Abstract:
:The factor structure of the 60-item version of the General Health Questionnaire was explored, using data collected in a community study in a rural area of northern Spain. Six principal components, similar to those previously reported with this instrument, were found to provide a good description of the data structure. The 30-item and 12-item versions of the GHQ were then disembedded from the parent version, and further principal components analyses carried out. Again, the results were similar to previous studies: in each of the three versions analysed here, the two most important components represented a disturbance of mood ('general dysphoria')--including aspects of anxiety, depression and irritability--and a disturbance of social performance ('social function/optimism'). The principal component structure of the GHQ-60 was then utilized to calculate factor scores, and these were compared with PSE ratings using Relative Operating Characteristic (ROC) analysis. While four of the six factors discriminated well (area under the ROC curve 0.75 or more) between PSE 'cases' and 'non-cases', only one, depressive thoughts, was a good discriminator between depressed and non-depressed PSE 'cases'.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Vázquez-Barquero JL,Williams P,Díez-Manrique JF,Lequerica J,Arenal Adoi
10.1017/s0033291700002038subject
Has Abstractpub_date
1988-02-01 00:00:00pages
211-8issue
1eissn
0033-2917issn
1469-8978journal_volume
18pub_type
杂志文章abstract::Increases in plasma noradrenaline were found in a group of 12 subjects smoking cigarettes. The associated rises in pulse rate, blood pressure and plasma free fatty acids could be prevented by beta-blockade with oxprenolol. This inhibition of the peripheral effects of catecholamines did not affect subjective satisfacti...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291700013799
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Although many case-control studies have replicated an association between dysfunctional parenting and a lifetime diagnosis of depression, few epidemiological studies have explored the association. In addition, little is known about the association in non-western countries. METHODS:Using logistic regression ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797006430
更新日期:1998-05-01 00:00:00
abstract::The variations in suicide mortality in England and Wales over a 100-year period (1876-1975) are explained by the development of a descriptive model. The model used in a stepwise linear regression using 5 variables including toxic gas production. The variables give a good description of the observed changes in suicide ...
journal_title:Psychological medicine
pub_type: 历史文章,杂志文章
doi:10.1017/s003329170005217x
更新日期:1981-05-01 00:00:00
abstract:BACKGROUND:Mental disorders often begin during the formative years of education. They may disrupt education and lead to social underachievement. METHODS:We examined the impact of mental disorders treated in hospital (ages 16-29) on educational attainment up to 31 years in the Northern Finland 1966 Birth Cohort (N = 10...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170100304x
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Sertraline has a proved efficacy in post-traumatic stress disorder (PTSD), but it is unknown which symptoms respond or in what sequence this occurs. Such information might be useful clinically and heuristically. METHOD:The study examined the effects of sertraline on the individual symptoms of PTSD. It also ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702005469
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Differences between verbal and non-verbal cognitive development from childhood to adulthood may differentiate between those with and without psychotic symptoms and affective symptoms in later life. However, there has been no study exploring this in a population-based cohort. METHOD:The sample was drawn from...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000393
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Counselling is frequently used in the management of common mental disorders (such as anxiety and depression) in primary care. However, there are concerns over the clinical effectiveness of counselling, both in comparison with usual general practitioner care, and with other treatments such as alternative psyc...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/s0033291702006979
更新日期:2003-02-01 00:00:00
abstract::Results are reported from a large population study (of working people) comparing Holocaust survivors and a control group in regard to emotional distress, satisfaction in life and psychosomatic symptoms. It was found that, even 40 years after the traumatic experience, this group of survivors exhibited a slightly higher...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700002580
更新日期:1986-02-01 00:00:00
abstract::This is a study of the criterion validity of a newly developed computerized assessment (PROQSY) of minor psychological morbidity based on the Clinical Interview Schedule, employing a single GP's assessments as criterion measures of such morbidity and Relative Operating Characteristic (ROC) analysis. Two-stage screenin...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700011193
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Preclinical and human studies suggest an association between chronic inflammation and the development of depressive behaviors. This is proposed to occur through downstream effects of inflammatory cytokines on neuroplasticity, neurogenesis and neurotransmitter function, although the neural correlates remain p...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002940
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Generalized anxiety disorder is a common condition of excessive worry and tension which tends to run a chronic course associated with significant psychiatric and medical problems. Cognitive behaviour therapy (CBT) has been shown to be of clinical value in about 50% of cases with treatment gains maintained ov...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702007079
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:There is substantial variability in the degree of cognitive impairment among older depressed persons. Inconsistencies in previous findings may be due to differences in clinical and demographic characteristics across study samples. We assessed the influence of unipolar depression and severity of depression on...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001736
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Parental characteristics and practices predict borderline personality disorder (BPD) symptoms in children. However, it is difficult to disentangle whether these effects are genetically or environmentally mediated. The present study examines the contributions of genetic and environmental influences by compari...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001260
更新日期:2020-06-01 00:00:00
abstract::Preliminary data from the National Institute of Mental Health-Clinical Research Branch Collaborative Program on the Psychobiology of Depression dealing with the human growth hormone (hGH) response to the Insulin Tolerance Test (ITT) during the pre-treatment (drug-free) period of the study are presented in this paper. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700043270
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Several case reports and reviews have suggested an increased incidence of schizophrenia or bipolar disorder among persons with sex chromosome aneuploidies, but this observation may have been caused by biased sampling. METHODS:The 1122 individuals with sex chromosome aneuploidies registered in the Danish Cyt...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003476
更新日期:2001-04-01 00:00:00
abstract::A structured assessment instrument, the Quality of Life Interview, was used to explain the quality of life of seventy patients with chronic psychiatric illness attending a day treatment programme. The interview was found to have acceptable psychometric properties. Factors that best predicted the quality of life of the...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700017220
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is accompanied by alterations in grey matter volume. However, the biological processes associated with regional structural perturbations remain elusive. METHODS:We applied integrative omics analysis to investigate specialized transcriptome signatures and translational determi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002676
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000166X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Bright light and high-density negative air ion exposure are efficacious for winter and non-seasonal depression compared with a low-density negative ion placebo. Similarly, auditory stimuli improve mood in clinical populations. This study compared the short-term effects of bright light, an auditory stimulus, ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291706008002
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Stress questionnaires are included in many epidemiological cohort studies but the psychometric characteristics of these questionnaires are largely unknown. The aim of this study was to describe these characteristics for two short questionnaires measuring the lifetime and past year occurrence of stress: the L...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000608
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:In other branches of epidemiology, stratum specific likelihood ratios (SSLRs) have been found to be preferable to fixed best threshold approaches to screening instruments. This paper presents SSLRs of GHQ-12 and GHQ-28 and compares the SSLR method with the traditional optimal threshold approach. METHODS:Ran...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1017/s0033291701003713
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:There is uncertainty about the incidence of breakthrough psychosis in treatment adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play in this phenomenon. METHODS:In a nationwide cohort of individuals treated for schizophrenia-spectrum disorders in Finland between 1 Ja...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001296
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Morphometric endophenotypes which have been proposed for psychotic disorders include lateral ventricular enlargement and hippocampal volume reductions. Genetic epidemiological studies support an overlap between schizophrenia and bipolar disorder, and COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes have been implica...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709990316
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:The processing of facial emotion involves a distributed network of limbic and paralimbic brain structures. Many of these regions are also implicated in the pathophysiology of mood disorders. Behavioural data indicate that depressed subjects show a state-related positive recognition bias for faces displaying ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704002557
更新日期:2004-07-01 00:00:00
abstract::The Geriatric Mental State and a new computerized diagnostic system, AGECAT, are briefly described. A nomenclature for designating cases for epidemiological work is introduced. Concordance between AGECAT and psychiatrists' diagnoses for these studies, hospital and community based (total of 541 subjects), achieved over...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700057779
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Spousal concordance for common mental disorders provides evidence of the relevance of social contextual factors. There are, however, limitations within the existing literature examining spousal similarity in mental health and little consensus as to the causes of spousal similarity. This study considers a lar...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705006677
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Meta-analyses support the efficacy of cognitive-behavioural therapy (CBT) for schizophrenia in western cultures. This study aimed to compare the efficacy of CBT and supportive therapy (ST) for patients with schizophrenia in China. METHOD:A multicentre randomized controlled, single-blinded, parallel-group tr...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1017/S0033291714002992
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Prevalence of childhood anxiety disorders at specific ages and genetic etiological influences on anxiety disorders in young children have been little studied. The present study reports prevalence estimates in a community sample of 6-year-old twins, and patterns of genetic and environmental influences on thes...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705006537
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Understanding the pathways to psychiatric care and recognition of delay points are crucial for the development of interventions that aim to improve access to mental health-care services. METHOD:Over a 2-month period in 2003, a total of 1044 patients at the commencement of new episodes of care at Amanuel Spe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708003929
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Factor analysis has been employed to identify latent variables that are unifying constructs and that parsimoniously describe correlations among a related group of variables. Confirmatory factor analysis is used to test hypothesized factor structures for a set of variables; it can also, as in this paper be us...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005710
更新日期:1998-01-01 00:00:00