The relationship of dementia prevalence in older adults with intellectual disability (ID) to age and severity of ID.

Abstract:

BACKGROUND:Previous research has shown that adults with intellectual disability (ID) may be more at risk of developing dementia in old age than expected. However, the effect of age and ID severity on dementia prevalence rates has never been reported. We investigated the predictions that older adults with ID should have high prevalence rates of dementia that differ between ID severity groups and that the age-associated risk should be shifted to a younger age relative to the general population. METHOD:A two-staged epidemiological survey of 281 adults with ID without Down syndrome (DS) aged 60 years; participants who screened positive with a memory task, informant-reported change in function or with the Dementia Questionnaire for Persons with Mental Retardation (DMR) underwent a detailed assessment. Diagnoses were made by psychiatrists according to international criteria. Prevalence rates were compared with UK prevalence and European consensus rates using standardized morbidity ratios (SMRs). RESULTS:Dementia was more common in this population (prevalence of 18.3%, SMR 2.77 in those aged 65 years). Prevalence rates did not differ between mild, moderate and severe ID groups. Age was a strong risk factor and was not influenced by sex or ID severity. As predicted, SMRs were higher for younger age groups compared to older age groups, indicating a relative shift in age-associated risk. CONCLUSIONS:Criteria-defined dementia is 2-3 times more common in the ID population, with a shift in risk to younger age groups compared to the general population.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Strydom A,Hassiotis A,King M,Livingston G

doi

10.1017/S0033291708003334

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

13-21

issue

1

eissn

0033-2917

issn

1469-8978

pii

S0033291708003334

journal_volume

39

pub_type

杂志文章
  • Psychosis breakthrough on antipsychotic maintenance: results from a nationwide study.

    abstract:BACKGROUND:There is uncertainty about the incidence of breakthrough psychosis in treatment adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play in this phenomenon. METHODS:In a nationwide cohort of individuals treated for schizophrenia-spectrum disorders in Finland between 1 Ja...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719001296

    authors: Rubio JM,Taipale H,Correll CU,Tanskanen A,Kane JM,Tiihonen J

    更新日期:2020-06-01 00:00:00

  • A taxometric analysis of health anxiety.

    abstract:BACKGROUND:A long-standing issue in the health anxiety literature is the extent to which health anxiety is a dimensional or a categorical construct. This study explores this question directly using taxometric procedures. METHOD:Seven hundred and eleven working adults completed an index of health anxiety [the Whiteley ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708003322

    authors: Ferguson E

    更新日期:2009-02-01 00:00:00

  • Emotional factors in forgetting.

    abstract::Levinger & Clarke (1961) found that subjects tended to forget more word associations to emotional rather than neutral words. Kline (1981) regarded this study as providing 'irrefutable evidence for the Freudian concept of repression'. On the other hand, results from Kleinsmith & Kaplan (1964) suggested that this effect...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700017669

    authors: Bradley BP,Baddeley AD

    更新日期:1990-05-01 00:00:00

  • Variations in referral pattern to the psychiatric services by general practitioners.

    abstract::Referral rates to psychiatric services in North-East Scotland by 147 individual urban and rural general practitioners were calculated. Among city doctors, the greater the number of years since qualification the more patients were referred. Single-handed city doctors also had very high referral rates. Subsequent interv...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700030865

    authors: Robertson NC

    更新日期:1979-05-01 00:00:00

  • Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis.

    abstract:BACKGROUND:Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719001314

    authors: Wu Y,Levis B,Riehm KE,Saadat N,Levis AW,Azar M,Rice DB,Boruff J,Cuijpers P,Gilbody S,Ioannidis JPA,Kloda LA,McMillan D,Patten SB,Shrier I,Ziegelstein RC,Akena DH,Arroll B,Ayalon L,Baradaran HR,Baron M,Bombardier

    更新日期:2020-06-01 00:00:00

  • Lateral interactions in the visual cortex of patients with schizophrenia and bipolar disorder.

    abstract:BACKGROUND:Schizophrenia is associated with perceptual organization deficits and abnormal neuronal connectivity has been described in early visual areas. The purpose of this study was to investigate the functional integrity of lateral connections in early visual areas of patients with schizophrenia and type I bipolar d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291705004381

    authors: Kéri S,Kelemen O,Benedek G,Janka Z

    更新日期:2005-07-01 00:00:00

  • Integrative omics analysis identifies differential biological pathways that are associated with regional grey matter volume changes in major depressive disorder.

    abstract:BACKGROUND:Major depressive disorder (MDD) is accompanied by alterations in grey matter volume. However, the biological processes associated with regional structural perturbations remain elusive. METHODS:We applied integrative omics analysis to investigate specialized transcriptome signatures and translational determi...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720002676

    authors: Sha Z,Banihashemi L

    更新日期:2020-07-29 00:00:00

  • The risk of minor depression before age 65: results from a community survey.

    abstract::Data from a general population survey of psychiatric disorder in Camberwell were used to calculate the risk of a CATEGO-defined depressive episode before the age of 65, using a modification of Strömgren's method. Current depression was defined as cases within the relevant categories of the CATEGO program and at thresh...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700012435

    authors: Bebbington P,Katz R,McGuffin P,Tennant C,Hurry J

    更新日期:1989-05-01 00:00:00

  • The general practitioner as the first contacted health professional by patients with psychosocial problems: a European study.

    abstract:BACKGROUND:There are considerable differences between and within countries in the involvement of general practitioners (GPs) in psychosocial care. This study aimed to describe the self-perceived role of GPs in 30 European countries as the first contacted professional for patients with psychosocial problems. and to exam...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329179900851x

    authors: Boerma WG,Verhaak PF

    更新日期:1999-05-01 00:00:00

  • Visual working memory encoding in schizophrenia and first-degree relatives: neurofunctional abnormalities and impaired consolidation.

    abstract:BACKGROUND:Working memory (WM) deficits in schizophrenia (SCZ) have been linked to impairments in the encoding phase that are associated with aberrant neuronal functioning. Similar abnormalities have been observed in unaffected first-degree relatives (REL) and are thus discussed as candidate endophenotypes. The process...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171800051X

    authors: Stäblein M,Storchak H,Ghinea D,Kraft D,Knöchel C,Prvulovic D,Bittner RA,Reif A,Oertel-Knöchel V

    更新日期:2019-01-01 00:00:00

  • Familial confounding of the association between maternal smoking during pregnancy and internalizing disorders in offspring.

    abstract:BACKGROUND:Maternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation. METHOD...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716003627

    authors: Meier SM,Plessen KJ,Verhulst F,Mors O,Mortensen PB,Pedersen CB,Agerbo E

    更新日期:2017-01-19 00:00:00

  • Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies.

    abstract:BACKGROUND:Psychotic symptoms occur more frequently in the general population than psychotic disorder and index risk for psychopathology. Multiple studies have reported on the prevalence of these symptoms using self-report questionnaires or clinical interviews but there is a lack of consensus about the prevalence of ps...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0033291711002960

    authors: Kelleher I,Connor D,Clarke MC,Devlin N,Harley M,Cannon M

    更新日期:2012-09-01 00:00:00

  • The incidence and prevalence of pervasive developmental disorders: a Danish population-based study.

    abstract:BACKGROUND:Based on prevalence studies and the few incidence studies of pervasive developmental disorders (PDDs) the prevalence and incidence of these disorders have been claimed to be increasing. METHOD:The annual and age-specific prevalence and incidence rates of childhood autism, atypical autism, Asperger's disorde...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291704002387

    authors: Lauritsen MB,Pedersen CB,Mortensen PB

    更新日期:2004-10-01 00:00:00

  • Negative cognition, affect, metacognition and dimensions of paranoia in people at ultra-high risk of psychosis: a multi-level modelling analysis.

    abstract:BACKGROUND:Paranoia is one of the commonest symptoms of psychosis but has rarely been studied in a population at risk of developing psychosis. Based on existing theoretical models, including the proposed distinction between ‘poor me’ and ‘bad me’ paranoia, we aimed to test specific predictions about associations betwee...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1017/S0033291715000689

    authors: Morrison AP,Shryane N,Fowler D,Birchwood M,Gumley AI,Taylor HE,French P,Stewart SL,Jones PB,Lewis SW,Bentall RP

    更新日期:2015-01-01 00:00:00

  • The expressed emotion of case managers of the seriously mentally ill: the influence of expressed emotion on clinical outcomes.

    abstract:BACKGROUND:Expressed emotion (EE) measured from relatives and informal carers has been consistently demonstrated to be associated with clinical outcome in schizophrenic patients. There have also been published studies that have investigated EE in professional carers that have suggested that the quality of the relations...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799001579

    authors: Tattan T,Tarrier N

    更新日期:2000-01-01 00:00:00

  • The prevalence of psychiatric illness among patients on home haemodialysis.

    abstract::An entire population of 32 patients on regular dialysis treatment (RDT) in their own homes were ranked according to their present mental state as assessed by a standardized semi-structured interview. The point-prevalence of psychiatric morbidity was 31% which compares closely with that of patients attending a general ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700032062

    authors: Farmer CJ,Snowden SA,Parsons V

    更新日期:1979-08-01 00:00:00

  • Training primary-care physicians to recognize, diagnose and manage depression: does it improve patient outcomes?

    abstract:BACKGROUND:We developed a comprehensive, 20-hour training programme for primary-care physicians, that sought to improve their ability to detect, diagnose and manage depression. We evaluated the effects of physician training on patient outcomes, using a pre-post design. METHODS:In the pre-training phase of the study, w...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799008545

    authors: Tiemens BG,Ormel J,Jenner JA,van der Meer K,Van Os TW,van den Brink RH,Smit A,van den Brink W

    更新日期:1999-07-01 00:00:00

  • Psychiatric morbidity in patients with Parkinson's disease.

    abstract::Forty patients with Parkinson's disease underwent a detailed assessment of their psychiatric state using a standardized, semi-structured interview, the Present State Examination. Analysis of the interviews yielded a profile of depressive and neurotic syndromes. Comparing the results with population norms, however, rev...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700013246

    authors: Brown RG,MacCarthy B

    更新日期:1990-02-01 00:00:00

  • Mental health problems in the Gomel region (Belarus): an analysis of risk factors in an area affected by the Chernobyl disaster.

    abstract::The epidemiology of mental problems in the Gomel region in the republic of Belarus was studied in a two-stage survey of a broad based population sample (N = 1617), using the General Health Questionnaire (12-item version) and the Munich Diagnostic Checklist for DSM-III-R. The Gomel region is one of the areas that was m...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700037879

    authors: Havenaar JM,Van den Brink W,Van den Bout J,Kasyanenko AP,Poelijoe NW,Wholfarth T,Meijler-Iljina LI

    更新日期:1996-07-01 00:00:00

  • Bulimia nervosa: a 5-year follow-up study.

    abstract::Fifty patients with bulimia nervosa were followed up for a minimum length of 5 years. Standardized interviews, observer-rated instruments and self-rated questionnaires were employed both at entry and at completion of the follow-up period. After tracing, the positive response rate was 72%; one patient had died. At the ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700038526

    authors: Johnson-Sabine E,Reiss D,Dayson D

    更新日期:1992-11-01 00:00:00

  • Social anxiety in the eating disorders: a systematic review and meta-analysis.

    abstract::Social anxiety disorder is one of the most common comorbid conditions in eating disorders (EDs). The aim of the current review and meta-analysis is to provide a qualitative summary of what is known about social anxiety (SA) in EDs, as well as to compare levels of SA in those with EDs and healthy controls. Electronic d...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析

    doi:10.1017/S0033291718000752

    authors: Kerr-Gaffney J,Harrison A,Tchanturia K

    更新日期:2018-11-01 00:00:00

  • Risk markers for both chronic fatigue and irritable bowel syndromes: a prospective case-control study in primary care.

    abstract:BACKGROUND:Fatigue syndromes and irritable bowel syndrome (IBS) often occur together. Explanations include being different manifestations of the same condition and simply sharing some symptoms. METHOD:A matched case-control study in UK primary care, using data collected prospectively in the General Practice Research D...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709005601

    authors: Hamilton WT,Gallagher AM,Thomas JM,White PD

    更新日期:2009-11-01 00:00:00

  • Eating disorders: lessons from a cross-cultural study.

    abstract::Five hundred and eighty schoolgirls living in a small North Indian industrial town were screened using the EAT-26. Although twenty-nine per cent scored above the threshold for the questionnaire (greater than or equal to 20), closer scrutiny of the pattern of responses revealed misinterpretations of a large number of q...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700005675

    authors: King MB,Bhugra D

    更新日期:1989-11-01 00:00:00

  • Patterns of co-morbidity of eating disorders and substance use in Swedish females.

    abstract:BACKGROUND:Little is known about the association of eating disorder subtypes across multiple categories of substance use in population-based samples. We examined the association between eating disorders and substance use in a large population-based sample. METHOD:Female participants (n=13 297) were from the Swedish Tw...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709005662

    authors: Root TL,Pisetsky EM,Thornton L,Lichtenstein P,Pedersen NL,Bulik CM

    更新日期:2010-01-01 00:00:00

  • Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis.

    abstract:BACKGROUND:Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719002794

    authors: González-Ortega I,González-Pinto A,Alberich S,Echeburúa E,Bernardo M,Cabrera B,Amoretti S,Lobo A,Arango C,Corripio I,Vieta E,de la Serna E,Rodriguez-Jimenez R,Segarra R,López-Ilundain JM,Sánchez-Torres AM,Cuesta MJ,PEPs

    更新日期:2020-12-01 00:00:00

  • Cost-effectiveness of cognitive behavioural therapy, graded exercise and usual care for patients with chronic fatigue in primary care.

    abstract:BACKGROUND:Chronic fatigue is a common condition, frequently presenting in primary care. The aim of this study was to compare the cost-effectiveness of cognitive behavioural therapy (CBT) and graded exercise therapy (GET), and to compare therapy with usual care plus a self-help booklet (BUC). METHOD:Patients drawn fro...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291704001928

    authors: McCrone P,Ridsdale L,Darbishire L,Seed P

    更新日期:2004-08-01 00:00:00

  • Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder.

    abstract:BACKGROUND:Neurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related disorders represents a core feature of these illnesses, possibly a marker of underlying pathophysiology. Substantial overlap in domains of neuropsychological deficits has been reported among these disorders after illness onset. Howeve...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291710001042

    authors: Lewandowski KE,Cohen BM,Ongur D

    更新日期:2011-02-01 00:00:00

  • Comparison of alternative models for personality disorders.

    abstract:BACKGROUND:The categorical classification system for personality disorder (PD) has been frequently criticized and several alternative dimensional models have been proposed. METHOD:Antecedent, concurrent and predictive markers of construct validity were examined for three models of PDs: the Five-Factor Model (FFM), the...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706009482

    authors: Morey LC,Hopwood CJ,Gunderson JG,Skodol AE,Shea MT,Yen S,Stout RL,Zanarini MC,Grilo CM,Sanislow CA,McGlashan TH

    更新日期:2007-07-01 00:00:00

  • History of childhood sexual or physical abuse in Japanese patients with eating disorders: relationship with dissociation and impulsive behaviours.

    abstract:BACKGROUND:Empirical data regarding prevalence of sexual and physical abuse histories in Japanese patients with eating disorders is lacking, in contrast to Western countries. This study investigated the prevalence of traumatic events in Japanese patients with eating disorders, and examined the relationship between such...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799008557

    authors: Nagata T,Kiriike N,Iketani T,Kawarada Y,Tanaka H

    更新日期:1999-07-01 00:00:00

  • Does cognitive-behavioural therapy influence the long-term outcome of generalized anxiety disorder? An 8-14 year follow-up of two clinical trials.

    abstract:BACKGROUND:Generalized anxiety disorder is a common condition of excessive worry and tension which tends to run a chronic course associated with significant psychiatric and medical problems. Cognitive behaviour therapy (CBT) has been shown to be of clinical value in about 50% of cases with treatment gains maintained ov...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291702007079

    authors: Durham RC,Chambers JA,MacDonald RR,Power KG,Major K

    更新日期:2003-04-01 00:00:00