Effect of propranolol and phenothiazines on electrodermal orienting and habituation in schizophrenia.

Abstract:

:Bilateral electrodermal orienting responses were measured to repeated auditory stimuli in schizophrenic patients and controls. In 3 studies phasic activity to moderate intensity sounds of patients on no drugs or phenothiazines was predominantly hyper- or hypo-responsive. Controls showed moderate or slow habituation. Propranolol was found to facilitate habituation in slow habituators and to reinstate responses in half of non-responders, especially when given as the sole drug. The effects seldom had a counterpart in changes in non-specific responses or levels of skin conductance. Modulatory influences on stimulus and response processing and on lateral asymmetries in responses may underlie propranolol's efficacy in treating schizophrenia.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Gruzelier J,Connolly J,Eves F,Hirsch S,Zaki S,Weller M,Yorkston N

doi

10.1017/s0033291700053319

subject

Has Abstract

pub_date

1981-02-01 00:00:00

pages

93-108

issue

1

eissn

0033-2917

issn

1469-8978

journal_volume

11

pub_type

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