Abstract:
BACKGROUND:Low IQ is a risk factor for psychosis, but the effect of high IQ is more controversial. The aim was to explore the association of childhood school success with prodromal symptoms in adolescence and psychoses in adulthood. METHODS:In the general population-based Northern Finland Birth Cohort 1986 (n = 8 229), we studied the relationship between teacher-assessed learning deficits, special talents and general school success at age 8 years and both prodromal symptoms (PROD-screen) at age 15-16 years and the occurrence of psychoses by age 30 years. RESULTS:More prodromal symptoms were experienced by those talented in oral presentation [boys: adjusted odds ratio (OR) 1.49; 95% confidence interval 1.14-1.96; girls: 1.23; 1.00-1.52] or drawing (boys: 1.44; 1.10-1.87). Conversely, being talented in athletics decreased the probability of psychotic-like symptoms (boys: OR 0.72; 0.58-0.90). School success below average predicted less prodromal symptoms with boys (OR 0.68; 0.48-0.97), whereas above-average success predicted more prodromal symptoms with girls (OR 1.22; 1.03-1.44). The occurrence of psychoses was not affected. Learning deficits did not associate with prodromal symptoms or psychoses. CONCLUSIONS:Learning deficits in childhood did not increase the risk of prodromal symptoms in adolescence or later psychosis in this large birth cohort. Learning deficits are not always associated with increased risk of psychosis, which might be due to, e.g. special support given in schools. The higher prevalence of prodromal symptoms in talented children may reflect a different kind of relationship of school success with prodromal symptoms compared to full psychoses.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Lassila M,Nordström T,Hurtig T,Mäki P,Jääskeläinen E,Oinas E,Miettunen Jdoi
10.1017/S0033291719000825subject
Has Abstractpub_date
2020-04-01 00:00:00pages
948-955issue
6eissn
0033-2917issn
1469-8978pii
S0033291719000825journal_volume
50pub_type
杂志文章abstract:BACKGROUND:Several lines of evidence indicate a role of the brain-derived neurotrophic factor (BDNF) in the modulation of eating behaviour. Therefore, alterations in the physiology of this neurotrophin may be involved in the pathogenesis of eating disorders. In the present study, we investigated serum levels of BDNF in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003368
更新日期:2005-06-01 00:00:00
abstract::Forty patients with Parkinson's disease underwent a detailed assessment of their psychiatric state using a standardized, semi-structured interview, the Present State Examination. Analysis of the interviews yielded a profile of depressive and neurotic syndromes. Comparing the results with population norms, however, rev...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700013246
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Transdiagnostic group cognitive-behavioral therapy (tCBT) is a delivery model that could help overcome barriers to large-scale implementation of evidence-based psychotherapy for anxiety disorders. The aim of this study was to assess the effectiveness of combining group tCBT with treatment-as-usual (TAU), com...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004316
更新日期:2020-12-02 00:00:00
abstract:BACKGROUND:The attenuated positive symptoms syndrome (APSS) is considered an at-risk indicator for psychosis. However, the characteristics and developmental aspects of the combined or enriched risk criteria of APSS and basic symptom (BS) criteria, including self-experienced cognitive disturbances (COGDIS) remain under-...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002627
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Several case reports and reviews have suggested an increased incidence of schizophrenia or bipolar disorder among persons with sex chromosome aneuploidies, but this observation may have been caused by biased sampling. METHODS:The 1122 individuals with sex chromosome aneuploidies registered in the Danish Cyt...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003476
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Several psychological and neurobiological models imply that patients with schizophrenia (SCZ) are more inclined to utilize emotional cues as response determinants to the detriment of more task-appropriate cognitive or contextual cues. However, there is a lack of behavioural data from human clinical studies t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713000445
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Previous studies have highlighted the role of the brain reward and cognitive control systems in the etiology of anorexia nervosa (AN). In an attempt to disentangle the relative contribution of these systems to the disorder, we used functional magnetic resonance imaging (fMRI) to investigate hemodynamic respo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002161
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Genetic influences on alcoholism risk are well-documented in men, but uncertain in women. We tested for gender differences in genetic influences on, and risk-factors for, DSM-III-R alcohol dependence (AD). METHOD:Diagnostic follow-up interviews were conducted in 1992-3 by telephone with twins from an Austra...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005643
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Breathlessness in asthma often cannot be explained with objective variables indicating airways obstruction. The hypothesis that unrealistic breathlessness results from false interpretation of sensations was tested. METHODS:Sixty-four children and adolescents with asthma, aged 9-18 years, were randomly assig...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291798007764
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Chronic fatigue is a common symptom of multiple sclerosis (MS). A randomized controlled trial (RCT) showed that cognitive behavioural therapy (CBT) was more effective in reducing MS fatigue than relaxation training (RT). The aim of the current study was to analyse additional data from this trial to determine...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291711000924
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Research suggests that the personality factor of self-critical or maladaptive perfectionism may be implicated in chronic fatigue syndrome (CFS). However, it is not clear whether self-critical perfectionism (SCP) also predicts daily symptoms in CFS. Method In the present study we investigated whether SCP pred...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001936
更新日期:2013-05-01 00:00:00
abstract::There are many reports which suggest that patients with effective illness (mania and/or depression) have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, thes...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700055057
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001161
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had jus...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000280
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Studies have suggested that patients with schizophrenia are impaired at recognizing emotions. Recently, it has been shown that the neuropeptide oxytocin can have beneficial effects on social behaviors. METHOD:To examine emotion recognition deficits in patients and see whether oxytocin could improve these de...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001413
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The potential effects of antipsychotic drugs on brain structure represent a key factor in understanding neuroanatomical changes in psychosis. This review addresses two issues: (1) do antipsychotic medications induce changes in total or regional human brain volumes and (2) do such effects depend on antipsycho...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709005315
更新日期:2009-11-01 00:00:00
abstract::The age of onset in bipolar affective disorder was determined in 200 hospitalized patients. The mean age of their first affective syndrome was 28.3 years, and the mean age of first hospitalization was 30.8 years. However, the median age for first affective syndrome was 23 years (26 years for first hospitalization), an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700003147
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:Evidence suggests some overlap between the pathological use of food and drugs, yet how impulsivity compares across these different clinical disorders remains unclear. Substance use disorders are commonly characterized by elevated impulsivity, and impulsivity subtypes may show commonalities and differences in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001834
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Genetic influences contribute significantly to co-morbidity between conduct disorder and substance use disorders. Estimating the extent of overlap can assist in the development of phenotypes for genomic analyses. METHOD:Multivariate quantitative genetic analyses were conducted using data from 9577 individua...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001518
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The effects of antidepressants for treating depressive disorders have been overestimated because of selective publication of positive trials. Reanalyses that include unpublished trials have yielded reduced effect sizes. This in turn has led to claims that antidepressants have clinically insignificant advanta...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291713000457
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Alterations in self-monitoring have been reported in patients with psychotic disorders, but it remains unclear to what degree they represent true indicators of familial vulnerability for psychosis. METHOD:An error-correction action-monitoring task was used to examine self-monitoring in 42 patients with schi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001152
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Psychiatric disorders and related intermediate phenotypes are highly heritable and have a complex, overlapping polygenic architecture. A large-scale genome-wide association study (GWAS) of anxiety disorders identified genetic variants that are significant on a genome-wide. The current study investigated the ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171900059X
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:A long-standing issue in the health anxiety literature is the extent to which health anxiety is a dimensional or a categorical construct. This study explores this question directly using taxometric procedures. METHOD:Seven hundred and eleven working adults completed an index of health anxiety [the Whiteley ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708003322
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Studies investigating neurocognitive impairment in subjects with eating disorders (EDs) have reported heterogeneous patterns of impairment and, in some instances, no dysfunction. The present study aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001303
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Major depressive disorder during pregnancy associates with potentially detrimental consequences for mother and child. The current study examined peripheral blood gene expression as a potential biomarker for prenatal depressive symptoms. METHOD:Maternal RNA from whole blood, plasma and the Beck Depression In...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002121
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Differences between verbal and non-verbal cognitive development from childhood to adulthood may differentiate between those with and without psychotic symptoms and affective symptoms in later life. However, there has been no study exploring this in a population-based cohort. METHOD:The sample was drawn from...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000393
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Classification of psychosis lacks a biological basis and current diagnostic categories may obscure underlying continuities. Data reduction methods of symptom profiles within a population-based cohort of people with a wide range of affective and non-affective psychoses may permit an empirical classification o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003745
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:This study aimed to explore the impacts of COVID-19 outbreak on mental health status in general population in different affected areas in China. METHODS:This was a comparative study including two groups of participants: (1) general population in an online survey in Ya'an and Jingzhou cities during the COVID...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004717
更新日期:2020-12-10 00:00:00
abstract:BACKGROUND:Exposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001080
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:The ability to appreciate humour is essential to successful human interactions. In this study, we hypothesized that individuals with schizophrenia would have diminished ability to recognize and appreciate humour. The relationship between humour experience and clinical symptoms, cognitive and social functioni...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707002528
更新日期:2008-06-01 00:00:00