Measuring depression: comparison and integration of three scales in the GENDEP study.

Abstract:

BACKGROUND:A number of scales are used to estimate the severity of depression. However, differences between self-report and clinician rating, multi-dimensionality and different weighting of individual symptoms in summed scores may affect the validity of measurement. In this study we examined and integrated the psychometric properties of three commonly used rating scales. METHOD:The 17-item Hamilton Depression Rating Scale (HAMD-17), the Montgomery-Asberg Depression Rating Scale (MADRS) and the Beck Depression Inventory (BDI) were administered to 660 adult patients with unipolar depression in a multi-centre pharmacogenetic study. Item response theory (IRT) and factor analysis were used to evaluate their psychometric properties and estimate true depression severity, as well as to group items and derive factor scores. RESULTS:The MADRS and the BDI provide internally consistent but mutually distinct estimates of depression severity. The HAMD-17 is not internally consistent and contains several items less suitable for out-patients. Factor analyses indicated a dominant depression factor. A model comprising three dimensions, namely 'observed mood and anxiety', 'cognitive' and 'neurovegetative', provided a more detailed description of depression severity. CONCLUSIONS:The MADRS and the BDI can be recommended as complementary measures of depression severity. The three factor scores are proposed for external validation.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Uher R,Farmer A,Maier W,Rietschel M,Hauser J,Marusic A,Mors O,Elkin A,Williamson RJ,Schmael C,Henigsberg N,Perez J,Mendlewicz J,Janzing JG,Zobel A,Skibinska M,Kozel D,Stamp AS,Bajs M,Placentino A,Barreto M,McGuf

doi

10.1017/S0033291707001730

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

289-300

issue

2

eissn

0033-2917

issn

1469-8978

pii

S0033291707001730

journal_volume

38

pub_type

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