Neurocognitive functioning in bulimia nervosa: the role of neuroendocrine, personality and clinical aspects.

Abstract:

BACKGROUND:Studies investigating neurocognitive impairment in subjects with eating disorders (EDs) have reported heterogeneous patterns of impairment and, in some instances, no dysfunction. The present study aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and to demonstrate that neuroendocrine, personality and clinical characteristics influence neurocognitive performance in BN. METHOD:Attention/immediate memory, set shifting, perseveration, conditional and implicit learning were evaluated in 83 untreated female patients with BN and 77 healthy controls (HC). Cortisol and 17β-estradiol plasma levels were assessed. Cloninger's Temperament and Character Inventory - Revised (TCI-R), the Bulimic Investigation Test Edinburgh (BITE) and the Montgomery-Asberg Depression Rating Scale (MADRS) were administered. RESULTS:No impairment of cognitive performance was found in subjects with BN compared with HC. Cortisol and 'Self-directedness' were associated with better performance on conditional learning whereas 17β-estradiol had a negative influence on this domain; 'Reward dependence' was associated with worse performance on implicit learning; and depressive symptomatology influenced performance on the Wisconsin Card Sorting Test (WCST) negatively. CONCLUSIONS:No cognitive impairment was found in untreated patients with BN. Neuroendocrine, personality and clinical variables do influence neurocognitive functioning and might explain discrepancies in literature findings.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Galderisi S,Bucci P,Mucci A,Bellodi L,Cassano GB,Santonastaso P,Erzegovesi S,Favaro A,Mauri M,Monteleone P,Maj M

doi

10.1017/S0033291710001303

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

839-48

issue

4

eissn

0033-2917

issn

1469-8978

pii

S0033291710001303

journal_volume

41

pub_type

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