Abstract:
BACKGROUND:A number of scales are used to estimate the severity of depression. However, differences between self-report and clinician rating, multi-dimensionality and different weighting of individual symptoms in summed scores may affect the validity of measurement. In this study we examined and integrated the psychometric properties of three commonly used rating scales. METHOD:The 17-item Hamilton Depression Rating Scale (HAMD-17), the Montgomery-Asberg Depression Rating Scale (MADRS) and the Beck Depression Inventory (BDI) were administered to 660 adult patients with unipolar depression in a multi-centre pharmacogenetic study. Item response theory (IRT) and factor analysis were used to evaluate their psychometric properties and estimate true depression severity, as well as to group items and derive factor scores. RESULTS:The MADRS and the BDI provide internally consistent but mutually distinct estimates of depression severity. The HAMD-17 is not internally consistent and contains several items less suitable for out-patients. Factor analyses indicated a dominant depression factor. A model comprising three dimensions, namely 'observed mood and anxiety', 'cognitive' and 'neurovegetative', provided a more detailed description of depression severity. CONCLUSIONS:The MADRS and the BDI can be recommended as complementary measures of depression severity. The three factor scores are proposed for external validation.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Uher R,Farmer A,Maier W,Rietschel M,Hauser J,Marusic A,Mors O,Elkin A,Williamson RJ,Schmael C,Henigsberg N,Perez J,Mendlewicz J,Janzing JG,Zobel A,Skibinska M,Kozel D,Stamp AS,Bajs M,Placentino A,Barreto M,McGufdoi
10.1017/S0033291707001730subject
Has Abstractpub_date
2008-02-01 00:00:00pages
289-300issue
2eissn
0033-2917issn
1469-8978pii
S0033291707001730journal_volume
38pub_type
杂志文章abstract:BACKGROUND:Epidemiological evidence suggests a link between cannabis use and psychosis. A variety of factors have been proposed to mediate an individual's vulnerability to the harmful effects of the drug, one of which is their psychosis proneness. We hypothesized that highly psychosis-prone individuals would report mor...
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