Abstract:
BACKGROUND:Neuropsychological impairment is a common finding in schizophrenia. However, a significant proportion of patients are not impaired in conventional neuropsychological tests. In this study, we investigated whether remitted patients with schizophreniform disorder exhibited dysfunctions in specific cognitive tasks. METHOD:Twenty remitted, highly functioning patients with schizophreniform disorder and 20 control subjects participated in the study. In addition to background neuropsychological evaluation (WAIS-R IQ, Wisconsin Card Sorting Test (WCST), Trail Making B, Rey Osterrieth Complex Figure), subjects received a category learning task. The categories consisted of geometric shapes systematically changing in shape and size. Training included the sequential presentation of category members (visual learning) and verbal description of categories. RESULTS:The patients with schizophreniform disorder had normal IQ, executive functions/psychomotor speed (WCST and Trail Making B) and visual memory (Rey-Osterrieth Complex Figure). In contrast, they displayed impaired categorization performances after visual learning. The performance of the patients improved markedly after verbal description of categories. Verbal knowledge about categories positively correlated with categorization performance in the patients, but not in the controls. CONCLUSIONS:Category learning functions, which include decision-making under uncertainty and feature integration, are impaired in patients with schizophreniform disorder who display normal executive functions and visual memory. These patients may use verbal knowledge as a compensatory strategy in visual tasks.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Kéri S,Kelemen O,Benedek G,Janka Zdoi
10.1017/s0033291703008754subject
Has Abstractpub_date
2004-02-01 00:00:00pages
247-53issue
2eissn
0033-2917issn
1469-8978journal_volume
34pub_type
杂志文章abstract::Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029305
更新日期:1977-05-01 00:00:00
abstract::We found diurnal weight gain to be abnormal among 28 institutionalized chronically psychotic patients. They were weighed daily for 15 days at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and th...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700011065
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Cognitive behavioral therapy (CBT) can be delivered efficaciously through various modalities, including telephone (T-CBT) and face-to-face (FtF-CBT). The purpose of this study was to explore predictors of outcome in T-CBT and FtF-CBT for depression. METHOD:A total of 325 depressed participants were randomiz...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291715001208
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for ...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S003329171600355X
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Temperament and personality traits, including negative emotionality/neuroticism, may represent risk factors for eating disorders. Further, risk factors may differ by sex. We examined longitudinal temperament/personality pathways of risk for purging and binge eating in youth stratified by sex using data from ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001818
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Depression is one of the most common and debilitating non-motor symptoms of Parkinson's disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal. METHODS:We investigated the role of striatal dopamine in reversal learning from reward and punishment...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000769
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:In people with bulimic eating disorders, exposure to high-calorie foods can result in increases in food craving, raised subjective stress and salivary cortisol concentrations. This cue-induced food craving can be reduced by repetitive transcranial magnetic stimulation (rTMS). We investigated whether rTMS has...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291710001881
更新日期:2011-06-01 00:00:00
abstract::A two-stage psychiatric survey of a random samples of adults aged 18-64 from Camberwell is described. Agency interviewers carried out the first stage (N = 800), using the shorter form of the Present State Examination (PSE). MRC interviewers, using the full PSE, saw a stratified sample of these (N = 310) in the second ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700052879
更新日期:1981-08-01 00:00:00
abstract::A number of computerized tests were used to study visual attention, memory and learning in elderly depressed patients. Impairment was found in approximately 70% of depressed patients and was seen particularly in memory and in measures of latency. Depressed patients showed equivalent impairment in short-term memory but...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700017025
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Neuroticism has been shown to increase the risk of depression whereas extraversion is associated with a reduction of risk. These personality traits play a central role in aetiological theories of affective disorder but their role in schizophrenia is unclear. In this study, the risk for schizophrenia associat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004044
更新日期:2001-08-01 00:00:00
abstract:INTRODUCTION:Cognitive therapy (CT) for bipolar disorder emphasizes the monitoring and regulation of mood, thoughts and behaviour. The Sense of Hyper-Positive Self Scale (SHPSS) measures the extent to which bipolar patients value themselves and perceive themselves to possess personal attributes (e.g. dynamism, persuasi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704002910
更新日期:2005-01-01 00:00:00
abstract::Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are post-synaptic receptors that are located in striatal and limbic areas known to be involved in cognition and mood. Consistent with this, 5-HT4 ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000604
更新日期:2020-04-03 00:00:00
abstract:BACKGROUND:A previous study of women 9 months after discharge from in-patient treatment for depression found that low self-esteem as measured by a self-report questionnaire at admission was associated with a worse prognosis. This study investigates the womens' outcome more than 4 years after discharge and the continued...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002986
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Different versions of the General Health Questionnaire (GHQ), including the GHQ-12 and GHQ-28 have been subjected to factor analysis in a variety of countries. The World Health Organization study of psychological disorders in general health care offered the opportunity to investigate the factor structure of ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291799002287
更新日期:2000-07-01 00:00:00
abstract::This paper presents the results of a study of unemployment among British Asians living in the north of England. The sample comprises 139 employed and unemployed men. Using standardized psychological questionnaires with a semi-structured interview schedule, the psychological consequences of unemployment are examined in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170002732x
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:In schizophrenia, affective disorders, and obsessive-compulsive disorder (OCD) dysfunction of frontal neuronal circuits has been suggested. Such impairments imply corresponding oculomotor deficits. METHOD:Eye movement response to foveofugal and foveopetal step-ramp stimuli was recorded within the same study...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703001314
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Attentional difficulties reported in individuals with anorexia nervosa (AN) may be due to preferential processing of disease-salient stimuli at a pre-attentive or at a conscious level or to a general problem in attention. Attentional difficulties may be associated with duration of illness. METHOD:Female par...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708002961
更新日期:2008-12-01 00:00:00
abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700024934
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that profoundly affects quality of life. Although mounting evidence now suggests uncontrolled mind-wandering as a core aspect of the attentional problems associated with ADHD, the neural mechanisms underpinning this deficit remains ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003598
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Breathlessness in asthma often cannot be explained with objective variables indicating airways obstruction. The hypothesis that unrealistic breathlessness results from false interpretation of sensations was tested. METHODS:Sixty-four children and adolescents with asthma, aged 9-18 years, were randomly assig...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291798007764
更新日期:1999-01-01 00:00:00
abstract::A sample of 77 women of high and low noise sensitivity in 1977, living in areas of high and low exposure to aircraft noise, were interviewed in the community in 1980. High, intermediate and low noise sensitive women were compared, using measures of blood pressure, heart rate, skin conductance, hearing threshold, uncom...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700023539
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Although many studies have addressed the topic of stability versus change in depressive symptoms, few have further decomposed the change to continuous accumulation versus non-systematic state fluctuations or measurement errors. This further step requires a longitudinal follow-up and an appropriate stochastic...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002000
更新日期:2013-05-01 00:00:00
abstract::In the past some workers have reported positive relationships between indices of noradrenaline activity and measures of hypothalamic-pituitary-adrenal (HPA)-axis function. In order to investigate these relations, the authors measured noradrenaline, adrenaline and vanillylmandelic acid (VMA) in 24 h urine samples of 72...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700017001
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Depression can impair the immunogenicity of vaccine administration in adults. Whereas many vaccinations are administered in childhood, it is not known whether adolescent or adult onset depression is associated with impairments in the maintenance of protection of childhood vaccines. This study tested the hypo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718000661
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:In other branches of epidemiology, stratum specific likelihood ratios (SSLRs) have been found to be preferable to fixed best threshold approaches to screening instruments. This paper presents SSLRs of GHQ-12 and GHQ-28 and compares the SSLR method with the traditional optimal threshold approach. METHODS:Ran...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1017/s0033291701003713
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:The methodology for measuring the needs of patients with severe mental illness is now well established through the MRC Needs for Care Assessment Schedule and its modification in the form of the Cardinal Needs Assessment. This paper reports the rationale and construction of a relatives' version of the Cardina...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329179800662x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Previous studies on assortment for psychiatric disorders have reported discrepant findings. We aimed to test whether there is a significant association for psychiatric diagnoses, including alcoholism, generalized anxiety disorder, major depressive disorder, panic disorder and phobias between husbands and wiv...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007326
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Low IQ is a risk factor for psychosis, but the effect of high IQ is more controversial. The aim was to explore the association of childhood school success with prodromal symptoms in adolescence and psychoses in adulthood. METHODS:In the general population-based Northern Finland Birth Cohort 1986 (n = 8 229)...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000825
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Certain personality traits predispose to criminal behavior (CB). We further clarify this relationship in a Swedish national sample. METHOD:Psychological strength (PS) was assessed on a nine-point scale at personal interview in 1 653 721 Swedish men aged 18-20 years. We examined the association between PS an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001403
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Euthanasia and assisted suicide (EAS) based on a psychiatric disorder (psychiatric EAS) continue to pose ethical and policy challenges, even in countries where the practice has been allowed for years. We conducted a systematic review of reasons, a specific type of review for bioethical questions designed to ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001543
更新日期:2020-06-01 00:00:00