White-matter markers for psychosis in a prospective ultra-high-risk cohort.

Abstract:

BACKGROUND:Subjects at 'ultra high risk' (UHR) for developing psychosis have differences in white matter (WM) compared with healthy controls. WM integrity has not yet been investigated in UHR subjects in relation to the development of subsequent psychosis. Hence, we investigated a prospective cohort of UHR subjects comparing whole brain fractional anisotropy (FA) of those later developing psychosis (UHR-P) to those who did not (UHR-NP). METHOD:We recruited 37 subjects fulfilling UHR criteria and 10 healthy controls. Baseline 3 Tesla magnetic resonance imaging (MRI) scans and Positive and Negative Syndrome Scale (PANSS) ratings were obtained. UHR subjects were assessed at 9, 18 and 24 months for development of frank psychosis. We compared baseline FA of UHR-P to controls and UHR-NP subjects. Furthermore, we related clinical data to MRI outcome in the patient population. RESULTS:Of the 37 UHR subjects, 10 had transition to psychosis. UHR-P subjects showed significantly lower FA values than control subjects in medial frontal lobes bilaterally. UHR-P subjects had lower FA values than UHR-NP subjects, lateral to the right putamen and in the left superior temporal lobe. UHR-P subjects showed higher FA values, compared with UHR-NP, in the left medial temporal lobe. In UHR-P, positive PANSS negatively correlated to FA in the left middle temporal lobe. In the total UHR group positive PANSS negatively correlated to FA in the right superior temporal lobe. CONCLUSIONS:UHR subjects who later develop psychosis have differences in WM integrity, compared with UHR subjects who do not develop psychosis and to healthy controls, in brain areas associated with schizophrenia.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Bloemen OJ,de Koning MB,Schmitz N,Nieman DH,Becker HE,de Haan L,Dingemans P,Linszen DH,van Amelsvoort TA

doi

10.1017/S0033291709991711

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

1297-304

issue

8

eissn

0033-2917

issn

1469-8978

pii

S0033291709991711

journal_volume

40

pub_type

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