Reward learning deficits in Parkinson's disease depend on depression.

Abstract:

BACKGROUND:Depression is one of the most common and debilitating non-motor symptoms of Parkinson's disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal. METHODS:We investigated the role of striatal dopamine in reversal learning from reward and punishment by combining a controlled medication withdrawal procedure with functional magnetic resonance imaging in 22 non-depressed PD patients and 19 PD patients with past or present depression. RESULTS:PD patients with a depression (history) exhibited impaired reward v. punishment reversal learning as well as reduced reward v. punishment-related BOLD signal in the striatum (putamen) compared with non-depressed PD patients. No effects of dopaminergic medication were observed. CONCLUSIONS:The present findings demonstrate that impairments in reversal learning from reward v. punishment and associated striatal signalling depend on the presence of (a history of) depression in PD.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Timmer MHM,Sescousse G,van der Schaaf ME,Esselink RAJ,Cools R

doi

10.1017/S0033291717000769

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

2302-2311

issue

13

eissn

0033-2917

issn

1469-8978

pii

S0033291717000769

journal_volume

47

pub_type

杂志文章
  • A comparison of the clinical characteristics of women with recurrent major depression with and without suicidal symptomatology.

    abstract:BACKGROUND:The relationship between recurrent major depression (MD) in women and suicidality is complex. We investigated the extent to which patients who suffered with various forms of suicidal symptomatology can be distinguished from those subjects without such symptoms. METHOD:We examined the clinical features of th...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171200058X

    authors: Bi B,Xiao X,Zhang H,Gao J,Tao M,Niu H,Wang Y,Wang Q,Chen C,Sun N,Li K,Fu J,Gan Z,Sang W,Zhang G,Yang L,Tian T,Li Q,Yang Q,Sun L,Li Y,Rong H,Guan C,Zhao X,Ye D,Zhang Y,Ma Z,Li H,He K,Chen J,Cai

    更新日期:2012-12-01 00:00:00

  • Sense of hyper-positive self and response to cognitive therapy in bipolar disorder.

    abstract:INTRODUCTION:Cognitive therapy (CT) for bipolar disorder emphasizes the monitoring and regulation of mood, thoughts and behaviour. The Sense of Hyper-Positive Self Scale (SHPSS) measures the extent to which bipolar patients value themselves and perceive themselves to possess personal attributes (e.g. dynamism, persuasi...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291704002910

    authors: Lam D,Wright K,Sham P

    更新日期:2005-01-01 00:00:00

  • Longitudinal records of anxiety and depression in general practice: the Second National Morbidity Survey.

    abstract::This paper analyses patterns of episodes of anxiety and depression as recorded by 22 general practices which took part in the Second National Morbidity Survey (RCGP, 1980). The data comprise 6 years' records. Simple Markov chains are fitted to each age-group of men and women, and the inter-practice variation in the re...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700051643

    authors: Dunn G

    更新日期:1983-11-01 00:00:00

  • Effect of neighbourhood deprivation and social cohesion on mental health inequality: a multilevel population-based longitudinal study.

    abstract:BACKGROUND:The common mental disorders (CMDs) of anxiety and depression are the most common form of poor mental health in the general population. Evidence from the small number of previous cohort studies on the role of neighbourhood factors in mental health is inconclusive. We tested the hypothesis that high levels of ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713003255

    authors: Fone D,White J,Farewell D,Kelly M,John G,Lloyd K,Williams G,Dunstan F

    更新日期:2014-08-01 00:00:00

  • Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls.

    abstract:BACKGROUND:The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002315

    authors: Haukvik UK,Schaer M,Nesvåg R,McNeil T,Hartberg CB,Jönsson EG,Eliez S,Agartz I

    更新日期:2012-06-01 00:00:00

  • Insulin tolerance test: human growth hormone response and insulin resistance in primary unipolar depressed, bipolar depressed and control subjects.

    abstract::Preliminary data from the National Institute of Mental Health-Clinical Research Branch Collaborative Program on the Psychobiology of Depression dealing with the human growth hormone (hGH) response to the Insulin Tolerance Test (ITT) during the pre-treatment (drug-free) period of the study are presented in this paper. ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700043270

    authors: Koslow SH,Stokes PE,Mendels J,Ramsey A,Casper R

    更新日期:1982-02-01 00:00:00

  • The clinical effectiveness of counselling in primary care: a systematic review and meta-analysis.

    abstract:BACKGROUND:Counselling is frequently used in the management of common mental disorders (such as anxiety and depression) in primary care. However, there are concerns over the clinical effectiveness of counselling, both in comparison with usual general practitioner care, and with other treatments such as alternative psyc...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/s0033291702006979

    authors: Bower P,Rowland N,Hardy R

    更新日期:2003-02-01 00:00:00

  • Factors associated with attempted suicide among hospitalized depressed patients.

    abstract::An attempt was made to identify background, sociodemographic and clinical variables which are associated with attempted suicide in depression. Within a sample of 308 depressed psychiatric inpatients, suicide attempters were younger than non-attempters and were identified by a pattern of chronic interpersonal maladjust...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700057007

    authors: Crook T,Raskin A,Davis D

    更新日期:1975-11-01 00:00:00

  • Effect of propranolol and phenothiazines on electrodermal orienting and habituation in schizophrenia.

    abstract::Bilateral electrodermal orienting responses were measured to repeated auditory stimuli in schizophrenic patients and controls. In 3 studies phasic activity to moderate intensity sounds of patients on no drugs or phenothiazines was predominantly hyper- or hypo-responsive. Controls showed moderate or slow habituation. P...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700053319

    authors: Gruzelier J,Connolly J,Eves F,Hirsch S,Zaki S,Weller M,Yorkston N

    更新日期:1981-02-01 00:00:00

  • Does staff-patient agreement on needs for care predict a better mental health outcome? A 4-year follow-up in a community service.

    abstract:BACKGROUND:Patients treated in primary care settings report better mental outcomes when they agree with practitioners about the nature of their core presenting problems. However, no study has examined the impact of staff-patient agreement on treatment outcomes in specialist mental health services. We investigated wheth...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707000785

    authors: Lasalvia A,Bonetto C,Tansella M,Stefani B,Ruggeri M

    更新日期:2008-01-01 00:00:00

  • The nature, frequency and course of psychiatric disorders in the first year after traumatic brain injury: a prospective study.

    abstract:BACKGROUND:Psychiatric disorders are common following traumatic brain injury (TBI). However, few studies have examined the course of disorder development and the influence of pre-injury psychiatric history. The present study aimed to examine the frequency of, and association between, psychiatric disorders occurring pre...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171100033X

    authors: Gould KR,Ponsford JL,Johnston L,Schönberger M

    更新日期:2011-10-01 00:00:00

  • Application of network methods for understanding mental disorders: pitfalls and promise.

    abstract::Galvanized with the availability of sophisticated statistical techniques and large datasets, network medicine has emerged as an active area of investigation. Following this trend, network methods have been utilized to understand the interplay between symptoms of mental disorders. This realistic approach that may provi...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291717001350

    authors: Guloksuz S,Pries LK,van Os J

    更新日期:2017-12-01 00:00:00

  • Sleep disturbance mediates the link between childhood trauma and clinical outcome in severe mental disorders.

    abstract:BACKGROUND:The experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the relationship between childhood trauma and sleep disturbances in severe mental disorders including the role of s...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000914

    authors: Laskemoen JF,Aas M,Vaskinn A,Berg AO,Lunding SH,Barrett EA,Melle I,Simonsen C

    更新日期:2020-04-23 00:00:00

  • Increased rates of schizophrenia among immigrants: some methodological concerns raised by Danish findings.

    abstract:BACKGROUND:Several studies during recent years have reported an increased occurrence of schizophrenia in selected immigrant groups. However, difficulties in establishing the population denominator for immigrant rates of mental disorder, selective referral for treatment, and other problems may have influenced such resul...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291797004741

    authors: Mortensen PB,Cantor-Graae E,McNeil TF

    更新日期:1997-07-01 00:00:00

  • Negative bias in fast emotion discrimination in borderline personality disorder.

    abstract:BACKGROUND:The ability to decode emotional information from facial expressions is crucial for successful social interaction. Borderline personality disorder (BPD) is characterized by serious problems in interpersonal relationships and emotional functioning. Empirical research on facial emotion recognition in BPD has be...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708004273

    authors: Dyck M,Habel U,Slodczyk J,Schlummer J,Backes V,Schneider F,Reske M

    更新日期:2009-05-01 00:00:00

  • The symptomatology of psychological trauma in the aftermath of war (1945-1980): UK army veterans, civilians and emergency responders.

    abstract:BACKGROUND:UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001460

    authors: Engelbrecht A,Burdett H,Silva MJ,Bhui K,Jones E

    更新日期:2019-04-01 00:00:00

  • The development and validation of a predictive index for postpartum depression.

    abstract::A sample of over 6000 women was recruited in the last trimester of pregnancy and administered a 40-item self-report questionnaire designed to detect the presence of factors that were likely to increase the risk of postpartum depression. The mental state of almost 5000 of these women was determined at around 6 to 8 wee...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700035698

    authors: Cooper PJ,Murray L,Hooper R,West A

    更新日期:1996-05-01 00:00:00

  • Predictors of outcome for telephone and face-to-face administered cognitive behavioral therapy for depression.

    abstract:BACKGROUND:Cognitive behavioral therapy (CBT) can be delivered efficaciously through various modalities, including telephone (T-CBT) and face-to-face (FtF-CBT). The purpose of this study was to explore predictors of outcome in T-CBT and FtF-CBT for depression. METHOD:A total of 325 depressed participants were randomiz...

    journal_title:Psychological medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0033291715001208

    authors: Stiles-Shields C,Corden ME,Kwasny MJ,Schueller SM,Mohr DC

    更新日期:2015-11-01 00:00:00

  • Interaction between a history of depression and rumination on neural response to emotional faces.

    abstract:BACKGROUND:Both past depressive episodes and the personality trait of depressive rumination are strong risk factors for future depression. Depression is associated with abnormal emotional processing, which may be a neurobiological marker for vulnerability to depression. A consistent picture has yet to emerge as to how ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711000043

    authors: Thomas EJ,Elliott R,McKie S,Arnone D,Downey D,Juhasz G,Deakin JF,Anderson IM

    更新日期:2011-09-01 00:00:00

  • Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort.

    abstract:BACKGROUND:Non-clinical psychosis-like symptoms (PLIKS) occur in about 15% of the population. It is not clear whether adverse events during early development alter the risk of developing PLIKS. We aimed to examine whether maternal infection, diabetes or pre-eclampsia during pregnancy, gestational age, perinatal cardiop...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708005126

    authors: Zammit S,Odd D,Horwood J,Thompson A,Thomas K,Menezes P,Gunnell D,Hollis C,Wolke D,Lewis G,Harrison G

    更新日期:2009-09-01 00:00:00

  • Stalkers and harassers of royalty: the role of mental illness and motivation.

    abstract:BACKGROUND:Public figures are at increased risk of attracting unwanted attention in the form of intrusions, stalking and, occasionally, attack. Whereas the potential threat to the British Royal Family from terrorists and organized groups is clearly defined, there is a dearth of knowledge about that from individual hara...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709005443

    authors: James DV,Mullen PE,Pathé MT,Meloy JR,Preston LF,Darnley B,Farnham FR

    更新日期:2009-09-01 00:00:00

  • Personality characteristics of the parents of autistic individuals.

    abstract::Personality characteristics of 87 parents of autistic probands and 38 parents of Down's syndrome probands were examined using a standardized personality interview. Using best-estimate ratings derived from subject and informant interviews, parents of autistic individuals were rated significantly higher than controls on...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700027938

    authors: Piven J,Wzorek M,Landa R,Lainhart J,Bolton P,Chase GA,Folstein S

    更新日期:1994-08-01 00:00:00

  • The factor structure of the GHQ-60 in a community sample.

    abstract::The factor structure of the 60-item version of the General Health Questionnaire was explored, using data collected in a community study in a rural area of northern Spain. Six principal components, similar to those previously reported with this instrument, were found to provide a good description of the data structure....

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700002038

    authors: Vázquez-Barquero JL,Williams P,Díez-Manrique JF,Lequerica J,Arenal A

    更新日期:1988-02-01 00:00:00

  • Which patients talk about stressful life events and social problems to the general practitioner?

    abstract:BACKGROUND:Life events and social problems are common in primary-care attenders and contribute to the high rate of emotional distress observed in this setting but are often not disclosed during the consultation. Physicians' characteristics associated with patients' disclosure of psychosocial problems are well documente...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291798007478

    authors: Del Piccolo L,Saltini A,Zimmermann C

    更新日期:1998-11-01 00:00:00

  • The capacity of people with a 'mental disability' to make a health care decision.

    abstract:BACKGROUND:Based on the developing clinical and legal literature, and using the framework adopted in draft legislation, capacity to make a valid decision about a clinically required blood test was investigated in three groups of people with a 'mental disability' (i.e. mental illness (chronic schizophrenia), 'learning d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700001768

    authors: Wong JG,Clare CH,Holland AJ,Watson PC,Gunn M

    更新日期:2000-03-01 00:00:00

  • The views and outcomes of consenting and non-consenting patients receiving ECT.

    abstract:BACKGROUND:Current mental health legislation in the UK makes provision for the use of certain treatments in severely ill patients who are unable, or unwilling, to give informed consent. Under the terms of this legislation, electroconvulsive therapy (ECT) may be used, usually to treat severely depressed patients. A numb...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291798007193

    authors: Wheeldon TJ,Robertson C,Eagles JM,Reid IC

    更新日期:1999-01-01 00:00:00

  • The influence of homeostatic mechanisms on neural regulation of food craving in anorexia nervosa.

    abstract:BACKGROUND:Restrictive food intake in anorexia nervosa (AN) has been related to an overactive cognitive control network inhibiting intuitive motivational responses to food stimuli. However, the influence of short-term homeostatic signaling on the neural regulation of cue-induced food craving in AN is still unclear. ME...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719003970

    authors: Stopyra MA,Friederich HC,Mönning E,Lavandier N,Bendszus M,Herzog W,Simon JJ

    更新日期:2020-01-14 00:00:00

  • Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis.

    abstract::Major depressive disorder (MDD) is a mental illness with high socio-economic burden, but its pathophysiology has not been fully elucidated. Recently, the cortical excitatory and inhibitory imbalance hypothesis and neuroplasticity hypothesis have been proposed for MDD. Although several studies have examined the neuroph...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004729

    authors: Kinjo M,Wada M,Nakajima S,Tsugawa S,Nakahara T,Blumberger DM,Mimura M,Noda Y

    更新日期:2021-01-01 00:00:00

  • Familiality and SNP heritability of age at onset and episodicity in major depressive disorder.

    abstract:BACKGROUND:Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715000215

    authors: Ferentinos P,Koukounari A,Power R,Rivera M,Uher R,Craddock N,Owen MJ,Korszun A,Jones L,Jones I,Gill M,Rice JP,Ising M,Maier W,Mors O,Rietschel M,Preisig M,Binder EB,Aitchison KJ,Mendlewicz J,Souery D,Hauser J,

    更新日期:2015-07-01 00:00:00

  • The neural basis of consciousness.

    abstract::Consciousness has evolved and is a feature of all animals with sufficiently complex nervous systems. It is, therefore, primarily a problem for biology, rather than physics. In this review, I will consider three aspects of consciousness: level of consciousness, whether we are awake or in a coma; the contents of conscio...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719002204

    authors: Frith CD

    更新日期:2019-09-04 00:00:00