Abstract:
:The CANTAB battery of neuropsychological tests was used to compare the performance of 28 patients with unipolar depression with that of 22 age and IQ matched controls. The patients were impaired on almost all tests studied with deficits in pattern and spatial recognition memory, matching to sample, spatial span, spatial working memory and planning. Most of the patients showed at least some impairment and deficits were seen across cognitive domains. An important finding was the detrimental effect of failure on subsequent performance; having solved one problem incorrectly, patients were far more likely than controls to fail the subsequent problem. Superimposed on the general deficits, there were also specific deficits in executive tasks characteristic of frontostriatal dysfunction and deficits in mnemonic tasks characteristic of temporal lobe dysfunction. This combination of a specific form of motivational deficit, resulting in oversensitivity to negative feedback, and superimposed specific neuropsychological deficits were correlated with severity of depression. The most significant correlations were seen between mnemonic deficits and clinical rating scores. Comparisons of the deficits seen in the depressed patients in this study with other patient groups assessed with the CANTAB neuropsychological battery, showed that one of the hypotheses of the neuropsychological deficits in depression, that of "frontosubcortical' or "frontostriatal' dysfunction, was not supported. These findings are discussed in relation to the likely neural substrates of depression.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Elliott R,Sahakian BJ,McKay AP,Herrod JJ,Robbins TW,Paykel ESdoi
10.1017/s0033291700035303subject
Has Abstractpub_date
1996-09-01 00:00:00pages
975-89issue
5eissn
0033-2917issn
1469-8978journal_volume
26pub_type
杂志文章abstract::The powerful genome-wide association studies (GWAS) revealed common mutations that increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority were not known to be functional or associated with these illnesses. To help fill this gap, their impact on human brain structure and functio...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291715000537
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The overlap between anxiety and major depressive disorder (MDD), the increased risk for depression and anxiety in offspring of depressed parents, the sequence of onset with anxiety preceding MDD, and anxiety as a predictor of depression are well established. The specificity of anxiety disorders in these rela...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708002894
更新日期:2008-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713002663
更新日期:2014-07-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700000635
更新日期:1987-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700017001
更新日期:1990-08-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700026878
更新日期:1994-02-01 00:00:00
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journal_title:Psychological medicine
pub_type: 历史文章,杂志文章
doi:10.1017/s0033291700026799
更新日期:1994-02-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001161
更新日期:2016-08-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700053381
更新日期:1981-02-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003220
更新日期:2020-08-24 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717003646
更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1017/S0033291712001419
更新日期:2013-03-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000203
更新日期:2015-07-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001517
更新日期:2014-04-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700051643
更新日期:1983-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004183
更新日期:2020-12-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709990791
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:The clinical picture of schizophrenia is frequently worsened by manifestations of impulsivity. However, the neural correlates of impulsivity in this disorder are poorly known. Although impulsivity has been related to disturbances of the neural processes underlying response inhibition, no studies have yet exa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710000796
更新日期:2011-02-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029275
更新日期:1977-05-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700027835
更新日期:1994-08-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
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更新日期:2003-07-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291713002985
更新日期:2014-09-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700015245
更新日期:1984-08-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704002387
更新日期:2004-10-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700029846
更新日期:1991-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700014331
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Sertraline has a proved efficacy in post-traumatic stress disorder (PTSD), but it is unknown which symptoms respond or in what sequence this occurs. Such information might be useful clinically and heuristically. METHOD:The study examined the effects of sertraline on the individual symptoms of PTSD. It also ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702005469
更新日期:2002-05-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002118
更新日期:2019-07-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002184
更新日期:2016-03-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000604
更新日期:2020-04-03 00:00:00