differences in how various demographic groups experience depressive symptoms, particularly somatic symptoms. The aim of the current study was to use methods based on item response theory (IRT) to examine whether, when equating fo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708003875
更新日期:2009-04-01 00:00:00
abstract::Sixty surviving patients from a community-based stroke register who had CT scan evidence of a single brain lesion and neurological signs appropriate to it were interviewed three to five years following their first-ever stroke. Mood disorder (anxiety and depression), physical disability, and intellectual impairment wer...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700036503
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Almost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-ana...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291716001562
更新日期:2016-10-01 00:00:00