Abstract:
BACKGROUND:Depression has been associated with abnormalities in neural underpinnings of Reward Learning (RL). However, inconsistencies have emerged, possibly owing to medication effects. Additionally, it remains unclear how neural RL signals relate to real-life behaviour. The current study, therefore, examined neural RL signals in young, mildly to moderately depressed - but non-help-seeking and unmedicated - individuals and how these signals are associated with depressive symptoms and real-life motivated behaviour. METHODS:Individuals with symptoms along the depression continuum (n = 87) were recruited from the community. They performed an RL task during functional Magnetic Resonance Imaging and were assessed with the Experience Sampling Method (ESM), completing short questionnaires on emotions and behaviours up to 10 times/day for 15 days. Q-learning model-derived Reward Prediction Errors (RPEs) were examined in striatal areas, and subsequently associated with depressive symptoms and an ESM measure capturing (non-linearly) how anticipation of reward experience corresponds to actual reward experience later on. RESULTS:Significant RPE signals were found in the striatum, insula, amygdala, hippocampus, frontal and occipital cortices. Region-of-interest analyses revealed a significant association between RPE signals and (a) self-reported depressive symptoms in the right nucleus accumbens (b = -0.017, p = 0.006) and putamen (b = -0.013, p = .012); and (b) the quadratic ESM variable in the left (b = 0.010, p = .010) and right (b = 0.026, p = 0.011) nucleus accumbens and right putamen (b = 0.047, p < 0.001). CONCLUSIONS:Striatal RPE signals are disrupted along the depression continuum. Moreover, they are associated with reward-related behaviour in real-life, suggesting that real-life coupling of reward anticipation and engagement in rewarding activities might be a relevant target of psychological therapies for depression.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Bakker JM,Goossens L,Kumar P,Lange IMJ,Michielse S,Schruers K,Bastiaansen JA,Lieverse R,Marcelis M,van Amelsvoort T,van Os J,Myin-Germeys I,Pizzagalli DA,Wichers Mdoi
10.1017/S0033291718003446subject
Has Abstractpub_date
2019-10-01 00:00:00pages
2441-2451issue
14eissn
0033-2917issn
1469-8978pii
S0033291718003446journal_volume
49pub_type
杂志文章abstract::The validity of the twin method depends on the equal environment assumption (EEA)--that monozygotic (MZ) and dizygotic (DZ) twins are equally correlated in their exposure to environmental factors of aetiological importance for the trait under study. Parents may treat MZ twins more similarly than DZ twins thereby poten...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700027732
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Different versions of the General Health Questionnaire (GHQ), including the GHQ-12 and GHQ-28 have been subjected to factor analysis in a variety of countries. The World Health Organization study of psychological disorders in general health care offered the opportunity to investigate the factor structure of ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291799002287
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Patients treated in primary care settings report better mental outcomes when they agree with practitioners about the nature of their core presenting problems. However, no study has examined the impact of staff-patient agreement on treatment outcomes in specialist mental health services. We investigated wheth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000785
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Hypochondriasis is recognized as an important disorder in clinical populations, associated with increased health care utilization, disability and psychiatric co-morbidity. Few studies have investigated hypochondriasis in the community. We report on the broader concept of illness worry in a community populati...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003737
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Early Intervention in Psychosis Services (EIS) for young people in England experiencing first-episode psychosis (FEP) were commissioned in 2002, based on an expected incidence of 15 cases per 100 000 person-years, as reported by schizophrenia epidemiology in highly urban settings. Unconfirmed reports from EI...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002461
更新日期:2011-05-01 00:00:00
abstract::Preliminary data from the National Institute of Mental Health-Clinical Research Branch Collaborative Program on the Psychobiology of Depression dealing with the human growth hormone (hGH) response to the Insulin Tolerance Test (ITT) during the pre-treatment (drug-free) period of the study are presented in this paper. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700043270
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:In schizophrenia, affective disorders, and obsessive-compulsive disorder (OCD) dysfunction of frontal neuronal circuits has been suggested. Such impairments imply corresponding oculomotor deficits. METHOD:Eye movement response to foveofugal and foveopetal step-ramp stimuli was recorded within the same study...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703001314
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors and personality traits is ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001997
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Retrospective studies have consistently indicated an association between maladaptive parenting and borderline personality disorder (BPD). This requires corroboration with prospective, longitudinal designs. We investigated the association between suboptimal parenting and parent conflict in childhood and BPD s...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000542
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:This study aimed to explore the impacts of COVID-19 outbreak on mental health status in general population in different affected areas in China. METHODS:This was a comparative study including two groups of participants: (1) general population in an online survey in Ya'an and Jingzhou cities during the COVID...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004717
更新日期:2020-12-10 00:00:00
abstract:BACKGROUND:Cognitive behaviour therapy (CBT) for chronic fatigue syndrome (CFS) leads to a significant decrease in CFS-related symptoms and disability. The primary objective of this study was to explore whether partners' solicitous responses and patients' and partners' perceived relationship satisfaction had an effect ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000288
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Affective instability (AI) is poorly defined but considered clinically important. The aim of this study was to examine definitions and measures of AI employed in clinical populations. METHOD:This study was a systematic review using the PRISMA guidelines. MEDLINE, Embase, PsycINFO, PsycArticles and Web of Sc...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291713002407
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Exclusion criteria are present in almost all diagnostic categories in both DSM-IV and ICD-10. These exclusion criteria state that one diagnosis is not made if it is 'due to' another disorder. However, there is little empirical evidence demonstrating that the hierarchy imposed by the exclusion criteria is mea...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291702006189
更新日期:2002-10-01 00:00:00
abstract::Recent literature on insight has paid little attention to patients' social backgrounds and cultures. Discharge summaries from 357 patients with a psychotic illness were examined to investigate factors associated with insight. A highly significant association was found between British white ethnic origin and being thou...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035406
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Social media platforms have long been recognised as major disseminators of health misinformation. Many previous studies have found a negative association between health-protective behaviours and belief in the specific form of misinformation popularly known as 'conspiracy theory'. Concerns have arisen regardi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000224X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:We examined the relationship between childhood sexual abuse (CSA), and interviewees' recollections of pathogenic parenting, testing for possible retrospective biases in the recollections of those who have experienced CSA. METHODS:Information about CSA, parental divorce and interviewees' recollections of par...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002809
更新日期:2000-11-01 00:00:00
abstract::91 women were assessed early in pregnancy and again 3 and 6 months postpartum. Women who persisted in breastfeeding were less neurotic on the EPI but did not differ from artificial feeders in psychiatric history or sexuality before pregnancy. Breast feeders showed greater impairment of sexuality and slightly more depr...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700007935
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Current mental health legislation in the UK makes provision for the use of certain treatments in severely ill patients who are unable, or unwilling, to give informed consent. Under the terms of this legislation, electroconvulsive therapy (ECT) may be used, usually to treat severely depressed patients. A numb...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007193
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Compassion-focused therapy (CFT) is a relatively novel form of psychotherapy that was developed for people who have mental health problems primarily linked to high shame and self-criticism. The aim of this early systematic review was to draw together the current research evidence of the effectiveness of CFT ...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291714002141
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The output of many healthy physiological systems displays fractal fluctuations with self-similar temporal structures. Altered fractal patterns are associated with pathological conditions. There is evidence that patients with bipolar disorder have altered daily behaviors. METHODS:To test whether fractal patt...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000331
更新日期:2020-04-01 00:00:00
abstract::Parental representation was assessed with the Parental Bonding Instrument (PBI) in 12 monozygotic (MZ) and 19 dizygotic (DZ) same-sexed twin pairs discordant for DSM-III-R schizophrenia. The schizophrenic twins reported less care and more overprotection from both parents than the non-schizophrenic co-twins. Multiple r...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700028439
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:The common mental disorders (CMDs) of anxiety and depression are the most common form of poor mental health in the general population. Evidence from the small number of previous cohort studies on the role of neighbourhood factors in mental health is inconclusive. We tested the hypothesis that high levels of ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713003255
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible alternative to electroconvulsive therapy for the treatment of selected patients with depression, bipolar affective disorder and schizophrenia. The aim of this study was to evaluate the evidence for the effectiveness of rTMS...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291701004378
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002794
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Major depressive disorder during pregnancy associates with potentially detrimental consequences for mother and child. The current study examined peripheral blood gene expression as a potential biomarker for prenatal depressive symptoms. METHOD:Maternal RNA from whole blood, plasma and the Beck Depression In...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002121
更新日期:2012-05-01 00:00:00
abstract::A standardized pegboard task was used to investigate changes in manipulative skill as a function of age in 119 right-handed subjects. The typical pattern of cognitive impairment in old age indicates a relative preservation of functions which depend on the integrity of the left hemisphere. In accord with these observat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700005109
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Studies have found associations between psychological distress (PD) and increased risk of myocardial infarction (MI). However, it is not clear whether the relationship reflects the subtle influence of pre-existing illness on both PD and MI. This study examines the association between PD and MI in a prospecti...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000402
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:As part of a collaborative linkage study, the authors obtained clinical and demographic data on 160 families in which more than one sibling was affected with a bipolar illness. The aim of the study was to identify clinical characteristics that had a high degree of familiality. METHOD:Data on age at onset, g...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004986
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000389X
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Several lines of evidence indicate a role of the brain-derived neurotrophic factor (BDNF) in the modulation of eating behaviour. Therefore, alterations in the physiology of this neurotrophin may be involved in the pathogenesis of eating disorders. In the present study, we investigated serum levels of BDNF in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003368
更新日期:2005-06-01 00:00:00